Gerontechnology最新文献

{"title":"A conceptual exploration of service delivery system for activation of rehabilitation and sports technology with the elderly","authors":"A. Lee, Shi-Hyun Park, S.-S. Kim, J.H. Kim, Y. Koo, H. Kwon, S. H. Ho, Yung-Hwi Bae","doi":"10.4017/gt.2022.21.s.695.pp6","DOIUrl":"https://doi.org/10.4017/gt.2022.21.s.695.pp6","url":null,"abstract":"","PeriodicalId":38859,"journal":{"name":"Gerontechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46319476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socially assistive robot-based alerts on indoor and outdoor air-quality for patients with chronic obstructive pulmonary disease","authors":"Y. Hwang, H. Jo, W. J. Kim, S. Sin","doi":"10.4017/gt.2022.21.s.593.4.sp3","DOIUrl":"https://doi.org/10.4017/gt.2022.21.s.593.4.sp3","url":null,"abstract":"","PeriodicalId":38859,"journal":{"name":"Gerontechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46346215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systems biology of human microbiome for the prediction of Alzheimer's disease prognosis","authors":"S. J. Lee, K. H. Lee","doi":"10.4017/gt.2022.21.s.821.5.sp3","DOIUrl":"https://doi.org/10.4017/gt.2022.21.s.821.5.sp3","url":null,"abstract":"","PeriodicalId":38859,"journal":{"name":"Gerontechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47023002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein dynamics-based control of proteotoxicity in neurodegenerative diseases","authors":"S. Lee","doi":"10.4017/gt.2022.21.s.808.sp3","DOIUrl":"https://doi.org/10.4017/gt.2022.21.s.808.sp3","url":null,"abstract":"one their key Herein toxicity is defined as all the pathological changes that from accumulation, mis-localization, and/or oligomerization of disease-associated toxic proteins such as α-synuclein in PD, polyglutamine (polyQ)-containing proteins in polyQ diseases (e.g., HD), and dipeptide repeat proteins and TDP-43 in ALS. Conventional understanding of protein toxicity is that protein toxicity simply reflects the amount of accumulated toxic proteins. For this our challenges done so far against protein toxicity have been based on a simple strategy of reducing the amount of toxic proteins. However, the exact nature of protein toxicity appears to be much more complex than we have conceived, and thus new paradigm for understanding protein toxicity is highly demanded. In this talk, I will present our current efforts to understand exact nature of proteotoxicity in neurodegenerative diseases and potential solutions that can effectively control proteotoxicity, named as protein dynamics-based control of proteotoxicity. I will tell you about our recent study unveiling cellular intrinsic mechanisms regulating nucleocytoplasmic transport of TDP-43 in neurons. Method We used Drosophila as a primary model to study intrinsic regulatory mechanisms underlying nucleocytoplasmic transport of TDP-43. We used various experimental techniques, such as genetic analyses, immunohistochemistry, behavioral analyses, neuronal imaging, and FRAP. Results and discussion Dysregulation of protein localization, often observed in various neurodegenerative diseases, impairs functionality of the protein, alters the pool of its interactors, or both, thereby leading to cellular toxicity. TDP-43, one of well-characterized disease-associated proteins in Lou Gehrig’s disease, are known to translocate from the nucleus to the cytoplasm in the disease condition, which is considered as a hallmark of the disease. Thus, unveiling the regulatory mechanism of intracellular localization of TDP-43 is very important to better understand the pathogenesis of Lou Gehrig’s disease. However, still our understanding on the neuronal intrinsic program regulating the intracellular localization of TDP-43 remains mostly unclear. Interestingly, we observed that the intracellular localization of TDP-43 dynamically changes even in normal condition of a specific neuronal cell type, named Drosophila classIV da sensory neurons, along development. We first identified intracellular Ca2+ level to be critical for the translocation of TDP-43 between the nucleus and the cytoplasm. Additionally, through fluorescence recovery after photobleaching (FRAP) imaging analyses, we found that the nuclear entry of TDP-43 is critically controlled by intracellular Ca2+ level. Further genetic analyses identified Calpain and Importin a3 as mediators of Ca2+-dependent control of TDP-43 translocation in classIV da sensory neurons. Finally, by modulating Ca2+-Calpain-Importing a3 pathway, we could significantly modify the locomotive phenotyp","PeriodicalId":38859,"journal":{"name":"Gerontechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48929666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Available technology applications to support sleep for people with dementia and their informal caregiver","authors":"C. Huisman, H. Kort","doi":"10.4017/gt.2022.21.s.530.2.sp1","DOIUrl":"https://doi.org/10.4017/gt.2022.21.s.530.2.sp1","url":null,"abstract":"","PeriodicalId":38859,"journal":{"name":"Gerontechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49494876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supporting home- and community-based organization activities through a customized videoconferencing platform","authors":"G. Mois, S. Shende, R. Mudar, D. Myers, W. A. Rogers","doi":"10.4017/gt.2022.21.s.575.opp4","DOIUrl":"https://doi.org/10.4017/gt.2022.21.s.575.opp4","url":null,"abstract":"), user friendly (e.g., large fonts, labeled buttons), supportive of social interactions (e.g., diverse engaging event content), and supportive of users’ privacy (e.g., HIPPA Compliant). They identified potential benefits of using the platform for staff applications such as trainings and administrative tasks (e.g., review and edit documents). Most challenges noted by participants were related to the introduction of a new platform: motivating people to adopt something new and potential staff burden to replace the platform they are currently using. Our research provides key insights pertaining to the potential benefits and concerns of implementing of a video conferencing platform to HCBOs. Our findings informed the design features needed to support delivery of social engagement programs by HCBOs. Furthermore, these insights informed development of a dashboard aimed to help organize and assist with the delivery of social engagement interventions.","PeriodicalId":38859,"journal":{"name":"Gerontechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45576969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can a communication robot contribute to the good relationship between the elderly with dementia and the staff?","authors":"T. Yamaguchi, Y. Saito, F. Nakamura, C. Maeda","doi":"10.4017/gt.2022.21.s.673.opp4","DOIUrl":"https://doi.org/10.4017/gt.2022.21.s.673.opp4","url":null,"abstract":"","PeriodicalId":38859,"journal":{"name":"Gerontechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42592986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential negative effects of neuromuscular electrical stimulation: Does it affect static balance and proprioception?","authors":"J. Je, W. Choi","doi":"10.4017/gt.2022.21.s.536.opp3","DOIUrl":"https://doi.org/10.4017/gt.2022.21.s.536.opp3","url":null,"abstract":"","PeriodicalId":38859,"journal":{"name":"Gerontechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48258811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomechanical effects of a mechanical lift on the risk of low back injury during transfers from bed to wheelchair","authors":"W. Choi, S. Lee, K. Lim","doi":"10.4017/gt.2022.21.s.527.5.sp3","DOIUrl":"https://doi.org/10.4017/gt.2022.21.s.527.5.sp3","url":null,"abstract":"","PeriodicalId":38859,"journal":{"name":"Gerontechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47864083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle activation pattern to distinguish balance recovery from falls at loss of balance","authors":"J. Park, S. Kim, W. Choi","doi":"10.4017/gt.2022.21.s.506.opp3","DOIUrl":"https://doi.org/10.4017/gt.2022.21.s.506.opp3","url":null,"abstract":"","PeriodicalId":38859,"journal":{"name":"Gerontechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43903701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}