Frontiers in Emergency Medicine最新文献_第3页

Efficacy and safety of sofosbuvir in the treatment of SARS-CoV-2: an open label phase II trial 索非布韦治疗SARS-CoV-2的有效性和安全性:一项开放标签II期试验

Frontiers in Emergency Medicine Pub Date : 2023-01-16 DOI: 10.18502/fem.v7i1.11697

M. Alavi-Moghaddam, Mohammad Sistanizad, M. Haghighi, Tahereh Sabaghian, Bahare Gholami Chaboki, Zahra Soroureddin

{"title":"Efficacy and safety of sofosbuvir in the treatment of SARS-CoV-2: an open label phase II trial","authors":"M. Alavi-Moghaddam, Mohammad Sistanizad, M. Haghighi, Tahereh Sabaghian, Bahare Gholami Chaboki, Zahra Soroureddin","doi":"10.18502/fem.v7i1.11697","DOIUrl":"https://doi.org/10.18502/fem.v7i1.11697","url":null,"abstract":"Objective: \u0000Despite the worldwide spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), an effective specific antiviral treatment for coronavirus disease of 2019 (COVID-19) is yet to be identified .We did this study to investigate the safety and efficacy of sofosbuvir as antiviral therapy among hospitalized adult patients with SARS-CoV-2. \u0000Methods: \u0000Patients were randomized into intervention arm receiving sofosbuvir or comparison arm receiving usual antiviral agents in addition to standard of care. The primary end point of the study was clinical recovery as defined by normal body temperature and normal oxygen saturation. The main secondary outcome was all-cause mortality during the admission in hospital or within 14 days after discharge if applicable. Reports of severe adverse events were observed in the intervention arm. \u0000Results: \u0000Fifty-seven patients enrolled into either the clinical trial arm (n=27) or the comparison arm (n=30). Primary outcome was achieved by 24 (88.9%) and 10 (33.3%) in the intervention and comparison arms, respectively. Median hospital length of stay was significantly shorter in the intervention arm (10 days [IQR: 5-12] vs. 11.5 days [IQR: 8.5-17.75], P = 0.016). \u0000All-cause mortality was two and thirteen in intervention and comparison groups, respectively. No serious adverse events were reported by the patients receiving sofosbuvir during the study. \u0000Conclusion: \u0000Among patients hospitalized with SARS-CoV-2, those who received sofosbuvir had more clinical recovery rate and had a shorter hospital length of stay than those who received usual antiviral agents in the study and these differences were statistically significant. \u0000 ","PeriodicalId":385617,"journal":{"name":"Frontiers in Emergency Medicine","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124210442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central retinal artery occlusion presenting with headache and sudden painless blurring of vision 视网膜中央动脉闭塞，表现为头痛和突然无痛性视力模糊

Frontiers in Emergency Medicine Pub Date : 2023-01-16 DOI: 10.18502/fem.v7i1.11700

Devendra Richhariya, Rakesh K. Gupta

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The meaning and importance of recording right-sided precordial leads 记录右侧心前导联的意义和重要性

Frontiers in Emergency Medicine Pub Date : 2022-08-31 DOI: 10.18502/fem.v6i4.10447

Jerry W. Jones, Facep Faaem

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Abdominal pain with oral pigmentations as a clue for Peutz-Jeghers syndrome 伴有口腔色素沉着的腹痛作为Peutz-Jeghers综合征的线索

Frontiers in Emergency Medicine Pub Date : 2022-08-31 DOI: 10.18502/fem.v6i4.10445

Mohammad Ebrahim Kalantari, Hossein Savadi, Hamzeh Sherafati, A. Bagherzadeh, T. Zandbaf

引用次数: 0

Wegner's granulomatosis presented as fever and anuria 韦格纳肉芽肿病表现为发热和无尿

Frontiers in Emergency Medicine Pub Date : 2022-08-31 DOI: 10.18502/fem.v6i4.10446

Mohammad Mahmoud Bourini, Basel Bassam Hasasnah, Afnan W M Jobran, Baraa Matoor, A. Benmelouka

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Telemedicine and natural disasters: various services, requirements, challenges, and general framework 远程医疗和自然灾害:各种服务、需求、挑战和总体框架

Frontiers in Emergency Medicine Pub Date : 2022-08-31 DOI: 10.18502/fem.v6i4.10440

N. Mohammadzadeh, Soheila Saeedi, S. Rezayi

{"title":"Telemedicine and natural disasters: various services, requirements, challenges, and general framework","authors":"N. Mohammadzadeh, Soheila Saeedi, S. Rezayi","doi":"10.18502/fem.v6i4.10440","DOIUrl":"https://doi.org/10.18502/fem.v6i4.10440","url":null,"abstract":"Providing early health care services in natural disaster is one of the essential applications of telemedicine. This narrative review aims to investigate the applications, advantages and challenges of telemedicine in natural disaster-stricken areas. Medline (through PubMed), Web of Science (WOS), and Scopus databases were searched for related articles published from beginning to 2022. The keywords used for the search included \"telemedicine\" and \"natural disaster.\" After removing duplicate papers, irrelevant review articles and letters to editors, 44 relevant papers were selected and reviewed. Information sharing through audio, visual, and data-oriented services is among critical approaches that telemedicine services mainly use. Teleconsultation, tele-education, remote interpretation, tele-psychiatry, and tele-surgery are among measures that can be implemented in emergencies like earthquakes, fires, floods, storms, and drought. The fundamental requirements of a telemedicine-oriented system for providing emergency services in natural disasters include wireless scales, conversation tools, blood pressure monitor, respiratory rate monitor, spo2 sensor, glucometer, portable ultrasound unit, wearable thermometers, virtual stethoscopes, portable three leads electrocardiograph monitor, and digital otoscopes. Simple telemedicine systems can have many advantages in the natural disasters. However, the main challenge in this regard is to adapt the necessary communication systems to a telemedicine paradigm. Another critical challenge is to interpret and apply the summary of acquired information and the inevitable interaction outcomes at the required time and place.","PeriodicalId":385617,"journal":{"name":"Frontiers in Emergency Medicine","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121316486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Herpes simplex encephalitis after receiving COVID-19 vaccine; A case report 接种COVID-19疫苗后发生单纯疱疹脑炎;病例报告

Frontiers in Emergency Medicine Pub Date : 2022-08-31 DOI: 10.18502/fem.v6i4.10443

Z. Ebadi, F. Ghadiri, E. Asadollahzade, A. Moghadasi

引用次数: 1

Incident Reporting Systems: How did we get here and where should we go? A narrative review 事件报告系统:我们是如何发展到今天的?我们应该如何发展?叙述性回顾

Frontiers in Emergency Medicine Pub Date : 2022-08-31 DOI: 10.18502/fem.v6i4.10441

Kenzie Kao, Saad Ahmed, Reshma Pyala, Mohammed Alsabri

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Spontaneous renal subcapsular hematoma; a case report and reviewing management options 自发性肾包膜下血肿;一份病例报告和审查管理方案

Frontiers in Emergency Medicine Pub Date : 2022-08-31 DOI: 10.18502/fem.v6i4.10444

M. Eid, T. Jaiganesh

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Management of pregnant trauma patients in emergency department: a narrative review to provide the most recent evidence 急诊科妊娠创伤患者的管理:提供最新证据的叙述性回顾

Frontiers in Emergency Medicine Pub Date : 2022-08-31 DOI: 10.18502/fem.v6i4.10442

Roghayeh Mousazadeh, M. Dehdilani

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