Muhammad Sholikhuddin Nafi’, Tri Hartini Yuliawati, Prijati Sri Irawati, Nurina Hasanatuludhhiyah
{"title":"The Contribution of Sex Difference on Different Liver Histopathology Between Male and Female Mice After Oral Administration of Caffeine","authors":"Muhammad Sholikhuddin Nafi’, Tri Hartini Yuliawati, Prijati Sri Irawati, Nurina Hasanatuludhhiyah","doi":"10.20473/iabj.v2i2.162","DOIUrl":"https://doi.org/10.20473/iabj.v2i2.162","url":null,"abstract":"Background : There are several studies reporting the effect of caffeine on liver histopathology, but it remains controversy. The laboratory animal used in those studies were predominantly male, whereas there is contribution of sex difference on different liver reaction to xenobiotic between male and female subject.\u0000Objective : It is necessary to conduct a study to explore the differences between the liver histopathology of male and female mice after oral administration of caffeine.\u0000Methods : This study used 36 mice (Mus musculus) that were divided into 4 groups: male & female untreated groups and male & female treated groups which were orally administered with caffeine 0.4 mg / 20 gramBW daily for 30 days. At the end of treatment, mice were euthanized and dissected. Histopathological examination was done to determine the percentage of liver cell death of each group.\u0000Results: The percentage of liver cell deathin female treated group was higher than male treated group (p = 0.0001). But there was no significant difference of liver cells death between male control and treated group and between female control and treated group.\u0000Conclusion : There was significant difference in liver histopathology between male and female mice after oral administration of caffeine.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126515796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Albert Salim, Yukhi Kurniawan, I. G. N. Pramesemara
{"title":"Relationship Between Smoker Male Partner and Intrauterine Insemination Success in Kasih Ibu General Hospital Denpasar","authors":"Albert Salim, Yukhi Kurniawan, I. G. N. Pramesemara","doi":"10.20473/iabj.v2i2.163","DOIUrl":"https://doi.org/10.20473/iabj.v2i2.163","url":null,"abstract":"Background : Assisted reproductive technology, one of which is intrauterine insemination (IUI) allows infertile couples to get pregnant. The pregnancy success of IUI procedure varies among individuals.\u0000Objective: The study aim is to determine whether there is a relationship between smoker male partners and IUI success.\u0000Methods: This research is an analytic study with cross-sectional approach conducted at Kasih Ibu General Hospital Denpasar with purposive sampling technique. There are 35 male couples aged 25-50 years who underwent the IUI procedure selected as samples. The research data was gathered from patient's medical records and statistically analyzed using the Chi-Square test.\u0000Results: The study found that of the 35 samples, 13 (37.1%) were smokers, whereas 22 (62.9%) male partners were non-smokers. There were 6 (17.1%) samples’ partners who were pregnant after undergoing the IUI procedure, and 29 (82.9%) samples’ partners were not pregnant. It was found that there was no significant relationship between male partner smokers and the success of IUI at Kasih Ibu General Hospital Denpasar (p=0.832). However, in descriptive analysis and relative risk calculation, smoker male partner is less likely to achieve pregnancy than non-smoker’s male partner (RR=0.85).\u0000Conclusion: Smoker male partners may not contribute to IUI success. Further studies should be done with a higher number of samples, multicenter, and more controlled risk factors to make it more accurate in determining the relationship.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115768552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Technology Updates in Male Infertility Management","authors":"A. Hinting, Agustinus Agustinus","doi":"10.20473/iabj.v2i2.138","DOIUrl":"https://doi.org/10.20473/iabj.v2i2.138","url":null,"abstract":"Background: Technologies are replacing manpower many fields including medical field. Several devices have been marketed for replacing/reducing manpower in the medical field including male infertility. Here we reviewed several technologies that developed in male infertility.\u0000Review: Computer assisted sperm analysis (CASA), Automatic assessment of biochemical marker of seminal plasma, B-mode ultrasound, and automatic sperm cryopreservation can be applied routinely. Several updates i.e. automatic histopathology assessment, ultrasound strain elastography, magnetic resonance imaging (MRI) stronger than 3.0 T, Artificial intelligence for predicting the presence of sperm in azoospermia cases, automatic sperm selection, and automatic intracytoplasmic sperm injection (ICSI) need more studies before their application.\u0000Summary: Prudent choice based on valid studies is needed in order to give a comprehensive management to patient with male infertility without using useless technology.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126823341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mikhael San Putra Wijanarko, Cathelin Stella, Gian Oktavianto
{"title":"Adult Male’s Penile Size Measurement and Its Affecting Factors","authors":"Mikhael San Putra Wijanarko, Cathelin Stella, Gian Oktavianto","doi":"10.20473/iabj.v2i2.124","DOIUrl":"https://doi.org/10.20473/iabj.v2i2.124","url":null,"abstract":"Background: In the general population, it is estimated that 91% of adult males perceive their penile size to be smaller than average. Concern about penile size can affect one’s self-esteem, which then affects its sexual function, satisfaction, as well as physical and mental health. Therefore, accurate penile measurements are needed for clinical and academic purposes.\u0000Reviews: Measurement of penile size can be performed in an erect, stretched, even flaccid condition. However, from various researches, there is no standardization of such a measurement method. Various researches have carried out average penile measurement but many factors can affect these results such as race, genital conditions, systemic diseases, surgical procedures, and aging. \u0000Summary: There is no internationally agreed way of measuring an adult male's penis and many other factors can make the results of penile measurements vary. Proper measurement and finding out the right average of penile size in adult male with regard to other affecting factors, will be indispensable for both clinical and academic purposes.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134124527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anak Agung Sagung Ari Lestari, I. G. N. Pramesemara, Yukhi Kurniawan
{"title":"Relationship Between Waist Circumference and The Event of Andropause in Male Employees in Government Institutions of Badung Regency","authors":"Anak Agung Sagung Ari Lestari, I. G. N. Pramesemara, Yukhi Kurniawan","doi":"10.20473/iabj.v2i1.37","DOIUrl":"https://doi.org/10.20473/iabj.v2i1.37","url":null,"abstract":"Background: Andropause occurs with slow development and is a physiological process in males. Andropause symptoms arise vary in individuals. One of the factors that influence these symptoms is obesity, especially central obesity with a waist circumference of >90 cm.\u0000Objective: The purpose of this study is to show the relationship between waist circumference and the event of andropause.\u0000Methods: This research is an analytical study with a cross-sectional study approach conducted in one of the government institutions of Badung Regency, Bali Province. The sampling technique used was purposive sampling. The subjects consisted of 40 male employees at aged around 35-60 years. The research data were obtained from filling out the Androgen Deficiency in Aging Male (ADAM) score questionnaire and direct measurement of waist circumference. The statistical analysis used was the Chi-Square test.\u0000Results: The results showed that from 40 subjects, 23 (57.5%) subjects had a waist circumference of >90 cm, and a normal waist circumference of <90 cm in 17 (42.5%) subjects. There were 22 subjects (55.0%) who experienced andropause and 18 (45.0%) subjects who did not experience andropause. It was found that there was a significant relationship between waist circumference and the event of andropause among male employees in government institutions of Badung Regency (p = 0.001, OR = 11.7).\u0000Conclusion: The study has found that higher in waist circumference may contribute in the event of andropause. For further studies should takes a higher number of subjects to make it more accurate in wider population.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128318247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexander Petra Sihite, I. G. N. Pramesemara, I. W. Surudarma
{"title":"Relationship of Type 2 Diabetes Mellitus Duration with The Occurrence of Erectile Dysfunction at Puskesmas Denpasar Barat I","authors":"Alexander Petra Sihite, I. G. N. Pramesemara, I. W. Surudarma","doi":"10.20473/iabj.v2i1.45","DOIUrl":"https://doi.org/10.20473/iabj.v2i1.45","url":null,"abstract":"Background: Type 2 diabetes mellitus is a metabolic disease that characterized by high blood sugar levels. This condition is often not noticed immediately and usually patient starting to realize it when complications have been occurred. A long-term complication of type 2 DM that occurred in men is erectile dysfunction (ED). ED is a condition when a person is unable to achieve or maintain an erection for sexual intercourse. One factor that influence the occurrence of ED and its severity in type 2 DM patients is the duration of the disease.\u0000Objective: The aim of this study was to determine the relationship of type 2 DM duration and the occurrence of ED.\u0000Methods: This study is an observational analytic cross-sectional study conducted at the Puskesmas (Public Health Center) Denpasar Barat I. The research data was obtained through medical record data and fill the International Index of Erectile Function (IIEF-5) questionnaire on 36 type 2 DM patients aged around 40-60 years. The statistical analysis used was Fisher's exact test.\u0000Results: The results showed that of the 36 samples, 19 (52.8%) samples had type 2 DM <24 months and 17 (47.2%) samples had type 2 DM >24 months. It was found that 5 (13.9%) samples did not experience ED while the rest experienced ED with different severity. There was a significant relationship between the type 2 DM duration and the occurrence of erectile dysfunction at Puskesmas Denpasar Barat I (p = 0.022).\u0000Conclusion: Study has found that type 2 DM patients with the longer duration (>24 months) have a higher occurrence of ED and tended to be more severe compared to those with shorter duration (<24 months). Further studies should be performed with higher number of patients and more controlled risk factor so it will be more accurate in determining the relationship between the duration of type 2 DM and ED.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122562265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rossy Sintya Marthasari, A. Marlinata, R. I’tishom
{"title":"Vaginismus and Infertility","authors":"Rossy Sintya Marthasari, A. Marlinata, R. I’tishom","doi":"10.20473/iabj.v1i2.33","DOIUrl":"https://doi.org/10.20473/iabj.v1i2.33","url":null,"abstract":"Background: Vaginismus described as persistent or reccurent difficulties for woman to allow vaginal entry of a penis, a finger or there is often avoidance and anticipation, fear or experience of pain, along with variable involuntary contraction of pelvic muscle. \u0000Reviews: Vaginismus can lead to unconsummated marriage, and also can be hidden caused of infertility. Vaginismus can be categorized as primary (lifelong), patient has never experiences non painful intercourse or secondary (acquired), patient has previously normal but now experience pain. Vaginismus should be considered as part of differential diagnosis in patient who has no satisfaction in sexual intercourse or do not tolerate penetration. Diagnosis is made by making a good history taking. A variety of intervention have been suggested in some case report study. Effective treatment to vaginismus include sex education, psychosexual therapy, systematic desensitization, anxiolytic and Botulinum Toxin (botox). While there are few controlled studies on the management of vaginismus, they are limited and poorly designed. \u0000Summary: Goal of treatment is not only to achieve pregnancy but also increase quality of life. Either natural or assisted, vaginismus is still have to be cured. A great teamwork is required to successfull therapy.","PeriodicalId":385352,"journal":{"name":"Indonesian Andrology and Biomedical Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128204143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}