Biosimilars [Working Title]最新文献

筛选
英文 中文
Biosimilars in Inflammatory Bowel Diseases: General Concepts and Clinical Implications 炎症性肠病的生物类似药:一般概念和临床意义
Biosimilars [Working Title] Pub Date : 2021-12-20 DOI: 10.5772/intechopen.100452
Sabrina Rodrigues de Figueiredo, Ana Elisa Rabe Caon, R. Saad Hossne, F. Vieira Teixeira, Sabine Murakami Winkler, N. Sousa Freitas Queiroz
{"title":"Biosimilars in Inflammatory Bowel Diseases: General Concepts and Clinical Implications","authors":"Sabrina Rodrigues de Figueiredo, Ana Elisa Rabe Caon, R. Saad Hossne, F. Vieira Teixeira, Sabine Murakami Winkler, N. Sousa Freitas Queiroz","doi":"10.5772/intechopen.100452","DOIUrl":"https://doi.org/10.5772/intechopen.100452","url":null,"abstract":"The treatment of inflammatory bowel disease (IBD) has changed over time with the increasing use of biologics to achieve therapeutic goals. As a result, the cost of treatment increased considerably, making it necessary to develop strategies that could increase access to biological therapies. In this scenario, the biosimilars were developed with the aim of reducing costs, maintaining safety and efficacy compared to the originator. Initially, its use in IBD was based on the extrapolation of studies in other specialties, such as rheumatology. More recently, studies in inflammatory bowel disease have emerged, with favorable results for its use. It is known that there are still knowledge gaps in the use of biosimilars and more experience is needed to increase clinicians’ confidence in their clinical practice. This chapter proposes a review of what is currently known about biosimilars in IBD. It discusses about aspects such as safety, efficacy, interchangeability, immunogenicity and switches.","PeriodicalId":383787,"journal":{"name":"Biosimilars [Working Title]","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127883483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Rheumatic Diseases and Biosimilars: Evidence about Switch from Originators to Biosimilars in the Real Life 风湿病和生物仿制药:现实生活中从发起人转向生物仿制药的证据
Biosimilars [Working Title] Pub Date : 2021-10-20 DOI: 10.5772/intechopen.100128
Maria Chiara Ditto, S. Parisi, R. Talotta, M. Priora, R. Borrelli, E. Fusaro
{"title":"Rheumatic Diseases and Biosimilars: Evidence about Switch from Originators to Biosimilars in the Real Life","authors":"Maria Chiara Ditto, S. Parisi, R. Talotta, M. Priora, R. Borrelli, E. Fusaro","doi":"10.5772/intechopen.100128","DOIUrl":"https://doi.org/10.5772/intechopen.100128","url":null,"abstract":"Biosimilars are broadly available for the treatment of several diseases including inflammatory arthritis. Thanks to biosimilars it has been possible to treat a greater number of rheumatic patients who previously were undertreated due to the high cost of originators, in several countries. There are a lot of data from double blind, randomized, controlled clinical trials, especially on TNF inhibitors (TNFi), concerning the maintenance of clinical efficacy after switching from originators to biosimilars; therefore, such a transition is increasingly encouraged both in the US and Europe mainly for economic reasons. However, despite the considerable saving, such shifts to biosimilar drugs are still being debated, principally over their ethical implications. Since the drugs are similar but not identical, the main issues are related to the possibility to compare the adverse events and/or the lack of efficacy and, to date, the variability in effectiveness for a single patient remains an unpredictable datum before effecting the switch. Despite encouraging data about the maintenance of efficacy and safety after the switch, there are many reports of discontinuation due both lack of efficacy or and adverse events. In this chapter we aim at showing the disease activity trend and the safety after the transition to TNF-i biosimilars in patients with rheumatic diseases in real life..","PeriodicalId":383787,"journal":{"name":"Biosimilars [Working Title]","volume":"160 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127085668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Monoclonal Antibodies for Cancer Treatment 单克隆抗体用于癌症治疗
Biosimilars [Working Title] Pub Date : 2021-07-20 DOI: 10.5772/INTECHOPEN.97915
A. Livinalli, T. Galvão
{"title":"Monoclonal Antibodies for Cancer Treatment","authors":"A. Livinalli, T. Galvão","doi":"10.5772/INTECHOPEN.97915","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.97915","url":null,"abstract":"Therapeutic monoclonal antibodies have emerged in the 1990 decade as an important option for cancer treatment. These molecules have a diverse set of clinically relevant antitumor mechanisms, directly targeting tumor cells. It has been established as “standard of care” for several human cancers. This chapter reviews the use of monoclonal antibodies in oncology and introduces available biosimilars. The requirements for biosimilar antibody development, mechanisms of action and current clinical applications for cancer treatment is also presented.","PeriodicalId":383787,"journal":{"name":"Biosimilars [Working Title]","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116733918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信