Pediatric Hematology/Oncology and Immunopathology最新文献

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The treatment of relapsed/refractory anaplastic large cell lymphoma expressing the anaplastic lymphoma kinase: a single-center experience 表达间变性淋巴瘤激酶的复发/难治性间变性大细胞淋巴瘤的治疗:单中心经验
Pediatric Hematology/Oncology and Immunopathology Pub Date : 2023-02-14 DOI: 10.24287/1726-1708-2023-22-1-22-31
A. N. Galimov, E. Lepik, A. Kozlov, A. G. Gevorgian, I. Kazantsev, T. Yukhta, V. Baikov, A. Shvetsov, I. Nikolaev, P. Tolkunova, N. Mikhaylova, K. Lepik, Y. Punanov, A. Kulagin, L. Zubarovskaya
{"title":"The treatment of relapsed/refractory anaplastic large cell lymphoma expressing the anaplastic lymphoma kinase: a single-center experience","authors":"A. N. Galimov, E. Lepik, A. Kozlov, A. G. Gevorgian, I. Kazantsev, T. Yukhta, V. Baikov, A. Shvetsov, I. Nikolaev, P. Tolkunova, N. Mikhaylova, K. Lepik, Y. Punanov, A. Kulagin, L. Zubarovskaya","doi":"10.24287/1726-1708-2023-22-1-22-31","DOIUrl":"https://doi.org/10.24287/1726-1708-2023-22-1-22-31","url":null,"abstract":"Anaplastic large cell lymphoma (ALCL) expressing the anaplastic lymphoma kinase (ALK) (ALK+ ALCL) is a rare type of lymphoma which comprises 10-15% of all non-Hodgkin lymphomas in children and 2–3% in young adults. Relapsed/refractory disease occurs even more rarely (25–40% of all cases). There is as yet no standard treatment for relapsed/refractory ALK+ ALCL. Patients with ALK+ ALCL usually present at advanced stages of the disease with extranodal involvement (skin, soft tissues, bones, lungs, liver, spleen and bone marrow) and B symptoms. ALK-positive ALCL affects males more often than females. There are two morphological variants: the common type (65% of cases) and the non-common type which is associated with a poorer prognosis. ALK+ ALCLs are often associated with t(2;5) and t(1;2), resulting in the formation of the NPM-ALK and the TPM3-ALK fusion proteins, respectively. Data about the treatment of relapsed/refractory ALK+ ALCL are limited. Earlier, targeted therapies (brentuximab vedotin (BV), ALK inhibitors) and risk-adapted chemotherapy followed by hematopoietic stem cell transplantation (HSCT) for remission consolidation were shown to be highly effective. A total of 15 patients with relapsed/refractory ALK+ ALCL were treated at the R.M. Gorbacheva Research Institute starting from 2002. Fourteen (93%) patients had ALK-positive ALCL of common morphology and one (7%) patient had the non-common variant (histiocytic). The study was approved by the Independent Ethics Committee and the Scientific Council of the Pavlov University. The expression of CD3 on tumor cells was assessed (CD3 positive: n = 4 (27%), CD3 negative: n = 8 (53%), no data: n = 3 (20%). The median age at the diagnosis was 26 years (11 months– 37 years). The median follow-up from the diagnosis was 9 years (1–19 years). Nine (60%) patients were aged > 18 years and six (40%) patients were aged < 18 years. There were 10 (67%) males and 5 (33%) females. At onset, 2 (13%) patients were diagnosed with early-stage disease (stage II), while the others were diagnosed with advanced-stage disease: 2 (13%) patients had stage III disease and 11 (74%) had stage IV disease. Staging was performed according to the St. Jude staging system (in children) and the Ann Arbour staging classification (in adults). Thirteen (86%) patients had extranodal involvement. Four (27%) patients had refractory disease (progression within the first three months or the absence of complete remission after the first-line treatment) and the rest 11 (73%) patients had recurrent ALK-positive ALCL. Six patients developed early relapse (< 12 months after remission was achieved); 5 patients had late relapse (after > 12 months of remission); local (1 site) and systemic relapses were diagnosed in 7 and 4 patients, respectively. Our patients received from 2 to 7 lines of treatment (the median is 4). In the first line of therapy, the patients were treated according to NHL-BFM based regimens (n = 9; 60%), the CHOP (n = 5; 33%), a","PeriodicalId":38370,"journal":{"name":"Pediatric Hematology/Oncology and Immunopathology","volume":"80 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84119355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The use of inotuzumab ozogamicin in children with relapsed/refractory B-lineage acute lymphoblastic leukemia 在复发/难治性b系急性淋巴细胞白血病患儿中使用inotuzumab ozogamicin
Pediatric Hematology/Oncology and Immunopathology Pub Date : 2023-02-14 DOI: 10.24287/1726-1708-2023-22-1-46-52
D. Evstratov, A. D. Shutova, Y. Y. Dyakonova, S. Radygina, Y. Abugova, L. K. Anderzhanova, L. A. Vavilova, D. Litvinov, G. Novichkova, A. Popov, V. Fominykh, L. Khachatryan, L. Shelikhova, N. Myakova
{"title":"The use of inotuzumab ozogamicin in children with relapsed/refractory B-lineage acute lymphoblastic leukemia","authors":"D. Evstratov, A. D. Shutova, Y. Y. Dyakonova, S. Radygina, Y. Abugova, L. K. Anderzhanova, L. A. Vavilova, D. Litvinov, G. Novichkova, A. Popov, V. Fominykh, L. Khachatryan, L. Shelikhova, N. Myakova","doi":"10.24287/1726-1708-2023-22-1-46-52","DOIUrl":"https://doi.org/10.24287/1726-1708-2023-22-1-46-52","url":null,"abstract":"Today, treatment results for acute lymphoblastic leukemia (ALL) look encouraging, yet 10–15% patients still end up relapsing. The success of relapse treatment is directly dependent on whether or not a tumor clone has been completely eradicated before hematopoietic stem cell transplantation (HSCT). Immunotherapy made it possible to achieve minimal residual disease (MRD) – negative remission even in refractory patients. One example of such immunotherapeutic agents is inotuzumab ozogamicin (InO), an anti-CD22 monoclonal antibody conjugated to the cytotoxic agent calicheamicin. We included 17 patients under the age of 18 with relapsed or refractory precursor B-cell ALL (pre-B ALL) who had been treated with InO at the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology of Ministry of Healthcare of Russia from 01.10.2016 to 01.09.2022. The study was approved by the Independent Ethics Committee and the Scientific Council of the Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology. The efficacy of the therapy was assessed based on the patients’ morphological response, MRD negativity and overall survival. Treatment toxicity was assessed according to CTCAE 5.0 (Common Terminology Criteria for Adverse Events). Statistical analysis was performed using the XLSTAT 2016 software. The majority of the patients (75%) responded to the therapy. MRD negativity was achieved in 41.2% of the study patients. The one-year overall survival rate was 40.3% (95% confidence interval 14.8–65.7). The treatment was well tolerated but 33% of the patients treated with standard-dose InO and subsequent HSCT developed veno-occlusive disease/sinusoidal obstruction syndrome. In our study, we demonstrated the high efficacy of InO both when used as a rescue therapy in patients with relapsed/refractory pre-B ALL and as a bridging therapy in patients before HSCT.","PeriodicalId":38370,"journal":{"name":"Pediatric Hematology/Oncology and Immunopathology","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75268748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of bone mineral density and bone turnover markers in patients with juvenile idiopathic arthritisy 青少年特发性关节炎患者骨密度和骨转换指标的评估
Pediatric Hematology/Oncology and Immunopathology Pub Date : 2023-02-14 DOI: 10.24287/1726-1708-2023-22-1-84-89
S. Soliman, D. Nofal, A. Labeeb, R. E. El Zaiat, D. Fotoh
{"title":"Assessment of bone mineral density and bone turnover markers in patients with juvenile idiopathic arthritisy","authors":"S. Soliman, D. Nofal, A. Labeeb, R. E. El Zaiat, D. Fotoh","doi":"10.24287/1726-1708-2023-22-1-84-89","DOIUrl":"https://doi.org/10.24287/1726-1708-2023-22-1-84-89","url":null,"abstract":"Juvenile idiopathic arthritis (JIA) is one of the most common chronic inflammatory diseases occurring in childhood, associated with decreased bone mineral density (BMD) and increased risk of osteopenia and osteoporosis, which increases the fracture risk. Aim of the work: to assess BMD and bone turnover markers (serum osteocalcin for bone formation and C terminal telopeptide of type 1 collagen for bone resorption) in JIA patients and their relation to disease activity. This study included 50 patients with JIA (female:male – 20:30). The study was approved by the Ethical Research Committee and Institutional Review Board of the Faculty of Medicine, Menoufia University, Egypt (Approval number: 19519INTPH48). Written informed consent was obtained from each patient or the parents. These patients were diagnosed with JIA according to the criteria of classification of the International League of Associations for Rheumatology. BMD was measured by Dual-energy X-ray absorptiometry (DEXA) of the lumbar spine using the Z-score. The results were correlated with JIA disease duration, disease activity, bone turnover markers and serum level of vitamin D. Clinical disease activity was evaluated by juvenile arthritis disease activity score (JADAS-27). There was a significant negative correlation between DEXA Z-score and disease activity (p-value < 0.001), bone turnover markers (p-value < 0.001), and duration of JIA (p-value < 0.05). There was a significant difference between vitamin D level and DEXA Z-score; DEXA Z-score was lower in vitamin D deficient patients. JIA patients with higher disease activity are at a higher risk of osteopenia and osteoporosis. Well-timed and efficient treatment of JIA and proper control of disease activity may help to improve the bone status and reduce the incidence of osteoporosis. Consequently, valuable targeted interventions are essential to preserve bone health during JIA.","PeriodicalId":38370,"journal":{"name":"Pediatric Hematology/Oncology and Immunopathology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79880654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Rosai–Dorfman disease (sinus histiocytosis with massive lymphadenopathy): personal observations and literature review Rosai-Dorfman病(窦性组织细胞增多症伴大量淋巴结病):个人观察和文献复习
Pediatric Hematology/Oncology and Immunopathology Pub Date : 2023-02-14 DOI: 10.24287/1726-1708-2023-22-1-99-109
A. Rudneva, D. Abramov, A. S. Sharlay, Y. Likar, I. N. Vorozhtsov, N. Myakova
{"title":"Rosai–Dorfman disease (sinus histiocytosis with massive lymphadenopathy): personal observations and literature review","authors":"A. Rudneva, D. Abramov, A. S. Sharlay, Y. Likar, I. N. Vorozhtsov, N. Myakova","doi":"10.24287/1726-1708-2023-22-1-99-109","DOIUrl":"https://doi.org/10.24287/1726-1708-2023-22-1-99-109","url":null,"abstract":"Rosai–Dorfman disease (RDD) is a rare histiocytic disorder, which occurs at any age, can affect almost any organs and tissues, does not have pathognomonic symptoms and could be confirmed only by histological examination of the affected tissue. The article describes the successful treatment of a child with RDD with lymph nodes, nasopharynx, subcutaneous tissue, spleen and bones involvement, by multistep surgical treatment and chemotherapy. A review of the literature is provided, including recommendations for the examination and treatment of patients with RDD. The patient's parents agreed to use the information, including the child's photo, in scientific research and publications.","PeriodicalId":38370,"journal":{"name":"Pediatric Hematology/Oncology and Immunopathology","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78499515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Malignant gastrointestinal neuroectodermal tumor 恶性胃肠道神经外胚层肿瘤
Pediatric Hematology/Oncology and Immunopathology Pub Date : 2022-12-26 DOI: 10.24287/1726-1708-2022-21-4-142-151
P. V. Kralichkin, M. Teleshova, I. Sidorov, D. Konovalov, A. E. Druy, N. Merkulov, D. Akhaladze, A. P. Troitskaya, I. E. Volkova, T. Shamanskaya, N. Zhukov, N. Myakova, D. Kachanov
{"title":"Malignant gastrointestinal neuroectodermal tumor","authors":"P. V. Kralichkin, M. Teleshova, I. Sidorov, D. Konovalov, A. E. Druy, N. Merkulov, D. Akhaladze, A. P. Troitskaya, I. E. Volkova, T. Shamanskaya, N. Zhukov, N. Myakova, D. Kachanov","doi":"10.24287/1726-1708-2022-21-4-142-151","DOIUrl":"https://doi.org/10.24287/1726-1708-2022-21-4-142-151","url":null,"abstract":"","PeriodicalId":38370,"journal":{"name":"Pediatric Hematology/Oncology and Immunopathology","volume":"791 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86815772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of low doses of olanzapine for the prevention of nausea and vomiting in children and adolescents receiving highly emetogenic chemotherapy. The interim results of a randomized trial 低剂量奥氮平预防儿童和青少年接受高致吐性化疗的恶心和呕吐的有效性和安全性随机试验的中期结果
Pediatric Hematology/Oncology and Immunopathology Pub Date : 2022-12-26 DOI: 10.24287/1726-1708-2022-21-4-70-82
N. Zhukov, L. L. Rabaeva, D. Litvinov
{"title":"Efficacy and safety of low doses of olanzapine for the prevention of nausea and vomiting in children and adolescents receiving highly emetogenic chemotherapy. The interim results of a randomized trial","authors":"N. Zhukov, L. L. Rabaeva, D. Litvinov","doi":"10.24287/1726-1708-2022-21-4-70-82","DOIUrl":"https://doi.org/10.24287/1726-1708-2022-21-4-70-82","url":null,"abstract":"","PeriodicalId":38370,"journal":{"name":"Pediatric Hematology/Oncology and Immunopathology","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88655658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chiasmatic gliomas with diencephalic syndrome in infants: challenges in the diagnosis and treatment 婴幼儿间脑综合征交交叉胶质瘤:诊断和治疗的挑战
Pediatric Hematology/Oncology and Immunopathology Pub Date : 2022-12-26 DOI: 10.24287/1726-1708-2022-21-4-118-123
L. Papusha, A. Merishavyan, M. Zaytseva, V. A. Degtyarev, Y. Alymova, A. Druy, A. Karachunskiy
{"title":"Chiasmatic gliomas with diencephalic syndrome in infants: challenges in the diagnosis and treatment","authors":"L. Papusha, A. Merishavyan, M. Zaytseva, V. A. Degtyarev, Y. Alymova, A. Druy, A. Karachunskiy","doi":"10.24287/1726-1708-2022-21-4-118-123","DOIUrl":"https://doi.org/10.24287/1726-1708-2022-21-4-118-123","url":null,"abstract":"","PeriodicalId":38370,"journal":{"name":"Pediatric Hematology/Oncology and Immunopathology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89796219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A clinical case of composite pheochromocytoma in a child and a literature review 儿童复合性嗜铬细胞瘤1例并文献复习
Pediatric Hematology/Oncology and Immunopathology Pub Date : 2022-12-26 DOI: 10.24287/1726-1708-2022-21-4-91-98
G. B. Sagoyan, A. M. Suleymanova, I. Sidorov, S. A. Sardalova, M. Rubanskaya, A. S. Temnyy, O. A. Ignatenko, A. Odzharova, D. Konovalov, O. Kosilo, A. P. Kazantsev, S. Varfolomeeva
{"title":"A clinical case of composite pheochromocytoma in a child and a literature review","authors":"G. B. Sagoyan, A. M. Suleymanova, I. Sidorov, S. A. Sardalova, M. Rubanskaya, A. S. Temnyy, O. A. Ignatenko, A. Odzharova, D. Konovalov, O. Kosilo, A. P. Kazantsev, S. Varfolomeeva","doi":"10.24287/1726-1708-2022-21-4-91-98","DOIUrl":"https://doi.org/10.24287/1726-1708-2022-21-4-91-98","url":null,"abstract":"","PeriodicalId":38370,"journal":{"name":"Pediatric Hematology/Oncology and Immunopathology","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75590633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A case report of autoinflammation and PLCy2-associated antibody deficiency and immune dysregulation 自身炎症和plcy2相关抗体缺乏和免疫失调1例报告
Pediatric Hematology/Oncology and Immunopathology Pub Date : 2022-12-26 DOI: 10.24287/1726-1708-2022-21-4-163-168
M. E. Leontyeva, D. V. Bogdanova, A. Moiseeva, V. Burlakov, Z. Nesterenko, A. Y. Merkushov, N. Kan, A. Khoreva, Y. Rodina, O. Shvets, E. Deordieva, N. Kuzmenko, A. Mukhina, I. Mersiyanova, E. Raikina, A. Kozlova
{"title":"A case report of autoinflammation and PLCy2-associated antibody deficiency and immune dysregulation","authors":"M. E. Leontyeva, D. V. Bogdanova, A. Moiseeva, V. Burlakov, Z. Nesterenko, A. Y. Merkushov, N. Kan, A. Khoreva, Y. Rodina, O. Shvets, E. Deordieva, N. Kuzmenko, A. Mukhina, I. Mersiyanova, E. Raikina, A. Kozlova","doi":"10.24287/1726-1708-2022-21-4-163-168","DOIUrl":"https://doi.org/10.24287/1726-1708-2022-21-4-163-168","url":null,"abstract":"","PeriodicalId":38370,"journal":{"name":"Pediatric Hematology/Oncology and Immunopathology","volume":"422 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84928834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spindle cell neoplasm harboring MAPK signaling pathway gene translocation from the spectrum of NTRK-rearranged spindle cell tumor 从ntrk重排梭形细胞肿瘤的频谱中发现含有MAPK信号通路基因易位的梭形细胞肿瘤
Pediatric Hematology/Oncology and Immunopathology Pub Date : 2022-12-26 DOI: 10.24287/1726-1708-2022-21-4-152-157
A. V. Tarakanova, A. S. Sharlay, A. Panferova, I. Sidorov, D. Konovalov
{"title":"Spindle cell neoplasm harboring MAPK signaling pathway gene translocation from the spectrum of NTRK-rearranged spindle cell tumor","authors":"A. V. Tarakanova, A. S. Sharlay, A. Panferova, I. Sidorov, D. Konovalov","doi":"10.24287/1726-1708-2022-21-4-152-157","DOIUrl":"https://doi.org/10.24287/1726-1708-2022-21-4-152-157","url":null,"abstract":"","PeriodicalId":38370,"journal":{"name":"Pediatric Hematology/Oncology and Immunopathology","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81623544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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