Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications最新文献

Drug Repurposing in Dermatology: Molecular Biology and Omics Approach 皮肤病学中的药物再利用:分子生物学和组学方法

Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications Pub Date : 2020-08-10 DOI: 10.5772/intechopen.93344

F. Badria, Abdullah A. Elgazar

引用次数: 1

Drug Repositioning for the Treatment of Glioma: Current State and Future Perspective 治疗胶质瘤的药物重新定位:现状与未来展望

Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications Pub Date : 2020-07-14 DOI: 10.5772/intechopen.92803

Sho Tamai, N. Hirai, Shabierjiang Jiapaer, T. Furuta, M. Nakada

引用次数: 1

Drug Repurposing (DR): An Emerging Approach in Drug Discovery 药物再利用(DR):一种新兴的药物发现方法

Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications Pub Date : 2020-07-13 DOI: 10.5772/intechopen.93193

M. Rudrapal, S. Khairnar, A. Jadhav

{"title":"Drug Repurposing (DR): An Emerging Approach in Drug Discovery","authors":"M. Rudrapal, S. Khairnar, A. Jadhav","doi":"10.5772/intechopen.93193","DOIUrl":"https://doi.org/10.5772/intechopen.93193","url":null,"abstract":"Drug repurposing (DR) (also known as drug repositioning) is a process of identifying new therapeutic use(s) for old/existing/available drugs. It is an effective strategy in discovering or developing drug molecules with new pharmacological/therapeutic indications. In recent years, many pharmaceutical companies are developing new drugs with the discovery of novel biological targets by applying the drug repositioning strategy in drug discovery and development program. This strategy is highly efficient, time saving, low-cost and minimum risk of failure. It maximizes the therapeutic value of a drug and consequently increases the success rate. Thus, drug repositioning is an effective alternative approach to traditional drug discovery process. Finding new molecular entities (NME) by traditional or de novo approach of drug discovery is a lengthy, time consuming and expensive venture. Drug repositioning utilizes the combined efforts of activity-based or experimental and in silico-based or computational approaches to develop/identify the new uses of drug molecules on a rational basis. It is, therefore, believed to be an emerging strategy where existing medicines, having already been tested safe in humans, are redirected based on a valid target molecule to combat particularly, rare, difficult-to-treat diseases and neglected diseases.","PeriodicalId":383661,"journal":{"name":"Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133115273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 96

Drug Repurposing in Neurological Diseases: Opportunities and Challenges 神经疾病药物再利用:机遇与挑战

Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications Pub Date : 2020-06-26 DOI: 10.5772/intechopen.93093

Xiaoquan Mao

{"title":"Drug Repurposing in Neurological Diseases: Opportunities and Challenges","authors":"Xiaoquan Mao","doi":"10.5772/intechopen.93093","DOIUrl":"https://doi.org/10.5772/intechopen.93093","url":null,"abstract":"Drug repurposing or repositioning refers to “studying of clinically approved drugs in one disease to see if they have therapeutic value and do not trigger side effects in other diseases.” Nowadays, it is a vital drug discovery approach to explore new therapeutic benefits of existing drugs or drug candidates in various human diseases including neurological disorders. This approach overcomes the shortage faced during traditional drug development in grounds of financial support and timeline. It is especially hopeful in some refractory diseases including neurological diseases. The feature that structure complexity of the nervous system and influence of blood–brain barrier permeability often becomes more difficult to develop new drugs in neuropathological conditions than diseases in other organs; therefore, drug repurposing is particularly of utmost importance. In this chapter, we discuss the role of drug repurposing in neurological diseases and make a summarization of repurposing candidates currently in clinical trials for neurological diseases and potential mechanisms as well as preliminary results. Subsequently we also outline drug repurposing approaches and limitations and challenges in the future investigations.","PeriodicalId":383661,"journal":{"name":"Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114964617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Repurposing Infectious Pathogen Vaccines in Cancer Immunotherapy 传染性病原体疫苗在癌症免疫治疗中的应用

Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications Pub Date : 2020-06-10 DOI: 10.5772/intechopen.92780

M. Conti

引用次数: 1

Drug Repurposing in Oncotherapeutics 肿瘤治疗中的药物再利用

Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications Pub Date : 2020-05-06 DOI: 10.5772/intechopen.92302

Alkesh Patel

{"title":"Drug Repurposing in Oncotherapeutics","authors":"Alkesh Patel","doi":"10.5772/intechopen.92302","DOIUrl":"https://doi.org/10.5772/intechopen.92302","url":null,"abstract":"Repurposing or repositioning means validating and application of previously approved drugs in the treatment of another disease that might be relevant or irrelevant to existing use in disease based on the principle of polypharmacology. Repurposed drugs are already well documented for pharmacokinetic, pharmacodynamic, drug interaction, and toxicity parameters. In 1962, thalidomide treatment in pregnant women led to phocomelia in their newborn but while repurposed based on anti-angiogenesis property, it showed efficacy in hematologic malignancies like multiple myeloma. The repurposing is becoming an essential tool in the anti-cancer drug development due to existing drugs are not effective, high cost of treatment, therapy may degrade the quality of life, improvement of survival after treatment is not guaranteed, relapse may occur, and drug resistance may develop due to tumor heterogeneity. Repurposing can be addressed well with the help of literature-based discovery, high throughput technology, bioinformatics multi-omics approaches, side effects, and phenotypes. Many regulatory bodies like EML, NIH, and FDA promote repurposing programs that support the identification of alternative uses of existing medicines. Cancer becomes the major health issue, and the need to discover promising anti-cancer drugs through repurposing remains very high due to decline in FDA approval since 1990, huge expenses incurred in the drug development and prediction of dangerous future burden.","PeriodicalId":383661,"journal":{"name":"Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications","volume":"204 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122347446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug Repurposing and Orphan Disease Therapeutics 药物再利用和孤儿疾病治疗

Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications Pub Date : 2020-04-23 DOI: 10.5772/intechopen.91941

N. Dhir, Ashish Jain, D. Mahendru, A. Prakash, B. Medhi

引用次数: 9

Repurposing Fumaric Acid Esters to Treat Conditions of Oxidative Stress and Inflammation: A Promising Emerging Approach with Broad Potential 利用富马酸酯治疗氧化应激和炎症:一种具有广泛潜力的有前途的新兴方法

Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications Pub Date : 2020-04-02 DOI: 10.5772/intechopen.91915

R. Jadeja, F. L. Powell, Pamela M. Martin

{"title":"Repurposing Fumaric Acid Esters to Treat Conditions of Oxidative Stress and Inflammation: A Promising Emerging Approach with Broad Potential","authors":"R. Jadeja, F. L. Powell, Pamela M. Martin","doi":"10.5772/intechopen.91915","DOIUrl":"https://doi.org/10.5772/intechopen.91915","url":null,"abstract":"The medicinal benefit of salts of fumaric acid and its esters (FAE), known as fumarates (mono and dimethyl fumarate), was realized many years ago. Early on, FAE were derived from plants and mushrooms (e.g., Fumaria officinalis, Boletus fomentarius var. pseudo-igniarius). The FAE containing formulation Fumaderm® was licensed in Germany for the treatment of psoriasis in 1994. Recently, a clinical formulation of dimethyl fumarate known as BG12 (Tecfidera) was approved for use in the United States, New Zealand, Australia, European Union, Switzerland, and Canada for the treatment of multiple sclerosis. Others and we have assessed the potential benefit of FAE in a number of disease conditions that are diverse with respect to etiology but unified with regard to the involvement of inflammation and oxidative stress. Hence, a FAE-based drug with robust anti-oxidative and anti-inflammatory effects that is already US-FDA approved is a perfect contender for repurposing and rapid clinical implementation for their management. There is a burgeoning literature on the use of FAE in the prevention and treatment of diseases, other than psoriasis and MS, in which oxidative stress and/or inflammation are prominent. This chapter highlights critical information gleaned from these studies, exposes lacunae of potential importance, and provides related perspectives.","PeriodicalId":383661,"journal":{"name":"Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124507151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3