传染性病原体疫苗在癌症免疫治疗中的应用

M. Conti
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引用次数: 1

摘要

文献报道表明,某些针对传染性病原体的疫苗在瘤内注射时可以有效地引发抗肿瘤免疫反应。在小鼠肿瘤模型中,轮状病毒、黄热病和流感疫苗的瘤内递送也已被证明与检查点抑制剂协同作用,这是当今临床实践中领先的免疫疗法。因此,这种联合方法可以成为一种非常有前途的抗癌免疫治疗新策略。在人类中,一种减毒脊髓灰质炎病毒疫苗、一种针对乳头瘤的基于肽的疫苗和一种基于解毒白喉蛋白的疫苗已经很容易地作为肿瘤内治疗进行了测试。在这些研究中,可用的抗病原体免疫的作用似乎是介导重新利用的抗癌疫苗活性的重要因素。因此,我们建议在肿瘤内递送前评估或最终开发抗病原体免疫可能有助于在癌症免疫治疗中重新利用感染性病原体疫苗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Repurposing Infectious Pathogen Vaccines in Cancer Immunotherapy
Reports in the literature show that certain vaccines against infectious pathogens, can be effective in eliciting antitumor immune response when injected intratumorally. In mouse tumor models, intratumoral delivery of rotavirus, yellow fever, and influenza vaccines have been shown to also synergize with checkpoint inhibitors, in the leading immunotherapy in the clinical practice today. The combined approach can thus become a very promising novel strategy for anticancer immunotherapy. In humans, an attenuated poliomyelitis virus vaccine, a peptide-based vaccines against papilloma and one based on detoxified diphtheria protein have already been tested as intratumoral treatments readily. In those studies, the role of available anti-pathogen immunity appears an important element in mediating the activity of the repurposed vaccines against cancer. We therefore suggest how evaluating or eventually developing anti-pathogen immunity before intratumoral delivery could be helpful in repurposing infectious pathogen vaccines in cancer immunotherapy.
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