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SYNTHESIS, HYDROLYTIC STABILITY AND ANTIVIRAL STUDIES OF SULFUR-BASED ANTI-INFLUENZA DRUGS 硫基抗流感药物的合成、水解稳定性及抗病毒研究
Journal of Chemical Technology and Metallurgy Pub Date : 2026-01-03 DOI: 10.59957/jctm.v61.i1.2026.6
Maya Chochkova, Boyka Stoykova, Petranka Petrova, Haiyan Yan, Nejc Petek, Y LI, Martin Štícha, Lubomira Nikolaeva–Glomb, Jurij Svete
{"title":"SYNTHESIS, HYDROLYTIC STABILITY AND ANTIVIRAL STUDIES OF SULFUR-BASED ANTI-INFLUENZA DRUGS","authors":"Maya Chochkova, Boyka Stoykova, Petranka Petrova, Haiyan Yan, Nejc Petek, Y LI, Martin Štícha, Lubomira Nikolaeva–Glomb, Jurij Svete","doi":"10.59957/jctm.v61.i1.2026.6","DOIUrl":"https://doi.org/10.59957/jctm.v61.i1.2026.6","url":null,"abstract":"Sulfur - containing building blocks represent highly favored scaffolds in various natural or synthetically obtained pharmacologically active molecules. Their diverse functionalities, including thioether, sulfonamide, sulfoxide, and others are often linked with the possibility to inhibit microbial growth and to regulate immune responses. Nowadays, approximately 25 % of all utilized small - molecule pharmaceuticals have been approved as organosulfur drugs or are clinical candidates. Herein, inspired by the medicinal power of such compounds, a series of potential sulfur based ligands against influenza A viruses was obtained by modification of amino group of anti - influenza drugs (rimantadine, amantadine and oseltamivir) and memantine. Furthermore, the structures of novel derivatives bearingversatile sulfur - containing acyl moieties (cysteinyl-, thienyl-) were established by spectroscopic methods (1H NMR, 13C NMR, (ATR)umax, and HRMS). The newly synthesized amides were tested in vitro for antiviral activity against four influenza A viruses (A/Fort Monmouth/1/1947 (H1N1), A/Wuhan/359/1995 (H3N2), A/Jinnan/15/2009 (H1N1), and A/Aichi/2/68 (H3N2). Amongst the evaluated amides 1, 6, and 7 were the most active ones, inhibiting both the A/Fort Monmouth/1/1947 (H1N1) and A/Wuhan/359/1995 (H3N2) influenza virus strains, while amides 3 and 5 showed pronounced antiviral efficacy specifically against the A/Wuhan/359/1995 (H3N2) strain. Moreover, compounds 6 and 7 indicated remarkable inhibitory activity against the oseltamivir-resistant A/Jinnan/15/2009 strain.Furthermore, the hydrolytic stability of desired amides was monitored in two model pH systems that mimic conditions in the stomach, and blood plasma, including pH 1.0, and 7.4, respectively.","PeriodicalId":38363,"journal":{"name":"Journal of Chemical Technology and Metallurgy","volume":"61 1","pages":"61-71"},"PeriodicalIF":0.0,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://j.uctm.edu/index.php/JCTM/article/download/883/484","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147912930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COMPOSITE MATERIALS BASED ON NANOSIZED FERRITE FOR MICROWAVE APPLICATIONS 基于纳米铁氧体的微波应用复合材料
Journal of Chemical Technology and Metallurgy Pub Date : 2024-07-05 DOI: 10.59957/jctm.v59.i4.2024.13
S. Kolev, Todor Cholakov, D. Kovacheva, Tatyana Koitzarova
{"title":"COMPOSITE MATERIALS BASED ON NANOSIZED FERRITE FOR MICROWAVE APPLICATIONS","authors":"S. Kolev, Todor Cholakov, D. Kovacheva, Tatyana Koitzarova","doi":"10.59957/jctm.v59.i4.2024.13","DOIUrl":"https://doi.org/10.59957/jctm.v59.i4.2024.13","url":null,"abstract":"The fabrication of composites with magnetite Fe3O4 nanoparticles was investigated in this research as a  method of shielding electromagnetic radiation. The effects were studied of various weight percentages of Fe3O4 nanoparticles on the microwave absorption. XRD, SEM, and a scalar network analyzer were used to characterize the sample. The results showed that the Fe3O4 nanoparticles had an average size of 175 nm. The nanocomposite sample with a thickness of 4 mm and a concentration of 1.5 g in 1 cm3 of silicon rubber had the highest level of reflection loss (-23 dB).","PeriodicalId":38363,"journal":{"name":"Journal of Chemical Technology and Metallurgy","volume":" 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141676335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COST ANALYSIS OF THE PERFORMANCE OF CO2 SEPARATION WITH VARIOUS CO2 CONCENTRATIONS FROM GAS WELLS 气井中不同浓度 CO2 分离性能的成本分析
Journal of Chemical Technology and Metallurgy Pub Date : 2024-07-05 DOI: 10.59957/jctm.v59.i4.2024.24
Vibianti Dwi Pratiwi, Renanto Renanto, J. Juwari, Ali Altway, R. P. Anugraha
{"title":"COST ANALYSIS OF THE PERFORMANCE OF CO2 SEPARATION WITH VARIOUS CO2 CONCENTRATIONS FROM GAS WELLS","authors":"Vibianti Dwi Pratiwi, Renanto Renanto, J. Juwari, Ali Altway, R. P. Anugraha","doi":"10.59957/jctm.v59.i4.2024.24","DOIUrl":"https://doi.org/10.59957/jctm.v59.i4.2024.24","url":null,"abstract":"The technical and economic challenges are enormous in developing gas wells with a high CO2 content (> 50 mol %), such as the East Natuna gas field, which has 71 mol % (86 mass %). Carbon capture technology in gas wells with high CO2 content is studied to find a more economical one. In this study, the technology for capturing high concentrations of CO2 is varied from gas wells, Controlled Freeze Zone (CFZ), and cryogenic distillation which will be analyzed based on cost. Variations in the CO2 content of gas wells are 75 %, 80 %, 85 %, 90 %, and 95 % in mass fraction simulated using Aspen Plus V.11.0. Based on this research, CFZ technology and cryogenic distillation can obtain purity up to 99 % and recovery above 78 %. However, the total annual cost (annual capital and operating costs) of CFZ technology is lower than cryogenic distillation technology, so CFZ technology is suitable for capturing CO2 in gas wells with high CO2 content.","PeriodicalId":38363,"journal":{"name":"Journal of Chemical Technology and Metallurgy","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
INFLUENCE OF CHITOSAN-BASED COMPOSITES ON THE PROPERTIES OF CHEMICALLY MODIFIED POLY-LACTIC ACID FILMS 壳聚糖基复合材料对化学改性聚乳酸薄膜性能的影响
Journal of Chemical Technology and Metallurgy Pub Date : 2024-07-05 DOI: 10.59957/jctm.v59.i4.2024.8
A. Grigorov, A. Viraneva, M. Marudova
{"title":"INFLUENCE OF CHITOSAN-BASED COMPOSITES ON THE PROPERTIES OF CHEMICALLY MODIFIED POLY-LACTIC ACID FILMS","authors":"A. Grigorov, A. Viraneva, M. Marudova","doi":"10.59957/jctm.v59.i4.2024.8","DOIUrl":"https://doi.org/10.59957/jctm.v59.i4.2024.8","url":null,"abstract":"The presented paper investigates the creation of chitosan-based composites on the surface of chemically modified poly-D-lactic acid (PDLA). PDLA was dissolved in chloroform and cast into a glass dish until the complete evaporation of the solvent. The surface of the created PDLA films was modified with 1,6-hexanediamine and glutaraldehyde for the creation of free aldehyde side groups. Composite layers of chitosan (CH) were deposited on the surface of the modified films. The mechanical properties of the composite films were investigated using a dynamometer. The surface morphology of the created composite films was studied with Scanning electron microscopy (SEM). Sessile drop method was used to determine the surface free energy of the created chitosan-based compositelayers.","PeriodicalId":38363,"journal":{"name":"Journal of Chemical Technology and Metallurgy","volume":" 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LASER-ASSISTED SYNTHESIS OF WATER COLLOIDAL METALLIC NANOCOMPOSITES 激光辅助合成水胶体金属纳米复合材料
Journal of Chemical Technology and Metallurgy Pub Date : 2024-07-05 DOI: 10.59957/jctm.v59.i4.2024.12
N. Stankova, Anna Dikovska, M. Koleva, N. Nedyalkov, A. Nikolov, Dimitar Dimov, Daniela Karashanova
{"title":"LASER-ASSISTED SYNTHESIS OF WATER COLLOIDAL METALLIC NANOCOMPOSITES","authors":"N. Stankova, Anna Dikovska, M. Koleva, N. Nedyalkov, A. Nikolov, Dimitar Dimov, Daniela Karashanova","doi":"10.59957/jctm.v59.i4.2024.12","DOIUrl":"https://doi.org/10.59957/jctm.v59.i4.2024.12","url":null,"abstract":"Picosecond and Nanosecond Nd:YAG laser systems with a fundamental wavelength of 1064 nm are utilizedfor green synthesis of bimetallic nanocomposites based on metal combinations of Pt/Ti, Pd/Ti, Pt/Zn and Pd/Zn. The laser assisted method is based on pulsed laser ablation of metal targets, which are immersed consecutively in bidistilled water to obtain water colloids of the corresponding bimetallic nanostructures. Comparative study of the structural and optical properties of the nanocomposites is conducted by means of transmission electron microscopy in its corresponding main modes and by optical spectrometer measurements, respectively. Suspensions of water colloids of the nanocomposites and methylene blue dye prepared in 1 : 2.5 ratio, respectively, are exposed under sunlight irradiation for 3 h. Photocatalytic activity of the nanocomposites against methylene blue (MB) dye is tested by measuring the optical absorbance of the suspensions before and after the sunlight irradiation.","PeriodicalId":38363,"journal":{"name":"Journal of Chemical Technology and Metallurgy","volume":" 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141673900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SEQUENTIAL IMPLEMENTATION OF ISOELECTRIC PRECIPITATION FOLLOWED BY ULTRAFILTRATION FOR PRODUCTION OF SUNFLOWER PROTEIN ISOLATES 用等电沉淀法和超滤法连续生产向日葵分离蛋白
Journal of Chemical Technology and Metallurgy Pub Date : 2024-07-05 DOI: 10.59957/jctm.v59.i4.2024.2
A. Iliev, Mariya Dushkova, Gabor Zsivanovits, D. Iserliyska
{"title":"SEQUENTIAL IMPLEMENTATION OF ISOELECTRIC PRECIPITATION FOLLOWED BY ULTRAFILTRATION FOR PRODUCTION OF SUNFLOWER PROTEIN ISOLATES","authors":"A. Iliev, Mariya Dushkova, Gabor Zsivanovits, D. Iserliyska","doi":"10.59957/jctm.v59.i4.2024.2","DOIUrl":"https://doi.org/10.59957/jctm.v59.i4.2024.2","url":null,"abstract":"The aim of this study was to improve the yield of protein isolates obtained from sunflower oil cakes by means ofsequential implementation of isoelectric precipitation and ultrafiltration. The proteins were extracted from sunflower oil cake in mild acidic conditions (pH = 6 with solution of NaCl with concentration of 0.5, 1 and 2M). The first fraction of protein isolate was obtained by means of isoelectric precipitation at pH = 4, 3.5 and 3. Total protein, ash and dry matter contents, and residual chlorides of raw material and precipitates were determined. The second fraction was obtained from supernatant taken from the highest yield precipitate by means of ultrafiltration. The ultrafiltration experiments were conducted with an UF10-PAN membrane at a transmembrane pressure of 0.2, 0.35 and 0.5 MPa, and a volume reduction ratio (VRR) of 2, 3, 4, and 5. Total protein, ash, and dry matter contents ofretentates and permeate were determined.","PeriodicalId":38363,"journal":{"name":"Journal of Chemical Technology and Metallurgy","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CHITOSAN/ALGINATE POLYELECTROLYTE MULTILAYERS: EFFECT OF pH AND IONIC STRENGTH ON FILM GROWTH AND MORPHOLOGY 壳聚糖/海藻酸盐聚电解质多层膜：pH 值和离子强度对薄膜生长和形态的影响
Journal of Chemical Technology and Metallurgy Pub Date : 2024-07-05 DOI: 10.59957/jctm.v59.i4.2024.9
M. Marudova, A. Viraneva, Alexandar Grigorov, S. Milenkova, T. Yovcheva
{"title":"CHITOSAN/ALGINATE POLYELECTROLYTE MULTILAYERS: EFFECT OF pH AND IONIC STRENGTH ON FILM GROWTH AND MORPHOLOGY","authors":"M. Marudova, A. Viraneva, Alexandar Grigorov, S. Milenkova, T. Yovcheva","doi":"10.59957/jctm.v59.i4.2024.9","DOIUrl":"https://doi.org/10.59957/jctm.v59.i4.2024.9","url":null,"abstract":"The growth process of chitosan/alginate polyelectrolyte films deposited by layer-by-layer assembly at different pH and ionic strength was studied in this work. The films were investigated using surface plasmon resonance (SPR) to examine the build-up kinetics, and atomic force microscopy (AFM) to visualize the surface topography. Each deposition step resulted in a progressive increase in mass. The film growth and thickness strongly depended on the polyelectrolyte charge density and complexation between the used polyelectrolytes. The film surface changed from smooth to rough when the pH increased. The results achieved could be used in estimating the potential of the multilayers to be applied as drug delivery systems.","PeriodicalId":38363,"journal":{"name":"Journal of Chemical Technology and Metallurgy","volume":" 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141675930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CHEMICAL COMPOSITION AND OPTICAL PROPERTIES OF REFINED SUNFLOWER OIL WITH ADDED VARIOUS OILS 添加了各种油的精炼葵花籽油的化学成分和光学特性
Journal of Chemical Technology and Metallurgy Pub Date : 2024-07-05 DOI: 10.59957/jctm.v59.i4.2024.1
G. Gentscheva, Nadezhda Petkova, Krastena Nikolova, Aleksandar Pashev, Albena Predoeva, T. Evtimov, Ina Yotkovska
{"title":"CHEMICAL COMPOSITION AND OPTICAL PROPERTIES OF REFINED SUNFLOWER OIL WITH ADDED VARIOUS OILS","authors":"G. Gentscheva, Nadezhda Petkova, Krastena Nikolova, Aleksandar Pashev, Albena Predoeva, T. Evtimov, Ina Yotkovska","doi":"10.59957/jctm.v59.i4.2024.1","DOIUrl":"https://doi.org/10.59957/jctm.v59.i4.2024.1","url":null,"abstract":"Some physicochemical characteristics and elemental composition of refined sunflower oil, as well as linseed oil added to it, were investigated; linseed oil and olive oil; truffle oil and rosemary oil. Fatty acid analysis shows substantial increases in monounsaturated fatty acids with the addition of truffle and rosemary oils (up to about 78 %). \u0000With the same supplements, a significant oxidative stability over 20 hours was also observed. High concentrations of chlorophyll were found with the addition of rosemary oils and oils of linseed oil and olive oil. β-carotene was affected three to six times in all supplements compared to the commonly refined oil. Eight elements (Mg, Cr, Mn, Zn, Ni, As, Pd and Cd) were analyzed in the studied oils, no presence of toxic elements As and Cd (< 0.02 mg kg-1), lead was up to 0.04 mg kg-1. The remaining elements vary in different concentrations depending on the additive oils used. The fluorescence spectra of the tested samples were obtained for excitation wavelengths of 380 nm, and the fluorescence maxima allowed to determine the relationship between the optical and chemical properties of the samples. In addition, infrared spectroscopic experiments (ATR and transmittance) were used to investigate the fatty acid profile of the analyzed oil samples.","PeriodicalId":38363,"journal":{"name":"Journal of Chemical Technology and Metallurgy","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141676268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFECT OF THE LIMITING DEFORMATION ZONE UNDER CONDITIONS OF ASYMMETRIC LOADING DURING ROLLING OF MEDIUM THICKNESS STRIPS 中厚带材轧制过程中不对称加载条件下极限变形区的影响
Journal of Chemical Technology and Metallurgy Pub Date : 2024-07-05 DOI: 10.59957/jctm.v59.i4.2024.30
Valery Chigirinsky, A. Naizabekov, S. Lezhnev, Sergey Kuzmin, E. Panin, A. Tolkushkin, I. Volokitina, R. Yordanova, Marcin Knapinski
{"title":"EFFECT OF THE LIMITING DEFORMATION ZONE UNDER CONDITIONS OF ASYMMETRIC LOADING DURING ROLLING OF MEDIUM THICKNESS STRIPS","authors":"Valery Chigirinsky, A. Naizabekov, S. Lezhnev, Sergey Kuzmin, E. Panin, A. Tolkushkin, I. Volokitina, R. Yordanova, Marcin Knapinski","doi":"10.59957/jctm.v59.i4.2024.30","DOIUrl":"https://doi.org/10.59957/jctm.v59.i4.2024.30","url":null,"abstract":"The aim of the work is to develop a physical and mathematical model of the process under complex asymmetric loading in conditions of single-area and two-area deformation zone during plastic processing of medium-thickness strips. The stress state in case of loss of stability during rolling of strips of medium thickness was investigated. The patterns of changes in the stress state of the strip under conditions of reach of the limiting deformation zone, as well as the effects of plastic shaping determined by a decrease in contact stresses under conditions of increasing deformation loading, are revealed. The described method is a visual approach to assessing the stress state of a plastic medium under conditions of complex interaction and asymmetric loading.","PeriodicalId":38363,"journal":{"name":"Journal of Chemical Technology and Metallurgy","volume":" 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141676623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CONTACT HARDENING BINDERS USING ROCK CRUSHING WASTE 使用碎石废料的接触硬化粘合剂
Journal of Chemical Technology and Metallurgy Pub Date : 2024-07-05 DOI: 10.59957/jctm.v59.i4.2024.23
Leonid Dvorkin, O. Bordiuzhenko, Ruslan Makarenko
{"title":"CONTACT HARDENING BINDERS USING ROCK CRUSHING WASTE","authors":"Leonid Dvorkin, O. Bordiuzhenko, Ruslan Makarenko","doi":"10.59957/jctm.v59.i4.2024.23","DOIUrl":"https://doi.org/10.59957/jctm.v59.i4.2024.23","url":null,"abstract":"This article is devoted to the production of pressed materials based on mechanically activated granite. The ability of granite after mechanical activation in the presence of sulphate activator to form a contact hardening binder - sulphopetrocement is studied. The influence of mechanical and sulphate activation factors, pressing parameters and hardening conditions on the binder properties has been studied.","PeriodicalId":38363,"journal":{"name":"Journal of Chemical Technology and Metallurgy","volume":"21 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141837279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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