03.03 - Mechanisms of lung injury and repair最新文献_第9页

Correction of structural changes of lung parenchyma in induced systemic sclerosis 系统性硬化症肺实质结构改变的矫正

03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.1000

B. Doskaliuk, L. Zaiats, R. Yatsyshyn

引用次数: 0

Serological markers of tissue remodeling are elevated in patients with COVID-19 who develop interstitial lung disease 在发生间质性肺病的COVID-19患者中，组织重塑的血清学标志物升高

03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.1676

H. Breisnes, P. Juhl, D. Leeming, T. Wilkinson, A. Fazleen, J. Sand

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Characterization of Mesenchymal Cell from BAL of post COVID-19 patient whit fibrosis COVID-19后白色纤维化患者BAL间充质细胞的特征

03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.2638

M. Della Zoppa, M. Avanzini, S. Bozzini, S. Croce, C. Bagnera, C. Valsecchi, L. Pandolfi, E. Lenta, S. Lettieri, V. Vertui, L. Saracino, F. Meloni

引用次数: 0

Short chain fatty acids reduce inflamm-aging and ameliorate enhanced severity of acute lung injury in old mice 短链脂肪酸可减轻老年小鼠炎症老化，改善急性肺损伤的加重程度

03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.1603

C. Hildebrand, A. Pich, C. Mühlfeld, M. Vital, C. Brandenberger

引用次数: 0

Prolonged stay and endothelial dysfunction in hospitalized patients with covid-19 covid-19住院患者住院时间延长与内皮功能障碍的关系

03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.1937

J. Marquez-Cordero, A. Orea-Tejeda, D. González-Islas, L. Cornejo-Cornejo, J. Aguilar-Meza, A. Rios-Pereda, I. Lopez-Vazquez, M. Salvatierra-Escobar, C. Sánchez-Moreno, G. Aztatzi-Aguilar, M. Sierra-Vargas, Y. Debray-Garcia, A. Loaeza-Roman, S. Galicia-Amor, E. Trejo-Mellado

{"title":"Prolonged stay and endothelial dysfunction in hospitalized patients with covid-19","authors":"J. Marquez-Cordero, A. Orea-Tejeda, D. González-Islas, L. Cornejo-Cornejo, J. Aguilar-Meza, A. Rios-Pereda, I. Lopez-Vazquez, M. Salvatierra-Escobar, C. Sánchez-Moreno, G. Aztatzi-Aguilar, M. Sierra-Vargas, Y. Debray-Garcia, A. Loaeza-Roman, S. Galicia-Amor, E. Trejo-Mellado","doi":"10.1183/13993003.congress-2022.1937","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.1937","url":null,"abstract":"Introduction: COVID-19 is not only a respiratory disease, produces a severe systemic and multi-organ response. This illness generates vascular disorders, leading the patient to endothelial dysfunction. It acutely and chronically affects the patient's evolution, prolonging the patient's stay and worsening life prognosis. Objective(s): To evaluate differences in endothelial dysfunction present in patients hospitalized for COVID-19 who had a hospital stay longer than 18 days compared to those who did not. Method(s): A prospective cohort study was conducted. Hospitalized patients with confirmed SARS-COV 2 andolder than 18 years were included. Subjects in whom endothelial function markers could not be processed wereexcluded. Endothelial dysfunction was evaluated using E-selectin, endothelin-1, glutathione-s-transferase, arginase, and MDAM. A prolonged hospital stay was established >=18 days. Result(s): A total of 165 patients were evaluated, the average age of the population was 57.18 +/- 13.37 years, 73.33% were men. Subjects with prolonged hospital stay were older (59.38 +/- 12.08 vs 51.15 +/- 14.96, p=0.004), a higher number of patients required intubation (87.60 % vs 75, p=0.049) and e-selectin (1 [0.79 - 1.32] vs 0.88 [0.68 -1.14], p=0.0323) compared to subjects without prolonged hospital stay. Conclusion(s): Hospitalized patients over 18 days showed elevated levels of E-selectin reflecting endothelial damage, affecting vascular homeostasis, added to this, a significant number of them were intubated, increasing the risk of mortality, as well as future cardiovascular complications.","PeriodicalId":382910,"journal":{"name":"03.03 - Mechanisms of lung injury and repair","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125089698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Omeg@Silica microencapsulated fish oil counteracts tumor-related inflammation in lung adenocarcinoma cells Omeg@Silica微胶囊鱼油对抗肺腺癌细胞的肿瘤相关炎症

03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.3105

C. D’Anna, C. Di Sano, G. Cammarata, S. Taverna, S. Di Vincenzo, M. Pagliaro, A. Scurria, R. Ciriminna, E. Pace

引用次数: 0

The role of MBD2 regulating M1 macrophage polarization in acute lung injury MBD2调节M1巨噬细胞极化在急性肺损伤中的作用

03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.2726

W. Sun

引用次数: 1

IL-33 and IL-4Rα blockade impact distinct and overlapping inflammatory mediators of airway disease IL-33和IL-4Rα阻断影响气道疾病的不同和重叠的炎症介质

03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.477

S. Asrat, G. Scott, J. Allinne, W. Lim, D. Birchard, L. Ben, A. Murphy, M. Sleeman, J. Orengo, A. Le Floch, K. Nagashima, S. Srivatsan

引用次数: 0

Exposure to particulate matter alters neutrophil lysosomal function and activation status 暴露于颗粒物会改变中性粒细胞溶酶体的功能和激活状态

03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.4686

E. Watts, R. Huff, C. Rider, M. Whyte, S. Walmsley, C. Carlsten

引用次数: 1

Establishment of a human in vitro model for airway epithelial repair and regeneration 人体外气道上皮修复与再生模型的建立

03.03 - Mechanisms of lung injury and repair Pub Date : 2021-03-11 DOI: 10.1183/23120541.LSC-2021.21

A. Chakraborty, M. Mastalerz, R. Hatz, J. Behr, M. Lindner, A. Hilgendorff, C. Staab-Weijnitz

{"title":"Establishment of a human in vitro model for airway epithelial repair and regeneration","authors":"A. Chakraborty, M. Mastalerz, R. Hatz, J. Behr, M. Lindner, A. Hilgendorff, C. Staab-Weijnitz","doi":"10.1183/23120541.LSC-2021.21","DOIUrl":"https://doi.org/10.1183/23120541.LSC-2021.21","url":null,"abstract":"The airway epithelium is constantly exposed to noxious substances and respiratory disease is among the major leading causes of death worldwide. Upon airway injury, restoration of the normal lung architecture would be desirable, but the mechanisms involved in human adult lung regeneration are poorly understood. Notably, most mechanistic studies have been performed in mouse models where exposition to chemicals, most frequently naphthalene (NP) or polidocanol (PL), causes depletion of bronchial epithelial cells followed by subsequent epithelial regeneration. Given the major differences in cellular composition in the upper respiratory epithelium between humans and mice, we have set out to develop a human in vitro model for the analysis of lung injury and regeneration using primary human bronchial epithelial cells (phBECs) cultured at the air-liquid interface. In contrast to the mouse model, NP treatment in human bronchial epithelium in vitro did not induce cell death, let alone specifically deplete club cells. PL treatment, however, led to a dose-dependent loss of epithelial cells with an IC50 of 0.047% PL. Furthermore, loss of differentiated cell types such as goblet, ciliated and club cells were observed post PL treatment followed by subsequent regeneration of the human bronchial epithelium with the appearance of differentiated cell types at the expense of basal cells within two weeks. During regeneration phase, an increase in cell count was observed based on DAPI count from immunofluorescence analysis indicates proliferation. For proof-of-concept, we will next use this human in-vitro model to assess modulation of bronchial epithelial regeneration by Notch signaling.","PeriodicalId":382910,"journal":{"name":"03.03 - Mechanisms of lung injury and repair","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133353270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0