03.03 - Mechanisms of lung injury and repair最新文献

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A novel neuropilin-2 (NRP2) antibody for immunohistochemical staining of patient tissue samples 一种用于患者组织样本免疫组化染色的新型神经匹林-2 (NRP2)抗体
03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.4531
Y. Chong, S. Förster, D. Siefker, Y. Becker, E. Escobedo, L. Burman, K. Rauch, S. Paz, C. Burkart, A. Cubitt, M. Muders, L. Nangle
{"title":"A novel neuropilin-2 (NRP2) antibody for immunohistochemical staining of patient tissue samples","authors":"Y. Chong, S. Förster, D. Siefker, Y. Becker, E. Escobedo, L. Burman, K. Rauch, S. Paz, C. Burkart, A. Cubitt, M. Muders, L. Nangle","doi":"10.1183/13993003.congress-2022.4531","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.4531","url":null,"abstract":"","PeriodicalId":382910,"journal":{"name":"03.03 - Mechanisms of lung injury and repair","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122995771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Proteomic profiling of severe lung diffusion impairment in the recovery stage of COVID-19-induced ARDS covid -19诱导的ARDS恢复期严重肺弥散损伤的蛋白质组学分析
03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.632
M. C. García-Hidalgo, J. González, I. Benítez, S. Santisteve, F. Rodríguez-Jara, M. Molinero, M. Pérez-Pons, G. Torres, A. Moncusí-Moix, C. Gort-Paniello, P. Carmona, J. Caballero, C. Barberà, A. Tedim, R. Almansa, A. Ceccato, L. Fernández-Barat, R. Ferrer, D. García-Casulla, R. Menéndez, A. Motos, Ó. Peñuelas, J. Riera, J. Bermejo-Martín, A. Torres, F. Barbé, D. de Gonzalo-Calvo
{"title":"Proteomic profiling of severe lung diffusion impairment in the recovery stage of COVID-19-induced ARDS","authors":"M. C. García-Hidalgo, J. González, I. Benítez, S. Santisteve, F. Rodríguez-Jara, M. Molinero, M. Pérez-Pons, G. Torres, A. Moncusí-Moix, C. Gort-Paniello, P. Carmona, J. Caballero, C. Barberà, A. Tedim, R. Almansa, A. Ceccato, L. Fernández-Barat, R. Ferrer, D. García-Casulla, R. Menéndez, A. Motos, Ó. Peñuelas, J. Riera, J. Bermejo-Martín, A. Torres, F. Barbé, D. de Gonzalo-Calvo","doi":"10.1183/13993003.congress-2022.632","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.632","url":null,"abstract":"","PeriodicalId":382910,"journal":{"name":"03.03 - Mechanisms of lung injury and repair","volume":"128 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123106154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of cigarette smoke exposure on airway epithelial barrier function in never-smokers and ex-smokers with and without COPD 香烟烟雾暴露对不吸烟者和已戒烟者(伴或不伴COPD)气道上皮屏障功能的影响
03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.2350
K. Nwozor, Q. Chen, Y. Yang, X. Zheng, T. Kole, D. Slebos, K. Klooster, M. van den Berge, T. Hackett, C. Brandsma, I. Heijink
{"title":"Effect of cigarette smoke exposure on airway epithelial barrier function in never-smokers and ex-smokers with and without COPD","authors":"K. Nwozor, Q. Chen, Y. Yang, X. Zheng, T. Kole, D. Slebos, K. Klooster, M. van den Berge, T. Hackett, C. Brandsma, I. Heijink","doi":"10.1183/13993003.congress-2022.2350","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.2350","url":null,"abstract":"","PeriodicalId":382910,"journal":{"name":"03.03 - Mechanisms of lung injury and repair","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125344228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular matrix formation reduction by nintedanib varies in the Scar-in-a-Jar fibroblast model depending on pathway induction nintedanib在Scar-in-a-Jar成纤维细胞模型中的细胞外基质形成减少取决于途径诱导
03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.1715
M. A. Christensen, P. Juhl, D. Leeming, J. Sand
{"title":"Extracellular matrix formation reduction by nintedanib varies in the Scar-in-a-Jar fibroblast model depending on pathway induction","authors":"M. A. Christensen, P. Juhl, D. Leeming, J. Sand","doi":"10.1183/13993003.congress-2022.1715","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.1715","url":null,"abstract":"","PeriodicalId":382910,"journal":{"name":"03.03 - Mechanisms of lung injury and repair","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116287901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
MSC extracellular vesicles ameliorate ARDS via activation of mitochondrial biogenesis 间充质干细胞外囊泡通过激活线粒体生物发生改善ARDS
03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.3450
C. McClintock, J. Silva, D. Doherty, C. O’Kane, D. Mc Auley, A. Krasnodembskaya
{"title":"MSC extracellular vesicles ameliorate ARDS via activation of mitochondrial biogenesis","authors":"C. McClintock, J. Silva, D. Doherty, C. O’Kane, D. Mc Auley, A. Krasnodembskaya","doi":"10.1183/13993003.congress-2022.3450","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.3450","url":null,"abstract":"","PeriodicalId":382910,"journal":{"name":"03.03 - Mechanisms of lung injury and repair","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126146344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Divergent effects of macrophage migration inhibitory factor and D-dopachrome tautomerase on lung epithelial regeneration 巨噬细胞迁移抑制因子和d -多巴胺自变性酶对肺上皮再生的不同影响
03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.2300
S. Song, H. Habibie, M. Jager, C. Brandsma, G. Poelarends, B. Melgert
{"title":"Divergent effects of macrophage migration inhibitory factor and D-dopachrome tautomerase on lung epithelial regeneration","authors":"S. Song, H. Habibie, M. Jager, C. Brandsma, G. Poelarends, B. Melgert","doi":"10.1183/13993003.congress-2022.2300","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.2300","url":null,"abstract":"","PeriodicalId":382910,"journal":{"name":"03.03 - Mechanisms of lung injury and repair","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131242226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Balance between α-1Antitrypsin and Human Neutrophil Elastase (a1AT/HNE) in Bronchoalveolar Lavage fluid (BALf) of severe COVID19 patients covid - 19重症患者支气管肺泡灌洗液(BALf) α-1抗胰蛋白酶与人中性粒细胞弹性酶(a1AT/HNE)的平衡
03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.2735
V. Vertui, M. D’Amato, S. Viglio, S. Bozzini, M. Morosini, L. Pandolfi, S. Lettieri, M. Della Zoppa, T. Fossali, R. Colombo, A. Aliberti, P. Iadarola, F. Meloni
{"title":"Balance between α-1Antitrypsin and Human Neutrophil Elastase (a1AT/HNE) in Bronchoalveolar Lavage fluid (BALf) of severe COVID19 patients","authors":"V. Vertui, M. D’Amato, S. Viglio, S. Bozzini, M. Morosini, L. Pandolfi, S. Lettieri, M. Della Zoppa, T. Fossali, R. Colombo, A. Aliberti, P. Iadarola, F. Meloni","doi":"10.1183/13993003.congress-2022.2735","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.2735","url":null,"abstract":"","PeriodicalId":382910,"journal":{"name":"03.03 - Mechanisms of lung injury and repair","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133216578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electronic cigarette liquids impair protein synthesis and alter proteomic profiles in V79 cells 电子烟液体损害蛋白质合成并改变V79细胞的蛋白质组学特征
03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.1934
M. Ljujić, S. Trifunovic, K. Smiljanic, F. Solari, A. Sickmann, A. D. Rankov, Info Metrics
{"title":"Electronic cigarette liquids impair protein synthesis and alter proteomic profiles in V79 cells","authors":"M. Ljujić, S. Trifunovic, K. Smiljanic, F. Solari, A. Sickmann, A. D. Rankov, Info Metrics","doi":"10.1183/13993003.congress-2022.1934","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.1934","url":null,"abstract":"Electronic cigarettes (e-cigarettes) have been found to affect range of cellular processes including oxidative stress, inflammation, DNA damage and cell death among others. The full extent of consequences of e-cigarettes use, especially their long term effect, is still largely unknown. Better understanding and characterization of their biological effects is needed in estimating their health consequences. We performed in-depth proteomic analysis in V79 lung fibroblasts treated with sub lethal concentrations of e-cigarette liquid (ECL), with and without nicotine (1.38%, 250µg/ml nicotine), for 72h via high resolution, trapped ion mobility mass spectrometry (TimsTOF). We found that both ECLs induced significant depletion in total number of proteins in treated cells. Mitochondrial proteins were among most significantly depleted cell components in treatments, while focal adhesion constituents were upregulated. In addition, there was an inclusion of glutamine metabolic process, all indicative of increased demand for ATP and increased cell motility. Decrease in translation aspect was evident in cell components, molecular functions and biological processes in both treatments. We also observed increased presence of posttranslational modifications including carbonylations, direct oxidative modifications and modifications most likely caused by ECL such as acetaldehyde, ethylation, dichlorynation of tyrosine, etc. Our results point to significant proteome alterations under influence of e-cigarette liquids, effects of which need to be further investigated.","PeriodicalId":382910,"journal":{"name":"03.03 - Mechanisms of lung injury and repair","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121236597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammation and membrane integrity of epithelial cells and macrophages infected by Pseudomonas aeruginosa and Streptococcus pneumoniae 铜绿假单胞菌和肺炎链球菌感染上皮细胞和巨噬细胞的炎症和膜完整性
03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.1222
E. Campaña Duel, L. Morales-Quinteros, A. Ceccato, A. Areny-Balagueró, P. Conde, L. Blanch, L. Fernández, M. Camprubí-Rimblas, A. Artigas
{"title":"Inflammation and membrane integrity of epithelial cells and macrophages infected by Pseudomonas aeruginosa and Streptococcus pneumoniae","authors":"E. Campaña Duel, L. Morales-Quinteros, A. Ceccato, A. Areny-Balagueró, P. Conde, L. Blanch, L. Fernández, M. Camprubí-Rimblas, A. Artigas","doi":"10.1183/13993003.congress-2022.1222","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.1222","url":null,"abstract":"","PeriodicalId":382910,"journal":{"name":"03.03 - Mechanisms of lung injury and repair","volume":"206 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121436429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of miR-328-3p targets during wound repair of bronchial epithelial cells 支气管上皮细胞伤口修复过程中miR-328-3p靶点的鉴定
03.03 - Mechanisms of lung injury and repair Pub Date : 2022-09-04 DOI: 10.1183/13993003.congress-2022.2977
B. Narożna, Z. Stachowiak, W. Langwiński, A. Szczepankiewicz
{"title":"Identification of miR-328-3p targets during wound repair of bronchial epithelial cells","authors":"B. Narożna, Z. Stachowiak, W. Langwiński, A. Szczepankiewicz","doi":"10.1183/13993003.congress-2022.2977","DOIUrl":"https://doi.org/10.1183/13993003.congress-2022.2977","url":null,"abstract":"","PeriodicalId":382910,"journal":{"name":"03.03 - Mechanisms of lung injury and repair","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115903925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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