{"title":"Evaluation of the influence of niacinamide and saccharide isomerate on the rheological behavior of a hydrogel for topical use","authors":"Mariane Massufero Vergilio , Jéssica Heline Lopes da Fonsêca , Marcos Akira d'Ávila , Gislaine Ricci Leonardi","doi":"10.1016/j.biotri.2023.100243","DOIUrl":"10.1016/j.biotri.2023.100243","url":null,"abstract":"<div><p>Among the cosmetic forms used to administer cosmetic actives, the gel form has been highly sought after, as it offers a non-greasy sensation and allows the application of the formulation associated with ultrasound techniques for skin rejuvenation, such as phonophoresis. The aim of the present study was to develop a stable system for delivering anti-aging actives to the skin containing niacinamide and saccharide isomerate. The formulation and base development stage included a stability and rheological study over 16 weeks. The rheological analysis consisted of steady-state flow measurements and amplitude sweep tests, followed by a frequency sweep test. Three-interval thixotropy testing (3ITT) was also performed. As a result, the developed system showed high stability throughout the 16-week period. The organoleptic and rheological stability profile of the base and the formulation was quite similar, indicating that the presence of actives is indifferent to gel stability. Furthermore, rheologically, the base and the formulation exhibited shear-thinning behavior. The addition of the actives in the formulation decreased the apparent viscosity value by nearly half of the original value. Strong viscoelastic behavior was evidenced in both samples. In the end, the 3ITT test revealed a high recovery of sample viscosity. It can be concluded that the developed gel is a promising formulation for the topical administration of the studied actives.</p></div>","PeriodicalId":38233,"journal":{"name":"Biotribology","volume":"35 ","pages":"Article 100243"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48249903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiotribologyPub Date : 2023-12-01Epub Date: 2022-12-30DOI: 10.1016/j.biotri.2022.100233
G.H. Majzoobi , K. Rahmani , M. Mohammadi , H. Bakhtiari , R. Das
{"title":"Tribological behaviour of Ti/HA and Ti/SiO2 functionally graded materials fabricated at different strain rates","authors":"G.H. Majzoobi , K. Rahmani , M. Mohammadi , H. Bakhtiari , R. Das","doi":"10.1016/j.biotri.2022.100233","DOIUrl":"10.1016/j.biotri.2022.100233","url":null,"abstract":"<div><p>Functionally graded materials (FGMs) have found extensive applications in the biomedical industry, due to their excellent mechanical and tribological properties. However, new FGM fabrication techniques are yet to be examined for possible enhancements in their properties. This study investigates the tribological properties of Titanium/Hydroxyapatite (Ti-HA) and Titanium/Silicon oxide (Ti-SiO<sub>2</sub>) FGM samples fabricated by three die compaction techniques for the application of dental implants. The constituting powder particles were functionally dispersed and mixed using a newly-designed mixer and consolidated by hot dynamic and quasi-static compaction techniques at three different strain rates. Microstructure, hardness, wear resistance, wear penetration depth, and friction coefficient of the FGM samples were then studied in this work. Optical microscopy images exhibited smooth dispersion of powders conforming to a linear grading function. Vickers hardness values of the FGM samples was found to be directly proportional to the strain rate and inversely proportional to the content of the reinforcing phase (HA or SiO<sub>2</sub>). Higher strain rate also resulted in higher wear resistance and lower wear penetration depth in all FGMs, with the highest wear resistance being observed in the samples prepared using the Split Hopkinson Bar. Similarly, the coefficient of friction was also shown to be the lowest in Ti-HA samples prepared using Split Hopkinson Bar. Further, microscopic observations revealed that adhesion, delamination and abrasion as the dominant wear mechanisms in all FGM samples. It was concluded that the Ti-HA sample produced by the SHB method enjoyed superior tribological properties, being comparable to that of natural human teeth.</p></div>","PeriodicalId":38233,"journal":{"name":"Biotribology","volume":"35 ","pages":"Article 100233"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45010889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiotribologyPub Date : 2023-12-01Epub Date: 2023-05-23DOI: 10.1016/j.biotri.2023.100244
Jawad K. Oleiwi , Qahtan A. Hamad , Noor K. Faheed
{"title":"Experimental, Theoretical, and Numerical Analysis of Laminated Composite Prosthetic Socket Reinforced with Flax and Cotton Fibers","authors":"Jawad K. Oleiwi , Qahtan A. Hamad , Noor K. Faheed","doi":"10.1016/j.biotri.2023.100244","DOIUrl":"10.1016/j.biotri.2023.100244","url":null,"abstract":"<div><p>A lot of work has been done to enhance the mechanical properties of natural fiber composites to increase their strength and applicability. This research aims to investigate the utilization of natural fibers for below-knee prosthesis socket manufacture using the vacuum bagging technique experimentally, theoretically, and numerically. Lamination groups of different layering arrangements were evaluated by tensile tests. The finite element methodology (FEM) was utilized by noting the dispersion of safety factors, equivalent Von-Mises stress, and total deformation, while the theoretical part estimated Poisson's ratio, volume fraction, failure index, and theoretical safety factor. The study found that the number and type of fibers affected mechanical properties, in addition, that combining natural and artificial reinforcements permits the creation of high-performance bio-composites. FEM results coincided with both the theoretical and experimental results, with lamination 9 having the highest modulus of elasticity (5.6 GPa) and tensile strength (423 MPa). This work uncovered the properties of the proposed hybrid fiber-reinforced composites that haven't been exasperated up to the present and showed that sockets can be assembled from sustainable, low-risk materials without sacrificing the composite materials' strength. The study found that bio-composites with better performance could be created by combining synthetic with natural reinforcements.</p></div>","PeriodicalId":38233,"journal":{"name":"Biotribology","volume":"35 ","pages":"Article 100244"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48259796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiotribologyPub Date : 2023-12-01Epub Date: 2023-10-18DOI: 10.1016/j.biotri.2023.100262
Konstantina Simou , Piaopiao Pan , Qingguo Li , Simon W. Jones , Edward Davis , Jon Preece , Zhenyu J. Zhang
{"title":"Nanoparticle formulation for intra-articular treatment of osteoarthritic joints","authors":"Konstantina Simou , Piaopiao Pan , Qingguo Li , Simon W. Jones , Edward Davis , Jon Preece , Zhenyu J. Zhang","doi":"10.1016/j.biotri.2023.100262","DOIUrl":"10.1016/j.biotri.2023.100262","url":null,"abstract":"<div><p>Based on a proven concept of using nanoparticles to lubricate an articulating interface, we developed a set of formulations to demonstrate the feasibility of using polymeric nanoparticles as physical intervention for early stage osteoarthritis (OA). The biocompatible polymeric nanoparticles (NPs), namely polymethylmethacrylate (PMMA), polycaprolactone (PCL), and polylactic acid (PLA) were accompanied with hyaluronic acid (HA) and surface actives, of which the lubrication effect was examined between a steel ball and a silicone elastomer substrate to replicate the bone-cartilage contact. All three types of polymer nanoparticles were found to reduce the overall Coefficient of Friction (CoF), with PLA NPs being the most effective - providing a reduction up to 24.3%, which suggests that soft (low Young's modulus) nanoparticles are the most efficient frictional additives. Based on the data acquired, it is likely that surface deposited NPs could smooth the solid substrates, hyaluronic acid ensures bulk viscosity, and the surfactant enhances formulation stability. We suggest that surface adsorbed nanoparticles are beneficial in providing interfacial lubrication, which offers insight on the development of early stage intervention strategies for OA.</p></div>","PeriodicalId":38233,"journal":{"name":"Biotribology","volume":"35 ","pages":"Article 100262"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S235257382300029X/pdfft?md5=5bddf49eb03388762e19bf45663187bb&pid=1-s2.0-S235257382300029X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135811867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiotribologyPub Date : 2023-12-01Epub Date: 2023-11-05DOI: 10.1016/j.biotri.2023.100263
Benjamin A. Clegg, Dilesh Raj Shrestha, Nazanin Emami
{"title":"Tribo-Mechanical Properties and Bioactivity of Additively Manufactured PAEK Materials for Load Bearing Medical Applications: A Systematic Review","authors":"Benjamin A. Clegg, Dilesh Raj Shrestha, Nazanin Emami","doi":"10.1016/j.biotri.2023.100263","DOIUrl":"https://doi.org/10.1016/j.biotri.2023.100263","url":null,"abstract":"<div><p>Additive manufacturing (AM) holds significant potential in transforming medical applications, with a particular focus on polyetheretherketone (PEEK) and its derivatives, collectively known as poly-aryl-ether-ketone (PAEK) materials. Advances in AM precision have paved the way for the successful 3D printing of high-performance thermoplastics like PEEK, offering new prospects in load-bearing medical applications. This systematic review comprehensively assesses recent scientific literature concerning the tribo-mechanical properties and bioactivity of additively manufactured PAEK materials, with a specific emphasis on PEEK, for load-bearing medical uses. Despite substantial research into AM of metallic biomaterials, knowledge gaps persist regarding AM processing parameters, structure-property relationships, biological behaviours, and implantation suitability of PAEKs. This review bridges these gaps by analysing existing literature on the tribo-mechanical properties and bioactivity of additively manufactured PAEK materials, providing valuable insights into their performance in load-bearing medical applications. Key aspects explored include printing conditions, strength limitations, and outcomes of in-vitro and in-vivo evaluations. Through this systematic review, we consolidate current knowledge, delivering essential information for researchers, clinicians, and manufacturers involved in advancing additively manufactured PAEK materials for load-bearing medical applications.</p></div>","PeriodicalId":38233,"journal":{"name":"Biotribology","volume":"35 ","pages":"Article 100263"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352573823000306/pdfft?md5=4ddf84967d41420a69241fc067f26026&pid=1-s2.0-S2352573823000306-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138087278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiotribologyPub Date : 2023-12-01Epub Date: 2023-06-29DOI: 10.1016/j.biotri.2023.100254
Alessandro Ruggiero, Marco De Stefano
{"title":"On the Biotribological Surfaces of Dental Implants: Investigation in the Framework of Osseointegration","authors":"Alessandro Ruggiero, Marco De Stefano","doi":"10.1016/j.biotri.2023.100254","DOIUrl":"https://doi.org/10.1016/j.biotri.2023.100254","url":null,"abstract":"","PeriodicalId":38233,"journal":{"name":"Biotribology","volume":"35 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49708090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiotribologyPub Date : 2023-12-01Epub Date: 2023-09-01DOI: 10.1016/j.biotri.2023.100256
Markus A. Wimmer , Elmira M. Rad , Michel P. Laurent , Robin Pourzal
{"title":"Striated pattern on worn surface of a retrieved TKR Tibial insert stems from microstructural changes in the UHMWPE","authors":"Markus A. Wimmer , Elmira M. Rad , Michel P. Laurent , Robin Pourzal","doi":"10.1016/j.biotri.2023.100256","DOIUrl":"10.1016/j.biotri.2023.100256","url":null,"abstract":"<div><p>Polyethylene wear has been a concern for the longevity of total knee replacements (TKR). A characteristic wear feature often observed on the articular surfaces of retrieved polyethylene tibial inserts is a striated pattern of hills and troughs. This pattern is of interest because its surface area has been found to correlate with increased tibial insert wear. We therefore addressed the following two research questions: (1) What is the prevalence of the striated pattern on a contemporary tibial insert design made from conventional ultra-high-molecular-weight polyethylene (UHMWPE)? (2) Are the peaks and troughs of the striated pattern connected with differences in crystallinity developed during the wear process? The prevalence and area coverage of the striated patterns were determined on a set of 81 retrieved tibial inserts of a cruciate-retaining TKR design. The striated areas were mapped using an optical coordinate measuring machine. Differences in crystallinity between troughs and hills were determined on a representative tibial insert using Raman spectroscopy. The striated pattern was observed on 61 out of 81 (75%) of the retrieved tibial inserts, covering an average of 32% of the total articular area. In the representative insert that was evaluated, the hills exhibited higher crystallinity (68%) than the troughs (54%) (<em>p</em> = 0.001). Conversely, the troughs exhibited higher amorphous phase content (22%) than the hills (19%) (<em>p</em> = 0.04). In conclusion, this pattern of hills and troughs is another example of microstructural changes in UHMWPE stemming from tribological stresses.</p></div>","PeriodicalId":38233,"journal":{"name":"Biotribology","volume":"35 ","pages":"Article 100256"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41334001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiotribologyPub Date : 2023-12-01Epub Date: 2022-12-07DOI: 10.1016/j.biotri.2022.100230
Lorenza Mattei, Francesca Di Puccio
{"title":"Effect of Friction on Finite Element Contact and Wear Predictions of Metal-on-Plastic Hip Replacements","authors":"Lorenza Mattei, Francesca Di Puccio","doi":"10.1016/j.biotri.2022.100230","DOIUrl":"10.1016/j.biotri.2022.100230","url":null,"abstract":"<div><p>Finite Element wear predictive modelling is a powerful tool that can replace or support costly and time-consuming wear tests. Despite the lively research in this field, particularly in applications to hip replacements, some issues are still open, such as the role of friction in numerical simulations. Indeed, in most wear models, frictionless contact conditions are assumed and wear routines are independent from <em>f</em>. However, the effect of friction on contact and wear modelling of metal-on-plastic hip replacements has never been fully explored in the literature.</p><p>In this study we analyse how the friction coefficient affects both the contact features (nominal contact point trajectory, components of the contact force and contact pressure) and the wear parameters, (wear volume and linear wear distribution). A case study of a 32 mm implant was simulated under two different loading and kinematic conditions, considering both vertical and 3D load, and varying the friction coefficient <em>f</em> within the range 0–0.3, for a given <em>k</em> value. Results show that a frictional contact has longer and wider trajectories of the nominal contact point, but slightly lower normal force and contact pressure values, with respect to a frictionless solution. Consequently, contact pressure maps are shifted with respect to the frictionless case but values remain almost the same changing <em>f.</em> The wear volume slightly decreases with <em>f</em> whilst wear maps are very sensitive to it. Results suggest that for <em>f</em> ≤ 0.1 the frictionless hypothesis can be adopted achieving accurate results with the advantage of reduced computational costs.</p></div>","PeriodicalId":38233,"journal":{"name":"Biotribology","volume":"35 ","pages":"Article 100230"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43743443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}