Brittany Butts, Christopher Herring, Chloe Park, Enid Swatson, Jordan Watson, Whitney Wharton
{"title":"Clinically Meaningful or Just Measurable? What Physiologic Outcomes Tell Us About Aging Interventions.","authors":"Brittany Butts, Christopher Herring, Chloe Park, Enid Swatson, Jordan Watson, Whitney Wharton","doi":"10.1007/s13670-025-00435-0","DOIUrl":"10.1007/s13670-025-00435-0","url":null,"abstract":"<p><strong>Purpose of review: </strong>As the aging population grows, identifying interventions that meaningfully improve physiologic health is increasingly important. This review examines recent evidence (2019-2025) on exercise, nutrition, pharmacologic, and multimodal interventions aimed at preserving function and extending healthspan in adults aged ≥65 years.</p><p><strong>Recent findings: </strong>Exercise and protein supplementation-particularly when combined-consistently improve muscle strength, mobility, and cardiovascular fitness. Multidomain lifestyle programs delay disability and enhance physical function. Novel approaches, including pharmaconutrition, senolytics, and stem cell therapies, target aging processes such as inflammation, cellular senescence, and sarcopenia. These early-phase interventions show promise for improving strength, reducing frailty, and potentially slowing biological aging.</p><p><strong>Summary: </strong>Targeted interventions can improve physiologic outcomes and functional status in older adults. Lifestyle strategies remain foundational, while emerging geroscience-based therapies may offer additive benefits. Future research should clarify optimal combinations, timing, and patient selection to guide personalized, integrative approaches to healthy aging.</p>","PeriodicalId":38089,"journal":{"name":"Current Geriatrics Reports","volume":"14 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149138590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jarratt D Pytell, Mariah L Robertson, Benjamin H Han, Noelle G Martinez
{"title":"Opioid Use Disorder in Older Adults: a Narrative Review.","authors":"Jarratt D Pytell, Mariah L Robertson, Benjamin H Han, Noelle G Martinez","doi":"10.1007/s13670-025-00431-4","DOIUrl":"10.1007/s13670-025-00431-4","url":null,"abstract":"<p><strong>Purpose of the review: </strong>The review synthesizes current literature on the epidemiology, treatment outcomes, and co-occurring conditions of opioid use disorder (OUD) in older adults, framed through the OUD cascade of care model.</p><p><strong>Recent findings: </strong>The prevalence of OUD among older adults has risen significantly, with Medicare data showing an increase from 4.6 to 15.7 per 1,000 beneficiaries between 2013 and 2018. Hospitalizations and overdose deaths have also escalated, particularly among racially minoritized groups. Despite policy changes expanding access to medications for OUD, including the removal of the X-Waiver and Medicare's coverage of opioid treatment programs, treatment rates remain low, and disparities are present based on geographic location, race, ethnicity, and gender. Studies indicate that buprenorphine and methadone significantly reduce mortality risk, yet optimal dosing and delivery models for older adults remain underexplored. Additionally, older adults with OUD experience high rates of comorbidities, including cardiovascular disease, psychiatric conditions, and chronic pain, further complicating the initiation and maintenance of medications for OUD.</p><p><strong>Summary: </strong>Older adults with OUD are growing and while treatment is increasing, research and best practices on age-friendly approaches to screening, treatment, and harm reduction remain unknown. The growing burden of OUD in this population underscores the urgent need for research on tailored interventions, particularly regarding medications for OUD initiation, polypharmacy management, and care delivery models that accommodate mobility and cognitive impairments. Expanding harm reduction strategies and integrating OUD treatment into general medical settings can enhance access and improve outcomes for older adults.</p>","PeriodicalId":38089,"journal":{"name":"Current Geriatrics Reports","volume":"14 1","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annalisa Na, Joke Bradt, G Peter Gliebus, Julie A Fritz, Laura Gitlin
{"title":"Exercise-Based Pain Interventions for People with Dementia Using a Biopsychosocial-Environmental (BPSE) Model.","authors":"Annalisa Na, Joke Bradt, G Peter Gliebus, Julie A Fritz, Laura Gitlin","doi":"10.1007/s13670-025-00450-1","DOIUrl":"10.1007/s13670-025-00450-1","url":null,"abstract":"<p><strong>Purpose of review: </strong>To introduce the Biopsychosocial-Environmental (BPSE) model to guide an exercise intervention to address pain related to osteoarthritis (OA) among people living with dementia (PLWD). This review [1] synthesizes literature on the biological, psychological, social, and environmental aspects of pain from OA in the knee, neurodegeneration in PLWD, and exercise implications for these comorbidities, and [2] demonstrates the clinical utility of the BPSE model in designing tailored exercise interventions to manage knee OA pain in PLWD.</p><p><strong>Recent findings: </strong>Research indicates that pain from knee OA and neurodegeneration from dementia interact across multiple factors, including psychological, social, and environmental. These factors compound the biological interactions of the comorbidities, further challenging function and quality of life.</p><p><strong>Summary: </strong>The BPSE model provides a structured framework for tailoring exercise interventions to PLWDs' interests and preserved abilities. Applying this model may improve pain management, mobility, and quality of life while informing future chronic disease management in PLWD.</p>","PeriodicalId":38089,"journal":{"name":"Current Geriatrics Reports","volume":"14 1","pages":"23"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12602601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145507404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pain Management for Older Adults Across the Cognitive Trajectory","authors":"Ann L. Horgas, Jianli Wu, Staja Q. Booker","doi":"10.1007/s13670-023-00403-6","DOIUrl":"https://doi.org/10.1007/s13670-023-00403-6","url":null,"abstract":"","PeriodicalId":38089,"journal":{"name":"Current Geriatrics Reports","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135585697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Catherine A. Clair, Karin E. Tobin, Janiece L. Taylor
{"title":"Caregiver Burden and its Limitations in Describing Black Caregivers’ Experience","authors":"Catherine A. Clair, Karin E. Tobin, Janiece L. Taylor","doi":"10.1007/s13670-023-00402-7","DOIUrl":"https://doi.org/10.1007/s13670-023-00402-7","url":null,"abstract":"","PeriodicalId":38089,"journal":{"name":"Current Geriatrics Reports","volume":"104 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135773397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lisa Kirk Wiese, Beth A. Pratt, Katherine Heinze, Lilah Besser, Antoinita Ifill, Christine L. Williams
{"title":"Community-Based Strategies to Reduce Alzheimer’s Disease and Related Dementia Incidence Among Rural, Racially/Ethnically Diverse Older Adults","authors":"Lisa Kirk Wiese, Beth A. Pratt, Katherine Heinze, Lilah Besser, Antoinita Ifill, Christine L. Williams","doi":"10.1007/s13670-023-00400-9","DOIUrl":"https://doi.org/10.1007/s13670-023-00400-9","url":null,"abstract":"","PeriodicalId":38089,"journal":{"name":"Current Geriatrics Reports","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135616854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jing Huang, Inga M. Antonsdottir, Richard Wang, Mengchi Li, Junxin Li
{"title":"Insomnia and Its Non-Pharmacological Management in Older Adults","authors":"Jing Huang, Inga M. Antonsdottir, Richard Wang, Mengchi Li, Junxin Li","doi":"10.1007/s13670-023-00397-1","DOIUrl":"https://doi.org/10.1007/s13670-023-00397-1","url":null,"abstract":"","PeriodicalId":38089,"journal":{"name":"Current Geriatrics Reports","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135200124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rebecca Wright, Natalie G. Regier, Ashley Booth, Valerie T. Cotter, Bryan R. Hansen, Janiece L. Taylor, Sarah Won, Gary Witham
{"title":"Considerations of Intersectionality for Older Adults with Palliative Care Needs in the Emergency Department: An Integrative Review","authors":"Rebecca Wright, Natalie G. Regier, Ashley Booth, Valerie T. Cotter, Bryan R. Hansen, Janiece L. Taylor, Sarah Won, Gary Witham","doi":"10.1007/s13670-023-00399-z","DOIUrl":"https://doi.org/10.1007/s13670-023-00399-z","url":null,"abstract":"","PeriodicalId":38089,"journal":{"name":"Current Geriatrics Reports","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135966688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martha Abshire Saylor, Chitchanok Benjasirisan, Suratsawadee Kruahong, Arum Lim, Jessica Gill, Sarah L. Szanton, Binu Koirala
{"title":"A Contemporary Review of Psychosocial Resilience in Heart Failure Using the Society to Cells Resilience Theory","authors":"Martha Abshire Saylor, Chitchanok Benjasirisan, Suratsawadee Kruahong, Arum Lim, Jessica Gill, Sarah L. Szanton, Binu Koirala","doi":"10.1007/s13670-023-00398-0","DOIUrl":"https://doi.org/10.1007/s13670-023-00398-0","url":null,"abstract":"","PeriodicalId":38089,"journal":{"name":"Current Geriatrics Reports","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47900200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Adult Congenital Heart Disease in the Aging and Elderly Population","authors":"A. Cai, Andrew R. Pistner, E. Krieger","doi":"10.1007/s13670-023-00396-2","DOIUrl":"https://doi.org/10.1007/s13670-023-00396-2","url":null,"abstract":"","PeriodicalId":38089,"journal":{"name":"Current Geriatrics Reports","volume":"1 1","pages":""},"PeriodicalIF":1.2,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46188977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}