International Journal of Epilepsy最新文献_第8页

Effect of Pentylenetetrazole-Induced Seizures on Serum Brain-Derived Neurotrophic Factor (BDNF) Levels and Cognition in Rats 戊四唑诱导癫痫发作对大鼠血清脑源性神经营养因子(BDNF)水平和认知的影响

International Journal of Epilepsy Pub Date : 2018-10-01 DOI: 10.1055/S-0039-1694903

Vibha Patel, J. Katyal, Haroon Rashid, Y. Gupta

引用次数: 2

A Home-Based, Primary-Care Model for Epilepsy Care in Low and Middle Income Countries: Basis and Design 低收入和中等收入国家基于家庭的癫痫初级保健模式：基础和设计

International Journal of Epilepsy Pub Date : 2018-10-01 DOI: 10.1055/s-0039-1694899

S. Sharma, Anuraag Chowdhury, Dr. Sarit Sharma, R. Bansal, Gagandeep Singh

引用次数: 0

Correlation between Distance from Health Centre and Adherence to Clinic Appointments and Medication Procurement among People with Epilepsy in the Community 社区癫痫患者与健康中心的距离与依从门诊预约和药物采购的相关性

International Journal of Epilepsy Pub Date : 2018-10-01 DOI: 10.1055/S-0039-1694865

Ch C Gupta, Gagandeep Singh, Karan Chouhan, Archita Chawla, R. Setia, S. Sharma, N. Bansal

引用次数: 0

Effect of Antidepressants (Sertraline, Escitalopram) in Combination with Antiepileptic Drugs (Sodium Valproate, Levetiracetam) on Seizures, Cognitive Impairment, and Oxidative Stress in Rats 抗抑郁药（舍曲林、依西酞普兰）联合抗癫痫药物（丙戊酸钠、左乙拉西坦）对大鼠癫痫发作、认知障碍和氧化应激的影响

International Journal of Epilepsy Pub Date : 2018-10-01 DOI: 10.1055/S-0039-1694883

Md. Hussain, J. Katyal, Haroon Rashid, Y. Gupta

引用次数: 0

Preclinical Screening of Antiepileptic Properties of Diltiazem in Chemically and Electrically Induced Battery of Seizures Tests in Laboratory Experimental Animal Models 地尔硫卓在实验室实验动物模型化学和电致癫痫发作试验中的抗癫痫特性的临床前筛选

International Journal of Epilepsy Pub Date : 2018-10-01 DOI: 10.1055/s-0039-1694893

S. K., P. G., M. C., P. G., M. K.

引用次数: 0

Status Epilepticus in Pediatric Patients Severity Score (STEPSS): A Clinical Score to Predict the Outcome of Status Epilepticus in Children 儿童癫痫持续状态严重程度评分(STEPSS):预测儿童癫痫持续状态预后的临床评分

International Journal of Epilepsy Pub Date : 2018-10-01 DOI: 10.1055/S-0039-1694897

Sidharth Yadav, Suvasini Sharma, Bijoy Patra, Rajeev Malhotra, Virendra Kumar

引用次数: 0

EEG Changes in Autoimmune Neuronal Synaptic Encephalitis—A Case Study 自身免疫性神经元突触性脑炎的脑电图变化——一例研究

International Journal of Epilepsy Pub Date : 2018-10-01 DOI: 10.1055/s-0039-1694880

L. Khanna, N. Agarwal

引用次数: 0

Safety and Efficacy of Perampanel as Adjunctive Therapy in Patients with Refractory Focal Epilepsy Over 12 Months: Clinical Experience in a Real-World Setting Perampanel辅助治疗12个月以上难治性局灶性癫痫的安全性和有效性：现实环境中的临床经验

International Journal of Epilepsy Pub Date : 2018-10-01 DOI: 10.1055/s-0038-1675546

F. Rinaldi, Giovanni De Maria

{"title":"Safety and Efficacy of Perampanel as Adjunctive Therapy in Patients with Refractory Focal Epilepsy Over 12 Months: Clinical Experience in a Real-World Setting","authors":"F. Rinaldi, Giovanni De Maria","doi":"10.1055/s-0038-1675546","DOIUrl":"https://doi.org/10.1055/s-0038-1675546","url":null,"abstract":"Abstract Background The main purpose of this study is to assess efficacy and tolerability of perampanel (PER), a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor antagonist, as an add-on treatment in adult patients with refractory focal-onset seizures. Patients and Methods A prospective, open label, observational study was conducted in patients with refractory focal-onset seizures treated with PER at our Epilepsy Unit, from May 2015 to February 2016. Patients were followed up for 1 year. Frequency of seizure and tolerability was assessed every 3 months. Patients were under a polytherapy, and the mean number of concomitant antiepileptic drugs (AEDs) at PER initiation was 2.9. Results We consecutively enrolled 52 patients (M/F = 18/34). Three were lost on follow-up. Mean age was 38.7 years, with a mean duration of disease of 28.1 years. After 1 year of treatment, 57.14% reported a 50% or greater reduction in seizure frequency; five (10.21%) were seizure free. Six (12.25%) patients reported a reduction lower than 50%. Mean dosage of PER was 7.57 mg. Thirty-one patients were taking enzyme-inducing AEDs (carbamazepine, oxcarbazepine, phenytoin). In this subgroup, the responder rate was 45.2%. Twenty-one patients reported side-effects, most frequently somnolence (11), vertigo/ataxia (6), and aggressiveness (5). Eleven (22.4%) patients reduced or discontinued at least one concomitant AED, while the electroencephalography improved in four (8.16%). Sixteen (32.65%) patients withdrew PER, after a mean duration of 163 days, the mean dosage being 6.4 mg (range 4–12). Conclusions Adjunctive PER can achieve clinically meaningful improvement, or even seizure freedom, in almost two-thirds of patients suffering from refractory focal-onset epilepsies. It seems similarly safe and well-tolerated. Enzyme-inducing AEDs may limit the efficacy of PER.","PeriodicalId":38086,"journal":{"name":"International Journal of Epilepsy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0038-1675546","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47610059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Social Cognition Abilities in Patients with Chronic Temporal Lobe Epilepsy 慢性颞叶癫痫患者的社会认知能力

International Journal of Epilepsy Pub Date : 2018-10-01 DOI: 10.1055/S-0039-1694887

N. P, R. Borgohain

引用次数: 0

Trazodone: A New Antiepileptic Drug for Dravet Syndrome? 曲唑酮:一种新的抗癫痫药物?

International Journal of Epilepsy Pub Date : 2018-10-01 DOI: 10.1055/s-0039-1677783

Linda Azevedo Kauppila, I. Amorim, C. Bentes, A. Peralta

{"title":"Trazodone: A New Antiepileptic Drug for Dravet Syndrome?","authors":"Linda Azevedo Kauppila, I. Amorim, C. Bentes, A. Peralta","doi":"10.1055/s-0039-1677783","DOIUrl":"https://doi.org/10.1055/s-0039-1677783","url":null,"abstract":"Abstract Dravet syndrome (DS) is associated with severely refractory seizures. Recent studies suggest possible antiepileptic effects of serotonergic drugs. We report the case of a 25-year-old woman with DS-related epilepsy (SCN1A mutation), with daily seizures since childhood, associated with developmental delay. Several antiepileptic drug regimens were tested, without clear benefit. Over the years, she maintained a pattern of diurnal and nocturnal seizures, with a nocturnal predominance averaging two tonic–clonic seizures per night, with periods of seizure clusters. On routine electroencephalography (EEG), frequent, subtle myoclonic seizures during sleep were detected. A seizure-free period or significant reduction in seizure frequency was never attained. Trazodone was started due to insomnia. This led to a remarkable as well as long-standing clinical and neurophysiological improvement: less than one reported tonic–clonic seizure per month during the next 18 months, reduction in interictal epileptiform activity (170/h vs. 30/h of sleep), myoclonic seizures (90/h vs. 0.7/h of sleep), and tonic–clonic seizures (2/night to 0) on video-EEG. Serotonergic pathway modulation effects on DS-related epilepsy were observed in animal studies, in addition to small case series using lorcaserin and fenfluramine. To the best of our knowledge, no clinical data exist showing that trazodone may be an efficacious agent in patients with DS. Despite limitation of an isolated case with possible chance factors, our data, given the striking effect, provide this clinical evidence for the first time, and may have important clinical implications in patients with DS, reinforcing the need for further research on this subject.","PeriodicalId":38086,"journal":{"name":"International Journal of Epilepsy","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1055/s-0039-1677783","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42637072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7