Rheumatology (Bulgaria)最新文献_第6页

Mitochondrial dysfunction and biological therapy: a new look at rheumatoid arthritis 线粒体功能障碍和生物治疗:类风湿关节炎的新研究

Rheumatology (Bulgaria) Pub Date : 2022-04-01 DOI: 10.35465/30.1.2022.pp51-65

引用次数: 1

Reactive arthritis (ReA) following the first dose of Covid-19 vaccine; A case report. 首次接种Covid-19疫苗后的反应性关节炎(ReA);一份病例报告。

Rheumatology (Bulgaria) Pub Date : 2022-03-01 DOI: 10.35465/30.1.2022.pp95-98

H. E. Draz, A. Khalifa

{"title":"Reactive arthritis (ReA) following the first dose of Covid-19 vaccine; A case report.","authors":"H. E. Draz, A. Khalifa","doi":"10.35465/30.1.2022.pp95-98","DOIUrl":"https://doi.org/10.35465/30.1.2022.pp95-98","url":null,"abstract":"Introduction: The development of vaccination against COVID-19 infection was a promising step during the battle against this pandemic; however, some vaccines were associated with some complications starting with just flu-like symptoms up to anaphylaxis; of the reported complications is joints pain. Here, we report a case who developed reactive arthritis (ReA) after receiving the first dose of the Pfizer-BioNTech Covid-19 vaccine. Case presentation: A healthy 54 years old male with no previous history of any medical condition was presented with bilateral hand and bilateral knee pain after one week of receiving his first dose of Pfizer-BioNTech Covid-19 vaccine. Clinical examination revealed swelling, tenderness, and erythema over the right index metacarpophalangeal joint and the medial aspect of the right knee. Radiographs of the hand and knee were normal. Laboratory investigations were within normal values except for an elevated ESR (15 mm/hr.) and a positive CRP titer of 48 mg/l. The symptoms entirely resolved after two weeks of non-steroidal anti-inflammatory medications. Conclusions: Although rare, however, ReA could be presented as a complication of Covid-19 vaccination, and physicians should be aware of the possibility of its occurrence.","PeriodicalId":380764,"journal":{"name":"Rheumatology (Bulgaria)","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114653513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

COVID-19 IN AUTOIMMUNE RHEUMATIC DISEASES - FREQUENCY, COURSE, EFFECTIVENESS AND COMPLICATIONS IN VACCINATION 自身免疫性风湿病中的COVID-19 -疫苗接种的频率、病程、有效性和并发症

Rheumatology (Bulgaria) Pub Date : 2021-12-01 DOI: 10.35465/29.4.2021.pp87-98

Z. Dimova, V. Boyadzhieva, N. Stoilov, S. Monov, R. Stoilov

{"title":"COVID-19 IN AUTOIMMUNE RHEUMATIC DISEASES - FREQUENCY, COURSE, EFFECTIVENESS AND COMPLICATIONS IN VACCINATION","authors":"Z. Dimova, V. Boyadzhieva, N. Stoilov, S. Monov, R. Stoilov","doi":"10.35465/29.4.2021.pp87-98","DOIUrl":"https://doi.org/10.35465/29.4.2021.pp87-98","url":null,"abstract":"The onset of the pandemic caused by the new coronavirus has raised many questions in the global rheumatology society regarding the clinical course of the disease, effectiveness and complications of SARS-SoV-2 vaccination. The aim of this review is to analyze the information available up to date on the course of COVID-19 in patients with autoimmune rheumatic diseases (ARD), the frequency of complications in these patients, the effectiveness and side effects of vaccination against COVID-19. Various studies in Europe and the United States have found that the risk of severe COVID-19 in patients with ARD is similar to that in the general population. Negative prognostic factors are thought to be old age, comorbidity, moderate / high ARD activity, and corticosteroid (CS) intake at doses> 10 mg / day. Patients with systemic ARD are considered to be at higher risk of thromboembolic events due to chronic inflammation and / or the presence of antiphospholipid syndrome, as well as the nature of COVID-19 - an endothelial lesion causing thrombosis and microangiopathy. It is observed a higher risk of severe pneumonia in patients treated with Rituximab, as well as an increase in hospitalizations and deaths amongst them. The opposite trend is observed in patients treated with anti-TNF. With the development of vaccines against COVID-19, questions arise about their effectiveness in patients with ARD, as well as the frequency of complications associated with them. In these studies, slightly lower levels of neutralizing antibodies were observed in patients with ARD compared to the general population, most commonly associated with Methotrexate or targeted synthetic DMARDs. The most common side effects seen in these patients after vaccination are pain at the injection site, fatigue and headache. Complaints of the musculoskeletal system are more common in patients with ARD than in the general population. Exacerbations of the underlying disease following vaccination, requiring hospitalization, are rare.","PeriodicalId":380764,"journal":{"name":"Rheumatology (Bulgaria)","volume":"25 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130970597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Association of vitamin D deficiency with carpal tunnel syndrome 维生素D缺乏与腕管综合征的关系

Rheumatology (Bulgaria) Pub Date : 2021-06-01 DOI: 10.35465/29.2.2021.pp11-14

引用次数: 0

Prevalence of sarcopenia in adult patients with ankylosing spondylitis 成人强直性脊柱炎患者肌肉减少症的患病率

Rheumatology (Bulgaria) Pub Date : 2021-06-01 DOI: 10.35465/29.2.2021.pp3-10

Marwa Younis, K. Albedri

{"title":"Prevalence of sarcopenia in adult patients with ankylosing spondylitis","authors":"Marwa Younis, K. Albedri","doi":"10.35465/29.2.2021.pp3-10","DOIUrl":"https://doi.org/10.35465/29.2.2021.pp3-10","url":null,"abstract":"Ankylosing Spondylitis is a chronic, progressive inflammatory rheumatic disease that involves primarily the sacroiliac joints and the axial skeleton. Sarcopenia is characterized by progressive and generalized loss of skeletal muscle mass and strength with a risk of adverse outcomes such as physical disability and poor quality of life. The study aimed to assess the prevalence of sarcopenia in patients with ankylosing spondylitis. A case-control study was conducted at Rheumatology Unit from January 2019 to July 2019. The study population consisted of 50 Iraqi patients diagnosed with AS and 50 healthy control. Demographic data, physical activity using General Practice Physical Activity Questionnaire (GPPAQ), disease activity scores using Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) were recorded. Sarcopenia assessment was done by using a dual-energy x-ray absorptiometry scan for body composition analysis and measuring skeletal mass index (SMI). The maximal voluntary grip strength of the hand was measured with an electronic dynamometer. Physical function was assessed by a 4-meter usual gait speed test. The prevalence of presarcopenia was 6% in both studied groups, while sarcopenia was 10% in AS patients. The mean value of BMI is significantly lower in patients with sarcopenia than in those without (p=0.001). The vast majority of the sarcopenic group (80%) were physically inactive which was statistically significant compared with the non-sarcopenic group (p=0.033). No significant association of treatment with anti-TNF or its duration was found between sarcopenia and non-sarcopenia groups (p=0.377; p=0.187). Both LM and handgrip showed fair validity to differentiate between AS patients and controls. Patients with AS are at higher risk of developing early sarcopenia than in healthy controls. Lower BMI and longer disease duration increase the risk of sarcopenia, while differences in gender, smoking and the use of anti-TNF do not influence the risk. Physical activity may improve muscle strength and perhaps decrease the risk.","PeriodicalId":380764,"journal":{"name":"Rheumatology (Bulgaria)","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132729742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical value of soluble urokinase-type plasminogen activator receptor (SuPAR) as a biomarker of disease activity in Behcet’s disease 可溶性尿激酶型纤溶酶原激活物受体(SuPAR)作为白塞氏病疾病活动性生物标志物的临床价值

Rheumatology (Bulgaria) Pub Date : 1900-01-01 DOI: 10.35465/29.4.2021.pp47-52

A. Rizk, Walaa Abdelfattah, Arwa Al-Shaarawy, N. Elsaid

{"title":"Clinical value of soluble urokinase-type plasminogen activator receptor (SuPAR) as a biomarker of disease activity in Behcet’s disease","authors":"A. Rizk, Walaa Abdelfattah, Arwa Al-Shaarawy, N. Elsaid","doi":"10.35465/29.4.2021.pp47-52","DOIUrl":"https://doi.org/10.35465/29.4.2021.pp47-52","url":null,"abstract":"Background: Behçet's disease (BD) is a chronic multisystemic vasculitic disease of unknown pathogenesis. Diagnosis and disease activity measurement has always been a challenge. Soluble urokinase plasminogen activator receptor (suPAR) is showing an increased utility as a promising diagnostic and prognostic inflammatory biomarker in different systemic inflammatory disorders. Objectives: To study the clinical value of plasma Soluble urokinase plasminogen activator receptor (suPAR) in patients with Behçet's disease, and if it can be used as a measure to disease activity. Methods: According to the International Criteria for Behcet's Disease (ICBD), fifty adult Behçet's disease patients were enrolled in the study, and forty healthy adult subjects were included in a case-control study. An enzyme-linked immunosorbent assay was used to obtain quantitative data. Results: The suPAR level was not statistically different between the patients with BD patients and the controls. No correlation was found between suPAR levels and disease activity (BDFAC). Conclusion: Very few studies analyzed the clinical value of suPAR level in patients with BD and its correlation with disease activity. Our results show that suPAR does not seem to play a role in the disease mechanism of BD.","PeriodicalId":380764,"journal":{"name":"Rheumatology (Bulgaria)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127499746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

National consensus on diagnosis and treatment of osteoarthritis 骨关节炎的诊断和治疗的全国共识

Rheumatology (Bulgaria) Pub Date : 1900-01-01 DOI: 10.35465/29.s.2021.pp46-63

R. Stoilov, T. Georgiev, M. Ivanova

引用次数: 0

Chylothorax as a rare manifestation of systemic lupus erythematosus flare up - case study 乳糜胸是系统性红斑狼疮发作的一种罕见表现

Rheumatology (Bulgaria) Pub Date : 1900-01-01 DOI: 10.35465/30.1.2022.pp90-94

引用次数: 1

National consensus on systemic lupus erythematosus 系统性红斑狼疮的全国共识

Rheumatology (Bulgaria) Pub Date : 1900-01-01 DOI: 10.35465/29.s.2021.pp3-25

R. Rashkov, S. Monov, M. Ivanova, D. Kalinova, N. Stoilov, Yana Zdravkova

引用次数: 0