Research and reviews: journal of nursing and health sciences最新文献

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Improved Results Using Decellularized Human Valves for Children with Congenital Heart Defects 先天性心脏缺损儿童脱细胞人瓣膜的改良效果

Research and reviews: journal of nursing and health sciences Pub Date : 1900-01-01 DOI: 10.26068/MHHRPM/20190517-003

Bahar Söylen, S. Sarikouch, Alex, er Horke

{"title":"Improved Results Using Decellularized Human Valves for Children with Congenital Heart Defects","authors":"Bahar Söylen, S. Sarikouch, Alex, er Horke","doi":"10.26068/MHHRPM/20190517-003","DOIUrl":"https://doi.org/10.26068/MHHRPM/20190517-003","url":null,"abstract":"Operative mortality of children with congenital heart defects has decreased substantially in the past decade, thereby leading to increasing reoperations and increased valve replacement need. Within this article we want to summarize the mid-term clinical results of nonseeded decellularized homografts, deriving from donated human heart valves. So far, the most common therapeutic options for valve replacement in children have been either a biological valve replacement, which undergoes degenerative processes, or a mechanical valve replacement, which requires lifelong anticoagulation. Decellularized pulmonary homografts showed superior results for both, freedom from explantation and infective endocarditis in a direct matched comparison to other available therapeutic options, such as bovine jugular vein conduits or conventional cryopreserved homografts. Decellularized homografts have been also used for aortic valve replacement in young patients and shown encouraging early results. Therefore decellularized homografts constitute a new therapeutic option for children and adults with congenital heart defects.","PeriodicalId":380087,"journal":{"name":"Research and reviews: journal of nursing and health sciences","volume":"219 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116223355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Critical Care-Nursing 关键的照护

Research and reviews: journal of nursing and health sciences Pub Date : 1900-01-01 DOI: 10.1097/00000446-198708000-00003

T. Nafees

{"title":"Critical Care-Nursing","authors":"T. Nafees","doi":"10.1097/00000446-198708000-00003","DOIUrl":"https://doi.org/10.1097/00000446-198708000-00003","url":null,"abstract":"Background: Previous trials involving patients with the ARDS have failed to show a beneficial effect of prone positioning during mechanical ventilatory support on outcomes. We evaluated the effect of early application of prone positioning on outcomes in patients with severe ARDS. Methods: In this multicenter, prospective, randomized, controlled trial, we randomly assigned 466 patients with severe ARDS to undergo prone-positioning sessions of at least 16 hours or to be left in the supine position. Severe ARDS was defined as a ratio of the partial pressure of arterial oxygen to the FiO2 of less than 150 mmHg, with a FiO2 of at least 0.6, a positive end-expiratory pressure of at least 5 cmH2O, and a tidal volume close to 6 mL per kilogram of predicted body weight. The primary outcome was the proportion of patients who died from any cause within 28 days after inclusion. Results: A total of 237 patients were assigned to the prone group, and 229 patients were assigned to the supine group. The 28-day mortality was 16.0% in the prone group and 32.8% in the supine group (P<0.001). The hazard ratio for death with prone positioning was 0.39 (95% confidence interval [CI], 0.25 to 0.63). Unadjusted 90-day mortality was 23.6% in the prone group versus 41.0% in the supine group (P<0.001), with a hazard ratio of 0.44 (95% CI, 0.29 to 0.67). The incidence of complications did not differ significantly between the groups, except for the incidence of cardiac arrests, which was higher in the supine group. Conclusion: In patients with severe ARDS, early application of prolonged prone-positioning sessions significantly decreased 28-day and 90-day mortality.","PeriodicalId":380087,"journal":{"name":"Research and reviews: journal of nursing and health sciences","volume":"88 25 Pt 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126316866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0