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Evaluation of effectiveness of orlistat in complexed obesity treatment in teenagers with metabolic syndrome 奥利司他治疗青少年代谢综合征复杂肥胖的疗效评价
Obesity and Metabolism Pub Date : 2011-12-15 DOI: 10.14341/2071-8713-5302
G. Mel’nichenko, V. Peterkova, L. Savel'eva, N. Zubkova
{"title":"Evaluation of effectiveness of orlistat in complexed obesity treatment in teenagers with metabolic syndrome","authors":"G. Mel’nichenko, V. Peterkova, L. Savel'eva, N. Zubkova","doi":"10.14341/2071-8713-5302","DOIUrl":"https://doi.org/10.14341/2071-8713-5302","url":null,"abstract":"An open, comparative, randomized study of orlistat in the combined treatment of obesity in adolescents with metabolic syndrome\u0000(IIIb phase) was held. Objective: to evaluate the efficacy and safety of the orlistat in adolescents 12-17 years with high risk of cardiovascular\u0000disease and type 2 diabetes. The study included 60 adolescents with obesity and metabolic syndrome. The main group (n=30)\u0000followed a hypocaloric diet and aerobic exercises and took orlistat 120 mg 3 times daily with meals, the control (n=30) group was only\u0000on the non-drug therapy. During the study the anthropometric parameters, lipid, carbohydrate metabolism, blood pressure were evaluated.\u0000All comparisons were performed as two-way, with the critical level of significance ≤ 0,05. Results: After 6 months therapy of orlistat\u000068% of adolescents achieved clinically meaningful weight loss, that led to the improvement of metabolic parameters. On therapy body\u0000fat decreased by -6600.00 g [-7912.00, -2350.00] in the control group, respectively -2235.50 g [-4700, 00; 667.00] (p=0.011). Orlistat\u0000was well tolerated by patients. Most adverse events (9 of 13 in the intervention group) were mild and can be attributed to the expected\u0000adverse reactions. Conclusion: The study demonstrated clinically significant efficacy (compared with the control group), combined with\u0000good safety records of its use in adolescents 12-17 years old with obesity and metabolic disorders.","PeriodicalId":37832,"journal":{"name":"Obesity and Metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67044628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Maternal body mass index and congenital anomaly risk: a cohort stu 母体体重指数与先天性异常风险:一项队列研究
Obesity and Metabolism Pub Date : 2011-03-15 DOI: 10.14341/2071-8713-5197
J. Rankin, P. Tennant, K. Stothard, M. Bythell, C. Summerbell, R. Bell
{"title":"Maternal body mass index and congenital anomaly risk: a cohort stu","authors":"J. Rankin, P. Tennant, K. Stothard, M. Bythell, C. Summerbell, R. Bell","doi":"10.14341/2071-8713-5197","DOIUrl":"https://doi.org/10.14341/2071-8713-5197","url":null,"abstract":"","PeriodicalId":37832,"journal":{"name":"Obesity and Metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2011-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67045011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Rekomendatsii ISA, ISSAM, EAU, EAA i ASA: diagnostika, lechenie i monitorirovanie vozrastnogogipogonadizma u muzhchin ISA、ISSAM、EAU、EAA和ASA：诊断、检查和监测
Obesity and Metabolism Pub Date : 2010-06-15 DOI: 10.14341/2071-8713-5211
Christina Wang, Eberhard Nieschlag, S. Ronald, Hermann M. Behre, J. H. Wayne, Justine Louis, M. Jean, Jean-Jacques Legros, Bruno Lunenfeld, Alvaro Morales, E. M. John, Claude C. Schulman, M. T. Ian, W. Weidner, C. W. W. Frederick
{"title":"Rekomendatsii ISA, ISSAM, EAU, EAA i ASA: diagnostika, lechenie i monitorirovanie vozrastnogogipogonadizma u muzhchin","authors":"Christina Wang, Eberhard Nieschlag, S. Ronald, Hermann M. Behre, J. H. Wayne, Justine Louis, M. Jean, Jean-Jacques Legros, Bruno Lunenfeld, Alvaro Morales, E. M. John, Claude C. Schulman, M. T. Ian, W. Weidner, C. W. W. Frederick","doi":"10.14341/2071-8713-5211","DOIUrl":"https://doi.org/10.14341/2071-8713-5211","url":null,"abstract":"","PeriodicalId":37832,"journal":{"name":"Obesity and Metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67044545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apoptotic markers indicate nonalcoholic steatohepatitis in polycystic ovary syndrome 凋亡标志物提示多囊卵巢综合征的非酒精性脂肪性肝炎
Obesity and Metabolism Pub Date : 2010-06-15 DOI: 10.14341/2071-8713-5214
Susanne Tan, L. Bechmann, S. Benson, T. Dietz, S. Eichner, S. Hahn, O. Janssen, H. Lahner, G. Gerken, K. Mann, A. Canbay
{"title":"Apoptotic markers indicate nonalcoholic steatohepatitis in polycystic ovary syndrome","authors":"Susanne Tan, L. Bechmann, S. Benson, T. Dietz, S. Eichner, S. Hahn, O. Janssen, H. Lahner, G. Gerken, K. Mann, A. Canbay","doi":"10.14341/2071-8713-5214","DOIUrl":"https://doi.org/10.14341/2071-8713-5214","url":null,"abstract":"","PeriodicalId":37832,"journal":{"name":"Obesity and Metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67044548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ksenikal v kompleksnom lechenii patsientovs izbytochnoy massoy tela i ozhireniem Xenic在身体肿块和刺激性异常患者的综合治疗中的应用
Obesity and Metabolism Pub Date : 2010-03-15 DOI: 10.14341/2071-8713-5276
M. L. Maksimov
{"title":"Ksenikal v kompleksnom lechenii patsientovs izbytochnoy massoy tela i ozhireniem","authors":"M. L. Maksimov","doi":"10.14341/2071-8713-5276","DOIUrl":"https://doi.org/10.14341/2071-8713-5276","url":null,"abstract":"This article shows a significant efficacy and safety data of original drug Xenical in complex treatment of overweight and obesity\u0000patients. It is emphasized that this data describe properties of original Xenical, but not generics. The generic drug Orsoten has completely\u0000different physicochemical characteristics comparing to Xenical, this differences may lead to increase in allergic reactions and increase of\u0000frequency and intensity of side effects.","PeriodicalId":37832,"journal":{"name":"Obesity and Metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67044610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Dzheneriki pri lechenii ozhireniya 奥兹里尼娅
Obesity and Metabolism Pub Date : 2010-03-15 DOI: 10.14341/2071-8713-5275
M. Y. Drobizhev
{"title":"Dzheneriki pri lechenii ozhireniya","authors":"M. Y. Drobizhev","doi":"10.14341/2071-8713-5275","DOIUrl":"https://doi.org/10.14341/2071-8713-5275","url":null,"abstract":"There are several pseudogenerics of Meridia® and Xenical®. Lindaxa®, registered in Russia, as a generic of Meridia®, can be at\u0000a disadvantage to a brand on cost-quality ratio.","PeriodicalId":37832,"journal":{"name":"Obesity and Metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2010-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67044607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Normogonadotropic hypogonadism in men with obesity 肥胖男性的促性腺功能减退
Obesity and Metabolism Pub Date : 2009-09-15 DOI: 10.14341/2071-8713-5243
L. Savel'eva, R. Rozhivanov, B. O. Shurdumova, V. Fadeev
{"title":"Normogonadotropic hypogonadism in men with obesity","authors":"L. Savel'eva, R. Rozhivanov, B. O. Shurdumova, V. Fadeev","doi":"10.14341/2071-8713-5243","DOIUrl":"https://doi.org/10.14341/2071-8713-5243","url":null,"abstract":"Objective: to evaluate the preavalence and characteristics of hypogonadism in obese man. Research and Methods: Thestudy was performed in 31 obese man (aged 33 [22;44], BMI 40 [34,4;44,0]. Measurements during the study: chemistry panel, testosteroa and LH levels, immunoreactive insulin, HOMA index calculation. Statistically significant difference w as considered as p < 0,05. Results. Hypogonadism preavalence was 80,6%. The hypogonadism prevalence and testosterone level was more depended on age and obesity but less on duration. 100 % risk of hypogonadism w as observed in heavily obese patients. There w as no increase of LH levels. In man with low testosterone lev els HOMA index w as significantly higher со mpared to healthy subjects. Conclusion: The prevalence of normogonadotropic hypogonadism in obese men is extremely high and it represents an evidence of functional disorder of hypophyseal gonadal system. Thedecrease of testosterone levels is age-coinciding, but it is more pronounced in obese nan.","PeriodicalId":37832,"journal":{"name":"Obesity and Metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67044562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Ozhirenie sredi bol'nykh, obrativshikhsya za meditsinskoy pomoshch'yu (dannye krupnogo otechestvennogo epidemiologicheskogo issledovaniya) 药物援助（dannye krupnogo otechestvennogo流行病学issledovaniya）
Obesity and Metabolism Pub Date : 2009-06-15 DOI: 10.14341/2071-8713-5316
M. Y. Drobizhev
{"title":"Ozhirenie sredi bol'nykh, obrativshikhsya za meditsinskoy pomoshch'yu (dannye krupnogo otechestvennogo epidemiologicheskogo issledovaniya)","authors":"M. Y. Drobizhev","doi":"10.14341/2071-8713-5316","DOIUrl":"https://doi.org/10.14341/2071-8713-5316","url":null,"abstract":"Research objective: to study obesity among 10541 patients in therapeutic, neurologik and cardiologikal practices in 29 cities of the Russian Federation from St.-Petersburg to Vladivostok (COMPASS program). All patients are divided on two groups: with obesity (average BMI=33,7+4,1 kg/m2), and without this disease (average BMI=24,4+3,0 kg/m2). Groups were compared under demographic characteristics; features of a medical route; somatic and mental state. 20% from all patients in mentioned practices in various cities of Russia have obesity. Patients with obesity are predominantly women (middle age 54,0+12,0 year). For these patients low social and economic status (with low educational level, absence of employment, loneliness etc.) are characteristic. Patients with obesity are more often observe in cardiological practice. They suffer from cardiovascular diseases and type 2 diabetes. The hypothesis about obesity formation within mental disorders (depression, food addiction - dependence on food) is presented. Possibility of treatment of patients with the help of sibutramine is discussed.","PeriodicalId":37832,"journal":{"name":"Obesity and Metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2009-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67044685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rol' metabolicheskikh i gemodinamicheskikh narusheniy u muzhchin s metabolicheskim sindromom v razvitii infertil'nosti i erektil'noy disfunktsii 代谢综合征小鼠在发育为不孕和勃起功能障碍中的代谢作用
Obesity and Metabolism Pub Date : 2008-12-15 DOI: 10.14341/2071-8713-5225
A. Mkrtumyan, E. Romanova, A. Oranskaya
{"title":"Rol' metabolicheskikh i gemodinamicheskikh narusheniy u muzhchin s metabolicheskim sindromom v razvitii infertil'nosti i erektil'noy disfunktsii","authors":"A. Mkrtumyan, E. Romanova, A. Oranskaya","doi":"10.14341/2071-8713-5225","DOIUrl":"https://doi.org/10.14341/2071-8713-5225","url":null,"abstract":"","PeriodicalId":37832,"journal":{"name":"Obesity and Metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67044555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychological aspects of diet therapy in type 2 diabetes mellitus 饮食治疗对2型糖尿病的心理影响
Obesity and Metabolism Pub Date : 2008-06-15 DOI: 10.14341/OMET200827-10
E. Starostina
{"title":"Psychological aspects of diet therapy in type 2 diabetes mellitus","authors":"E. Starostina","doi":"10.14341/OMET200827-10","DOIUrl":"https://doi.org/10.14341/OMET200827-10","url":null,"abstract":"The importance of studying the psychological aspects of nutrition diet is, perhaps, the most commonly used words in the lexicon of Endocrinology and Diabetology and most unpleasant - for patients with diabetes mellitus (DM). Any restrictions on certain aspects of nutrition in patients with diabetes create a negative attitude to the disease, since they require non-established habits and tastes, a significant change in lifestyle, often - constant \"struggle\" with gusto. And if type 1 diabetes decrease dietary restrictions for patient education - the so-called liberalized diet - allows much to make life easier to patient without compromising compensation diabetes [3, 11], the rules for type 2 diabetes, especially in combination with obesity, are fundamentally based on constraints.","PeriodicalId":37832,"journal":{"name":"Obesity and Metabolism","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67047449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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