2010 17th Iranian Conference of Biomedical Engineering (ICBME)最新文献_第6页

Multilevel modeling in human microarray time course gene expression data 人类微阵列时间过程基因表达数据的多层次建模

2010 17th Iranian Conference of Biomedical Engineering (ICBME) Pub Date : 2010-11-01 DOI: 10.1109/ICBME.2010.5705026

M. Ghaderi-Zefrehei, H. Memari, S. Kadkhodaei

引用次数: 0

Design and implementation of an ultra low power wireless neuro-stimulator system 一种超低功耗无线神经刺激系统的设计与实现

2010 17th Iranian Conference of Biomedical Engineering (ICBME) Pub Date : 2010-11-01 DOI: 10.1109/ICBME.2010.5704971

M. M. Samani, A. Mahnam

{"title":"Design and implementation of an ultra low power wireless neuro-stimulator system","authors":"M. M. Samani, A. Mahnam","doi":"10.1109/ICBME.2010.5704971","DOIUrl":"https://doi.org/10.1109/ICBME.2010.5704971","url":null,"abstract":"Long term Behavioral and neurophysiological studies of freely moving animals require a wireless portable low power neurostimulator which can provide precisely controllable input(s) to the nervous system. In this paper, we have reported design of a long range, wireless neuro-stimulat or for electrical stimulation of central nervous system, optimized to consume ultra low power and therefore suitable for long-term neurophysiological studies on freely moving animals. The system consists of two parts: (1) a programmable remote controller and, (2) a back-pack current stimulator. The controller provides a simple interface to configure the stimulus pulse and stimulation pattern parameters, and wirelessly controls the back-pack. The stimulator can deliver programmed trains of monophasic or biphasic current pulses up to ±2mA, and its total power consumption is only 5.1mW. Therefore the system is ideal for long-term neural stimulation, while it is flexible enough to be used in different applications of electrical stimulation of centeral nerve system (CNS). Keywords: Stimulator, Electrical Tele-stimulation, ultra low power, freely moving animal, central nervous system.","PeriodicalId":377764,"journal":{"name":"2010 17th Iranian Conference of Biomedical Engineering (ICBME)","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124597063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visualization of coronary atherosclerotic plaques in patients using different imaging modalities 不同成像方式对患者冠状动脉粥样硬化斑块的可视化研究

2010 17th Iranian Conference of Biomedical Engineering (ICBME) Pub Date : 2010-11-01 DOI: 10.1109/ICBME.2010.5704969

M. K. Moridani

引用次数: 0

Synthesis and release study of tissue plasminogen activators (tPA) loaded chitosan coated poly (lactide-co-glycolide acid) nanoparticles 壳聚糖包被聚乳酸-乙醇酸纳米颗粒组织型纤溶酶原激活剂的合成与释放研究

2010 17th Iranian Conference of Biomedical Engineering (ICBME) Pub Date : 2010-11-01 DOI: 10.1109/ICBME.2010.5705015

M. Mahmoodi, M. E. Khosroshahi, F. Atyabi

{"title":"Synthesis and release study of tissue plasminogen activators (tPA) loaded chitosan coated poly (lactide-co-glycolide acid) nanoparticles","authors":"M. Mahmoodi, M. E. Khosroshahi, F. Atyabi","doi":"10.1109/ICBME.2010.5705015","DOIUrl":"https://doi.org/10.1109/ICBME.2010.5705015","url":null,"abstract":"Polyelectrolyte coated nanopatrticles (NPs) interact with bioactive molecules such as, peptides, proteins or nucleic acids and have been proposed as delivery systems for these molecules. In this study, cationic NPs were prepared by coating chitosan (CS) on the surface of PLGA NPs. The tPA encapsulated PLGA and PLGA/ CS NPs were fabricated via the W/O/W double emulsion solvent evaporation surface coating method. The CS coating was confirmed by zeta potential and FTIR. The surface morphology of NPs was also studied by TEM. In vitro drug release experiments of tPA encapsulated PLGA and PLGA/CS are determined by HPLC and showed a sustained release profile for three days with little initial burst release for PLGA/CS NPs. The mean particle size and encapsulation efficiency of tPA NPs were in the range of 280-360 nm and 46.7%±1.56, 50.8%±1.09, respectively. The encapsulation efficiency and the particles size were increased as a result of coating with CS. The release kinetics was evaluated by fitting the experimental data to standard release equation (Higuchie equation). This model was used to find the best fit for NPs. These results suggest that PLGA/CS NPs could serve as an effective vehicle for local delivery of tPA.","PeriodicalId":377764,"journal":{"name":"2010 17th Iranian Conference of Biomedical Engineering (ICBME)","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129880710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Gradient vector flow snake segmentation of breast lesions in Dynamic Contrast-Enhanced MR images 动态增强MR图像中乳腺病变梯度向量流蛇形分割

2010 17th Iranian Conference of Biomedical Engineering (ICBME) Pub Date : 2010-11-01 DOI: 10.1109/ICBME.2010.5704954

L. Bahreini, E. Fatemizadeh, M. Gity

{"title":"Gradient vector flow snake segmentation of breast lesions in Dynamic Contrast-Enhanced MR images","authors":"L. Bahreini, E. Fatemizadeh, M. Gity","doi":"10.1109/ICBME.2010.5704954","DOIUrl":"https://doi.org/10.1109/ICBME.2010.5704954","url":null,"abstract":"The development of computer-aided diagnosis (CAD) for breast magnetic resonance (MR) images has encountered some big challenges. One of these challenges is related to breast lesion segmentation. Accurate segmentation of breast lesions has a vital role in other consequent applications such as feature extraction. Since malignant breast lesions typically appear with irregular borders and shapes in MR images whereas benign masses appear with more regular shapes, and smooth and lobulated borders, it seems that the accurate segmentation of breast lesion borders in MR images are important. To achieve this purpose, we have used the Gradient Vector Flow (GVF) snake segmentation method. This study included 52 (33 malignant and 19 benign) histopathologically proven breast lesions and the stages of the proposed method are as follows: selecting the region of interest (ROI), segmentation using GVF, evaluation of GVF snake segmentation method. The results of GVF segmentation method in this study were satisfactory referred to the radiologist's manual segmentation. The results showed the GVF snake segmentation method correctly segmented 97% of malignant lesion borders and 89.5% of benign lesion borders at the overlap threshold of 0.6. This indicates GVF snake segmentation method could provide us with a powerful method that can make an accurate segmentation in breast lesion borders.","PeriodicalId":377764,"journal":{"name":"2010 17th Iranian Conference of Biomedical Engineering (ICBME)","volume":"01 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128293503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Effect of load direction on fracture type in tibia 载荷方向对胫骨骨折类型的影响

2010 17th Iranian Conference of Biomedical Engineering (ICBME) Pub Date : 2010-11-01 DOI: 10.1109/ICBME.2010.5704991

B. Sepehri, G. Rouhi, A. A. Yazdi, M. Bahari Kashani

引用次数: 3

Dynamics of TMAFM in liquid: Application to molecular metrology and biological sciences TMAFM在液体中的动力学:在分子计量学和生物科学中的应用

2010 17th Iranian Conference of Biomedical Engineering (ICBME) Pub Date : 2010-11-01 DOI: 10.1109/ICBME.2010.5705006

M. Korayem, N. Ebrahimi

{"title":"Dynamics of TMAFM in liquid: Application to molecular metrology and biological sciences","authors":"M. Korayem, N. Ebrahimi","doi":"10.1109/ICBME.2010.5705006","DOIUrl":"https://doi.org/10.1109/ICBME.2010.5705006","url":null,"abstract":"Application of atomic force microscopy (AFM) in liquid is necessary for imaging and manipulation of biological specimens. The atomic force microscope (AFM) has become an indispensable tool in biology because it permits the imaging and probing of nanomechanical properties of biological samples such as biopolymers and viruses under physiological (liquid environments) conditions. In this paper, we have simulated a tapping-mode AFM (TMAFM) cantilever in liquid environment near a surface. Contact forces have some differences in liquid in comparison to air or vacuum in magnitude or formulation. Hydrodynamic forces are also applied on the cantilever due to the motion in liquid. For modeling we have used a continuous beam model with its first mode and forward-time simulation method for simulation of its hybrid dynamics. The results show a good agreement with experiments. They also show that the effect of separation on free vibration amplitude is great. Its effect on resonance frequency is considerable too. The resonance frequency in liquid is so small in comparison to air due to additional mass and also additional damping created by the viscosity of the liquid around.","PeriodicalId":377764,"journal":{"name":"2010 17th Iranian Conference of Biomedical Engineering (ICBME)","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131966028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Parkinson's disease: Classification and complexity analysis 帕金森病的评估:分类和复杂性分析

2010 17th Iranian Conference of Biomedical Engineering (ICBME) Pub Date : 2010-11-01 DOI: 10.1109/ICBME.2010.5704930

Y. Rakhshani Fatmehsari, F. Bahrami

{"title":"Assessment of Parkinson's disease: Classification and complexity analysis","authors":"Y. Rakhshani Fatmehsari, F. Bahrami","doi":"10.1109/ICBME.2010.5704930","DOIUrl":"https://doi.org/10.1109/ICBME.2010.5704930","url":null,"abstract":"In this paper we present a new algorithm to analyze gait patterns of subjects with Parkinson's disease (PD) under two conditions of deep brain stimulation (DBS) off and on. Our goal is to study the complexity and predictability of gait of PD subjects in comparison to the gait of normal subjects. At the same time we used the features extracted for this purpose to classify PD subjects with DBS off or on from healthy control subjects. The angular velocity signals obtained from four uni-axial gyroscopes were used for feature extraction. These four gyroscopes were attached to the right and left shanks and thighs. Approximate Entropy (ApEn), Hurst Exponent (HE) and Higuchi Fractal Dimension (HFD) are the three nonlinear features used for classification. 9 PD subjects and 10 healthy controls were participated in the experiments. The results showed that ApEn and HFD have greater values for PD subjects (with DBS off) indicating more complexity and irregularity in their walking dynamics. Also HE had smaller values for PD subjects (with DBS off) indicating less predictability in their gait time series. The k-nearest neighbor classifier with leave-one-out cross validation method were used for classification and we succeeded to discriminate PD subjects (with DBS off) from the normal ones with the high accuracy of 100%. The accuracy for discrimination of PD subjects with DBS on from the normal ones was 89.47%. Then we analyzed the signals of each single gyroscope, one by one, to find the most informative signal. We achieved the high classification accuracy of 100% (for PD subjects with DBS off) using only the signals of the right shank or the right thigh. It indicates that, among our participants, the signals obtained from the right side of the body are more informative than the left side.","PeriodicalId":377764,"journal":{"name":"2010 17th Iranian Conference of Biomedical Engineering (ICBME)","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128734710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Mathematical modeling of burst drug release from a simple monolithic dispersion 单一分散体爆发药物释放的数学模型

2010 17th Iranian Conference of Biomedical Engineering (ICBME) Pub Date : 2010-11-01 DOI: 10.1109/ICBME.2010.5705014

P. Nemati, M. Imani, Mohammad Khalifeh

引用次数: 1

3D MRI brain segmentation based on MRF and hybrid of SA and IGA 基于MRF和SA和IGA混合的3D MRI脑分割

2010 17th Iranian Conference of Biomedical Engineering (ICBME) Pub Date : 2010-11-01 DOI: 10.1109/ICBME.2010.5704956

Sahar Yousefi, M. Zahedi, R. Azmi

引用次数: 7