ANKEM DERGİSİ最新文献

{"title":"Evaluation of Non-invasive Scores Before and After Direct-acting Antiviral Treatment in Patients with Chronic Hepatitis C","authors":"A. Hamidi, Cüneyt Kuru","doi":"10.5222/ankem.2020.086","DOIUrl":"https://doi.org/10.5222/ankem.2020.086","url":null,"abstract":"The sustained virological response is achieved in patients with chronic hepatitis C infection using direct-acting antiviral (DAA) therapy. However, it is not known whether there is a decrease in liver fibrosis level. Non-invasive serum scores are successful in determining the level of liver fibrosis before treatment. There are no adequate studies in the literature about the use of these scores after treatment. This study aimed to determine the change in inflammation and fibrosis levels after treatment by using non-invasive scores. Adult patients who applied to the Karabuk University Training and Research Hospital between January 2019 and January 2020 and used DAA treatment were included in the study. Clinical and laboratory findings of the cases were recorded retrospectively from the hospital information system. Fibrosis-4 (FIB-4), aspartate aminotransferase (AST)-platelet ratio index (APRI), γ glutamate transpeptidase-platelet ratio (GPR) and AST / ALT ratio scores were calculated before and after (24th week) treatment. Forty-two patients with a mean age of 56.4 were evaluated. 52% of these patients were women. All patients developed a sustained virological response. Genotype 1b was the most common (67 %). The most commonly used treatment regimen (60 %) was paritaprevir + ritonavir + ombitasvir + dasabuvir. After treatment compared to pretreatment, mean AST value decreased from 24.69 to 20.67, mean ALT value decreased from 20.57 to 15.31 and APRI from 0.33 to 0.29 (p=0.01; p=0.03; p=0.01, respectively). Although not statistically significant, FIB-4 was low after treatment. In conclusion, the use of non-invasive serum biomarker scores may be useful in the follow-up of chronic hepatitis C cases using DAA treatment.","PeriodicalId":376680,"journal":{"name":"ANKEM DERGİSİ","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129554928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Septic Arthritis of Shoulder Joint Due to Streptococcus anginosus Following Dental Treatment","authors":"A. Olut, Funda Balaylar, Mehmet Umut Çayıröz, T. Altay","doi":"10.5222/ANKEM.2019.191","DOIUrl":"https://doi.org/10.5222/ANKEM.2019.191","url":null,"abstract":"Septic arthritis is classified in acute rheumatologic emergencies and prompt diagnosis and treatment is critical for prognosis since the infection may lead to permanent destruction. Etiology varies due to routes of infection and host factors. Gram positive cocci are responsible in most of the cases (75-80 %) but in case of immune supression, elderly patients, intravenous drug usage and iatrogenic cases, Gram negative bacilli may also be involved. S.anginosus group are non-motile, facultative anaerobe and catalase-negative Gram-positive cocci that are recognized as normal flora of the human oral cavity and gastrointestinal tract. The unique characteristic of the S.anginosus group that sets these streptococci apart from other pathogenic streptococci is their ability to cause abscesses and should be considered as true pathogens when isolated. Infections vary from dental abscesses, gingivitis and other periodontal infections to deep neck infections, metastatic lung, liver, intra-abdominal and brain abscesses. In the literature soft tissue infections, septic arthritis and osteomyelitis are very rarely reported. In this case report we present a case of septic arthritis due to S.anginosus in an otherwise immunocompetant 64 year old woman that presented with pain and swelling of the left shoulder one month after a dental treatment. The sinoviyal fluid analyses revealed a WBC count of 26,000/ mm3 with 82 % polymorphonuclear leukocytes with a negative Gram stain. The patient was started on ampirical intravenous treatment with piperacilin-tazobactam and daptomycine. At the fourth day, the synovial fluid culture results yielded S.anginosus, then piperacilin-tazobactam was stopped and daptomycine continued till the 14th day. The patient was discharged with oral amoxiciline-clavulanic acid 1 gr/day for 14 days. After two weeks the therapy was stopped due to clinical improvement.","PeriodicalId":376680,"journal":{"name":"ANKEM DERGİSİ","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122377568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic resistance rates of Escherichia coli and Klebsiella pneumoniae strains isolated from urine culture: A four-year analysis","authors":"Hülya Duran, Nihan Çeken, T. Atik","doi":"10.5222/ankem.2020.041","DOIUrl":"https://doi.org/10.5222/ankem.2020.041","url":null,"abstract":"kelimeler","PeriodicalId":376680,"journal":{"name":"ANKEM DERGİSİ","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127782731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kan Kültürlerinden Soyutlanan Bakterilerin ID Tanımlanması ve Antimikrobiyal Direnç Oranlarının Saptanması","authors":"Tuğba Kula Atik, Yener Özel, Umut Yılmaz, M. Ünlü, Gulhan Vardar Unlu","doi":"10.5222/ankem.2021.053","DOIUrl":"https://doi.org/10.5222/ankem.2021.053","url":null,"abstract":"","PeriodicalId":376680,"journal":{"name":"ANKEM DERGİSİ","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121034968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV/AIDS Hastalığı Eğitimi Sağlık Meslek Lisesi ID Stajyer Öğrencilerinde Neyi Değiştirdi","authors":"Hülya Özkan Özdemir, S. Tosun, Selda Sayın","doi":"10.5222/ankem.2021.033","DOIUrl":"https://doi.org/10.5222/ankem.2021.033","url":null,"abstract":"","PeriodicalId":376680,"journal":{"name":"ANKEM DERGİSİ","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126601377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro antibiotic resistance profile of Corynebacterium striatum strains isolated from clinical samples","authors":"Nergis ­Aşgin","doi":"10.5222/ankem.2019.102","DOIUrl":"https://doi.org/10.5222/ankem.2019.102","url":null,"abstract":"Corynebacterium striatum is a normal inhabitant of human skin and mucous membranes. However, it has recently been reported as the cause of invasive infections and outbreaks. In addition, multidrug resistance of the bacterium is a significant concern. In this study, we aimed to determine the antimicrobial resistance of C.striatum strains to contribute to empirical antibiotic usage protocols. A total of 235 C.striatum strains isolated from inpatients between January 2017-December 2018 were investigated retrospectively. The strains were identified using the Phoenix 100 (Becton Dickinson, MD, USA) fully automated system and antibiotic susceptibilities of isolates was determined by using Kirby-Bauer disc diffusion method. Antimicrobial susceptibilities of strains were interpreted according to The European Committee on Antimicrobial Susceptibility Testing standards. Of the 235 patients in whom strains were isolated, 114 were female and 121 were male. The mean age was 72 years and 70 % (n=165) of the patients were in the geriatric age group (65 years, and older). C.striatum strains were isolated from intensive care units at a rate of 71 %. The strains were mostly isolated from the surgical intensive care unit (27 %) internal intensive care unit (26 %) and palliative care unit (14 %). C.striatum strains obtained from the respiratory tract samples (41 %), blood (32 %), and wound samples (27 %). All strains were susceptible to vancomycin and linezolid. However, the resistance rate to gentamicin was 37 % and for erythromycin, it was 55 %. The resistance rates to clindamycin, tetracycline, ciprofloxacin, and cefotaxime were extremely high at 87 %, 93 %, 94 %, and 96 %, respectively. According to our study results, treatment options for C.striatum infections are limited. Therefore vancomycin or linezolid can be preferred in empirical antibiotic treatment.","PeriodicalId":376680,"journal":{"name":"ANKEM DERGİSİ","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131525347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Investigation of OXA-48 and Sub-Derivatives in Klebsiella pneumoniae Strains and Phenotypic Reflection","authors":"Arzu Uyanık Parlak, H. Güdücüoğlu, M. Parlak, Y. Bayram, B. Otlu","doi":"10.5222/ANKEM.2021.001","DOIUrl":"https://doi.org/10.5222/ANKEM.2021.001","url":null,"abstract":"The number of infections caused by carbapenem-resistant Gram negative bacteria is increasing among nosocomial infections. These bacteria are a serious threat to health because they are usually resistant to other antibiotics. This study was aimed to determine the carbapenemase resistance of OXA-48 and its subderivatives in Klebsiella pneumoniae isolates isolated from various clinical samples by phenotypic and genotypic methods and to investigate the presence of OXA-48 gene region genotypically in isolates without resistance. A total of 127 K.pneumoniae strains isolated from patients treated in various clinics and intensive care units were included in this study from March 2015 to March 2016. The isolates were identified and susceptibilities were tested using BD Phoenix automated system and also with Kirby-Bauer disk diffusion method. The presence of resistance was examined phenotypically with the disk of temosillin, which is considered to indicate the presence of OXA-48 type enzymes. The presence of OXA-48 type enzyme was investigated by “in-house” polymerase chain reaction (PCR) in all isolates and the presence of OXA-48 variant was investigated by DNA sequencing analysis on positive isolates. Carbapenem resistance rate was 35 % and ESBL positivity was determined as 46 %. The sensitivity of temocillin disk method in the identification of OXA-48 gene presence in K. pneumoniae strains was found to be 88 %, and specificity 89 %. Ertapenem was the best carbapenem with sensitivity and specificity balance to detect carbapenem resistance caused by OXA-48. The presence of blaOXA-48 gene region was 80 % in K. pneumoniae isolates detected as resistant to carbapenems by an automated system. All sequences obtained by DNA sequence analysis of 42 OXA-48 positive isolates were OXA-48 and there was no variant OXA-48 gene among the sequences. It was observed that the phenotypic reflection of resistance did not occur immediately in three isolates genotypically having OXA-48 gene region. The presence of blaOXA-48 gene region in carbapenems-resistant K.pneumoniae isolates is common. In addition, in some isolates having OXA-48 gene region, should be kept in mind in patients who do not recover despite treatment, due to phenotypic reflection of resistance does not occur immediately","PeriodicalId":376680,"journal":{"name":"ANKEM DERGİSİ","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125441316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Urinalysis and Urine Culture Test in Pregnancy","authors":"E. Avcı, Nihan Çeken","doi":"10.5222/ankem.2019.192","DOIUrl":"https://doi.org/10.5222/ankem.2019.192","url":null,"abstract":"","PeriodicalId":376680,"journal":{"name":"ANKEM DERGİSİ","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126172096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistance to primary anti-tuberculosis drugs between 2011-2018 in Sivas Cumhuriyet University Faculty of Medicine Hospital","authors":"Ayşe Hümeyra Taşkın Kafa, M. Hasbek, C. Çelik, M. Z. Bakıcı","doi":"10.5222/ankem.2019.1914","DOIUrl":"https://doi.org/10.5222/ankem.2019.1914","url":null,"abstract":"","PeriodicalId":376680,"journal":{"name":"ANKEM DERGİSİ","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126428668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Investigation of Antibiotic Resistance and Extended Spectrum Beta-Lactamase Presence in Escherichia coli Strains Isolated from Drinking Water Collected from Gümüşhane Province","authors":"F. Orhan, Ü. Altoparlak, Levent Odaci","doi":"10.5222/ankem.2019.193","DOIUrl":"https://doi.org/10.5222/ankem.2019.193","url":null,"abstract":"Waterborne infections are important causes of morbidity and mortality worldwide. Drinking water that adheres to the bacterial standards at the water treatment plant output, may be contaminated during distribution and an increase in bacterial count may occur. The use of antimicrobial agents in animal husbandry and agriculture in addition to the uses in humans, contributes to the emergence of antimicrobial resistant microorganisms and their transmission to nature, especially to water and soil. The aim of this study was to determine the resistance of E.coli isolates isolated from drinking water and brought to the Public Health Laboratory of Gümüşhane province for control and follow-up analysis. The study included 50 E.coli isolates isolated from the water samples collected from the samples taken from the province of Gümüşhane and its surroudings from June to September 2016. The samples were drained by membrane filtration method and cultured on Chromogenic Coliform Agar (CCA-sartorius, Almanya) and incubated at 36 ± 2 °C for 21 ± 3 hours. The isolated E.coli strains were confirmed as described in the standard and the resistance of the strains to 13 antibiotics, which were frequently used in clinical treatment, were tested by disc diffusion method and the presence of extended spectrum beta-lactamase (ESBL) was investigated. At the end of the study, 38 of the E.coli isolates were susceptible to all tested antibiotics, while 12 of them were resistant or intermediate to various antibiotics. The isolates were 16 % resistant, 6 % intermediate to cefoxitine; 2 % resistant to cefepime; 2 % resistant to ceftazidime; 2 % resistant, 2 % intermediate to ampicillin sulbactam; 2 % resistant to piperacillin; 2 % resistant, 6 % intermediate to cefuroxime. There was no resistance to trimethoprim/sulfamethoxazole, ertapenem, ampicillin, gentamicin and amikacin, and no ESBL presence. This study showed fecal contamination in drinking water, because E.coli isolates, which are the indicator of fecal contamination were detected in drinking water. However, in terms of antimicrobial resistance in E.coli isolates, it suggested that the problem was not at threatening levels for the public.","PeriodicalId":376680,"journal":{"name":"ANKEM DERGİSİ","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133499639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}