Journal of Advanced Pharmacy Education and Research最新文献_第2页

Application of DPPH assay for the evaluation of the antiradical activity of Creatine Lysinate 应用DPPH法评价溶肌酸酯的抗自由基活性

Journal of Advanced Pharmacy Education and Research Pub Date : 2023-01-01 DOI: 10.51847/guimkn4fkf

D. Tsvetkova, I. Kostadinova, B. Landzhov, L. Vezenkov, Lyubomir Marinov, Ivalina Ivanova

{"title":"Application of DPPH assay for the evaluation of the antiradical activity of Creatine Lysinate","authors":"D. Tsvetkova, I. Kostadinova, B. Landzhov, L. Vezenkov, Lyubomir Marinov, Ivalina Ivanova","doi":"10.51847/guimkn4fkf","DOIUrl":"https://doi.org/10.51847/guimkn4fkf","url":null,"abstract":"The aim of the current study was the estimation of the radical-scavenging activity of Creatine lysinate against 0.05 mM methanol solution of DPPH radical by measuring the decrease in the absorbance at λ = 516 in methanol. The antiradical effect of the compound examined is presented with the following parameters calculated: radical scavenging activity in [%], IC 50 value; antioxidant power 1/IC 50 , and Trolox equivalent activity. relative radical scavenging activity (RRSA, [%]), and a relative decrease in radical scavenging activity (RDRSA, [%]).From the experimental results, it was observed that the DPPH binding ability of Creatine lysinate (IC 50 = 73.75 mM) is lower compared to the standard Trolox (IC 50 = 0.001154 mM), which antioxidant power (1/IC 50 = 8.67) is higher in comparison with Creatine lysinate (1/IC 50 = 0.014). The experimental data show that Creatine lysinate (IC 50 = 73.75 mM) is more active compared to Creatine monohydrate (IC 50 = 102.48 mM) due to lower IC 50 and higher scavenging activity. In comparison with mono application of alone antioxidant, the beneficial effect of the combination of Creatine monohydrate and Creatine lysinate with other antioxidants in form of food supplements could be an important strategy for a synergistic effect in the reduction of free radicals in the treatment of disorders resulted from oxidative stress.","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70821608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of break hours on work quality among respiratory care providers in Saudi Arabia's eastern province 沙特阿拉伯东部省份呼吸系统护理人员休息时间对工作质量的影响

Journal of Advanced Pharmacy Education and Research Pub Date : 2023-01-01 DOI: 10.51847/jgzs6wxisu

Heba Ahmed Albhair, B. Bugis

引用次数: 0

Journal of Advanced Pharmacy Education and Research Pub Date : 2023-01-01 DOI: 10.51847/rgpup8aeb3

I. Cahyaningsih, N. Hikmah, Nurul Maziyyah

引用次数: 0

Effect of clerkship modification during the COVID-19 pandemic towards competency achievement in hospital pharmacy ‎ 新冠肺炎疫情期间办事员制度调整对医院药学人员胜任力实现的影响

Journal of Advanced Pharmacy Education and Research Pub Date : 2023-01-01 DOI: 10.51847/sxbq0i2ago

Nurul Maziyyah, Sri Tasminatun, Wahyu Prastyo Aji

引用次数: 0

Study of blood-ocular barrier permeability by Fluoroquinolone group drugs 氟喹诺酮类药物对血眼屏障通透性的影响

Journal of Advanced Pharmacy Education and Research Pub Date : 2023-01-01 DOI: 10.51847/tkubytphaq

Arzigul Hamidovna Yahyaeva, Margusheva Maryana Aslanovna, Kyamalya Azadovna Yariyeva, Artem Olegovich Pogosov, Nargiz Asadullaevna Ilyasova, Diana Rezuanovna Kokova

{"title":"Study of blood-ocular barrier permeability by Fluoroquinolone group drugs","authors":"Arzigul Hamidovna Yahyaeva, Margusheva Maryana Aslanovna, Kyamalya Azadovna Yariyeva, Artem Olegovich Pogosov, Nargiz Asadullaevna Ilyasova, Diana Rezuanovna Kokova","doi":"10.51847/tkubytphaq","DOIUrl":"https://doi.org/10.51847/tkubytphaq","url":null,"abstract":"Blood-ocular barrier-specialized morphological structures that regulate the transport of fluids and substances between the vascular bed and the tissues of the eye, prohibiting the penetration of foreign cells and molecules. The permeability of various substances into the non-vascular and vascular tissues of the eye is not the same. In conditions of pathology, the blood-ocular barrier can be permeable to various endogenous, exogenous, and other substances that are not correct with respect to the cells and tissues of the eye. In this article, the permeability of the blood-ocular barrier with fluoroquinolone group drugs in the pathologies of the visual organs is considered. For this purpose, a laboratory study was conducted, during which three groups of experimental rabbits were formed (5 individuals in each group). Clinically healthy animals were included in group 1, and sick animals with experimentally induced ophthalmopathology were included in groups 2 and 3. The treatment of individuals was carried out with a solution of ciprofloxacin. A comprehensive examination of animals was carried out: clinical examination, determination of the concentration of antibacterial drugs in biological fluids, histological examination of the blood-ocular barrier, biochemical studies; hematological studies","PeriodicalId":37660,"journal":{"name":"Journal of Advanced Pharmacy Education and Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70834727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the impact of different rheumatoid arthritis stages on the quality of life of a sample of Iraqi patients 评估不同类风湿关节炎阶段对伊拉克患者生活质量的影响

Journal of Advanced Pharmacy Education and Research Pub Date : 2023-01-01 DOI: 10.51847/41nl6ig253

Khdair Sura Abbas, Abbas Shaymaa Hasan, Nafea Lubab Tareq

引用次数: 1

Toxicity assessment of the selenium nanoparticles in vitro ‎ 纳米硒的体外毒性评价

Journal of Advanced Pharmacy Education and Research Pub Date : 2023-01-01 DOI: 10.51847/4i6jd9dehl

Sofya Olegovna Budagova, Gregory Vadimovich Nadvodnyk, Polina Alexandrovna Belskaia, A. A. Obukhova, Ivan Gennadievich Lebedev, Ramazan Magomedgadjievich Osmanov, Gamzat Temurovich Dzhumaev, Maxim Mavludinovich Agarzaev

引用次数: 0

Hypolipidemic activity of Ceciwis ethanol extract on wistar rats induced by high fat in vivo 茜草乙醇提取物对高脂大鼠体内降血脂作用的研究

Journal of Advanced Pharmacy Education and Research Pub Date : 2023-01-01 DOI: 10.51847/enxiiqzxm1

H. Nurcahyo, A. B. Riyanta, Rizki Febriyanti, Heri Sutanto, Wiwin Herdwiani

引用次数: 0

Reference indicators for kidney dimensions in Sudanese children using Ultrasound 苏丹儿童肾脏尺寸的超声参考指标

Journal of Advanced Pharmacy Education and Research Pub Date : 2023-01-01 DOI: 10.51847/hokhfdjpej

M. Elbashir, RaniaMohammed Ahmed, Awatif M. Omer, Marzoug A. Al, Elbashir A. Hussien, Eman M. Algorashi, S. Ali, Amel F. Alzain, Salwa Siddig

引用次数: 0

Interprofessional education in pharmacogenomics: perspective of pharmacy and nursing students 药物基因组学的跨专业教育:药学和护理专业学生的视角

Journal of Advanced Pharmacy Education and Research Pub Date : 2023-01-01 DOI: 10.51847/pi4ggrk1z0

引用次数: 0