Modernising Cancer Services最新文献_第2页

Cancer screening 癌症筛查

Modernising Cancer Services Pub Date : 2018-12-14 DOI: 10.1201/9781315385310-4

J. Wilkinson

{"title":"Cancer screening","authors":"J. Wilkinson","doi":"10.1201/9781315385310-4","DOIUrl":"https://doi.org/10.1201/9781315385310-4","url":null,"abstract":"CITES ONLY THESE RESULTS SAYING THAT AT LEAST 1 IN 3 ARE OVERDIAGNOSED Method 1: tries to account for the relatively lower incidence of advanced cancers in the screening areas and includes older women • 9.9% invasive • 16.4% invasive plus DCIS Method 2: does not account for the relatively lower incidence of advanced cancers in the screening areas • 38% invasive • 48% invasive plus DCIS Both methods: overdiagnosis is expressed relative to cases that would be detected without screening, not as a fraction of screen-detected cases “The numbers match those found in other studies that cast doubt on whether mammograms actually reduce the risk of dying from breast cancer. A 2012 study published in the New England Journal of Medicine that found that as many as a third of cancers detected through routine mammograms may not be life threatening.” “It’s simply not valid to cherry-pick findings of nonrandomized studies to support one’s views.” What about clinical trials of screening? Screening trials should be ideal for estimating overdiagnosis • Concurrent control group Most screening trials do not generally produce unbiased estimates • Depends on design (stop-screen or continuous-screen) • Depends on measure used (cumulative or annual incidence) • Depends on timing of the estimation procedure – need to wait","PeriodicalId":375740,"journal":{"name":"Modernising Cancer Services","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114228834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}