BMC Obesity最新文献

{"title":"Quality of life, food tolerance, and eating disorder behavior after laparoscopic gastric banding and sleeve gastrectomy - results from a middle eastern center of excellence.","authors":"Khalid Al Khalifa,&nbsp;Ahmed Al Ansari","doi":"10.1186/s40608-018-0220-6","DOIUrl":"https://doi.org/10.1186/s40608-018-0220-6","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a major health problem in Arab countries. Bariatric surgery can improve the quality of life of an obese individual. However, different types of bariatric surgery result in varying levels of food intolerance as a side effect. Many patients who undergo bariatric surgery are also at risk of subsequently developing eating disorder behaviors. The aim of the study was to compare the quality of life, food tolerance, and behaviors of eating disorders related to laparoscopic sleeve gastrectomy and gastric banding.</p><p><strong>Methods: </strong>A retrospective review of medical records and a questionnaire-based survey was completed for all patients who had undergone either bariatric sleeve gastrectomy or gastric banding at the Bahrain Defense Force Hospital between 2011 and 2014. Each patient was administered 3 questionnaires to assess the quality of life, food tolerance, and eating disorder behaviors.</p><p><strong>Results: </strong>Forty-eight patients who had undergone sleeve gastrectomy and 36 who had undergone gastric banding participated in the study. Sleeve gastrectomy patients showed better food tolerance (<i>P</i> < 0.001) and better eating behaviors (<i>P</i> = 0.001) post-surgery compared with gastric banding patients. Health-related quality of life (HRQOL) did not differ significantly between the 2 groups. Only sleeve patients had preoperative evaluation of these parameters (HRQOL). However, in the gastric sleeve group, after the surgery, significant improvement was found in all parameters of HRQOL except for mental health status.</p><p><strong>Conclusion: </strong>Laparoscopic gastric sleeve surgery patients had superior outcomes in both food tolerance and eating disorder behaviors. The quality of life did not significantly differ between the gastric sleeve and gastric banding surgery groups.</p>","PeriodicalId":37440,"journal":{"name":"BMC Obesity","volume":"5 ","pages":"44"},"PeriodicalIF":0.0,"publicationDate":"2018-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40608-018-0220-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36832624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in bariatric surgical care pathways: a national costing study on the variability of services and impact on costs.","authors":"Eleanor Grieve, Ruth M Mackenzie, Jane Munro, Joanne O'Donnell, Sally Stewart, Abdulmajid Ali, Duff Bruce, Miranda Trevor, Jennifer Logue","doi":"10.1186/s40608-018-0223-3","DOIUrl":"10.1186/s40608-018-0223-3","url":null,"abstract":"<p><strong>Background: </strong>We undertook a survey of all bariatric centres in Scotland in order to describe current pre- and post-operative care, to estimate their costs and explore differences in financial impact.</p><p><strong>Methods: </strong>A questionnaire was distributed to each health centre. Descriptive statistics were used to present average cost per patient along with 95% confidence intervals, and the range of costs.</p><p><strong>Results: </strong>Results show nearly a five-fold difference in costs per patient for pre-operative services (range £226 - £1071) and more than a three-fold difference for post-operative services (range £259 - £896).</p><p><strong>Conclusions: </strong>There is a lack of evidence base and a clear requirement for the evaluation of bariatric surgical services to identify the care pathways pre- and post-surgery which lead to largest improvements in health outcomes and remain cost-effective.</p>","PeriodicalId":37440,"journal":{"name":"BMC Obesity","volume":"5 ","pages":"43"},"PeriodicalIF":0.0,"publicationDate":"2018-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36832623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy Life Centre participants' perceptions of living with overweight or obesity and seeking help for a perceived \"wrong\" lifestyle - a qualitative interview study.","authors":"Elin Salemonsen, Britt Sætre Hansen, Georg Førland, Anne Lise Holm","doi":"10.1186/s40608-018-0218-0","DOIUrl":"10.1186/s40608-018-0218-0","url":null,"abstract":"<p><strong>Background: </strong>Overweight and obesity are complex conditions, associated with a wide range of serious health issues. In contemporary society, body size is an important part of a person's self-representation. Lifestyle changes are difficult and long-term weight management is associated with a high risk of failure. In primary health care in Norway, lifestyle interventions are offered by Healthy Life Centres (HLCs) to those seeking help with weight management. The aim of this study was to explore HLC participants' experiences of living with overweight or obesity and perceptions of seeking help to change dietary and activity habits.</p><p><strong>Method: </strong>This exploratory study employed a qualitative design. Semi-structured in-depth interviews were conducted with 13 participants. Data were transcribed verbatim and analysed using qualitative content analysis.</p><p><strong>Results: </strong>The analysis resulted in one main theme: <i>Searching for dignity</i>, based on two themes: 1) <i>Needing to justify avoidance of personal responsibility</i> and 2<i>) A desire to change.</i></p><p><strong>Conclusion: </strong>Changing dietary and activity habits is difficult as the emotional alternation between shame, guilt and pride influences the ability to assume personal responsibility. A deeper understanding of each participant's perceptions and experiences is important for the ability to tailor and provide a high quality health service. Addressing participants' emotional distress and search for dignity is necessary for enabling dietary and activity change. This should be considered in the future development of HLCs and health promotion interventions in order to educate service users about emotions and the role they play in food consumption and inactivity. Weight stigma at individual and system level as well as responsibility related to dilemmas about \"right\" or \"wrong\" lifestyle should be addressed.</p>","PeriodicalId":37440,"journal":{"name":"BMC Obesity","volume":"5 ","pages":"42"},"PeriodicalIF":0.0,"publicationDate":"2018-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36768877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain activation to high-calorie food images in healthy normal weight and obese children: a fMRI study.","authors":"Amjad Samara,&nbsp;Xuehua Li,&nbsp;R T Pivik,&nbsp;Thomas M Badger,&nbsp;Xiawei Ou","doi":"10.1186/s40608-018-0209-1","DOIUrl":"10.1186/s40608-018-0209-1","url":null,"abstract":"<p><strong>Background: </strong>Understanding how normal weight and obese young children process high-calorie food stimuli may provide information relevant to the neurobiology of eating behavior contributing to childhood obesity. In this study, we used fMRI to evaluate whether brain activation to high-calorie food images differs between normal weight and obese young children.</p><p><strong>Methods: </strong>Brain activation maps in response to high-calorie food images and non-food images for 22 healthy, 8-10-years-old children (<i>N</i> = 11/11 for normal weight/obese respectively) were generated and compared between groups.</p><p><strong>Results: </strong>When comparing brain activation differences in response to viewing high-calorie food versus non-food images between normal weight and obese children, group differences were observed in areas related to memory and cognitive control. Specifically, normal weight children showed higher activation of posterior parahippocampal gyri (PPHG) and dorsomedial prefrontal cortex (DMPFC). Further ROI analyses indicated higher activation strength (Z scores) in the right PPHG (<i>p</i> = 0.01) and higher activation strength (<i>p</i> < 0.001) as well as a larger activation area (<i>p</i> = 0.02) in the DMPFC in normal weight than obese children.</p><p><strong>Conclusions: </strong>Normal weight and obese children process high-calorie food stimuli differently even from a young age. Normal weight children exhibit increased brain activation in regions associated with memory and cognitive control when viewing high-calorie food images.</p>","PeriodicalId":37440,"journal":{"name":"BMC Obesity","volume":"5 ","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2018-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40608-018-0209-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36760218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discriminative ability of adiposity measures for elevated blood pressure among adolescents in a resource-constrained setting in northeast Nigeria: a cross-sectional analysis.","authors":"Oghenebrume Wariri,&nbsp;Iliya Jalo,&nbsp;Fidelia Bode-Thomas","doi":"10.1186/s40608-018-0211-7","DOIUrl":"https://doi.org/10.1186/s40608-018-0211-7","url":null,"abstract":"<p><strong>Background: </strong>Several studies examining the association and discriminative ability of adiposity measures for prehypertension and hypertension among adolescents have reported varying outcomes. We aimed to determine the discriminative ability of the Body Mass index (BMI), Waist Circumference (WC), and Waist-to-Height Ratio (WHtR) adiposity measures for elevated blood pressure (prehypertension and hypertension combined) among adolescents in Gombe, northeast Nigeria.</p><p><strong>Methods: </strong>This cross-sectional study used a multi-stage sampling technique and involved 367 secondary school adolescent (10-18 years) boys and girls in Gombe Local Government Area, Gombe State, northeast Nigeria from January to September 2015. We examined and compared the associations and discriminative ability of the BMI, WC and the WHtR for elevated blood pressure using multiple logistic regression and receiver operating characteristics (ROC) curves. Area under the curves (AUC), odds ratio (OR) and 95% confidence intervals (CI) are reported.</p><p><strong>Results: </strong>All three measures of adiposity were strongly and positively associated with elevated blood pressure. The BMI obesity showed the strongest association with elevated blood pressure with odds that was double the odds of WC and triple that of WHtR [adjusted OR for BMI 15.3, 95% CI (4.8-27.9)]. The discriminative ability of adiposity measures for elevated blood pressure using AUC was comparable (0.786 for BMI, vs 0.780 for WC, vs 0.761 for WHtR).</p><p><strong>Conclusion: </strong>We provide evidence, here on the BMI, WC and WHtR to support the use of simple indirect measures of adiposity in evaluating adiposity-related risk including prehypertension and hypertension among Nigerian adolescents.</p>","PeriodicalId":37440,"journal":{"name":"BMC Obesity","volume":"5 ","pages":"35"},"PeriodicalIF":0.0,"publicationDate":"2018-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40608-018-0211-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36760222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a patient-centered outcome for targeting early childhood obesity across multiple stakeholders.","authors":"Byron A Foster,&nbsp;Paula Winkler,&nbsp;Kelsey Weinstein,&nbsp;Deborah Parra-Medina","doi":"10.1186/s40608-018-0216-2","DOIUrl":"https://doi.org/10.1186/s40608-018-0216-2","url":null,"abstract":"<p><strong>Background: </strong>Patient-centered outcome measures for childhood obesity are limited. Identifying outcomes that patients and families consider important could be a viable avenue for better engagement of patients and interventions that are efficacious and acceptable to patients. Latino children experience high rates of obesity, and under-recognition of obesity in preschool aged children is common.</p><p><strong>Methods: </strong>We used growth chart data to identify low-income, Latino children 2-5 years of age with obesity who decreased their adiposity (positive deviants) and a set of controls. We used qualitative interview data to identify themes around goals parents used in addressing weight. Then, we applied a modified Delphi approach across groups of caregivers and providers to identify common goals. We conducted focus groups to explore conflicts and congruency between caregivers and providers related to goals. Using the focus group data, we developed a decision tool for use between patients and providers relevant for early childhood obesity.</p><p><strong>Results: </strong>We identified 257 children who successfully reduced adiposity (positive deviants) from 1621 eligible growth charts. From interviews with 44 parents (21 positive deviants and 23 controls), we coded and categorized outcomes such as increased happiness, clothing size and improved activity. We recruited 81 parents, grandparents and health care providers to participate in the modified Delphi process of ranking outcomes by importance and feasibility. Focus groups (2, total <i>n</i> = 24) suggested potential methods for a common framework to discuss goals, including a modified growth chart. We created a decision-tool that incorporated a growth chart and a section for discussion of patient-centered goals. A final focus group (1, <i>n</i> = 10) provided feedback on the tool as acceptable and potentially useful.</p><p><strong>Conclusions: </strong>The development of a patient-centered tool around achieving a healthy weight in early childhood identified common goals between providers and parents. While the tool has been developed, prospective testing of this patient-centered tool and its effects on engagement, parent motivation, and behavior change would be a useful next step.</p>","PeriodicalId":37440,"journal":{"name":"BMC Obesity","volume":"5 ","pages":"39"},"PeriodicalIF":0.0,"publicationDate":"2018-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40608-018-0216-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36749058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How does childhood socioeconomic position affect overweight and obesity in adolescence and early adulthood: a longitudinal study.","authors":"Per Hoegh Poulsen,&nbsp;Karin Biering,&nbsp;Trine Nøhr Winding,&nbsp;Ellen Aagaard Nohr,&nbsp;Johan Hviid Andersen","doi":"10.1186/s40608-018-0210-8","DOIUrl":"https://doi.org/10.1186/s40608-018-0210-8","url":null,"abstract":"<p><strong>Background: </strong>Childhood socioeconomic position (SEP) has previously been associated with increased risk of overweight among children and adolescents. However, it remains uncertain whether the timing of exposure is important in relation to developing overweight in early adulthood. We aimed to examine how SEP during early (0-8 years) and late childhood (9-14 years) relates to overweight at age 15, 18 and 21.</p><p><strong>Methods: </strong>Longitudinal study in Western Denmark of 2879 young people (aged 15 in 2004). Exposure variables from registers were yearly household income, parental highest educational level and parental labour market participation (LMP), supplemented with questionnaire information about \"family functioning\" (age 15). Outcome variables were overweight and obesity, measured at three-time points.We analyzed the adjusted associations between childhood SEP and overweight and obesity using multinomial logistic regression, stratified on gender.</p><p><strong>Results: </strong><b>Early childhood:</b> Parental lower educational level increased girls' risk of overweight and obesity at age 18 and 21 between RR = 1.8 (95% CI 1.0;3.4) and RR = 5.2 (95% CI 1.4;19.3). Girls reporting poor \"family functioning\" had up to twice the risk of overweight and obesity at age 21. Boys, whose fathers had a lower level of education had up to 2.4 times the risk of obesity at age 21. Parental low LMP increased boys' risk of obesity at age 18 and 21 between RR = 2.2 (95% CI 1.3;3.8) and RR = 2.8 (95% CI 1.3;6.1). <b>Late childhood:</b> Parental lower level of education tripled the risk of overweight and obesity among girls at age 18 and among both genders at age 21.</p><p><strong>Conclusion: </strong>This study confirmed to some extent that economic, social and psychological insecurity and inequality as measured by lower parental educational level, lower household income, low labour market participation and poor family function during childhood was associated with an increased risk of overweight and especially obesity in adolescence and early adulthood in both genders. Despite some imprecise measures, the direction of the associations pointed to several associations, which all were in the hypothesized direction. Timing of lower household income and parental low LMP in childhood seemed to be gender-specific in some way, but this warrants more studies.</p>","PeriodicalId":37440,"journal":{"name":"BMC Obesity","volume":"5 ","pages":"34"},"PeriodicalIF":0.0,"publicationDate":"2018-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40608-018-0210-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36760221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the psychosocial impact of weight loss following bariatric surgery: a qualitative study.","authors":"Dina H Griauzde,&nbsp;Andrew M Ibrahim,&nbsp;Natalie Fisher,&nbsp;Amanda Stricklen,&nbsp;Rachel Ross,&nbsp;Amir A Ghaferi","doi":"10.1186/s40608-018-0215-3","DOIUrl":"https://doi.org/10.1186/s40608-018-0215-3","url":null,"abstract":"<p><strong>Background: </strong>Bariatric surgery leads to changes in mental health, quality of life and social functioning, yet these outcomes differ among individuals. In this study, we explore patients' psychosocial experiences following bariatric surgery and elucidate the individual-level factors that may drive variation in psychosocial outcomes.</p><p><strong>Methods: </strong>Eleven semi-structured focus groups with Michigan Bariatric Surgery Collaborative (MBSC) patients (<i>n</i> = 77). Interviews were audio recorded, transcribed verbatim, and analyzed using a grounded theory approach. Data on participant demographic characteristics were abstracted from the MBSC clinical registry.</p><p><strong>Results: </strong>Most focus group participants were female (89%), white (64%), and married (65%). We identified three major themes: (1) change in self-perception; (2) change in perception by others; and (3) change in relationships. Each theme includes 3 sub-themes, demonstrating a range of positive and negative psychosocial experiences. For example, weight loss led to increased self-confidence among many participants while others described a loss of self-identity. Some noted improved relationships with family or friends while others experienced worsening or even loss of relationships due to perceived jealousy.</p><p><strong>Conclusion: </strong>Weight loss following bariatric surgery leads to complex changes in self-perception and inter-personal relationships, which may be proximal mediators of commonly assessed mental health outcomes such as depression. Individuals considering bariatric surgery may benefit from anticipatory guidance about these diverse experiences, and post-surgical longitudinal monitoring should include evaluation for adverse psychosocial events.</p>","PeriodicalId":37440,"journal":{"name":"BMC Obesity","volume":"5 ","pages":"38"},"PeriodicalIF":0.0,"publicationDate":"2018-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40608-018-0215-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36749057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between gestational weight gain and rate of infancy weight gain in Hawai'i and Puerto Rico WIC participants.","authors":"Cheryl L K Gibby,&nbsp;Cristina Palacios,&nbsp;Maribel Campos,&nbsp;Eunjung Lim,&nbsp;Jinan Banna","doi":"10.1186/s40608-018-0219-z","DOIUrl":"10.1186/s40608-018-0219-z","url":null,"abstract":"<p><strong>Background: </strong>Excessive gestational weight gain and rapid infancy weight gain (RIWG) are associated with increased susceptibility to childhood obesity. Since low-income and minority children are particularly at risk, investigation of the associations between gestational weight gain and rate of infancy weight gain may inform childhood obesity prevention. This study investigated the associations between gestational weight gain and rate of infancy weight gain during the first four to six months postpartum in participants from the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in Hawai'i and Puerto Rico.</p><p><strong>Methods: </strong>This was a cross-sectional secondary data analysis from a text message-based intervention in WIC participants in Hawai'i and Puerto Rico. The analysis included 80 mother/infant pairs from the control group who completed the follow-up visit when infants were four to six months old. Maternal weight, height, and gestational weight gain were self-reported. Infant weight was measured at baseline and follow-up. A proportional odds model was used to investigate the association between gestational weight gain and infancy weight gain rate (rapid or extremely rapid, on-track, or slow), adjusting for maternal age, pregravid body mass index (BMI) status, parity, and being up-to-date with infant vaccinations.</p><p><strong>Results: </strong>In comparison to recommended gestational weight gain, excessive and inadequate (under the recommended amount) gestational weight gain was associated with 77% decreased (adjusted odds ratio [AOR] = 0.23; 95% confidence interval [CI] = 0.08, 0.70; <i>p</i> = 0.01) and 71% decreased (AOR = 0.29; 95% CI = 0.09, 0.94; <i>p</i> = 0.04) odds of RIWG versus on-track or slow infant weight gain, respectively. In comparison to women with one child, women with two children (AOR = 0.31; 95% CI = 0.11, 0.87; <i>p</i> = 0.03) or three or four children (AOR = 0.24; 95% CI = 0.07, 0.88; <i>p</i> = 0.03) had significantly lower odds of RIWG versus on-track or slow infancy weight gain.</p><p><strong>Conclusions: </strong>Women with excessive or inadequate gestational weight gain had lower proportional odds of RIWG and were more likely to have slower infant weight gain than women who gained the recommended amount of weight.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier; NCT02903186; September 16, 2016.</p>","PeriodicalId":37440,"journal":{"name":"BMC Obesity","volume":"5 ","pages":"41"},"PeriodicalIF":0.0,"publicationDate":"2018-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40608-018-0219-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36749060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Separating \"good\" from \"bad\" faecal dysbiosis - evidence from two cross-sectional studies.","authors":"Per G Farup,&nbsp;Martin Aasbrenn,&nbsp;Jørgen Valeur","doi":"10.1186/s40608-018-0207-3","DOIUrl":"https://doi.org/10.1186/s40608-018-0207-3","url":null,"abstract":"<p><strong>Background: </strong>Faecal dysbiosis associated with the use of metformin has been conceived as a favourable (\"good\") dysbiosis and that with intake of non-nutritive sweeteners (NNS) as unfavourable (\"bad\"). The study aimed to construct an alternative dysbiosis index (ADI) for the separation of the dysbioses into \"good\" and \"bad\", and to validate the ADI.</p><p><strong>Methods: </strong>Subjects with morbid obesity were included. Use of NNS and drugs were noted, IBS was classified according to the Rome III criteria and the severity measured with the Irritable bowel severity scoring system (IBSSS). Faecal dysbiosis was tested with GA-Map ™ Dysbiosis test (Genetic Analysis AS, Oslo, Norway). The result was given as Dysbiosis Index (DI) scores 1-5, score > 2 indicates dysbiosis. An ADI was constructed and validated in subjects with IBS at another hospital.</p><p><strong>Results: </strong>Seventy-six women and 14 men aged 44.7 years (SD 8.6) with BMI 41.8 kg/m² (SD 3.6) were included. Dysbiosis was associated with the use of NNS and metformin, but not with IBS or IBSSS. An ADI based on differences in 7 bacteria was positively and negatively associated with the \"good\" metformin dysbiosis and the \"bad\" NNS dysbiosis respectively. The ADI was also negatively associated with IBSSS (a \"bad\" dysbiosis). The negative associations between ADI and IBS and IBSS were confirmed in the validation group.</p><p><strong>Conclusions: </strong>The new ADI, but not the DI, allowed separation of the \"good\" and \"bad\" faecal dysbiosis. Rather than merely reporting dysbiosis and degrees of dysbiosis, future diagnostic tests should distinguish between types of dysbiosis.</p>","PeriodicalId":37440,"journal":{"name":"BMC Obesity","volume":"5 ","pages":"30"},"PeriodicalIF":0.0,"publicationDate":"2018-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s40608-018-0207-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36760217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}