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Biological Activities of Metal Complexes with Rutin and Bio-Conjugate of Citrus Extract 芦丁金属配合物及柑桔提取物生物偶联物的生物活性研究

Universal Journal of Chemistry Pub Date : 2020-07-01 DOI: 10.13189/ujc.2020.070101

O. Prakash, Babita Belal, J. Dhanik, Anil Verma, H. Joshi, V. Vivekanand

{"title":"Biological Activities of Metal Complexes with Rutin and Bio-Conjugate of Citrus Extract","authors":"O. Prakash, Babita Belal, J. Dhanik, Anil Verma, H. Joshi, V. Vivekanand","doi":"10.13189/ujc.2020.070101","DOIUrl":"https://doi.org/10.13189/ujc.2020.070101","url":null,"abstract":"The main aim of this study is to determine the changes occurred in the antioxidant capacity and UV-protection capacity of rutin with a different redox-potential metal cation. The complexes were characterized by UV-Visible and IR spectroscopy. Rutin belongs to the flavonols and it is a glycoside form of quercetin. Chelate formation is a result of interaction of rutin with metal ions. The chelation of metals can be crucial in the prevention of radical generation, which damages target biomolecules. The interactions between flavonoids and transition metal ions to form complexes that prevent the participation of metal ions in free radical generating processes, thus exhibit an anti-oxidant behavior, metal-flavonoid complexes various biological and pharmacological activities. The coordination of Rutin (Rut) with Rut-Zr, Rut-Mo, Rut-Zn, Rut-Cu, Rut-Ni, Rut-Fe, Cit-Zn, Cit-Mo, Cit-Zr, Cit-Cu, Cit-Fe, and Cit-Ni may simulate the catalyzed centre of the hyperoxide dismutase in the metal coordinate structure, thus displayed the DPPH, hydroxyl radical scavenging activity, metal chelating, and nitric oxide (NO) and superoxide dismutase (SOD) radical scavenging. Therefore, the metal flavonoid complexes are very helpful in discovery and development of new drugs.","PeriodicalId":374066,"journal":{"name":"Universal Journal of Chemistry","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121499532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4