芦丁金属配合物及柑桔提取物生物偶联物的生物活性研究

O. Prakash, Babita Belal, J. Dhanik, Anil Verma, H. Joshi, V. Vivekanand
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引用次数: 4

摘要

研究不同氧化还原电位金属阳离子对芦丁抗氧化能力和抗紫外线能力的影响。用紫外可见光谱和红外光谱对配合物进行了表征。芦丁属于黄酮醇类,是槲皮素的糖苷形式。络合物是芦丁与金属离子相互作用的结果。金属的螯合在防止自由基的产生中起着至关重要的作用,自由基会破坏目标生物分子。黄酮类化合物与过渡金属离子相互作用形成配合物,阻止金属离子参与自由基的生成过程,从而表现出抗氧化的行为,金属-黄酮类化合物具有多种生物学和药理活性。芦丁(Rut)与Rut- zr、Rut- mo、Rut- zn、Rut- cu、Rut- ni、Rut- fe、Cit-Zn、Cit-Mo、Cit-Zr、Cit-Cu、Cit-Fe和Cit-Ni配位可以模拟金属配位结构中超氧化物歧化酶的催化中心,从而表现出DPPH、羟基自由基清除活性、金属螯合、一氧化氮(NO)和超氧化物歧化酶(SOD)自由基清除能力。因此,金属类黄酮配合物对新药的发现和开发有很大的帮助。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biological Activities of Metal Complexes with Rutin and Bio-Conjugate of Citrus Extract
The main aim of this study is to determine the changes occurred in the antioxidant capacity and UV-protection capacity of rutin with a different redox-potential metal cation. The complexes were characterized by UV-Visible and IR spectroscopy. Rutin belongs to the flavonols and it is a glycoside form of quercetin. Chelate formation is a result of interaction of rutin with metal ions. The chelation of metals can be crucial in the prevention of radical generation, which damages target biomolecules. The interactions between flavonoids and transition metal ions to form complexes that prevent the participation of metal ions in free radical generating processes, thus exhibit an anti-oxidant behavior, metal-flavonoid complexes various biological and pharmacological activities. The coordination of Rutin (Rut) with Rut-Zr, Rut-Mo, Rut-Zn, Rut-Cu, Rut-Ni, Rut-Fe, Cit-Zn, Cit-Mo, Cit-Zr, Cit-Cu, Cit-Fe, and Cit-Ni may simulate the catalyzed centre of the hyperoxide dismutase in the metal coordinate structure, thus displayed the DPPH, hydroxyl radical scavenging activity, metal chelating, and nitric oxide (NO) and superoxide dismutase (SOD) radical scavenging. Therefore, the metal flavonoid complexes are very helpful in discovery and development of new drugs.
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