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The roads to ferroptosis under homeostatic versus pathological conditions. 内稳态与病理条件下的铁下垂之路。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-10-06 eCollection Date: 2021-01-01 DOI: 10.1080/23723556.2021.1970477
Vincent Chen, Chu Bo, Wei Gu
{"title":"The roads to ferroptosis under homeostatic versus pathological conditions.","authors":"Vincent Chen,&nbsp;Chu Bo,&nbsp;Wei Gu","doi":"10.1080/23723556.2021.1970477","DOIUrl":"https://doi.org/10.1080/23723556.2021.1970477","url":null,"abstract":"<p><p>The calcium-independent phospholipase iPLA2β has been identified as a transcriptional target of the tumor suppressor <i>TP53</i> (or p53). Unlike GPX4 (glutathione peroxidase 4), iPLA2β is not required for normal homeostasis but critical for ferroptosis during stress responses. Our results implicate iPLA2β as an essential regulator in a noncanonical ferroptosis pathway.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 5","pages":"1970477"},"PeriodicalIF":2.1,"publicationDate":"2021-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632319/pdf/KMCO_8_1970477.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate. 从发现到癌症患者疗效验证的科学之旅:哈姆雷特和α 1-油酸酯。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-09-30 eCollection Date: 2021-01-01 DOI: 10.1080/23723556.2021.1974278
James C S Ho, Ines Ambite, K H Mok, Marek Babjuk, Catharina Svanborg
{"title":"A scientific journey from discovery to validation of efficacy in cancer patients: HAMLET and alpha1-oleate.","authors":"James C S Ho,&nbsp;Ines Ambite,&nbsp;K H Mok,&nbsp;Marek Babjuk,&nbsp;Catharina Svanborg","doi":"10.1080/23723556.2021.1974278","DOIUrl":"https://doi.org/10.1080/23723556.2021.1974278","url":null,"abstract":"<p><p>The protein-lipid complex alpha1-oleate, derived from HAMLET (Human Alpha-lactalbumin Made LEthal to Tumor cells), is identified as a molecular entity with significant therapeutic potential. Structural characterization of the complex and results of a successful placebo-controlled clinical trial are presented.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 5","pages":"1974278"},"PeriodicalIF":2.1,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/74/68/KMCO_8_1974278.PMC8632289.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Mitochondrial homeostasis is maintained in the absence of autophagy. 在没有自噬的情况下，线粒体也能保持稳定。
IF 2.6
Molecular and Cellular Oncology Pub Date : 2021-09-30 eCollection Date: 2021-01-01 DOI: 10.1080/23723556.2021.1984162
Christina G Towers
{"title":"Mitochondrial homeostasis is maintained in the absence of autophagy.","authors":"Christina G Towers","doi":"10.1080/23723556.2021.1984162","DOIUrl":"10.1080/23723556.2021.1984162","url":null,"abstract":"<p><p>Autophagy is a central recycling process, and it plays a complex role in cancer. We discovered that when autophagy is blocked, cancer cells compensate by increasing mitochondrial-derived vesicles. However, there are many unanswered questions remaining, particularly in the context of the dual roles of autophagy in cancer.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 5","pages":"1984162"},"PeriodicalIF":2.6,"publicationDate":"2021-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632333/pdf/KMCO_8_1984162.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From mouse genetics to targeting the Rag GTPase pathway. 从小鼠遗传学到靶向Rag GTPase途径。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-09-24 eCollection Date: 2021-01-01 DOI: 10.1080/23723556.2021.1979370
Ana Ortega-Molina, Alejo Efeyan
{"title":"From mouse genetics to targeting the Rag GTPase pathway.","authors":"Ana Ortega-Molina,&nbsp;Alejo Efeyan","doi":"10.1080/23723556.2021.1979370","DOIUrl":"https://doi.org/10.1080/23723556.2021.1979370","url":null,"abstract":"<p><p>The identification of the Rag GTPases initiated the deciphering of the molecular puzzle of nutrient signaling to the mechanistic target of rapamycin (mTOR), and spurred interest in targeting this pathway to combat human disease. Recent mouse genetic studies have provided pathophysiological insight and pointed to potential indications for inhibitors of the Rag GTPase pathway.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 5","pages":"1979370"},"PeriodicalIF":2.1,"publicationDate":"2021-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632321/pdf/KMCO_8_1979370.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1. 解读securin和CDK1-CCNB1对人分离酶的抑制模式。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-09-24 eCollection Date: 2021-01-01 DOI: 10.1080/23723556.2021.1975473
Pierre Raia, Jun Yu, Andreas Boland
{"title":"Deciphering the modes of human separase inhibition by securin and CDK1-CCNB1.","authors":"Pierre Raia,&nbsp;Jun Yu,&nbsp;Andreas Boland","doi":"10.1080/23723556.2021.1975473","DOIUrl":"https://doi.org/10.1080/23723556.2021.1975473","url":null,"abstract":"<p><p>Accurate chromosome segregation depends on tight regulation of the protease separase, which cleaves the ring-shaped cohesin complex that entraps the two sister chromatids. We recently reported structures of human separase bound to its inhibitors securin or the cyclin-dependent kinase 1 (CDK1)-cyclin B1 (CCNB1)-cyclin-dependent kinases regulatory subunit 1 (CKS1) complex and discovered an array of molecular mechanisms that block cohesin-cleavage.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 4","pages":"1975473"},"PeriodicalIF":2.1,"publicationDate":"2021-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489941/pdf/KMCO_8_1975473.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39491987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix. sgk1调控的代谢:细胞脱离细胞外基质存活的关键。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-09-24 eCollection Date: 2021-01-01 DOI: 10.1080/23723556.2021.1976583
Jordan A Cockfield, Zachary T Schafer
{"title":"SGK1-regulated metabolism: key for the survival of cells detached from the extracellular matrix.","authors":"Jordan A Cockfield,&nbsp;Zachary T Schafer","doi":"10.1080/23723556.2021.1976583","DOIUrl":"https://doi.org/10.1080/23723556.2021.1976583","url":null,"abstract":"<p><p>Cells that lack attachment to the extracellular matrix (ECM) experience metabolic defects that can lead to caspase-independent cell death. Recently, we discovered that serum and glucocorticoid kinase-1 (SGK1) plays a critical role in the regulation of glucose metabolism, the promotion of energy production, and ultimately the survival of ECM-detached cells. <b>Abbreviations</b>: ECM, extracellular matrix; SGK1, serum and glucocorticoid kinase-1; ROS, reactive oxygen species; CCCP, cyanide m-chlorophenyl hydrazine; PPP, pentose phosphate pathway; G3P, glyceraldhyde-3-phosphate; shRNA, short hairpin RNA; TCA, tricarboxylic acid.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 5","pages":"1976583"},"PeriodicalIF":2.1,"publicationDate":"2021-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8632271/pdf/KMCO_8_1976583.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects. 简化癌症：根据 YAP/TEAD 的相反效应分层的二元泛癌症超类。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-09-24 eCollection Date: 2021-01-01 DOI: 10.1080/23723556.2021.1981111
Joel D Pearson, Rod Bremner
{"title":"Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects.","authors":"Joel D Pearson, Rod Bremner","doi":"10.1080/23723556.2021.1981111","DOIUrl":"10.1080/23723556.2021.1981111","url":null,"abstract":"<p><p>The inherent complexity of cancer complicates treatment. Identifying higher-order principles that govern cancer biology can circumvent this problem and pinpoint broadly applicable treatment options. We recently found that opposite expression and pro- versus anti-cancer activity of a single transcriptional complex functionally stratifies cancer into binary superclasses.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 5","pages":"1981111"},"PeriodicalIF":2.1,"publicationDate":"2021-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/da/bb/KMCO_8_1981111.PMC8632326.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39687921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential. SWI/SNF复合物、转录复制冲突与癌症:具有高治疗潜力的联系
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-09-23 eCollection Date: 2021-01-01 DOI: 10.1080/23723556.2021.1976582
Aleix Bayona-Feliu, Andrés Aguilera
{"title":"The SWI/SNF complex, transcription-replication conflicts and cancer: a connection with high therapeutic potential.","authors":"Aleix Bayona-Feliu,&nbsp;Andrés Aguilera","doi":"10.1080/23723556.2021.1976582","DOIUrl":"https://doi.org/10.1080/23723556.2021.1976582","url":null,"abstract":"<p><p>Genome instability is a hallmark of cancer. ATP-dependent chromatin remodelers are frequently altered in cancer. We have recently reported that the SWItch/Sucrose Non-Fermentable (SWI/SNF) complex protects the genome by limiting R-loop-mediated genome instability, mainly that caused by transcription-replication conflicts. Here we discuss the significance and biomedical applications of this finding.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 4","pages":"1976582"},"PeriodicalIF":2.1,"publicationDate":"2021-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489945/pdf/KMCO_8_1976582.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39491988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Hydrogen sulfide operates as a glioblastoma suppressor and is lost under high fat diet. 硫化氢是一种胶质母细胞瘤抑制剂，在高脂肪饮食中会减少。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-09-16 eCollection Date: 2021-01-01 DOI: 10.1080/23723556.2021.1973312
Daniel J Silver, Justin D Lathia, Christopher Hine
{"title":"Hydrogen sulfide operates as a glioblastoma suppressor and is lost under high fat diet.","authors":"Daniel J Silver,&nbsp;Justin D Lathia,&nbsp;Christopher Hine","doi":"10.1080/23723556.2021.1973312","DOIUrl":"https://doi.org/10.1080/23723556.2021.1973312","url":null,"abstract":"<p><p>Glioblastoma (GBM) is one of the deadliest and aggressive forms of brain cancer. Environmental and intrinsic factors such as Western Diet and advanced age can function as powerful accelerants to the progression of GBM. Recently, we discovered that pre-clinical GBM models subject to an obesogenic and age-accelerating high fat diet (HFD) presented with hyperaggressive GBM phenotypes, including treatment-refractory cancer stem cell (CSC) enrichment. Mechanistically, HFD suppressed production of the gasotransmitter hydrogen sulfide (H<sub>2</sub>S) and its downstream sulfhydration signaling in the brain. Likewise, we observed dramatic loss of sulfhydration in brains of GBM patients. Importantly, we showed the tumor suppressive effects of H<sub>2</sub>S against GBM in cell culture and <i>in vivo</i>. Here, we discuss these recent findings and provide insight into how they can be leveraged to improve treatment modalities, prognosis, and quality of life for GBM patients.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 4","pages":"1973312"},"PeriodicalIF":2.1,"publicationDate":"2021-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489903/pdf/KMCO_8_1973312.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39491986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer. 在乳腺癌中偶联PI3Kα和WNT/β-catenin信号的晚期核内体信号中枢。
IF 2.1
Molecular and Cellular Oncology Pub Date : 2021-09-09 eCollection Date: 2021-01-01 DOI: 10.1080/23723556.2021.1954470
Samuel J Rodgers, Sabryn A Hamila, Christina A Mitchell, Lisa M Ooms
{"title":"A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer.","authors":"Samuel J Rodgers,&nbsp;Sabryn A Hamila,&nbsp;Christina A Mitchell,&nbsp;Lisa M Ooms","doi":"10.1080/23723556.2021.1954470","DOIUrl":"https://doi.org/10.1080/23723556.2021.1954470","url":null,"abstract":"<p><p>AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, <i>PIK3CA</i> (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER<sup>+</sup>) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly characterized. We discovered that a subset of <i>PIK3CA</i>-mutant ER<sup>+</sup> breast cancers exhibit increased inositol polyphosphate 4-phosphatase type II (INPP4B) expression, which promotes late endosome formation and glycogen synthase kinase 3 beta (GSK3β) trafficking, leading to enhanced Wingless-related integration site (WNT)/catenin beta 1 (β-catenin) activation.</p>","PeriodicalId":37292,"journal":{"name":"Molecular and Cellular Oncology","volume":"8 4","pages":"1954470"},"PeriodicalIF":2.1,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8489923/pdf/KMCO_8_1954470.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39491985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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