Indonesian Journal of Perinatology最新文献

{"title":"Characteristics of pregnancy with Systemic Lupus Erythematosus (SLE) in Dr. Mohammad Hoesin Hospital, Palembang","authors":"Nyimas Aliyah Faizatun Muthmainnah, Nuswil Bernolian, E. Roflin, C. Kesty","doi":"10.51559/inajperinatol.v2i1.10","DOIUrl":"https://doi.org/10.51559/inajperinatol.v2i1.10","url":null,"abstract":"Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease with complex pathogenesis with broad clinical manifestations, more common in women of reproductive age between 15-44 years, so there is an increased incidence in pregnancies. \u0000Methods: This study was a descriptive observational study with a cross-sectional design using medical records of patients in Dr. Mohammad Hoesin Hospital Palembang from January 2018-June 2020. Sampling was carried out by total sampling with the presentation of data in tables and narratives. Data processing was performed using SPSS 25. \u0000Results: There were 1,039 pregnancies in January 2018-June 2020 with 26 pregnancies with SLE and 8 patients (30.8%) of moderate degree SLE. The demographic characteristics were 26-30 age range (30.8%), high school education status (53.8%), the number of pregnancies 2-3 times (53.8%), the number of primiparous births (46.2%), and the number of miscarriages was never experienced (65.4%). Based on clinical signs and symptoms, malaise (15.4%), malar rash, photosensitivity spots and alopecia (15.4%), inflammatory arthritis (46.2%), lupus nephritis (11.5%), abdominal pain ( 34.6%), lymphadenopathy (3.8%), anemia or lymphopenia (15.4%), and cephalgia (7.7%). Meanwhile, the parameter of diagnosis was lymphopenia (15.4%), eGFR stage 1 (34.6%), proteinuria or proteinuria and cylindruria (11.5%), ANA test (+) (19.2%), anti-dsDNA test (+) (19.2%), and the complement test decreased (7.7%). Pregnancy outcomes were found to have intrauterine growth restriction (IUGR) (19.2%) and preeclampsia and IUGR (11.5%). \u0000Conclusion: From the 26 pregnant patients with SLE, most were found with a moderate degree. Most demographic characteristics were age range 26-30 years old, high school education status, number of pregnancies 2-3 times, primipara, and never miscarriage. Characteristics of clinical signs and symptoms most commonly found in patients were malaise, malar rash, photosensitivity spots and alopecia, inflammatory arthritis, and abdominal pain. The diagnosis parameters were lymphopenia, stage 1 eGFR, proteinuria or proteinuria and cylindruria, ANA test (+), and anti-dsDNA test (+). Most pregnancy outcome is intrauterine growth restriction (IUGR).","PeriodicalId":371343,"journal":{"name":"Indonesian Journal of Perinatology","volume":"218 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122394839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early detection of Fetal Acrania on first-trimester sonography: a case report","authors":"I. Sanjaya, Cokorda istri Mirayani Pemayun, Ni Komang Anik Pirgantari, Made Diah Vendita Sakuntari, Niken Purwanti, N. Gianni, Ni Luh Made Diah Mas Cahyani Putri, Ni Luh Md Dwi Laxmi Satriani, Firsta Sesarina Mintariani, Ni Luh Putu Yulia Padmawati, Anak Agung Wahyu Putri Agustini","doi":"10.51559/inajperinatol.v2i1.8","DOIUrl":"https://doi.org/10.51559/inajperinatol.v2i1.8","url":null,"abstract":"Introduction. Fetal Acrania is a rare fetal malformation characterized by the complete or partial absence of a skull covering the fetal brain. In the absence of a hard covering of the soft brain tissue, Acrania is known as a universally lethal malformation.  Here we present a Fetal Acrania case detected by sonographic examination at our Center. \u0000Case Description. A 36 years old female was referred to the obstetric department to undergo an in-depth sonographic evaluation as a previous examination reveals a potential congenital fetal anomaly. Our sonographic evaluation revealed a singleton, live fetus, 12 weeks gestational age in cephalic presentation and longitudinal lie. One obvious malformation was a well-formed fetal brain without the surrounding cranium (Acrania). The absence of cranium was the main and only malformation. The absence of cranium was evident as the fetal brain was easily compressed on probe pressure, and the brain appeared like floating in the amniotic fluid over the base of the skull. Therapeutic abortion was carried out. The termination was conducted by administering four tablets of 200 mcg misoprostol sublingually and repeated 24 hours later. No adverse reaction or complication on termination. The aborted fetal examination confirmed the lack of fetal cranium. \u0000Conclusion. Although seemingly obvious, the first-trimester diagnosis of fetal Acrania must be made with caution as the fetal cranium is not fully calcified before 10- 11 weeks. As Acrania is a universally lethal malformation, therapeutic abortion is indicated.","PeriodicalId":371343,"journal":{"name":"Indonesian Journal of Perinatology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133379524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the COVID-19 pandemic on the frequency of routine visits and breastfeeding plans on Kasih Medika Clinic","authors":"I. Sanjaya, Cokorda istri Mirayani Pemayun, Firsta Sesarina Mintariani, Made Diah Vendita Sakuntari, Niken Purwanti, N. Gianni, Ni Luh Made Diah Mas Cahyani Putri, Ni Luh Md Dwi Laxmi Satriani, Ni Komang Anik Pirgantari, Ni Luh Putu Yulia Padmawati, Anak Agung Wahyu Putri Agustini","doi":"10.51559/inajperinatol.v2i1.9","DOIUrl":"https://doi.org/10.51559/inajperinatol.v2i1.9","url":null,"abstract":"Introduction. The SARS-CoV-2 pandemic has affected every part of the population, including pregnant mothers, breastfeeding mothers, and infants. There is an inadequate comprehension of SARS-CoV-2 transmission potential as of now. As expected, it will result in anxiety among the public, including a specific issue such as breastfeeding practice for the suspected or confirmed novel coronavirus infection. This study aimed to assess whether such anxiety was present in a population of patients that routinely visit Kasih Medika clinic. \u0000Methods. This is a simple study conducted on August 5-10, 2020. This study used a questionnaire instrument with samples of pregnant and postpartum mothers. The questionnaire includes a question regarding the anxiety surrounding breastfeeding, visiting the clinic and their everyday activity. \u0000Results. We reported that COVID-19 has an impact on the breastfeeding plans from the respondent's questionnaire. All respondents felt anxious about COVID-19, although only 18% of patients reduce their routine visits to Kasih Medika, while the rest keep visiting as scheduled. Eighty-six percent of respondents restricted their outdoor activities during the COVID-19 pandemic. The COVID-19 pandemic causes 27% of the respondents to feel afraid of their breastfeeding plans. However, in the primigravida population, 45.45% of respondents were afraid of their breastfeeding plans. Meanwhile, in the multigravida and postpartum respondents, 90.90%  were not afraid about their breastfeeding plans during the COVID-19 period. \u0000Conclusion. COVID-19 pandemic brings a certain degree of anxiety to the mothers, including anxiety of safety during breastfeeding practice. Despite the risk of transmission, breastfeeding has more benefits than disadvantages. Breastfeeding makes the infant have a good immune system, which prevents any disease, including COVID-19. Breastfeeding during the COVID-19 is still recommended under health protocol.","PeriodicalId":371343,"journal":{"name":"Indonesian Journal of Perinatology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132507511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methylglyoxals, Thiocyanate, and Hydrogen Peroxide in saliva of newborns at risk of sepsis: Methylglyoxals as a promising biomarker of early-onset neonatal sepsis","authors":"A. Yunanto, Pricilia Gunawan H, E. Suhartono","doi":"10.51559/inajperinatol.v2i1.7","DOIUrl":"https://doi.org/10.51559/inajperinatol.v2i1.7","url":null,"abstract":"Introduction. Sepsis represents a severe problem for newborns. The relatively high incidence rate of 1 to 10 cases per 1000 live births, with even higher rates in low-birth-weight neonates. Given its high incidence, identifying markers to optimize the early diagnosis and therapeutic interventions is highly desirable. This study investigates three oxidative markers taken from saliva, methylglyoxal (MG), Thiocyanate (SCN-) and hydrogen peroxide (H2O2), as early-onset neonatal sepsis markers. \u0000Methods. This study was conducted from June to August 2014, and saliva specimens were taken from 30 newborns of mothers with one major risk factor or two minor risk factors (case group) and 30 healthy newborns for the control group. Saliva levels of MG were determined by calculating the percentage of MG absorbance compared with the carbonyl compounds. Data were analyzed by using Kolmogorov-Smirnov and Student's t test. \u0000Results. We found a significant increase of SCN-, and MG level case group (28.91 mmol and 0.01%, respectively) compared to the control group (19.49 mmol and 0.005%, respectively) p-value = 0.03. In contrast, the H2O2 in the case group (32.56 mmol) was lower than the control group (37.47 mmol), with a p-value = 0.04. \u0000Conclusion. We found the increased levels of SCN–, MG and the decreased levels of H2O2 in neonates' saliva with the risk of sepsis. MG measurements as a routine diagnostic for suspected sepsis should be taken into consideration.","PeriodicalId":371343,"journal":{"name":"Indonesian Journal of Perinatology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131956035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}