{"title":"A randomized trial comparing the effects of single-dose preemptive ketorolac and dexamethasone on postoperative pain and morphine consumption following lumbar laminectomy","authors":"Terdsak Phonchan, Surachai Sae-Jung","doi":"10.1016/j.wnsx.2025.100498","DOIUrl":"10.1016/j.wnsx.2025.100498","url":null,"abstract":"<div><h3>Background</h3><div>Lumbar laminectomy is a common surgical option for treating lumbar stenosis, but it can result in moderate to severe pain. Proper pain management is important for patients to recover quickly. This randomized trial aimed to compare ketorolac and dexamethasone for postoperative pain and morphine use in lumbar laminectomy patients.</div></div><div><h3>Methods</h3><div>This study included 120 patients, ranging in age from 18 to 75 years old, who underwent lumbar laminectomy. The patients were randomly assigned to either the ketorolac or dexamethasone group. The study aimed to evaluate two main factors: the amount of morphine used and the pain levels measured by the visual analog scale (VAS) at specific times after surgery, including the post-anesthetic care unit (PACU), as well as at 12, 24, and 48 h following the procedure. Furthermore, any adverse events that occurred during the study were thoroughly recorded.</div></div><div><h3>Results</h3><div>After 48 h, the patients who were given ketorolac required less morphine than those in the dexamethasone group (<em>p</em>-value = 0.01). However, patients in the dexamethasone group had lower VAS scores than those in the ketorolac group after 24 h (<em>p</em>-value = 0.01). Importantly, no serious adverse events occurred, including respiratory depression and surgical site infections.</div></div><div><h3>Conclusions</h3><div>After a lumbar laminectomy procedure, a single preemptive dose of ketorolac showed a slight decrease in postoperative morphine usage 48 h later when compared to dexamethasone. However, there was no noticeable effect on the patient's pain scores.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100498"},"PeriodicalIF":2.0,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144738756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recurrence rate of chronic cerebral arterial occlusion with mean transit time more than 6 s: a case series","authors":"Ittipon Gunnarut , Kritsada Buakate , Nisarat Phatisuwan","doi":"10.1016/j.wnsx.2025.100497","DOIUrl":"10.1016/j.wnsx.2025.100497","url":null,"abstract":"<div><h3>Objective</h3><div>Chronic cerebral arterial occlusion and stenosis are significant medical conditions which can cause hemodynamic impairment, leading to symptoms such as transient ischemic attacks and progressive or recurrent strokes. Surgical bypass is a treatment modality available for these conditions, but its results are only similar to those of the best medical treatment. The CMOSS study analyzed a subgroup of patients receiving the best medical treatment and found that individuals with prolonged mean transit time may benefit from the surgical bypass procedure.</div><div>The objective of this report was to investigate the recurrence rate of unilateral chronic cerebral arterial occlusion with a mean transit time of more than 6 s treated with STA-MCA by-pass procedure during the follow-up period.</div></div><div><h3>Methods</h3><div>A retrospective review was conducted between January 2010 and December 2024 at Rajavithi Hospital, including patients who received the best medical treatment, had a mean transit time (MTT) greater than 6 s, and also had a relative cerebral blood flow (rCBF) of ≤0.5 m. All patients underwent STA-MCA bypass surgery. Data collected included demographic information, recurrence rates, pre- and post-operative Glasgow Coma Scores, and modified Rankin Scores.</div></div><div><h3>Results</h3><div>The demographic data of the predominantly male patients showed a mean age of 57.2 years. Regarding CT perfusion, all patients had an MTT greater than 6 s, and 93.3 % had an rCBF below 0.5. The postoperative results indicated that the modified Rankin Scale (MRS) was similar to the preoperative condition, but also that 80 % of symptoms improved. The recurrence rate was 0 % during the follow-up period; however, 3 patients died, and the cause of death in all cases was pneumonia (not due to ipsilateral stroke).</div></div><div><h3>Conclusion</h3><div>This report demonstrates that STA-MCA bypass is potentially useful for patients with single-vessel chronic ICA/MCA stenosis or occlusion who do not respond to the best medical treatment, as indicated by CT perfusion showing an MTT >6 s and an rCBF ≤0.5.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100497"},"PeriodicalIF":0.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nikita Das , Ravi Dhamija , Orlando Martinez , John Francis , Rohit Mauria , Collin M. Labak , Eric Z. Herring , Gabriel Smith
{"title":"Structural and compensatory trends in spinopelvic parameters of lumbosacral transitional vertebrae: A retrospective cohort analysis","authors":"Nikita Das , Ravi Dhamija , Orlando Martinez , John Francis , Rohit Mauria , Collin M. Labak , Eric Z. Herring , Gabriel Smith","doi":"10.1016/j.wnsx.2025.100492","DOIUrl":"10.1016/j.wnsx.2025.100492","url":null,"abstract":"<div><h3>Objective</h3><div>Lumbosacral transitional vertebrae (LSTV) are an underdiagnosed source of low back pain (LBP), or Bertolotti Syndrome. This study identifies trends in radiographic lumbo–pelvic parameters among LSTV patients that may serve as prognostic indicators for surgery.</div></div><div><h3>Methods</h3><div>A retrospective chart review identified LSTV patients using a free-text search of our institution's electronic medical record for terms related to “LSTV” and \"Bertolotti.\" Patients lacking radiographic evidence of abnormal fusion between L5 and the sacrum/ilium were excluded. Clinical features and spinopelvic parameters, including lumbar lordosis (LL), pelvic incidence (PI), and pelvic tilt (PT) were analyzed.</div></div><div><h3>Results</h3><div>Of 122 LSTV patients, 108 (88.5 %) had LBP consistent with Bertolotti Syndrome. Median L4-L5 lordosis was 17.9° [16.9°, 18.9°], L5-S1 lordosis was 15.2° [14.2°, 16.2°]. Median PI was 65.7° [63.4°, 67.9°], with a PI-LL mismatch of 8.4° [6.1°, 10.7°]. Median PT was estimated at 25.1° [23.3°, 26.9°]. Significant associations existed between pain severity and PT > 35° (<em>p</em> = 0.004), as well as increased PI (<em>p</em> = 0.03). Castellvi Type II LSTV patients were more likely to have an L5/S1 angle >15° (<em>p</em> = 0.02).</div></div><div><h3>Conclusions</h3><div>This study aims to improve and understand the impact of spinopelvic parameters for patients with LSTV. Elevated Pelvic Tilt and Pelvic Incidence are associated with increased risk of LSTV manifesting as Bertolotti Syndrome. Additionally, the lumbosacral transition may not be located at L5/S1 in these patients. Development of algorithm-based technologies that identify LSTV radiographically and measure corresponding spinopelvic parameters using standardized protocols may facilitate improvements in care for this patient population.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100492"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Osman Efe Efeoğlu , Serdar Onur Aydın , Fırat Demir , Lütfi Postalcı , Bekir Can Kendirlioğlu , Gaye Filinte , Evren Aydoğmuş , Tufan Hiçdönmez
{"title":"Retrospective analysis of surgical management and aesthetic outcomes in trigonocephaly: A decade of experience","authors":"Osman Efe Efeoğlu , Serdar Onur Aydın , Fırat Demir , Lütfi Postalcı , Bekir Can Kendirlioğlu , Gaye Filinte , Evren Aydoğmuş , Tufan Hiçdönmez","doi":"10.1016/j.wnsx.2025.100494","DOIUrl":"10.1016/j.wnsx.2025.100494","url":null,"abstract":"<div><h3>Background</h3><div>This study aims to examine the demographic and clinical data of patients who underwent surgery for trigonocephaly at our clinic to evaluate the characteristics, assess cosmetic outcomes, and compare our results with findings reported in the existing literature.</div></div><div><h3>Materials and methods</h3><div>The clinical records and surgical techniques of patients who underwent surgery for trigonocephaly between 2010 and 2020 were retrospectively analyzed. Preoperative and postoperative photographs of the frontoorbital region were evaluated by two experienced surgeons using the Whitaker Classification to assess cosmetic outcomes. Statistical analysis was performed to compare the assessments made by the surgeons.</div></div><div><h3>Results</h3><div>Among 23 patients (15 males and 8 females), the median age at surgery was 7 months, and the median follow-up period was 6 years. A family history of craniosynostosis was present in 13 % of cases. Preoperative computed tomography (CT) imaging was performed in 57 % of patients, while the remaining were diagnosed clinically. Open reconstruction techniques were employed in all cases. According to the Whitaker Classification, 96 % of patients were categorized in the first two groups (excellent or good outcomes) by both surgeons, showing strong interobserver agreement.</div></div><div><h3>Conclusion</h3><div>Surgical intervention for trigonocephaly not only corrects cranial deformities but also supports proper brain development. Early surgical intervention is recommended to achieve optimal outcomes. The Whitaker Classification serves as a practical tool for standardizing the evaluation of both cosmetic and functional outcomes.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100494"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Occipital transtentorial approach for posterior cranial fossa lesions located away from the midsagittal plane: A technical note","authors":"Hideo Ohba , Toshiyuki Tsuboi , Yuko Miyazaki , Yosuke Kajihara , Shigeyuki Sakamoto , Kazutoshi Mukada , Shinji Ohba","doi":"10.1016/j.wnsx.2025.100493","DOIUrl":"10.1016/j.wnsx.2025.100493","url":null,"abstract":"<div><h3>Background</h3><div>The occipital transtentorial approach (OTA) is a well-established technique for accessing lesions in the pineal region, posterior third ventricle, and dorsal midbrain. Compared to the supracerebellar infratentorial approach, OTA provides superior visualization without cerebellar obstruction. However, its application to posterior cranial fossa lesions located away from the midsagittal plane remains underexplored, and its lateral limitations have not been clearly defined.</div></div><div><h3>Case presentation</h3><div>A 65-year-old woman with a symptomatic cerebellar tentorial meningioma located away from the midsagittal plane underwent tumor resection via OTA. A stepwise cerebrospinal fluid drainage strategy was employed to minimize brain retraction and optimize surgical exposure. The craniotomy extended across the superior sagittal and transverse sinuses to maximize visualization. The cranial limit was defined by the ascending vein joining the superior sagittal sinus, while the lateral limit was delineated by the confluence of the Vein of Labbé with the transverse sinus. No postoperative complications or permanent neurological deficits were observed.</div></div><div><h3>Discussion</h3><div>A literature review revealed a lack of detailed reports on OTA for posterior fossa lesions located away from the midsagittal plane. We propose that the Vein of Labbé serves as a key anatomical landmark defining the lateral boundary of OTA. Embryological evidence further supports its validity as an anatomical constraint.</div></div><div><h3>Conclusion</h3><div>This report provides a detailed description of OTA for posterior fossa lesions located away from the midsagittal plane. Our findings highlight the importance of the Vein of Labbé as a lateral boundary, necessitating further case accumulation and comparative studies to refine OTA indications.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100493"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdulaziz M. Alghamdi , Abdulrahman Ahmad Takroni , Abdulwhab M. Alotaibi , Razan Ayed Alboqami , Orjwan Hashem Ateeq , Fares F. Alsayegh , Faisal Alotaibi
{"title":"Single versus double burr holes craniostomy drainage for chronic subdural hematoma: A systematic review and meta-analysis of randomized clinical trials","authors":"Abdulaziz M. Alghamdi , Abdulrahman Ahmad Takroni , Abdulwhab M. Alotaibi , Razan Ayed Alboqami , Orjwan Hashem Ateeq , Fares F. Alsayegh , Faisal Alotaibi","doi":"10.1016/j.wnsx.2025.100495","DOIUrl":"10.1016/j.wnsx.2025.100495","url":null,"abstract":"<div><h3>Objective</h3><div>This systematic review and meta-analysis aimed to compare the efficacy and safety of single- and double-burr hole craniostomies (sBHC) and (dBHC) in the management of chronic subdural hematoma (cSDH).</div></div><div><h3>Methods</h3><div>The PubMed, MEDLINE, Embase, and Cochrane CENTRAL databases were systematically searched for relevant articles. The included articles were randomized controlled trials (RCTs) written in English that compared the efficacy or safety of sBHC to that of dBHC for the treatment of patients with cSDH.</div></div><div><h3>Results</h3><div>Nine RCTs were included in this systematic review. The length of surgery was significantly shorter in the sBHC group (mean difference = −20.65, 95 % CI [-28.58, −12.72], <em>p</em> < 0.00001, I<sup>2</sup> = 96 %). <strong><u>The mean length of surgery in sBHC was 34.9 min, compared to 55.5 min for a dBHC. There was no significant difference in the postoperative Glasgow Coma Scale (GCS) between the groups, presence of postoperative infections, presence of postoperative pneumocephalus, length of hospital stay, recurrence rates, and mortality rate.</u></strong></div></div><div><h3>Conclusion</h3><div>Both sBHC and dBHC are efficacious surgical techniques for managing cSDH. Based on this meta-analysis of RCTs, the safety and efficacy of sBHC and dBHC were comparable without statistically significant differences.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100495"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Santos , Helena Calvo-Rubio , Dario Gandara , Carles Lorenzo-Bosquet , Marta Rubiera , Silvia Vazquez , Alejandro Tomasello , Fuat Arikan
{"title":"EC-IC direct bypass revascularization for intracranial atherosclerosis. Insights beyond the COSS trial","authors":"Carlos Santos , Helena Calvo-Rubio , Dario Gandara , Carles Lorenzo-Bosquet , Marta Rubiera , Silvia Vazquez , Alejandro Tomasello , Fuat Arikan","doi":"10.1016/j.wnsx.2025.100496","DOIUrl":"10.1016/j.wnsx.2025.100496","url":null,"abstract":"<div><h3>Purpose</h3><div>Despite the results of the EC-IC Bypass International Trial and the Carotid Occlusion Surgery Study (COSS), high-volume centers continue to treat symptomatic intracranial atherosclerotic patients with bypass revascularization. This study aimed to analyze our data and assess whether patient characteristics and outcomes differ from those in EC-IC Bypass and COSS trials.</div></div><div><h3>Methods</h3><div>Patients with intracranial atherosclerotic occlusions treated by EC-IC bypass from January 2012 to June 2022 were included. Inclusion criteria were: (1) intracranial atherosclerotic occlusion >70 %, (2) transient or permanent ischemic events in the affected territory, and (3) impaired cerebrovascular reactivity demonstrated by acetazolamide-challenged SPECT.</div></div><div><h3>Results</h3><div>Forty-nine patients were included. Half presented bilateral occlusions, and 53.1 % had hemodynamic symptoms. Most were asymptomatic or had mild strokes preoperatively. Postoperatively, mRS worsened in 34.78 % of patients without hemodynamic symptoms, compared to 15 % of symptomatic patients. No significant differences in NIHSS or mRS were observed between pre- and postoperative evaluations. The 30-day complication rate was 20.4 %, with one procedure-related death. High rates of bypass patency (97.95 %) and SPECT improvement (87.75 %) were achieved. Long-term ipsilateral ischemic stroke rate was 2 %.</div></div><div><h3>Conclusion</h3><div>EC-IC bypass remains a viable option in carefully selected patients with symptomatic intracranial stenosis and impaired cerebrovascular reserve. Patient selection based on clinical and functional criteria is essential. Our results contrast with those of the COSS trial, showing lower recurrence of ipsilateral ischemic stroke, neurological stability in most patients, and favorable outcomes in individuals with hemodynamic symptoms and contralateral stenosis.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100496"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Examining the correlation between hemoglobin-red blood cell distribution width ratio and hospital mortality among patients with spontaneous intracerebral hemorrhage","authors":"Yu-Hua Huang , Tsung-Han Lee , Yu-Ming Chang","doi":"10.1016/j.wnsx.2025.100491","DOIUrl":"10.1016/j.wnsx.2025.100491","url":null,"abstract":"<div><h3>Objective</h3><div>Spontaneous intracerebral hemorrhage (ICH) is a public health concern due to its high mortality rate. Although the hemoglobin to red blood cell distribution width ratio (Hb-RDW ratio) has been recognized as a prognostic indicator in numerous malignant conditions, its correlation with cerebrovascular event outcomes remains unclear. This study sets out to explore the association between the Hb-RDW ratio and hospital mortality after spontaneous ICH.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of 201 patients, gathering information on Glasgow Coma Score (GCS), existing medical conditions, and laboratory results. The Hb-RDW ratio was calculated using the formula: Hb (gm/dl)/RDW (%). The primary endpoint was hospital mortality. We performed a multivariable logistic regression analysis to pinpoint independent predictors of hospital mortality.</div></div><div><h3>Results</h3><div>The results disclosed a substantial inverse relationship between the Hb-RDW ratio and hospital mortality (OR: 0.06, 95 % CI: 0.004–0.90, <em>p</em> = 0.04). For every unit decrease in the Hb-RDW ratio, a 94 % increase in the risk of mortality was observed. A receiver operating characteristic curve analysis was performed, and the area under the curve for the Hb-RDW ratio was 0.633 (<em>p</em> = 0.01). Admission GCS was also an independent predictor of mortality (OR: 17.86, 95 % CI: 2.60–122.64, <em>p</em> < 0.01).</div></div><div><h3>Conclusions</h3><div>The Hb-RDW ratio serves as a significant predictor of hospital mortality in patients with spontaneous ICH. Lower Hb-RDW ratio values corresponded to a heightened mortality risk, underscoring the potential usefulness of this composite index in guiding clinical decisions and risk stratification.</div></div>","PeriodicalId":37134,"journal":{"name":"World Neurosurgery: X","volume":"28 ","pages":"Article 100491"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}