Tropical Journal of Natural Product Research最新文献

Formulation and Evaluation of Vitamin C Peel-off Masks Using Different Skin Penetration Enhancers 使用不同皮肤渗透增强剂的维生素C剥脱面膜的配方和评价

Tropical Journal of Natural Product Research Pub Date : 2025-08-31 DOI: 10.26538/tjnpr/v9i8.33

Agnes Anania Triavika Sahamastuti, Shania Foustine, Gisella Edny Tjugianto, J Rebecca, Shakila Angjaya Adiyanto, Giovanni Batista Christian Daeli, Anton Sumarpo

{"title":"Formulation and Evaluation of Vitamin C Peel-off Masks Using Different Skin Penetration Enhancers","authors":"Agnes Anania Triavika Sahamastuti, Shania Foustine, Gisella Edny Tjugianto, J Rebecca, Shakila Angjaya Adiyanto, Giovanni Batista Christian Daeli, Anton Sumarpo","doi":"10.26538/tjnpr/v9i8.33","DOIUrl":"https://doi.org/10.26538/tjnpr/v9i8.33","url":null,"abstract":"Vitamin C is widely used as antioxidant in various cosmetic products; however, its effectiveness is limited by poor skin permeability. Aloe vera, vitamin E, Tween-20, and Tween-80 have been reported as skin penetration enhancers (SPEs). Nevertheless, their effectiveness as vitamin C enhancers has not been extensively studied. This study aimed to compare the effectiveness of the aforementioned SPEs in enhancing the permeation of vitamin C in peel-off mask formulations using Franz diffusion method. Several peel-off mask formulations containing vitamin C and different SPEs at concentrations of 0.5% and 2% were prepared and evaluated for their characteristics, stability, and vitamin C permeation using porcine ear skin. All formulations exhibited a pH range of 4.19 - 4.33, a viscosity range of 18802 - 113094 cps, and a drying time of approximately 18 minutes. After 45 days of storage at 4 ◦C, room temperature and 44 ◦C, vitamin C concentrations and viscosity values generally decreased, while pH remained relatively stable. All formulations demonstrated higher permeation compared to the control group, with the greatest permeation-enhancing effect observed in the 2% vitamin E formulation (Jss = 21.06 ± 2.17 µg/cm2/min; Kp = 5 ± 0.51 x 10-4 cm/min; ER = 1.749). This in vitro study concludes that 2% vitamin E was the most effective SPE for enhancing vitamin C permeation in peel-off mask formulations.","PeriodicalId":36743,"journal":{"name":"Tropical Journal of Natural Product Research","volume":"9 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.tjnpr.org/index.php/home/article/download/7185/6358","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147893161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

K2CO3-MeOH-Catalyzed Synthesis and Computational Studies of 3-Chloro-2- Hydroxypropyl Stearate: Toxicity and Microspecies Distribution k2co3 - meoh催化合成3-氯-2-羟丙基硬脂酸酯及其计算研究：毒性和微物种分布

Tropical Journal of Natural Product Research Pub Date : 2025-07-01 DOI: 10.26538/tjnpr/v9i6.62

Offiong, Ohaekenyem, Ntukidem, Magu, Alani, Ari Ari, Ibuotenang, Dabo

{"title":"K2CO3-MeOH-Catalyzed Synthesis and Computational Studies of 3-Chloro-2- Hydroxypropyl Stearate: Toxicity and Microspecies Distribution","authors":"Offiong, Ohaekenyem, Ntukidem, Magu, Alani, Ari Ari, Ibuotenang, Dabo","doi":"10.26538/tjnpr/v9i6.62","DOIUrl":"https://doi.org/10.26538/tjnpr/v9i6.62","url":null,"abstract":"Catalysts have found application in the production of a wide variety of useful chemicals. The ring opening of epichlorohydrin by fatty acids using various catalysts are among the major routes for the derivation of multifunctional organic chemicals. Existing methods are marred by complexities. In this present study, we demonstrated the use of potassium carbonate suspension in methanol as a cheaper alternative for catalyzing this important reaction using stearic acid and epichlorohydrin as precursors. The synthesized product was characterized using FTIR, NMR, and computational methods, confirming the presence of key functional groups, including a C=O ester stretch, a pronounced C–Cl stretch and a strong C–O stretch. NMR results also supported these findings, with ¹³C NMR signals at δ 171.55 (C=O), 63.73 (CCH₂O), and 48.29 (CH₂Cl). The molecular weight (MW) of 376.27, total polar surface area (TPSA) of 46.53, Log P of 7.33, and Log S of - 8.52 suggest amphiphilic properties, indicating potential surfactant applications. Computational studies revealed a flexible molecular structure (nRot = 20) and a single stereocenter (nStereo = 1), further supporting its suitability for surfactant-related applications. Additionally, toxicity predictions suggested a low environmental risk profile, making the compound a promising candidate for industrial applications. These findings highlight the potential of K₂CO₃/MeOH as an efficient catalyst for epoxide ring-opening reactions while providing insights into the physicochemical behavior of the synthesized compound.","PeriodicalId":36743,"journal":{"name":"Tropical Journal of Natural Product Research","volume":"6 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.tjnpr.org/index.php/home/article/download/6657/5951","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147920795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Secondary Metabolites from The Active Antioxidant Fraction of The Stem Bark of Syzygium zeylanicum. L. DC. 泽兰茎皮活性抗氧化部位的次生代谢物研究。l。

Tropical Journal of Natural Product Research Pub Date : 2025-03-28 DOI: 10.26538/tjnpr/v9i3.23

Muhammad Evan, Elfita, Ferlinahayati, Eliza, Heni Yohandini

{"title":"Secondary Metabolites from The Active Antioxidant Fraction of The Stem Bark of Syzygium zeylanicum. L. DC.","authors":"Muhammad Evan, Elfita, Ferlinahayati, Eliza, Heni Yohandini","doi":"10.26538/tjnpr/v9i3.23","DOIUrl":"https://doi.org/10.26538/tjnpr/v9i3.23","url":null,"abstract":"Syzygium zeylanicum (L.) DC, known by the local community in South Sumatra, Indonesia, as jambu nasi-nasi. This plant has been used to treat various diseases including hypertension, diabetes, joint pain, headaches, and fever. The use of plants as medicine is closely related to their secondary metabolite content. This research is an experimental study aimed at determining the antioxidant activity of fractions from the stem bark of S.zeylanicum and isolating and determining the chemical structure of its active compounds. The fractionation of the dry powder of S. zeylanicum stem bark was carried out using a gradient extraction method with solvents n-hexane, ethyl acetate, and methanol. Each fraction was tested for antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. The active antioxidant fractions were further isolated into pure compounds using chromatography techniques, and their chemical structures were identified through spectroscopy, including 1D and 2D Nuclear Magnetic Resonance (NMR). The antioxidant activity test results (IC50) for each fraction, namely n-hexane, ethyl acetate, and methanol, were 338.1: 114.1: and 88.71 µg/mL. The results of the separation of the ethyl acetate and methanol fractions using a chromatography column showed that the SE7 subfraction from the ethyl acetate fraction had the highest IC50, which is 83.25 µg/mL. The SE7 fraction was further separated by column chromatography until compound 1 was obtained as a white solid with an IC50 value of 62.22 µg/mL. Based on spectroscopic analysis including 1H-NMR, 13C-NMR, HSQC, HMBC and UV, compound 1 is proposed as 1-(4-isopropoxyphenyl)propane-1,2,3-triol","PeriodicalId":36743,"journal":{"name":"Tropical Journal of Natural Product Research","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.tjnpr.org/index.php/home/article/download/6037/5499","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147909614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Use of Lactic Acid in Food Fermentation: Overview, Current Trends and Future Perspectives 乳酸在食品发酵中的功能利用：综述、现状及展望

Tropical Journal of Natural Product Research Pub Date : 2024-12-02 DOI: 10.26538/tjnpr/v8i11.2

Olubukola Oziegbe, Joy I. Azeta, Yemisi D. Obafemi

{"title":"Functional Use of Lactic Acid in Food Fermentation: Overview, Current Trends and Future Perspectives","authors":"Olubukola Oziegbe, Joy I. Azeta, Yemisi D. Obafemi","doi":"10.26538/tjnpr/v8i11.2","DOIUrl":"https://doi.org/10.26538/tjnpr/v8i11.2","url":null,"abstract":"The functional use of lactic acid in food fermentation has gained considerable attention in recent years due to its role in enhancing the safety, shelf life, and nutritional properties of various food products. Fermented foods are the first processed staple human diet that has been produced and consumed since the development of human civilizations. The production and consumption of a significant portion of fermented foods involve controlled microbial growth and enzymatic conversions of both major and minor food components. These processes elevate the value of fermented foods due to the enhancement of their organoleptic properties. This review begins with an introduction that underscores the historical significance and enduring relevance of lactic acid fermentation in the food industry. It then delves into the various types of lactic acid, namely L-(+)-lactic acid and D-(-)-lactic acid, elucidating their distinct chemical properties and roles in different fermentation processes. Current trends in the use of lactic acid in food fermentation are addressed, reflecting the growing consumer demand for natural, health-oriented, and plant-based fermented products. This review provides a comprehensive overview of the functional aspects of lactic acid in food fermentation. It further exhibited the resultant effects of ethnic and cultural diversity in the use of lactic acid for food processing in Africa, explores current trends in its application, and outlines future perspectives emphasizing advancements in biotechnology, exploration of novel substrates, and the potential for more sustainable fermentation processes.","PeriodicalId":36743,"journal":{"name":"Tropical Journal of Natural Product Research","volume":"8 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.tjnpr.org/index.php/home/article/download/5230/4998","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147890462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Gastroprotective Effect of the Methanol Fraction of the Stem Bark Extract of Entada africana Guill. & Perr. in Wistar Rats 非洲海参茎皮提取物甲醇组分的胃保护作用。和穗青葱。Wistar大鼠

Tropical Journal of Natural Product Research Pub Date : 2024-10-02 DOI: 10.26538/tjnpr/v8i9.43

Millicent L. Umaru, Gabriel N. Uyaiabasi, Rabiu G. Tijjani, Celestina O. Alebiosu, Ekaete I. Oviawe, Aliyu Salihu, Abdullahi Sulaiman, Amina Y. Jega

{"title":"Gastroprotective Effect of the Methanol Fraction of the Stem Bark Extract of Entada africana Guill. & Perr. in Wistar Rats","authors":"Millicent L. Umaru, Gabriel N. Uyaiabasi, Rabiu G. Tijjani, Celestina O. Alebiosu, Ekaete I. Oviawe, Aliyu Salihu, Abdullahi Sulaiman, Amina Y. Jega","doi":"10.26538/tjnpr/v8i9.43","DOIUrl":"https://doi.org/10.26538/tjnpr/v8i9.43","url":null,"abstract":"Peptic ulcer disease (PUD), is a debilitating condition characterized by the formation of sores in the stomach or duodenum, usually presenting with gastrointestinal pain and bleeding. Entada africana is used locally as herbal decoction to treat fever, dysentery and stomach ache. This study aimed to evaluate the anti-ulcer properties of the methanol stembark extract of Entada africana (MEA). The anti-ulcer activity of MEA was evaluated at graded doses (100, 200 and 400 mg/kg), using ethanol-induced, indomethacin-induced and pylorus-ligated (PL) ulcer models on Wistar rats. The ulcer index was calculated and histological assessments were carried out on isolated rat stomachs. MEA was shown to be safe orally. The ethanol model showed dose-dependent and statistically significant (p<0.0001) gastroprotective effects at all doses, with the highest dose of MEA (400 mg/kg) having the highest percentage inhibition of 98.1%, while omeprazole was 80.5%. Similarly, in the indomethacin model, MEA exerted a significant gastroprotective effect at the highest dose with a percentage inhibition of 74.9% while the standard drug was 85.9%. Increases in acidity and volume of acid output were observed with the PL model in all groups when compared to the control, however not statistically significant. Histological evaluation revealed regenerating mucosa at 100 and 200 mg/kg in the ethanol-induced model while the indomethacin-induced model showed almost complete re-epithelisation at the optimum dose of 200 mg/kg. Findings from this study show that MEA has good anti-ulcer and wound healing properties and this effect may be attributed to the mucosa protection rather than the anti-secretory properties.","PeriodicalId":36743,"journal":{"name":"Tropical Journal of Natural Product Research","volume":"8 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://tjnpr.org/index.php/home/article/download/4854/4823","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147908501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug-Piperaceae Herb Interaction Potency Through Analgesic, Anxiolytic, and AntiInflammatory Activity Studies 通过镇痛、抗焦虑和抗炎活性研究了解药物与蒌科草本植物的相互作用潜力

Tropical Journal of Natural Product Research Pub Date : 2024-05-01 DOI: 10.26538/tjnpr/v8i4.6

引用次数: 0

Alpha-Amylase Inhibitory and Antioxidant Activity of Red Galls Induced by Forda riccobonii in Pistacia atlantica Desf. Leaves: In vitro and In silico Studies 楷属（Pistacia atlantica Desf.叶：体外和硅学研究

Tropical Journal of Natural Product Research Pub Date : 2024-05-01 DOI: 10.26538/tjnpr/v8i4.8

引用次数: 0

Ethanol Extract of Caryota urens Lour Fruits Alleviates Oxidative Stress in a Murine Model of Rheumatoid Arthritis Induced by Freund's Complete Adjuvant 金合欢果实乙醇提取物可缓解弗罗因德完全佐剂诱导的类风湿性关节炎小鼠模型的氧化应激反应

Tropical Journal of Natural Product Research Pub Date : 2024-05-01 DOI: 10.26538/tjnpr/v8i4.28

引用次数: 0

In vitro Anti-diabetic and Anti-oxidative Evaluation of Hydro-methanol Bark Extract of Bauhinia acuminata (L.) 洋紫荆树皮水甲醇提取物的体外抗糖尿病和抗氧化评估

Tropical Journal of Natural Product Research Pub Date : 2024-05-01 DOI: 10.26538/tjnpr/v8i4.26

引用次数: 0

Nutritional Qualities of Different Commercial Raspberries Consumed in Morocco 摩洛哥食用的不同商用树莓的营养成分

Tropical Journal of Natural Product Research Pub Date : 2024-05-01 DOI: 10.26538/tjnpr/v8i4.17

引用次数: 0