International Journal of Pediatrics and Adolescent Medicine最新文献

{"title":"The ethics of “net-risk” pediatric research:Views of IRB members and the US public","authors":"David Wendler, Will Schupmann, Xiaobai Li","doi":"10.1016/j.ijpam.2023.02.001","DOIUrl":"https://doi.org/10.1016/j.ijpam.2023.02.001","url":null,"abstract":"","PeriodicalId":36646,"journal":{"name":"International Journal of Pediatrics and Adolescent Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47027458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral venous thrombosis in adolescence: Looking beyond the obvious","authors":"Sara Madureira Gomes ,&nbsp;Rita Figueiredo ,&nbsp;Ricardo Morais ,&nbsp;Sérgia Soares ,&nbsp;Jacinta Fonseca ,&nbsp;Cláudia Melo ,&nbsp;Mafalda Sampaio ,&nbsp;Raquel Sousa","doi":"10.1016/j.ijpam.2022.09.001","DOIUrl":"10.1016/j.ijpam.2022.09.001","url":null,"abstract":"<div><p>Behçet's disease (BD) is a rare systemic vasculitis with multisystemic involvement. Neurological involvement, called neuro-Behçet's disease (NBD), mostly involves the central nervous system and cerebral venous thrombosis (CVT) is the predominant neurological manifestation in the pediatric age.</p><p>A 12-year-old female with a past medical history of a CVT, without an identifiable etiology, was admitted with a five-day right fronto-orbital headache. Neuroimage showed a subacute thrombosis of a right superficial sylvian vein, with indirect signs of intracranial hypertension and no imaging signs of vasculitis. Prothrombotic screening and immunologic study were normal. She was started on acetazolamide and hypocoagulation with progressively improving. She had a history of frequent oral aphthae and an episode of a genital ulcer three months before admission. Pathergy test was negative. HLA-B51 was positive. She was diagnosed with NBD and started therapy with colchicine and infliximab. After discharge, the patient remains without symptoms, hypocoagulated, and on infliximab regimen, without complications to report.</p><p>This case, only diagnosed in the second episode of CVT, is paradigmatic of the difficulty in establishing the diagnosis of BD.</p></div>","PeriodicalId":36646,"journal":{"name":"International Journal of Pediatrics and Adolescent Medicine","volume":"9 4","pages":"Pages 186-189"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/86/ba/main.PMC10019955.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9146912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characterization of pediatric supratentorial tumors and prediction of pituitary insufficiency in two tertiary centers in Saudi Arabia","authors":"Amir Babiker ,&nbsp;Amani Idris ,&nbsp;Mohammed Aldawsari ,&nbsp;Moath Abu Abah ,&nbsp;Bothainah Alaqeel ,&nbsp;Asim Almotawa ,&nbsp;Emad Masuadi ,&nbsp;Adnan AlShaikh ,&nbsp;Moutasem Azzubi ,&nbsp;Mohammed Al Dubayee ,&nbsp;Ibrahim Al Alwan ,&nbsp;Mohamad Maghnie","doi":"10.1016/j.ijpam.2022.11.001","DOIUrl":"10.1016/j.ijpam.2022.11.001","url":null,"abstract":"<div><h3>Background</h3><p>Post-operative pituitary insufficiency (PI) occurs in children with supra-tentorial tumors (STT) because of surgery or the mass effect of the tumor. We assessed the prevalence and clinical characteristics of STTs and predicted postoperative PI in our patients.</p></div><div><h3>Methods</h3><p>This retrospective cohort study included children who underwent surgery for STT in two tertiary hospitals in Saudi Arabia (2009–2019). We focused on clinical, radiological, and histopathological features of STTs. We also used a linear regression model to predict post-operative PI.</p></div><div><h3>Results</h3><p>The study included 55 children (1–18 years, mean: 9.5 ± 4.9 years, 32 [54%] females) with an initial presentation of STT that required surgery excluding recurrent episodes. The calculated period prevalence of STT was 18.2%, and the prevalence of postoperative PI was 58.2% (n = 32/55). The most common symptoms were headache and visual disturbances, and 20% patients had preoperative symptoms of PI. Baseline preoperative investigations for PI were performed in 60% of patients, and dynamic tests were conducted in only seven patients. A residual cortisol deficiency was presumed in 24 (43.7%) patients and 18 (32.7%) patients who developed central diabetes insipidus (DI) post-operatively. Overall, the brain imaging correlated well with the histopathological diagnosis (kappa = 0.48; <em>P</em> &lt; .001). Craniopharyngioma (n = 15/55, 27.3%) was the commonest STT. Predictive factors for a postoperative residual PI included age (10.9 ± 4.8 years; p-value = .027), female gender (p-value = .016 [OR = 8.31; 95% CI (1.48–46.71)], presentation with headache (<em>P</em> value = .039 [OR = 9.27; 95% CI (1.12–76.72)]), and visual disturbances (p-value = .044 [OR = 5.07; 95% CI (1.04–24.61)].</p></div><div><h3>Conclusion</h3><p>STTs commonly occurred in our study population, and females were more prone to develop a residual PI. On-time surveillance of an intact endocrine system during the perioperative period is essential for the prediction and early management of PI.</p></div>","PeriodicalId":36646,"journal":{"name":"International Journal of Pediatrics and Adolescent Medicine","volume":"9 4","pages":"Pages 196-202"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/31/main.PMC10019957.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9152940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of new indicators of pediatric malnutrition and comparison to previous indicators","authors":"Mai Adnan Ezzat ,&nbsp;Ebtsam Mohmmed Albassam ,&nbsp;Eman Abdullah Aldajani ,&nbsp;Raneem Abdulaziz Alaskar ,&nbsp;Edward Bentz Devol","doi":"10.1016/j.ijpam.2022.12.003","DOIUrl":"10.1016/j.ijpam.2022.12.003","url":null,"abstract":"<div><h3>Background</h3><p>Early identification of childhood malnutrition is imperative to improve overall health outcomes, and more importantly, to start early intervention to decrease the risk of future complications. This study aimed to evaluate new malnutrition Z-score growth indicators for detecting pediatric malnutrition and degrees of severity and compare their accuracy with that of growth chart centiles.</p></div><div><h3>Patients and Methods</h3><p>This retrospective study included 475 pediatric patients from several pediatric nutrition clinics for six months. The participant's weight, height, age, and growth parameters were recorded using both traditional growth charts (centiles) and updated malnutrition indicators (z-scores). The percentage and degree of malnutrition using centiles and Z-scores were compared.</p></div><div><h3>Results</h3><p>In children aged &lt;2 years, the percentage of malnutrition was 4.7% higher when measured using new malnutrition indicators (weight-for-length Z-score) compared with (weight-for-length centiles). Our results also showed 9.6% higher number of malnourished children &gt;2 years of age when BMI-for-age Z-score was used compared to weight-for-height centiles while there were 15.8% higher malnourished children when BMI-for-age Z-score was compared to BMI-for-age centiles for the same group. We found a significant difference (X² = 202.548, <em>P</em>=&lt;.0001) between the degree of malnutrition in children aged &gt;2 years using BMI-for-age Z-score (normal vs. malnourished) and the degree of malnutrition using BMI centiles (normal vs. malnourished). Approximately 34% of the children classified as normal using centiles were classified as malnourished using Z-scores. Comparing the degrees of Malnutrition, approximately 23% (45 of 196) of children classified as normal based on centiles were classified as having mild malnutrition when Z-scores were used, and 42% (80 of 192) of children who were classified as having mild malnutrition based on centiles were classified as having moderate malnutrition when Z-scores were used.</p></div><div><h3>Conclusions</h3><p>In our study, a higher percentage of children showed malnutrition when assessed using the Z-score (BMI-for-age for children &gt;2 years/weight-for-length for children &lt;2 years of age) than the centiles growth chart.</p></div>","PeriodicalId":36646,"journal":{"name":"International Journal of Pediatrics and Adolescent Medicine","volume":"9 4","pages":"Pages 216-224"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/04/86/main.PMC10019954.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9200081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the epidemiology and impact of the COVID-19 pandemic on domestic violence and child abuse in Saudi Arabia: A cross-sectional study","authors":"Fadiah Alkhattabi ,&nbsp;Nawaf Al Faryan ,&nbsp;Manar Alsaleh ,&nbsp;Maureen Long ,&nbsp;Abdullah Alkhani ,&nbsp;Salma Alwahibah ,&nbsp;Margarita Frederico ,&nbsp;Raghad Alhuthil","doi":"10.1016/j.ijpam.2022.12.002","DOIUrl":"10.1016/j.ijpam.2022.12.002","url":null,"abstract":"<div><h3>Objectives</h3><p>The purpose of this paper is to highlight the impact of a pandemic on the lives of vulnerable members of the community who have experienced or are ‘at risk’ of experiencing intimate family violence and child abuse in Saudi Arabia. By reviewing the experience in Saudi Arabia in the context of the international literature, the study explores similarities and differences in the impact of the pandemic on family violence.</p></div><div><h3>Methods</h3><p>The study investigated the impact of the COVID-19 pandemic on family violence and child abuse in Saudi Arabia by conducting a comparative analysis of the prevalence of cases, types of abuse, and geographical location of those experiencing violence between the years 2019 and 2020. Data were obtained from the Family Violence Reporting Center 1919 in Saudi Arabia.</p></div><div><h3>Results</h3><p>The study found that the risk of family violence and child abuse increased during the COVID-19 pandemic in Saudi Arabia, similar to findings in other countries. Conversely, there was a decrease in the number of reports due to factors associated with COVID-19.</p></div><div><h3>Conclusions</h3><p>The study highlighted the importance of ensuring that existing policies and services are sufficient to ensure the risks arising from the impact of COVID-19 responses and minimize the negative consequences.</p></div>","PeriodicalId":36646,"journal":{"name":"International Journal of Pediatrics and Adolescent Medicine","volume":"9 4","pages":"Pages 209-215"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/40/e8/main.PMC9828939.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9404171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epiploic appendagitis: Not so unusual cause of paediatric abdominal pain","authors":"Deepika Rustogi ,&nbsp;Chetan Khare ,&nbsp;Karunesh Kumar","doi":"10.1016/j.ijpam.2023.01.001","DOIUrl":"10.1016/j.ijpam.2023.01.001","url":null,"abstract":"<div><p>Paediatric abdominal pain continues to pose a diagnostic challenge in the acute hospital care setting. We describe an eleven-year-old boy who presented to the emergency department with acute-onset, sharp abdominal pain localised to right lower quadrant. Abdominal imaging was diagnostic for epiploic appendagitis (EA), with pathognomonic ‘ring sign’ and ‘central dot’ visualised on the axial computed tomography images. He responded well to conservative treatment, including a short course of non-steroidal anti-inflammatory drugs. EA is a lesser-known paediatric entity mimicking surgical conditions. However, steady but sharp and non-migratory characteristic of the pain in either of the lower abdominal quadrants should raise suspicion for EA. Early accurate diagnosis can prevent unnecessary surgical exploration in these patients.</p></div>","PeriodicalId":36646,"journal":{"name":"International Journal of Pediatrics and Adolescent Medicine","volume":"9 4","pages":"Pages 225-226"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/21/32/main.PMC10019949.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9146908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"8-year-long journey of the International Journal of Pediatrics and Adolescent Medicine","authors":"Sami Alhajjar,&nbsp;Kimberly Cristobal,&nbsp;Janelle Vales-Yasay","doi":"10.1016/j.ijpam.2023.01.002","DOIUrl":"10.1016/j.ijpam.2023.01.002","url":null,"abstract":"","PeriodicalId":36646,"journal":{"name":"International Journal of Pediatrics and Adolescent Medicine","volume":"9 4","pages":"Page 185"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4e/66/main.PMC10019953.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9193736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of blood and marrow transplantation in children less than 2-years of age: 23 years of experience at a single center","authors":"Saadiya Khan,&nbsp;Khawar Siddiqui,&nbsp;Hasan ElSolh,&nbsp;Abdullah AlJefri,&nbsp;Ali AlAhmari,&nbsp;Ibrahim Ghemlas,&nbsp;Hawazen AlSaedi,&nbsp;Awatif AlEnazi,&nbsp;Amal AlSeraihi,&nbsp;Mouhab Ayas","doi":"10.1016/j.ijpam.2022.09.002","DOIUrl":"10.1016/j.ijpam.2022.09.002","url":null,"abstract":"<div><h3>Objectives</h3><p>Allogeneic hematopoietic cell transplantation (Allo-HCT) is a curative option for children with various malignant and non-malignant diseases. Most reports studied all age groups amongst children. Herein we analyzed our data in children transplanted at or less than 2-years of age.</p></div><div><h3>Patients and methods</h3><p>We reviewed medical charts of 618 patients who underwent 666 transplantation at our center between 1993 and 2015. There were 340 boys and 278 girls. Median age was 0.7 years (range 0.04–2). Stem cell source was bone marrow (BM) in 492 (73.9%), unrelated umbilical cord blood (UCB) in 161 (24.2%) followed by peripheral blood stem cell (PBSC) in 13 (2%) patients. Matched siblings were the most common donors (n = 356, 53.5%), followed by unrelated (n = 161, 24.2%) with haploidentical family member donors in 29 (4.4%) transplants. Disease groups were categorized as benign hematology (Thalassemia, Fanconi, Aplastic anemia etc.), benign neoplasm (Langerhans cell histiocytosis, Hemophagocytic Lymphohistiocytosis etc.), non-neoplasms (metabolic disorders, immunodeficiency disorders etc.) and Leukemia/lymphomas (myeloid and lymphoid malignancies etc.)</p></div><div><h3>Results</h3><p>Cumulative incidence of acute GvHD (I-IV) was 31.5% (n = 210) and grade III-IV GvHD was 8.7% (n = 58). At median follow-up of 115.1 months, the cumulative probability of overall survival (OS) at 5 years was 70.0% ± 1.9%. Our mortality rate was 31.2% (n = 193). The five-year OS was significantly better in patients transplanted for benign hematological disorders (<em>P</em> = <em>.001</em>). Patients transplanted using BM/PBSC as source of stem cells fared significantly better compared to those in which CB was used (<em>P&lt;.001</em>). Post-transplant graft failure remains the leading cause requiring further transplants in this age group. In conclusion, the cumulative probability of OS at 5 years was about 70.0% for all with an OS of 61% in our haploidentical recipients.</p></div><div><h3>Conclusion</h3><p>Analyzing our institutional data over time has enabled us to develop tentative strategies to minimize transplant related toxicities in very young children who are candidates for allo-HCT.</p></div>","PeriodicalId":36646,"journal":{"name":"International Journal of Pediatrics and Adolescent Medicine","volume":"9 4","pages":"Pages 190-195"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/93/63/main.PMC10019952.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9152943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Admission temperature and neonatal outcomes - single-centre experience in Saudi Arabia","authors":"Ammar Fneish ,&nbsp;Mohammad Alhasoon ,&nbsp;Amenah Al Essa ,&nbsp;Radha Mahlangu ,&nbsp;Noura Alshami ,&nbsp;Saif Alsaif ,&nbsp;Kamal Ali","doi":"10.1016/j.ijpam.2022.12.001","DOIUrl":"10.1016/j.ijpam.2022.12.001","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to investigate the association between admission hypothermia (AH), neonatal mortality and major neonatal morbidities in preterm infants &lt;33 weeks’ gestation. An additional aim of the study was to examine changes in the prevalence of admission hypothermia after the initiation of a thermoregulation quality improvement (QI) project.</p></div><div><h3>Method</h3><p>This is a retrospective cohort study of preterm infants &lt; 33 weeks’ gestation born at King AbdulAziz Medical City Riyadh (KAMC-R) between January 2017 to December 2020.</p></div><div><h3>Results</h3><p>Eight-hundred infants were born during the study period. Four hundred and one infants (50.1%) had an admission temperature of &lt;36.5 °C and a further 399 (49.9%) had an admission temperature of &gt;36.5 °C. The mortality before discharge was 15.7% in infants with AH compared to 4.8% among those with an admission temperature above 36.5 °C. This remained statistically significant after adjustments for gestational age and maternal PET status on a multivariate analysis (<em>P</em> = .001, OR 2.7,95%CI 1.5–4.7). The need for mechanical ventilation (<em>P</em> = .005) and incidence of surgical NEC (<em>P</em> = .030) were significantly different between the two temperature groups. Mean (SD) admission temperature increased from 36.3 °C to 36.6 °C following the thermoregulation intervention program (<em>P</em> &lt;.001). Admission temperature &lt;36 °C is associated with higher mortality in the first week (<em>P</em> = .001, OR 3.3,95% CI (1.7–6.6)) and increased incidence of cystic PVL (<em>P</em> = .04, OR 2.1, CI (1.03–4.3)).</p></div><div><h3>Conclusion</h3><p>Preterm infants with AH suffered higher mortality and greater neonatal morbidities.</p></div>","PeriodicalId":36646,"journal":{"name":"International Journal of Pediatrics and Adolescent Medicine","volume":"9 4","pages":"Pages 203-208"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/03/main.PMC10019951.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9200084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological characteristics, clinical course, and laboratory investigation of pediatric COVID-19 patients in a tertiary care center in Saudi Arabia","authors":"Bayan Duabie ,&nbsp;Areej Alfattani ,&nbsp;Sahar Althawadi ,&nbsp;Abdullah Taha ,&nbsp;Haroon Ahmed Javaid ,&nbsp;Omar Mobarak ,&nbsp;Esam Albanyan","doi":"10.1016/j.ijpam.2022.05.001","DOIUrl":"10.1016/j.ijpam.2022.05.001","url":null,"abstract":"<div><h3>Background</h3><p>Since the initial emergence of the novel SARS-CoV-2 coronavirus responsible for the 2019 coronavirus disease (COVID-19) pandemic, many studies have been exploring the nature and characteristics of this virus and its associated clinical manifestations. The present study aimed to describe the clinical presentation and outcomes of COVID-19 infections in pediatric patients.</p></div><div><h3>Methods</h3><p>A retrospective review of findings associated with 143 pediatric patients (age &lt;14 years) with a confirmed COVID-19 diagnosis who had undergone inpatient or outpatient treatment at King Faisal Specialist Hospital and Research Center in Riyadh, Saudi Arabia, between March 2020 and October 2020, was conducted. The analyzed data included patient demographic information, pre-existing medical conditions, symptoms, interventions, and outcomes.</p></div><div><h3>Results</h3><p>The median age of this patient population was 7 years. Of these 143 patients, 67 (46.8%) had known pre-existing medical conditions including bronchial asthma (12.8%), chronic lung disease (CLD) (3%), congenital heart disease (CHD) (17%), primary immunodeficiencies (1.5%), malignancies (9.8%), and 7.5% were post-transplant patients. Thirty-seven patients (26%) were overweight or obese. Sixty-three of these patients (51%) were symptomatic, with the most common symptom being fever (55%). Ultimately, 45 patients (31%) required admission to the hospital, with a median duration of hospitalization of 9.6 days for admitted patients. There were no documented cases of infection-related mortality among this pediatric cohort, although 11 patients experienced post-infectious complications that primarily manifested as a loss of taste and smell.</p></div><div><h3>Conclusion</h3><p>These findings suggest that pediatric COVID-19 patients tend to experience mild forms of the disease, without any significant differences in disease severity as a function of patient gender or immune status.</p></div>","PeriodicalId":36646,"journal":{"name":"International Journal of Pediatrics and Adolescent Medicine","volume":"9 3","pages":"Pages 153-159"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352646722000308/pdfft?md5=20514dc19b5a9b1d50a432ef6c84f52d&pid=1-s2.0-S2352646722000308-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89959387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}