Iranian Journal of Breast Diseases最新文献

{"title":"The Relationship Between Social Support and Hope in Women with Breast Cancer Undergoing Chemotherapy in Hospitals of Ahvaz Jundishapur University of Medical Sciences","authors":"Bayan Saberipour, Mahin Gheibizadeh, S. Ghanbari, A. Hemmatipour","doi":"10.30699/acadpub.ijbd.12.2.56","DOIUrl":"https://doi.org/10.30699/acadpub.ijbd.12.2.56","url":null,"abstract":"Introduction: Breast cancer greatly affects the life expectancy of patients. Since social support can greatly improve complications in chronic diseases, this study was conducted to determine the relationship between social support and hope in patients with breast cancer. Methods: In this cross-sectional study, 100 women with breast cancer undergoing chemotherapy in hospitals of Ahvaz Jundishapur University of Medical Sciences were studied. Samples were selected using convenience sampling and according to inclusion criteria. After collecting data using Snyder’s Adult Trait Hope Scale and Sherburne and Stewart’s Social Support Scale, data analysis was done using the SPSS software. Results: According to the findings, 80% of the studied women reported high levels of social support and 53% had moderate levels of life hope. The findings also showed that the participants received the most support in the emotional dimension (30.83 ± 31.40), the least support in the social interaction dimension (11.79 ± 3.60). Findings showed a direct and significant relationship between hope and social support (r = 0.278, P = 0.004). Conclusion: Strengthening and promoting social support in women with breast cancer can be a good way to create hope for life and thus better tolerance of and compromise with problems associated with the disease and its treatments.","PeriodicalId":36641,"journal":{"name":"Iranian Journal of Breast Diseases","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78519061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Psychometric Evaluation of a Protection Motivation Theory–Based Scale Assessing the Adherence of Iranian Women Breast Cancer Prevention Behaviors","authors":"مهسا خدایاریان, فاطمه پیغمبری, سید سعید مظلومی محمودآباد, محمدعلی مروتی شریف آباد, مینور لمیعیان میاندوآب","doi":"10.30699/ACADPUB.IJBD.12.01.8","DOIUrl":"https://doi.org/10.30699/ACADPUB.IJBD.12.01.8","url":null,"abstract":"Introduction: Breast cancer is the most common type of cancer that has concerned Iranian women. Early detection is a major determinant of disease prognosis. Thus, participation in prevention behaviors is the only available option for women. The aim of this study was to develop and validate a protection motivation theory (PMT)-based scale for assessing the participation of Iranian women in breast cancer prevention behaviors. Methods: A sequential exploratory mixed methods design was used. In the qualitative phase, 14 semistructured interviews were done with women. After directed qualitative content analysis, primary items were phrased. Validity of the questionnaire was assessed by a panel of experts, calculation of CVR and CVI, and using confirmatory factor analysis. Reliability of the scale was measured using Cronbach’s alpha. Then, a cross-sectional study was performed on 420 women. The data were analyzed using SPSS 19 and AMOS 16 software packages. Results: All of the items gained impact scores >1.5 in qualitative and quantitative face validity assessment. In the dimension of content validity, 9 items were deleted. Reliability of the questionnaire was acceptable. The final draft of the questionnaire was prepared in two sections including demographics and PMT constructs comprising 56 items and 8 domains. Factor analysis confirmed the fitness of the model representing the measurement theory. Conclusion: The present study is a pioneer in assessing the applicability of PMT for assessing the participation of Iranian women in breast cancer prevention behaviors. The developed scale has acceptable psychometric properties among Iranian women, and it can be used as a reliable instrument.","PeriodicalId":36641,"journal":{"name":"Iranian Journal of Breast Diseases","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76499685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotropic-induced Galactorrhea","authors":"Mohammadreza Shalbafan","doi":"10.30699/ACADPUB.IJBD.12.01.67","DOIUrl":"https://doi.org/10.30699/ACADPUB.IJBD.12.01.67","url":null,"abstract":"Psychiatric disorders are one of the most common health problems among different communities including Iran. According to the latest national-width survey, the prevalence of psychiatric disorders among Iranian general population is 23.44% by (1). Therefore, psychotropics, which are prescribed by psychiatrists, other specialists, and general practitioners, are among the most popular and best-selling medications. Galactorrhea is one of the noticeable side effects of some psychotropics, which can be annoying, especially, for young women. Galactorrhea is defined as the secretion of breast milk without being pregnant or breast feeding. It is a common manifestation of hormonal dysregulation which can be induced by medications or pituitary adenomas. Other causes such as hypothyroidism, pregnancy and renal failure should also be considered. Several symptoms like amenorrhea, decrease in sexual desire and infertility may be present in patients with galactorrhea. This complication may be diagnosed by surgeons, internists or gynecologists (2). As rates of prescription of medications which can cause galactorrhea continue to increase, it is important for specialists to have knowledge about this side effects. Antipsychotics, used in a broad range of disorders such as schizophrenia, bipolar disorders and depression, are a common cause of prolactin increase and galactorrhea. They decrease dopamine which inhibits prolactin through tuberoinfundibular pathway. This agents are divided into two main groups: First Generation Antipsychotics (FGAs) and Second Generation Antipsychotics (SGAs). The main effect of FGAs like haloperidol, chlorpromazine, trifluoperazine, perphenazine, thiothixene, thioridazine and fluphenazine includes the reduction of D2 level, a subtype of dopamine, and therefore it causes increasing of Prolactin which may cause decreased sexual desire, amenorrhea and infertility. It is important for physicians to take the drug history because some of these medications have long-acting injectable forms which are injected every 2-4 weeks. (3) SGAs such as risperidone, clozapine, olanzapine, quetiapine, aripiprazole act in a different way on neurotransmitters. Risperidone inhibits both D2 and 5-hydroxy-tryptamine 2A (5HT2A) receptors and is mostly likely to cause sexual side effects as well as galactorrhea among antipsychotics (3, 4). Other SGAs have lower risk of this adverse effect due to less affinity to dopamine. Interestingly aripiprazole, which is a dopamine partial agonist, can reduce prolactin and, subsequently, cause relative improvement of galactorrhea (5). Antidepressants, which are one the most popular psychiatric medications, do not have significant effects on dopamine receptors, so, they don`t cause, usually, dysregulation of prolactin or galactorrhea (6). Nevertheless, there are several case reports of galactorrhea induced by some antidepressants such as paroxetine, citalopram, venlafaxine and duloxetine. Other psychotropics like lithium, sodiu","PeriodicalId":36641,"journal":{"name":"Iranian Journal of Breast Diseases","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74035547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of Breast Cancer Subtypes using the Selection of Effective Genes from Microarray Data","authors":"Abolfazl Tabatabaei, V. Derhami, R. Sheikhpour, Mohammad-Reza Pajoohan","doi":"10.30699/ACADPUB.IJBD.12.01.39","DOIUrl":"https://doi.org/10.30699/ACADPUB.IJBD.12.01.39","url":null,"abstract":"Introduction: Early diagnosis of breast cancer and the identification of effective genes are important issues in the treatment and survival of the patients. Gene expression data obtained using DNA microarray in combination with machine learning algorithms can provide new and intelligent methods for diagnosis of breast cancer. Methods: Data on the expression of 9216 genes from 84 patients across 5 different types of cancer was obtained using microarray technology. In this study, we proposed a feature selection method based on the correlation between abnormal expression of genes and cancer for diagnosis of breast cancer. Then, we used K-nearest neighbor (KNN), support vector machine (SVM), and naive Bayesian (NB) classifiers to evaluate the performance of the proposed method in the selection of relevant genes. Results: The proposed feature selection method coupled with the KNN classifier predicted all types of cancer with 100% accuracy and using 38 of the 9216 genes. The proposed method could also identify the genes associated with each class. Moreover, the proposed feature selection method coupled with NB and SVM classifiers achieved accuracy rates of 90% and 96.67% using 17 and 22 genes, respectively. Conclusion: The results of this study demonstrated that the proposed feature selection method has better performance compared with other methods. The proposed method is able to distinguish the genes involved in each cancer class and detect overexpression or underexpression of selected genes, which can be used by physicians and researchers in the field of health care.","PeriodicalId":36641,"journal":{"name":"Iranian Journal of Breast Diseases","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88340549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Activity and Breast Cancer Prevalence: A Case- Control Study in Arak, Iran 2017-2018","authors":"A. Saremi, Rahmatalah Moradzadeh, Sajad Mohammadi Bonchenari","doi":"10.30699/ACADPUB.IJBD.12.01.29","DOIUrl":"https://doi.org/10.30699/ACADPUB.IJBD.12.01.29","url":null,"abstract":"Introduction: Both physical inactivity and breast cancer incidence have increased dramatically during the last two decades in Iranian women. The purpose of this study was to investigate the association of physical activity with breast cancer incidence in premenopausal women. Methods: In this case-control study, which was performed from March 2017 to May 2018, 150 incident cases with histological confirmation of breast cancer and 146 age-matched controls were recruited (aged 20-55 years). The patients were selected from Ayatollah Khonsari hospital in Arak, Iran. Height and weight were measured by standard methods and used for calculation of body mass index. Demographics, fertility status, and physical activity level were obtained by interview using valid questionnaires. Data were analyzed using descriptive statics and logistic regressions on SPSS 18. Results: Household activities accounted for about 78% of the total lifetime physical activities. Only about 2.5% of the total lifetime physical activities were in the form of recreational/sports. The results of logistic regressions showed that except for the common risk factors for breast cancer (older marital age, family history of breast cancer, and smoking), occupational activities, transportation activities, recreational/sport activities, and total lifetime physical activities had a protective effect against breast cancer incidence in young women. Conclusion: These findings suggest that lifestyle factors such as physical inactivity are risk factors associated with the incidence of premenopausal breast cancer in Arak.","PeriodicalId":36641,"journal":{"name":"Iranian Journal of Breast Diseases","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91091562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Interval Training on the Expression of Mesenchymal Biomarker Vimentin and Tumor Volume in Mice with Breast Cancer","authors":"S. Gholamian, R. Hosseini, A. Rashidlamir, H. Agha-alinejad","doi":"10.30699/ACADPUB.IJBD.11.01.19","DOIUrl":"https://doi.org/10.30699/ACADPUB.IJBD.11.01.19","url":null,"abstract":"Introduction Many deaths from cancer are due to metastases, a process which involves the epithelial-mesenchymal transition (EMT). On the other hand, regular exercise plays an important role in inhibiting the progression of breast cancer. Therefore, the purpose of this study was to investigate the influence of interval training on the expression of VIM, the gene encoding for EMT biomarker vimentin, and tumor volume in mice with breast","PeriodicalId":36641,"journal":{"name":"Iranian Journal of Breast Diseases","volume":"385 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89977373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge Attitude and Performance of Female Students of Medical versus Nonmedical Sciences toward Breast Self-examination","authors":"زهرا ایمانی گوغری, محمدرضا زیدآبادی نژاد, محدثه بلوردی","doi":"10.30699/ACADPUB.IJBD.12.01.48","DOIUrl":"https://doi.org/10.30699/ACADPUB.IJBD.12.01.48","url":null,"abstract":"Introduction: Breast cancer is the most common type of cancer in Women, which, if diagnosed at an early stage, can be treated. Breast selfexamination is a simple and inexpensive way to screen for breast cancer. Students, especially medical students, as the educated class of the community, are expected to be knowledgeable with good attitudes and performance in this field. The purpose of this study was to compare the knowledge, attitude and performance of female Students of medical versus nonmedical Sciences toward Breast Self-examination in the city of Sirjan. Methods: In this cross-sectional study, 228 medical students and 240 nonmedical students were enrolled. A researcher-made survey questionnaire was used for data collection. Content validity of the questionnaire was confirmed by 10 nursing and midwifery experts, and its reliability was assessed by calculating Cronbach's alpha coefficient. Data were analyzed using SPSS software. Results: The mean breast self-examination knowledge scores for medical students and nonmedical students were 34 ± 3.81 and 32.84 ± 4.40, respectively. The mean score of attitude toward breast self-examination was 68.11 ± 8.69 for medical students and 63.54 ± 8.90 for nonmedical students. Finally, the mean score of performance of breast self-examination was 23.88 ± 6.37 for medical students versus 22.89 ± 7.45 for nonmedical students. There was a significant difference in knowledge and attitude between medical and nonmedical students (P < 0.05), but the difference in performance was not significant (P > 0.05). Conclusion: Knowledge scores of medical and nonmedical students were moderate, and attitude scores of both groups were high, although medical students’ scores were significantly higher than those of nonmedical students. Nonetheless, both groups had poor performance of breast selfexamination. This indicates that efforts must be made on the part of the education system to promote awareness, attitude and performance of breast self-examination through effective and new methods.","PeriodicalId":36641,"journal":{"name":"Iranian Journal of Breast Diseases","volume":"93 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79434018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a Rational Emotive Behavior Therapy–Based Education Program on Marital Stress in Couples Coping with Breast Cancer","authors":"Bahman Pirmardvand Chegini, K. Zahrakar, B. S. Zaker","doi":"10.30699/ACADPUB.IJBD.11.04.28","DOIUrl":"https://doi.org/10.30699/ACADPUB.IJBD.11.04.28","url":null,"abstract":"Introduction: Being diagnosed with breast cancer is usually associated with stress, and the overflow of this stress in the form of marital stress affects the marital relationship of couples. The purpose of this study was to determine the effect of an education program based on rational emotive behavior therapy (REBT) on marital stress of couples coping with breast","PeriodicalId":36641,"journal":{"name":"Iranian Journal of Breast Diseases","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78492822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Effect of Aloe vera Extract and Aerobic Training on Tumor Weight and Volume and Levels of Interleukin 6 and Vascular Endothelial Growth Factor in Mice with Breast Cancer","authors":"Ghasem Masoudzade, A. Barari, S. Amini","doi":"10.30699/ACADPUB.IJBD.11.04.17","DOIUrl":"https://doi.org/10.30699/ACADPUB.IJBD.11.04.17","url":null,"abstract":"Introduction: Breast cancer is one of the most common cancers among women. Various studies have shown that taking medicinal herbs and physical activity can play an effective role in the prevention and treatment of cancer. The aim of this study was to investigate the synergistic effect of Aloe vera extract and aerobic exercise on levels of interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) in mice with breast cancer. Methods: In this experimental study, 35 female BALB/c mice were randomly assigned to 5 groups: (1) control (healthy), (2) control (cancer), (3) training (cancer), (4) extract (cancer), and (5) Exercise+ Extract (Cancer). The induction of breast cancer in mice was done by tumor implantation. Aloe vera extract was injected subperitoneally at 300 mg/kg of body weight per day. Training (swimming) duration was 10 minutes on the first day, gradually increasing to 60 minutes per day through 5-minute increments. At the end of the study, tumor weight and volume and levels of IL-6 and VEGF were measured. Results: After six weeks, the mean tumor volume and weight decreased in all cancer groups. IL-6 levels were significantly lower in the training group (p= 0.008) and the Exercise+ Extract group (p= 0.006) compared with the cancer controls. In addition, the levels of VEGF were significantly lower in the training group (p= 0.006) and the Exercise+ Extract group (p= 0.005). However, Aloe vera extract alone did not have a significant effect on the levels of IL-6 and VEGF (p= 0.224 and p= 0.012, respectively). Conclusion: It is likely that the combination of swimming exercises and consumption of Aloe vera extract can improve inflammatory status by reducing the levels of IL-6 and VEGF proinflammatory cytokines.","PeriodicalId":36641,"journal":{"name":"Iranian Journal of Breast Diseases","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81579968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Light-Intensity Physical Activity on Lifestyle and Socio-cognitive Factors Affecting Sedentary Behavior in Breast Cancer Survivors in Isfahan City","authors":"Mehdi Rafei Borujeni, Niloofar Nikoobin, V. Goharian","doi":"10.30699/ACADPUB.IJBD.11.04.53","DOIUrl":"https://doi.org/10.30699/ACADPUB.IJBD.11.04.53","url":null,"abstract":"Introduction: Lifestyle improvement is one of the main strategies to increase treatment persistence in breast cancer survivors. The purpose of the present study was to determine the effect of a light-intensity physical activity program on Socio-cognitive factors that affect sedentary behavior and lifestyle in breast cancer survivors in Isfahan city. Methods: Twenty-four female breast cancer survivors were recruited via convenience sampling and randomly assigned to experiment and control groups (12 subjects for each group). Both groups were assessed using Busschaert’s context-specific sedentary behavior questionnaire and the Miller-Smith Lifestyle Assessment Inventory before and after the intervention. The light-intensity physical activity program was conducted for one month in the experimental group based on Australia’s Physical Activity and Sedentary Behavior Guidelines for Adults. Data were analyzed using descriptive statistics including mean and standard deviation and inferential statistics including ANCOVA and MANCOVA with a significance level of 0.05. Results: There was a significant difference between the two groups in lifestyle and Sociocognitive factors affecting sedentary behavior (except for the sedentary behavior modelling)","PeriodicalId":36641,"journal":{"name":"Iranian Journal of Breast Diseases","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85465224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}