The Journal of pharmacy and pharmacology最新文献

Quanzhen Yiqi decoction attenuates inflammation in mice with smoking-induced COPD by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome. 全真益气煎剂通过激活Nrf2/HO-1通路和抑制NLRP3炎性体，减轻吸烟诱导的慢性阻塞性肺病小鼠的炎症反应。

The Journal of pharmacy and pharmacology Pub Date : 2024-04-26 DOI: 10.1093/jpp/rgae047

Jiamin Zeng, Zhenqiu Li, Wanyan Li, Zhu Liang, Yuewen Luo, Caiping Li, Sida Liao, Kexin Wang, Yuanlong Hu, Yuanyuan Li, Qiuling Liang, Wenju Lu, Lu Li, Zhijuan Wu, Da-Peng Zhang, Zhiming Zhang

{"title":"Quanzhen Yiqi decoction attenuates inflammation in mice with smoking-induced COPD by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome.","authors":"Jiamin Zeng, Zhenqiu Li, Wanyan Li, Zhu Liang, Yuewen Luo, Caiping Li, Sida Liao, Kexin Wang, Yuanlong Hu, Yuanyuan Li, Qiuling Liang, Wenju Lu, Lu Li, Zhijuan Wu, Da-Peng Zhang, Zhiming Zhang","doi":"10.1093/jpp/rgae047","DOIUrl":"https://doi.org/10.1093/jpp/rgae047","url":null,"abstract":"OBJECTIVE\u0000Quanzhen Yiqi decoction (QZYQ) is a traditional Chinese medicine for treating chronic obstructive pulmonary disease.\u0000\u0000\u0000METHODS\u0000Mice were exposed to cigarette smoke (CS) 6 days/week (40 cigarettes/day) for 24 weeks and then intragastrically administered QZYQ (4.72, 9.45, or 18.89 g/kg) or dexamethasone (DEX, 0.6 mg/kg) for 6 weeks. We examined the lung function and collected bronchoalveolar lavage fluid for inflammatory cell and cytokine quantification. The pathological lung changes, ROS and oxidative biomarkers were measured. We used immunohistochemistry and western blotting to evaluate the levels of Nrf2/HO-1, NLRP3/ASC/Caspase1/IL-1β/IL-18.\u0000\u0000\u0000RESULTS\u0000The CS group showed significant increases in the forced vital capacity, lung resistance, and chord compliance and a lower FEV50/FVC compared with the control, and QZYQ improved these changes. In addition, QZYQ effectively reduced emphysema, immune cell infiltration, and airway remodeling. QZYQ stimulated HO-1 expression and reduced oxidative stress through the Nrf2 pathway. QZYQ inhibited the production of NLRP3/ASC/Caspase-1 to inhibit IL-1β and IL-18.\u0000\u0000\u0000CONCLUSION\u0000Our study suggested that QZYQ can improve the function and histology of the lungs and reduce inflammatory cell recruitment. QZYQ inhibits ROS production and NLRP3 inflammasome activation by upregulating Nrf2 to reduce lung injury. The anti-inflammatory effects of QZYQ are similar to those of DEX.","PeriodicalId":366080,"journal":{"name":"The Journal of pharmacy and pharmacology","volume":"9 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140652281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D DLP-printed cannabinoid microneedles patch and its pharmacokinetic evaluation in rats. 三维 DLP 打印大麻素微针贴片及其在大鼠体内的药代动力学评估。

The Journal of pharmacy and pharmacology Pub Date : 2024-04-24 DOI: 10.1093/jpp/rgae043

A. Bagde, Keb Mosley-Kellum, Shawn D Spencer, Mandip Singh

{"title":"3D DLP-printed cannabinoid microneedles patch and its pharmacokinetic evaluation in rats.","authors":"A. Bagde, Keb Mosley-Kellum, Shawn D Spencer, Mandip Singh","doi":"10.1093/jpp/rgae043","DOIUrl":"https://doi.org/10.1093/jpp/rgae043","url":null,"abstract":"OBJECTIVE\u0000The objective of the present study was to enhance the bioavailability of cannabidiol (CBD) using 3D Digital Light Processing (DLP)-printed microneedle (MN) transdermal drug delivery system.\u0000\u0000\u0000METHODS\u0000CBD MN patch was fabricated and optimized using 3D DLP printing using CBD (8% w/v), Lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) (0.49% w/v), distilled water (20% w/v), and poly (ethylene glycol) dimethacrylate 550 (PEGDAMA 550) (up to 100% w/v). CBD MNs were characterized for their morphology, mechanical strength, in vitro release study, ex vivo permeation study, and in vivo pharmacokinetic (PK) profile.\u0000\u0000\u0000KEY FINDINGS\u0000Microscopic images showed that sharp CBD MNs with a height of ~800 μm, base diameter of ~250 μm, and tip with a radius of curvature (RoC) of ~15 μm were successfully printed using optimized printing parameters. Mechanical strength studies showed no significant deformation in the morphology of CBD MNs even after applying 0.5N/needle force. Ex vivo permeation study showed significant (P < .0001) permeation of CBD in the receiving media as compared to CBD patch (control). In vivo PK study showed significantly (P < .05) enhanced bioavailability in the case of CBD MN patch as compared to CBD subcutaneous inj. (control).\u0000\u0000\u0000CONCLUSION\u0000Overall, systemic absorption of CBD was significantly enhanced using 3D-printed MN drug delivery system.","PeriodicalId":366080,"journal":{"name":"The Journal of pharmacy and pharmacology","volume":"67 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140664152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shikonin in breast cancer treatment: a comprehensive review of molecular pathways and innovative strategies. Shikonin 在乳腺癌治疗中的应用：分子途径和创新策略的全面回顾。

The Journal of pharmacy and pharmacology Pub Date : 2024-04-23 DOI: 10.1093/jpp/rgae041

Saeid Iranzadeh, Davood Dalil, Soroush Kohansal, Mahdi Isakhani

{"title":"Shikonin in breast cancer treatment: a comprehensive review of molecular pathways and innovative strategies.","authors":"Saeid Iranzadeh, Davood Dalil, Soroush Kohansal, Mahdi Isakhani","doi":"10.1093/jpp/rgae041","DOIUrl":"https://doi.org/10.1093/jpp/rgae041","url":null,"abstract":"OBJECTIVES\u0000Breast cancer is a prevalent disease that has a substantial impact on women's mortality rates. Shikonin, a naphthoquinone derived from Lithospermum erythrorhizon, has demonstrated substantial anticancer effects. This study aims to conduct a comprehensive review of the latest research findings regarding the therapeutic efficacy of shikonin in the context of breast cancer treatment, with a specific emphasis on elucidating the underlying molecular mechanisms.\u0000\u0000\u0000METHODS\u0000A comprehensive literature review was conducted on shikonin and breast cancer by searching PubMed, Scopus, Web of Science, and Google Scholar databases.\u0000\u0000\u0000KEY FINDINGS\u0000Shikonin significantly reduces tumor cell viability, proliferation, migration, invasion, and metastasis in both in vivo and in vitro across all breast cancer subtypes. Additionally, when combined with other pharmaceutical agents, it exhibits synergistic effects. Shikonin stimulates immunogenic cell death, resulting in apoptosis and necroptosis. The induction of immunogenic cell death by shikonin enhances the immunogenicity of breast cancer cells, leading to its involvement in the development of dendritic cell-based tumor vaccines against breast cancer.\u0000\u0000\u0000CONCLUSION\u0000Shikonin exhibits potent anti-breast cancer properties and shows significant potential for the advancement of immunotherapeutic approaches against breast cancer, as well as enhancing the efficacy of conventional treatment strategies.","PeriodicalId":366080,"journal":{"name":"The Journal of pharmacy and pharmacology","volume":"26 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140671482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dopamine signalling in pancreatic islet cells and role in adaptations to metabolic stress. 胰岛细胞中的多巴胺信号以及在适应代谢压力中的作用。

The Journal of pharmacy and pharmacology Pub Date : 2024-04-23 DOI: 10.1093/jpp/rgae049

A. Sridhar, Peter R. Flatt, Matthew Draper, Andrei I Tarasov, R. Moffett, Nigel Irwin, D. Khan

{"title":"Dopamine signalling in pancreatic islet cells and role in adaptations to metabolic stress.","authors":"A. Sridhar, Peter R. Flatt, Matthew Draper, Andrei I Tarasov, R. Moffett, Nigel Irwin, D. Khan","doi":"10.1093/jpp/rgae049","DOIUrl":"https://doi.org/10.1093/jpp/rgae049","url":null,"abstract":"OBJECTIVES\u0000Dopamine and related receptors are evidenced in pancreatic endocrine tissue, but the impact on islet β-cell stimulus-secretion as well as (patho)physiological role are unclear.\u0000\u0000\u0000METHODS\u0000The present study has evaluated islet cell signalling pathways and biological effects of dopamine, as well as alterations of islet dopamine in rodent models of diabetes of different aetiology.\u0000\u0000\u0000KEY FINDINGS\u0000The dopamine precursor L-DOPA partially impaired glucose tolerance in mice and attenuated glucose-, exendin-4, and alanine-induced insulin secretion. The latter effect was echoed by the attenuation of glucose-induced [Ca2+]i dynamics and elevation of ATP levels in individual mouse islet cells. L-DOPA significantly decreased β-cell proliferation rates, acting predominantly via the D2 receptor, which was most abundant at the mRNA level. The administration of streptozotocin (STZ) or high-fat diet (HFD) in mice significantly elevated numbers of dopamine-positive islet cells, with HFD also increasing colocalization of dopamine with insulin. At the same time, colocalization of dopamine with glucagon was increased in STZ-treated and pregnant mice, but unaffected by HFD.\u0000\u0000\u0000CONCLUSION\u0000These findings highlight a role for dopamine receptor signalling in islet cell biology adaptations to various forms of metabolic stress.","PeriodicalId":366080,"journal":{"name":"The Journal of pharmacy and pharmacology","volume":"48 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140667047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indobufen alleviates ischemic stroke injury by regulating transcription factor NRF2 and inhibiting ATG5 expression. 吲哚布芬通过调节转录因子NRF2和抑制ATG5的表达减轻缺血性脑卒中的损伤。

The Journal of pharmacy and pharmacology Pub Date : 2024-04-11 DOI: 10.1093/jpp/rgae038

Yang Wang, Ge Bai, Shanshan Mu, Fenglian Zhang, Yan Wang

{"title":"Indobufen alleviates ischemic stroke injury by regulating transcription factor NRF2 and inhibiting ATG5 expression.","authors":"Yang Wang, Ge Bai, Shanshan Mu, Fenglian Zhang, Yan Wang","doi":"10.1093/jpp/rgae038","DOIUrl":"https://doi.org/10.1093/jpp/rgae038","url":null,"abstract":"BACKGROUND\u0000Ischemic stroke (IS) is a detrimental neurological disease and IS lacks valuable methods to recover body function. Indobufen (IND) could alleviate IS. However, the possible mechanism remains undefined.\u0000\u0000\u0000METHODS\u0000SH-SY5Y cells were cultured under the oxygen-glucose deprivation/reoxygenation (OGD/R) environment and then were treated with small interfering RNA (siRNA) of NRF2 and ATG5. The influence of various concentrations of IND (50 μM, 100 μM, 200 μM, and 400 μM) was determined by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide. Levels of superoxide dismutase (SOD) and malonaldehyde (MDA) were examined by ELISA. Reactive oxygen species (ROS) production was determined by DCFH-DA staining. The protein levels of LC3II/LC3I, Beclin1, p62, NRF2, and ATG5 were detected by western blot.\u0000\u0000\u0000RESULTS\u0000IND increased cell viability, while depressed the rate of apoptosis in SH-SY5Y cells of OGD/R environment. IND inhibited autophagy by suppressing the levels of LC3II/LC3I, Beclin1 protein, and increasing p62 protein expression in SH-SY5Y cells of OGD/R environment. IND limited the contents of ROS and MDA, while amplifying the activity of SOD in SH-SY5Y cells with OGD/R exposure. IND also promoted NRF2 expression in OGD/R environment.\u0000\u0000\u0000CONCLUSION\u0000IND could inhibit autophagy, oxidative stress, and apoptosis in SH-SY5Y cells with OGD/R exposure, further alleviating IS injury by regulating transcription factor NRF2 and inhibiting ATG5 expression.","PeriodicalId":366080,"journal":{"name":"The Journal of pharmacy and pharmacology","volume":"5 6part2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140714141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cannabidiol prevents chemotherapy-induced neuropathic pain by modulating spinal TLR4 via endocannabinoid system activation. 大麻二酚通过内源性大麻素系统激活调节脊髓TLR4来预防化疗引起的神经性疼痛。

The Journal of pharmacy and pharmacology Pub Date : 2023-03-22 DOI: 10.2139/ssrn.4199529

R. D. dos Santos, F. Veras, G. Netto, L. Elisei, C. Sorgi, L. Faccioli, G. Galdino

{"title":"Cannabidiol prevents chemotherapy-induced neuropathic pain by modulating spinal TLR4 via endocannabinoid system activation.","authors":"R. D. dos Santos, F. Veras, G. Netto, L. Elisei, C. Sorgi, L. Faccioli, G. Galdino","doi":"10.2139/ssrn.4199529","DOIUrl":"https://doi.org/10.2139/ssrn.4199529","url":null,"abstract":"OBJECTIVES\u0000This study aimed to investigate the effect of cannabidiol (CBD) on type 4 Toll-like receptors (TLR4), glial cells and pro-inflammatory cytokines during the neuropathic pain induced by the chemotherapy agent paclitaxel (PTX), as well as the involvement of the endocannabinoid system in this process.\u0000\u0000\u0000METHODS\u0000Male C57BL6 mice were subjected to PTX-induced neuropathic pain. To evaluate the involvement of the TLR4, glial cells and cannabinoid CB2 receptor, specific inhibitors or antagonists were intrathecally administered. The western blotting and immunofluorescence assay was performed to evaluate the spinal expression of TLR4, microglia, astrocytes and cannabinoid CB2 receptor. The levels of spinal pro-inflammatory cytokines and endocannabinoids were determined by enzyme-linked immunosorbent assay and liquid chromatography-mass spectrometry analysis, respectively.\u0000\u0000\u0000KEY FINDINGS\u0000CBD prevented PTX-induced neuropathic pain, and the cannabinoid CB2 receptor antagonist AM630 reversed this effect. In addition, CBD treatment inhibited the spinal expression of TLR4 and Iba1 in mice with neuropathic pain. CBD also increased spinal levels of endocannabinoids anandamide and 2-arachidonoylglycerol, and reduced levels of cytokines in mice with neuropathic pain.\u0000\u0000\u0000CONCLUSIONS\u0000CBD was efficient in preventing PTX-induced neuropathic pain, and this effect may involve inhibition of the TLR4 on microglia spinal with activation of the endocannabinoid system.","PeriodicalId":366080,"journal":{"name":"The Journal of pharmacy and pharmacology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128653145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Ephedra sinica polysaccharide alleviates airway inflammations of mouse asthma-like induced by PM2.5 and ovalbumin via the regulation of gut microbiota and short chain fatty acid. 麻黄多糖通过调节肠道菌群和短链脂肪酸，减轻PM2.5和卵清蛋白诱导的小鼠哮喘样气道炎症。

IF 3.3

The Journal of pharmacy and pharmacology Pub Date : 2022-11-25 DOI: 10.1093/jpp/rgac078

Jun-Xi Liu, Hong-Yu Yuan, Ya-Nan Li, Zhen Wei, Yang Liu, Jun Liang

{"title":"Ephedra sinica polysaccharide alleviates airway inflammations of mouse asthma-like induced by PM2.5 and ovalbumin via the regulation of gut microbiota and short chain fatty acid.","authors":"Jun-Xi Liu, Hong-Yu Yuan, Ya-Nan Li, Zhen Wei, Yang Liu, Jun Liang","doi":"10.1093/jpp/rgac078","DOIUrl":"https://doi.org/10.1093/jpp/rgac078","url":null,"abstract":"Objectives: Epidemiological investigations show that long-term exposure to PM2.5 is directly related to asthma-like and other respiratory diseases. This study aims to further explore the pharmacological effect of Ephedra sinica polysaccharide (ESP) on lung injury caused by atmospheric PM2.5.Methods: To achieve the aim, we explored the therapeutic effect of ESP on an aggravated asthma-like mouse induced by PM2.5 combined with ovalbumin (OVA), and explored mechanisms underlying the connection between gut microbiota and lung function.Key findings: Preliminary results showed that ESP alleviated the symptoms of aggravated allergic asthma-like in mice; reduced the number of eosinophils in BALF; reduced the levels of serum Ig-E, IL-6, TNF-α, and IL-1β. Further qRT-PCR detected that ESP inhibited the NF-κB pathway. The final analysis detected by 16S rRNA and short chain fatty acid (SCFA) confirmed that ESP increased relative proportions of Bacteroides, Lactobacillus, Prevotella, Butyricicoccus and Paraprevotella, but decreased that of Enterococcus and Ruminococcus; increased acetic acid, propionic acid, butyric acid, isobutyric acid, valeric acid, isovaleric acid, and isohexanic acid in the meanwhile.Conclusions: The study showed that ESP has a potential for future therapeutical applications in the prevention and treatment of asthma-like disease induced by PM2.5 and OVA via regulation of gut microbiota and SCFA.","PeriodicalId":366080,"journal":{"name":"The Journal of pharmacy and pharmacology","volume":" ","pages":"1784-1796"},"PeriodicalIF":3.3,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40650285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Anti-tumor effects of Thymus Caramanicus Jalas extract in mice through oxidative stress, inflammation and apoptosis. 胸腺提取物通过氧化应激、炎症和细胞凋亡对小鼠的抗肿瘤作用。

IF 3.3

The Journal of pharmacy and pharmacology Pub Date : 2022-11-25 DOI: 10.1093/jpp/rgac060

Jalal Hassanshahi, Zahra Hajializadeh, Seddigheh Niknia, Mehdi Mahmoodi, Ayat Kaeidi

{"title":"Anti-tumor effects of Thymus Caramanicus Jalas extract in mice through oxidative stress, inflammation and apoptosis.","authors":"Jalal Hassanshahi, Zahra Hajializadeh, Seddigheh Niknia, Mehdi Mahmoodi, Ayat Kaeidi","doi":"10.1093/jpp/rgac060","DOIUrl":"https://doi.org/10.1093/jpp/rgac060","url":null,"abstract":"Objective: Breast cancer causes death in women. Thymus Caramanicus Jalas (TCJ) as a polyphenolic plant has an antiproliferative effect. Accordingly, this investigation studied the TCJ extract anti-tumor effects in a breast cancer model.Methods: Twenty-four female BALB/c mice were used in 4 groups including (1) breast cancer (control); (2), (3) and (4) breast cancer + 100, 300 and 500 mg/kg of TCJ extract (once daily for 20-days after breast tumor induction). The breast tumour was induced by 4T1 cell carcinoma injection. Then tumor size and weight were measured. Tumor necrosis factor-α (TNF-α), nuclear factor κ-B (NF-κB), interleukin-6 (IL-6) as inflammatory markers and also Bcl-2, Bax, cytosolic cytochrome-c, apoptosis-inducing factor, and cleaved caspase-3 as biochemical apoptosis markers were evaluated in tumor tissue with western blotting analysis. Also, malondialdehyde (MDA) concentration, hydrogen peroxidase (H2O2), catalase, glutathione peroxidase (GPx) and superoxide dismutase (SOD) activities were exanimated.Key findings: Treatment with TCJ extract (500 mg/kg) decreased the tumor volume, tumor weight, GPx, SOD, and catalase enzyme activity versus the control group (P < 0.05). Also, TCJ (500 mg/kg) extract increased MDA, H2O2, inflammatory and apoptosis markers versus control (P < 0.05).Conclusions: Current study showed that TCJ can induce anti-tumour effects via promoting inflammation, apoptosis, and oxidative stress in breast tumour tissue.","PeriodicalId":366080,"journal":{"name":"The Journal of pharmacy and pharmacology","volume":" ","pages":"1797-1804"},"PeriodicalIF":3.3,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40649111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The role of microRNAs in the pathophysiology, diagnosis, and treatment of diabetic cardiomyopathy. microrna在糖尿病性心肌病的病理生理、诊断和治疗中的作用。

IF 3.3

The Journal of pharmacy and pharmacology Pub Date : 2022-11-25 DOI: 10.1093/jpp/rgac066

Mahasin Abdel Rhman, Peter Owira

{"title":"The role of microRNAs in the pathophysiology, diagnosis, and treatment of diabetic cardiomyopathy.","authors":"Mahasin Abdel Rhman, Peter Owira","doi":"10.1093/jpp/rgac066","DOIUrl":"https://doi.org/10.1093/jpp/rgac066","url":null,"abstract":"Introduction: Diabetic cardiomyopathy (DCM) is an end-point macrovascular complication associated with increased morbidity and mortality in 12% of diabetic patients. MicroRNAs (miRNAs) are small noncoding RNAs that can act as cardioprotective or cardiotoxic agents in DCM.Methods: We used PubMed as a search engine to collect and analyse data in published articles on the role of miRNAs on the pathophysiology, diagnosis and treatment of DCM.Results: MiRNAs play an essential role in the pathophysiology, diagnosis and treatment of DCM due to their distinct gene expression patterns in diabetic patients compared to healthy individuals. Advances in gene therapy have led to the discovery of potential circulating miRNAs, which can be used as biomarkers for DCM diagnosis and prognosis. Furthermore, targeted miRNA therapies in preclinical and clinical studies, such as using miRNA mimics and anti-miRNAs, have yielded promising results. Application of miRNA mimics and anti-miRNAs via different nanodrug delivery systems alleviate hypertrophy, fibrosis, oxidative stress and apoptosis of cardiomyocytes.Conclusion: MiRNAs serve as attractive potential targets for DCM diagnosis, prognosis and treatment due to their distinctive expression profile in DCM development.","PeriodicalId":366080,"journal":{"name":"The Journal of pharmacy and pharmacology","volume":" ","pages":"1663-1676"},"PeriodicalIF":3.3,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40374795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A comprehensive review of traditional uses, phytochemistry and pharmacology of Reynoutria genus. 雷茅属植物的传统用途、植物化学和药理研究综述。

IF 3.3

The Journal of pharmacy and pharmacology Pub Date : 2022-11-25 DOI: 10.1093/jpp/rgac068

Zi-Long Zhang, Yu-Ze Li, Guo-Qing Wu, Dong-Dong Zhang, Chong Deng, Zhi-Min Wang, Xiao-Mei Song, Wei Wang

{"title":"A comprehensive review of traditional uses, phytochemistry and pharmacology of Reynoutria genus.","authors":"Zi-Long Zhang, Yu-Ze Li, Guo-Qing Wu, Dong-Dong Zhang, Chong Deng, Zhi-Min Wang, Xiao-Mei Song, Wei Wang","doi":"10.1093/jpp/rgac068","DOIUrl":"https://doi.org/10.1093/jpp/rgac068","url":null,"abstract":"Objectives: The genus Reynoutria belonging to the family Polygonaceae is widely distributed in the north temperate zone and used in folk medicine. It is administered as a sedative, tonic and digestive, also as a treatment for canities and alopecia. Herein, we reported a review on traditional uses, phytochemistry and pharmacology reported from 1985 up to early 2022. All the information and studies concerning Reynoutria plants were summarized from the library and digital databases (e.g. ScienceDirect, SciFinder, Medline PubMed, Google Scholar, and CNKI).Key findings: A total of 185 articles on the genus Reynoutria have been collected. The phytochemical investigations of Reynoutria species revealed the presence of more than 277 chemical components, including stilbenoids, quinones, flavonoids, phenylpropanoids, phospholipids, lactones, phenolics and phenolic acids. Moreover, the compounds isolated from the genus Reynoutria possess a wide spectrum of pharmacology such as anti-atherosclerosis, anti-inflammatory, antioxidative, anticancer, neuroprotective, anti-virus and heart protection.Summary: In this paper, the traditional uses, phytochemistry and pharmacology of genus Reynoutria were reviewed. As a source of traditional folk medicine, the Reynoutria genus have high medicinal value and they are widely used in medicine. Therefore, we hope our review can help genus Reynoutria get better development and utilization.","PeriodicalId":366080,"journal":{"name":"The Journal of pharmacy and pharmacology","volume":" ","pages":"1718-1742"},"PeriodicalIF":3.3,"publicationDate":"2022-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40358940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2