Journal of Advances in Medical and Biomedical Research最新文献

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Epidemiological Characteristic and Spatial Analysis of the Admission Rate of Hypertension in Zanjan Province, Iran 伊朗赞詹省高血压发病率的流行病学特征及空间分析
Journal of Advances in Medical and Biomedical Research Pub Date : 2022-09-01 DOI: 10.30699/jambs.30.142.443
Mohsen Soleimani, A. Jalilvand, H. Ahangar
{"title":"Epidemiological Characteristic and Spatial Analysis of the Admission Rate of Hypertension in Zanjan Province, Iran","authors":"Mohsen Soleimani, A. Jalilvand, H. Ahangar","doi":"10.30699/jambs.30.142.443","DOIUrl":"https://doi.org/10.30699/jambs.30.142.443","url":null,"abstract":"","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42348257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Exceptional Occurrence of Uterus Mullerian Adenosarcoma in a Young Iranian Woman 一名年轻伊朗妇女罕见的子宫穆勒管腺肉瘤
Journal of Advances in Medical and Biomedical Research Pub Date : 2022-07-01 DOI: 10.30699/jambs.30.141.385
Fatemeh Samiee-Rad
{"title":"An Exceptional Occurrence of Uterus Mullerian Adenosarcoma in a Young Iranian Woman","authors":"Fatemeh Samiee-Rad","doi":"10.30699/jambs.30.141.385","DOIUrl":"https://doi.org/10.30699/jambs.30.141.385","url":null,"abstract":"A 24-year-old woman with menometrorrhagia for 8 months was referred without any personal risk factor and family history of malignancy. In the bimanual pelvic examination, the uterine indicated increased size. The ultrasound findings showed the enlargement of the uterus and a polypoid heterogeneous echo, M:53*40*20 mm. She underwent hysteroscopy polypectomy. Histopathological findings showed endometrial polyp.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49627777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epidemiology of Psychiatric Disorders among Children and Adolescents in Kohgiloyeh and Boyer- Ahmad Province, Iran 伊朗Kohkiloyeh和Boyer-Ahmad省儿童和青少年精神疾病流行病学
Journal of Advances in Medical and Biomedical Research Pub Date : 2022-07-01 DOI: 10.30699/jambs.30.141.365
Nourrollah Yadegari, L. Jouybari, M. Fathi, Mohammad Reza Mohammadi, S. Mostafavi, A. Khaleghi, S. Elahi, Mohammad Reza Godarzi, Sajad Ramezani, Eshagh Karami, R. Ostovar
{"title":"Epidemiology of Psychiatric Disorders among Children and Adolescents in Kohgiloyeh and Boyer- Ahmad Province, Iran","authors":"Nourrollah Yadegari, L. Jouybari, M. Fathi, Mohammad Reza Mohammadi, S. Mostafavi, A. Khaleghi, S. Elahi, Mohammad Reza Godarzi, Sajad Ramezani, Eshagh Karami, R. Ostovar","doi":"10.30699/jambs.30.141.365","DOIUrl":"https://doi.org/10.30699/jambs.30.141.365","url":null,"abstract":"Background & Objective: Given the growing rate of psychiatric disorders, especially in young populations, detailed data on frequency of these disorders for further national public health strategiesis of great importance.We aimed to survey the frequency of different psychiatric disorders among children and adolescents in Kohgiloyeh and Boyer-Ahmad province. Materials & Methods: 20.5% (205 out of 1001) of studied cases showed at least one psychiatric disorder and 79.5 % showed no sign of any disorders. Anxiety disorders were the most frequent disorders (15.5%) followed by the behavioral disorders (7%), smoking and drug abuse (6%), behavioral disorders (2.4%) and neurodevelopmental disorders (2%), but no case was observed with psychosis. Results: Our study indicated that pretreatment of rats with KET, HAL and YOH abolished MPH induced - mood and motor activity disturbances. Conclusion: in comparison with other studies from Iran or other countries the prevalence of psychiatric disorders in Kohgiloyeh and Boyer-Ahmad is relatively high and special policies and efforts are suggested for enhancement of mental health values in this region.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43697499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Description of the Clinical Course and Severity Score Progression in Critically Ill Children with Acute Bronchiolitis on High-Flow Nasal Cannula Support 高流量鼻插管支持下危重急性毛细支气管炎患儿的临床病程和严重程度评分进展的描述
Journal of Advances in Medical and Biomedical Research Pub Date : 2022-07-01 DOI: 10.30699/jambs.30.141.340
Nelson M Durán Ochoa, Tammy Edel Nudelman, Hernando Mulett Hoyos, A. Bastidas, C. Diaz Ritter, J. Fernández-Sarmiento
{"title":"Description of the Clinical Course and Severity Score Progression in Critically Ill Children with Acute Bronchiolitis on High-Flow Nasal Cannula Support","authors":"Nelson M Durán Ochoa, Tammy Edel Nudelman, Hernando Mulett Hoyos, A. Bastidas, C. Diaz Ritter, J. Fernández-Sarmiento","doi":"10.30699/jambs.30.141.340","DOIUrl":"https://doi.org/10.30699/jambs.30.141.340","url":null,"abstract":"10.30699/jambs.30.141.340 Background & Objective: Bronchiolitis is one of the main causes of morbidity and mortality in children. High-flow nasal cannulas (HFNCs) are an alternative for managing moderate to severe cases. Our aim was to describe the outcomes in critically ill children with bronchiolitis who receive HFNC support. Materials & Methods: This was a retrospective cohort study of critically ill children who had bronchiolitis and received HFNC support while hospitalized in the pediatric intensive care unit (PICU) between January 2013 and January 2020. The primary outcome was deterioration in the Wood-Downes scale. Secondary outcomes included length of hospitalization, duration of oxygen therapy, SpO2/FiO2, and the ROX index (respiratory rate – oxygenation). Results: During this period, 2,390 children were admitted, 87 of whom had bronchiolitis and met the inclusion criteria. The median age was 4.4 months (IQR: 2.4 – 8.6). In 87.3% of cases there was no worsening in the scale with the use of HFNCs. In the group that worsened, 79.3% had moderate and 20.7% severe bronchiolitis on admission, and they had a higher rate of congenital heart disease (p=0.03), chronic respiratory diseases (p=0.03) and neurological (p=0.05) diseases. At 12 hours, this group had a lower SpO2/FiO2 (< 180) and ROX index (< 4.0). None of the patients required mechanical ventilation. Conclusion: The use of HFNCs in children with moderate to severe bronchiolitis was associated with a modified clinical course, avoiding mechanical ventilation even in risk groups. SpO2/FiO2 and ROX index 12-hour cut-off points suggestive of patients with a delayed response to HFNC support were identified.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49330172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Dill Extract on Blood Lipid Levels (TC, TG, LDL and HDL): A Systematic Review and Meta-Analysis 莳萝提取物对血脂水平(TC, TG, LDL和HDL)的影响:系统综述和荟萃分析
Journal of Advances in Medical and Biomedical Research Pub Date : 2022-07-01 DOI: 10.30699/jambs.30.141.306
M. Azimi, M. Deldar, A. Moayeri, K. Sayehmiri
{"title":"Effects of Dill Extract on Blood Lipid Levels (TC, TG, LDL and HDL): A Systematic Review and Meta-Analysis","authors":"M. Azimi, M. Deldar, A. Moayeri, K. Sayehmiri","doi":"10.30699/jambs.30.141.306","DOIUrl":"https://doi.org/10.30699/jambs.30.141.306","url":null,"abstract":"10.30699/jambs.30.141.306 Background & Objective: In recent years,there has been a growing trend towards the use of herbal medicine in the treatment and prevention of diseases. Blood lipid-lowering drugs have many side effects. On the other hand, various studies have reported the effect of dill ( Anethum graveolens ) on the reduction of blood lipids in different ways. This study aimed to evaluate the effect of dill on reducing the blood lipid levels. Materials & Methods: In this systematic review, 12 papers that evaluated the effect of dill on blood lipid levels up to the end of 2018 were studied using valid key words such as Lipid Profile, Dill ( Anethum graveolens ), and Hyperlipidemia in Pubmed, Medlib, Scopus, Sciencedirect, Embase, Google Scholar, Magiran, IranMedex, and SID. The results of the studies were combined using the random effects method of meta-analysis. The heterogeneity of studies was investigated using Q statistics and I 2 Index. Results: In 12 studies, the weighted mean differences (WMDs) of cholesterol reduction (TC) before and after intervention were estimated to be WMD = -19.22 mg / dl (95% CI: -30.68, -7.77), triglyceride, WMD = -25.47 mg / dl (95% CI: -49.28, -1.66) and low density lipoprotein (LDL), WMD = -14.01 mg / dl (95% CI: -22.14, -5.89) which were statistically significant ( p = 0.001). Meta-analysis after intervention in the case and placebo groups were (SMD=-2.71, 95% CI:-3.28,-1.06), for TC (SMD=-1.77, 95%CI:-2.71,-0.82) for TG and (SMD=-2.64, 95%CI:-3.88,-1.41)for LDL which indicated statistically significant reduction. Conclusion: Dill reduces cholesterol, triglyceride and low-density lipoprotein, but does not have a significant effect on high-density lipoprotein levels.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42249221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Global Longitudinal Strain Pattern (GLS) and Echocardiographic Parameters in the Sleeve Gastrectomy Patients Before and After Surgery 袖状胃切除术前后整体纵向应变图(GLS)和超声心动图参数的评价
Journal of Advances in Medical and Biomedical Research Pub Date : 2022-07-01 DOI: 10.30699/jambs.30.141.327
Abdolvahab Baradaran, Somayeh Zamanifard, Maryam Parham, Farahnaz Nikdoust
{"title":"Evaluation of Global Longitudinal Strain Pattern (GLS) and Echocardiographic Parameters in the Sleeve Gastrectomy Patients Before and After Surgery","authors":"Abdolvahab Baradaran, Somayeh Zamanifard, Maryam Parham, Farahnaz Nikdoust","doi":"10.30699/jambs.30.141.327","DOIUrl":"https://doi.org/10.30699/jambs.30.141.327","url":null,"abstract":"10.30699/jambs.30.141.327 Background & Objective: Obesity is one of the problems associated with cardiovascular complications. Patients' heart function improves after sleeve gastrectomy. Global Longitudinal Strain (GLS) is one of the methods used to monitor heart function before and after sleeve gastrectomy. In this study, we evaluated the echocardiographic parameters pre and post sleeve gastrectomy. Materials & Methods: In this cross-sectional study, 22 patients including 17 female and 5 maleundergoing sleeve gastrectomy were studied. They had referred to Shariati Hospital in Tehran during 2019 – 2020. All patients underwent 2D echocardiography using speckle-tracking to evaluate left ventricular function and measure GLS. Results: Data analysis showed that GLS increased after surgery compared to preoperative period (15.4 ± 3.8 vs. 18.4 ± 3.04). Also, PAP, LVEDV, LVESV, LVDD, LVDS and AO were higher in the mentioned period; these findings were statistically significant (p-value <0.05). However, the RVSM mean, TAPSE, RVFAC and LVH parameters were higher post-surgery in comparison to the pre- surgery; a significant relationship was observed between the parameters before and after surgery. Conclusion: It can be concluded that GLS method, which evaluates echocardiographic parameters in obese patients undergoing sleeve gastrectomy can be highly significant in monitoring patients.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48362822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Educational view of Pathological Fracture of Femur due to Hydatid Cysts: A Case Report and Review of Literature 女性棘球蚴病理性骨折的教育观——附1例报告及文献复习
Journal of Advances in Medical and Biomedical Research Pub Date : 2022-07-01 DOI: 10.30699/jambs.30.141.374
Ramin Farzam, M. Abdi, Maryam Farhangi, M. Zibaei, H. Torkmandi
{"title":"Educational view of Pathological Fracture of Femur due to Hydatid Cysts: A Case Report and Review of Literature","authors":"Ramin Farzam, M. Abdi, Maryam Farhangi, M. Zibaei, H. Torkmandi","doi":"10.30699/jambs.30.141.374","DOIUrl":"https://doi.org/10.30699/jambs.30.141.374","url":null,"abstract":"10.30699/jambs.30.141.374 Hydatid cysts can be caused by Echinococcus species in various tissues. Skeletal cystic lesions are very rare and may be neglected. Here, we report a case of pathologic fracture following primary hydatid cystic lesions in the proximal and femoral shaft bone. A 62-year-old man suffered a sudden fracture followed by swelling of the thigh. Intramedullary femoral fixation was made and during the surgery, numerous cystic lesions of the hydatid cysts were observed. After the surgery ultrasound and CT-Scans of the abdomen, lung, spine, and brain did not confirm any sign of mass or cyst elsewhere. The patient was followed up for one year. During this period, the union was not yet completely established and the patient was stillreceiving treatment. Orthopedic surgeons need to be aware of this parasitic complication in bones and joints and provide the best outcome for the patients with proper treatment. Surgery along with albendazole and/or mebendazole therapy remains the treatment of choice. For this purpose, it is recommended that attention be paid to long-term follow-up in continuous professional development courses.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46717072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Comparison of the Effect of Cydonia oblonga and Phyllanthus Emblica on Gastric Residual Volume and Pulmonary Aspiration in Patients under Mechanical Ventilation in Mousavi Hospital ICU of Zanjan in 2020 2020年赞詹穆萨维医院ICU机械通气条件下冬凌草叶和余甘子对患者胃残积和肺抽吸的影响比较
Journal of Advances in Medical and Biomedical Research Pub Date : 2022-07-01 DOI: 10.30699/jambs.30.141.357
Batool Dahar, Narjes Khavasi, K. Kamali, Vahideh Rashtchi
{"title":"Comparison of the Effect of Cydonia oblonga and Phyllanthus Emblica on Gastric Residual Volume and Pulmonary Aspiration in Patients under Mechanical Ventilation in Mousavi Hospital ICU of Zanjan in 2020","authors":"Batool Dahar, Narjes Khavasi, K. Kamali, Vahideh Rashtchi","doi":"10.30699/jambs.30.141.357","DOIUrl":"https://doi.org/10.30699/jambs.30.141.357","url":null,"abstract":"10.30699/jambs.30.141.357 Background & Objective: The gastric residual volume has a direct effect on the volume and timing of the subsequent feeding and causes gastric emptying and pulmonary aspiration. The present study compares the effect of Cydonia oblonga and Phyllanthus Emblica (Amla) fruit on gastric residual volume and pulmonary aspiration in mechanically- ventilated patients. Materials & Methods: This is a single-blind randomized clinical trial, including 48 patients (divided into three groups) under mechanical ventilation admitted to the intensive care unit (ICU) of Mousavi Hospital in Zanjan. Amla product and cydonia juice were gavaged in intervention groups A and, B, respectively. In all groups, the same gavage solution was prepared every three hours. Eventually, pulmonary secretion aspiration was measured (on the first, third and fifth days). Results: The difference of the mean gastric residual volume was not statistically significant in the intervention groups (on thefirst three days). The mean residual volume of the fourth and fifth days was statistically different and the rate of pulmonary aspiration in the intervention groups (on the fifth day) was significantly lower than the control group (P<0.001). The mean gastric residual volume of the two groups had no significant difference (P<0.471). Conclusion: The present study shows the effectiveness of cydonia juice and Amla on the gastric residual volume in patients admitted to ICU. The incidence of pulmonary aspiration in intervention groups has a decreasing trend (on the fifth day). Therefore, cydonia juice and Amla can be appropriate alternatives to chemical drugs.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48715850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study of Pregnant Women Infected with COVID-19 During Pregnancy: A Case Report 孕妇妊娠期感染新冠肺炎的研究报告
Journal of Advances in Medical and Biomedical Research Pub Date : 2022-07-01 DOI: 10.30699/jambs.30.141.379
F. Zare, S. Daliri, Sakineh Kolahdouzan, M. Rohani-Rasaf
{"title":"Study of Pregnant Women Infected with COVID-19 During Pregnancy: A Case Report","authors":"F. Zare, S. Daliri, Sakineh Kolahdouzan, M. Rohani-Rasaf","doi":"10.30699/jambs.30.141.379","DOIUrl":"https://doi.org/10.30699/jambs.30.141.379","url":null,"abstract":"This case study includes three pregnant women with COVID-19 diagnosed during pregnancy or delivery between March 28 and May 13, 2020. All cases were confirmed by a positive pharyngeal reverse transcription polymerase chain reaction (RT-PCR) test and one case by computed tomography scan (CT Scan) in addition to the (RT-PCR). Clinical and laboratory information was extracted from hospital records during pregnancy and delivery. The adverse effects during pregnancy and after the birth of the newborn, the possibility of vertical transmission from positive pregnant mothers to the neonates were investigated.Of the three women with COVID-19 infection, one patient was diagnosed two weeks before delivery and two were diagnosed during delivery and hospitalization. No adverse effects including preeclampsia, gestational hypertension, rupture of the amniotic sac during pregnancy and premature delivery were observed but one of the patients suffered from intrauterine fetal death (IUFD). in this study, adverse pregnancy outcome was not observed in pregnant women with Covid-19 infection based on hospital observations. No vertical transmission was observed following vaginal delivery or cesarean section and during pregnancy. As the effect of the virus on different people in society varies according to their individual characteristics, our conclusion in this study on pregnant women is also affected by these individual differences, which requires further studies in this field with more samples.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46056085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Long-Term Survival in Non-Metastatic Young Breast Cancer Patients in South of Iran 伊朗南部非转移性年轻乳腺癌患者的长期生存评估
Journal of Advances in Medical and Biomedical Research Pub Date : 2022-07-01 DOI: 10.30699/jambs.30.141.333
Behnam Kadkhodaei, A. Mosalaei, S. Omidvari, M. Ansari, M. Mohammadianpanah, N. Ahmadloo, H. Nasrollahi, Seyed Hasan Hamedi, M. Shariat, Mozhdeh Zamani
{"title":"Evaluation of the Long-Term Survival in Non-Metastatic Young Breast Cancer Patients in South of Iran","authors":"Behnam Kadkhodaei, A. Mosalaei, S. Omidvari, M. Ansari, M. Mohammadianpanah, N. Ahmadloo, H. Nasrollahi, Seyed Hasan Hamedi, M. Shariat, Mozhdeh Zamani","doi":"10.30699/jambs.30.141.333","DOIUrl":"https://doi.org/10.30699/jambs.30.141.333","url":null,"abstract":"10.30699/jambs.30.141.333 Background & Objective: The lack of breast cancer screening in young women leads to late disease diagnosis and worse outcomes in this age group. This study was designed to evaluate clinicopathological features and long-term outcomes of young breast cancer women in south of Iran. Materials & Methods: This is a retrospective study of breast cancer patients who were pathologically diagnosed during 2005 to 2017. Data from 284 breast cancer patients aged 40 years or younger were included in this study. Demographic, clinicopathological properties as well as treatment modalities including type of surgery, adjuvant radiotherapy, and adjuvant or neoadjuvant chemotherapy were recorded and analyzed. Results: Median age of the patients was 36 (range 23-40) years. After a median follow-up of 68 months, 21 patients had died due to the disease, 59 patients were alive with the disease, and 204 patients were alive without the disease. The univariate COX regression demonstrated that the disease -free survival (DFS) was significantly low in patients who had undergone breast conservation surgery (BCS) and also patients with higher stages, estrogen/progesterone-negative and human epidermal growth factor receptor 2-positive (ER-/PR-/HER2+) status. Low overall survival (OS) was also significantly associated with stage. According to multivariate COX regression, BCS, stages II, III and also young age were independent predictive factors for low DFS. Conclusion: Given the aggressive features and worse outcome of young breast cancer patients, treatment remains tough and screening seems to be required at young age. Further studies are required to find best management and therapeutic protocols for these patients.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47163492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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