Journal of Advances in Medical and Biomedical Research最新文献

{"title":"Clinical Manifestation, Laboratory Findings and Adverse Outcomes of COVID 19 Infection in Pregnant Women: A Cross-Sectional Study in the West of Iran","authors":"Robabeh Hatami, Z. Najmi, Shabnam Tofighi, Atousa Dabiri Oskoei, N. Emami, H. Gholami","doi":"10.30699/jambs.31.146.282","DOIUrl":"https://doi.org/10.30699/jambs.31.146.282","url":null,"abstract":"10.30699/jambs.31.146.282 Background & Objective: Pregnancy is a unique immunological condition in which the immune system is affected and therefore there is a greater risk of severe disease and mortality from COVID-19 disease. The present study aimed to evaluate the clinical manifestation, laboratory findings, and adverse outcomes among a population of pregnant women confirmed with COVID 19 infection. Materials & Methods: In present cross-sectional study, all pregnant women with COVID-19 referred to Mousavi Hospital in Zanjan City from February 2020 to August 2021 including 232 patients were examined. We used a researcher-made checklist to extract the required information, including socio-demographic data, potential risk factors, clinical manifestations, laboratory parameters, and fetal, and neonatal outcomes of the patients. Comparison of laboratory parameters in women with COVID-19 according to ICU admission was made using independent t-test and Mann-Whitney U test. Results: 47.4%, of women were 30 to 40 years old, 45.7% were illiterate. Weakness, myalgia, dry cough, and fatigue were the most common clinical symptoms (>90%). Patients had abnormal levels of ALT and AST, whereas the means of other laboratory parameters were in the normal range. Forty-one (17.6%) of patients were admitted to the ICU. The means of C - reactive protein (46.58 vs. 25.87), lactate dehydrogenase (586.31 vs. 480.97), Blood urea nitrogen (9.43 vs. 8.26), and erythrocyte sedimentation rate (62.40 vs. 46.11) were statistically higher in patients admitted to ICU than those who were not in the ICU ( P <0.05). Mortality rates among women who had a vaginal delivery and C-section were 3% and 6.1%, respectively. Conclusion: The most common laboratory findings in COVID-19-infected mothers were lymphopenia and elevated CRP, ALT, D-Dimer, and LDH. An increased hospitalization in ICU and higher rates of mother and fetal death were complications of pregnancy and childbirth in COVID-19-infected women.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45245142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Study of Platelet-Derived Growth Factor A and Its Ligand among Patients with Glioblastoma and Astrocytoma in Imam Khomeini Hospital Complex, Tehran","authors":"Fateme Behrouzi Pouya, M. Saffari, A. Muhammadnejad, Maryam Monsef Shokri, R. Shirkoohi","doi":"10.30699/jambs.31.146.230","DOIUrl":"https://doi.org/10.30699/jambs.31.146.230","url":null,"abstract":"10.30699/jambs.31.146.230 Background&Objective: The platelet-derived growth factor receptor (PDGFR) signaling pathway has a vital function as a regulator of glioma development. PDGFRA alterations have been observed in a variety of cancers and have been important clinical targets for tyrosine kinase inhibitors like Imatinib. The aim of this study was to evaluate the role of PDGFRA and PDGFA in the pathogenesis of GBM and to determine whether the constitutive activation of PDGFRA is driven by gene mutations or protein expression. Materials&Methods: PDGFRA-activating gene mutations (exons 12, 18) were assessed in a subset of 75 samples, of which 65 were GBM and 10 were pilocytic astrocytoma, using PCR followed by direct sequencing. PDGFA expression was evaluated by immunohistochemistry in a series of 20 cases including 15 cases of glioblastoma multiforme and 5 cases of pilocytic astrocytoma. Results: No PDGFRA-activating mutations were found by Sanger sequencing. In addition, this study found polymorphism in PDGFRA exon 12, c.1701A> G, which was a silent mutation. Immunohistochemical analysis showed elevated PDGFA expression in 25% (5 out of 20) of glioma cases. PDGFA expression was not detected in any pilocytic astrocytoma; however, 33.33% (5 out of 15) of GBM samples showed increased PDGFA expression. Conclusion: Consistent with previous studies, the findings of the present study underline the importance of PDGFA and PDGFRA alterations as a possible potential predictive biomarker and a therapeutic target in GBM. Further research is needed to better understand the underlying genetic mechanisms driving abnormal PDGFRA activity in gliomas.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42541649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of RT-PCR and CT Scan in Terms of Their Diagnostic Performance for Coronavirus 2019 in Yazd, Iran","authors":"Atefe Daya, N. Namiranian, Seyyed Kazem Razavi Ratki, Amirpasha Amlelshahbaz, Roghaye Razavi, Reza Nafisi Moghadam","doi":"10.30699/jambs.31.146.261","DOIUrl":"https://doi.org/10.30699/jambs.31.146.261","url":null,"abstract":"10.30699/jambs.31.146.261 Background & Objective: Due to the importance of the rapid diagnosis of SARS-COV-2, many studies have been performed on various diagnostic methods. In this vein, the aim of this study is to compare the diagnostic value of chest CT with RT-PCR in patients with suspected COVID-19. Materials & Methods: This cross-sectional research was conducted at Shahid Sadoughi Hospital in Yazd. A total of 531 patients were randomly referred to the CT scan department for chest imaging (spiral or HRCT).Based on the PCR findings, they were divided into: positive and negative PCR groups. The CT scan findings were then recorded in a data collection form. Finally, the CT scan results of the two groups were compared. Results: In this study, 531 patients (306 males and 225 females with the mean age of 55.14 ± 19.7) were examined. The findings of reverse hallo (P = 0.000) and strict consolidation (P= 0.001) in CT scan were significantly different for the positive and negative PCR groups. Through the comparative analysis of the results, the sensitivity of CT scan and PCR findings emerged to be 97.42 and 55.75, respectively. However, the specificity of both diagnostic methods was 100%. Conclusion: The results of this study show that, owing to the higher sensitivity of chest CT for the diagnosis of COVID-19 pneumonia, performing CT scan for quick diagnosis is recommended for COVID suspected people with negative RT-PCR test results.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46852729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Anti-fungal Activity of Different Concentrations of Aloe vera in Candida albicans Infection under In Vitro Conditions","authors":"A. Pouyafard, Negin Jabbaripour, A. Jafari, F. Owlia","doi":"10.30699/jambs.31.146.268","DOIUrl":"https://doi.org/10.30699/jambs.31.146.268","url":null,"abstract":"10.30699/jambs.31.146.268 Background & Objective: A variety of synthetic and chemical drugs have been established for the treatment of candidiasis, but each has some limitations and its probable side effects. This study attempts to touch upon the antifungal activity of different concentrations of hydroalcoholic extracts of Aloe vera against Candida albicans in in vitro conditions. Materials & Methods: Hydroalcoholic extract from Aloe vera leaves was tested for anti-fungal activity via an in vitro study. Anti-fungal activity and minimum inhibitory concentration (MIC) were determined by the disk diffusion method. Aloe vera hydroalcoholic extracts (75%, 50%, 25%, and 12.5%) were used as test groups. The data were analyzed by ANOVA using SPSS 23 software. The level of statistical significance was set at p≤ 0.05 . Results: The results revealed that Aloe v era contained substantial anti-fungal activity. There was a significant discrepancy in the mean diameter of the inhibition zone of C . albicans growth among different concentrations of Aloe vera (p-value=0.001). Also, there was a statistically significant difference between the average diameter of the inhibition zone of C . albicans growth at a concentration of 12.5% of Aloe vera extract compared to concentrations of 25%, 50%, and 75% Aloe vera, and concentration of 50% with 25% and 75% extracts. Aloe vera extract at 75% concentration effectively inhibited the growth of C. albicans compared with the positive control-nystatin. In this study, Aloe vera concentration of 20% was determined as the MIC for C. albicans . Conclusion: In adherence to the present results, it seems that Aloe vera extract, which is inexpensive and has no side effects, could be introduced as an alternative to nystatin.","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45894504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Findings of COVID-19 Outbreak Investigation in a Rehabilitation Center: How SARS-CoV-2 Affects Disabled Persons","authors":"Reyhaneh Jashaninejad, M. Mirzaei, M. Karami, F. Keramat, Alireza Madrakian, J. Bathaei, F. Azizi Jalilian","doi":"10.30699/jambs.31.146.291","DOIUrl":"https://doi.org/10.30699/jambs.31.146.291","url":null,"abstract":"","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48755914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Temulawak (Curcuma xanthorrhiza) Extract on Sperm Counts, Morphology, and Motility of Nicotine-Induced Mice","authors":"D. S. Wibisono, Josephine Fiona Sucahyo, F. Fulyani, Mahayu Dewi Ariani, E. Nugroho, N. Daniswara","doi":"10.30699/jambs.31.145.191","DOIUrl":"https://doi.org/10.30699/jambs.31.145.191","url":null,"abstract":"","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46464410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report of Ellis–Van Creveld Syndrome: A Chondroectodermal Dysplasia","authors":"H. Goli, Alia Jalalodini, M. Ansari","doi":"10.30699/jambs.31.145.207","DOIUrl":"https://doi.org/10.30699/jambs.31.145.207","url":null,"abstract":"","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45455402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CXCL12/CXCR4 Gene Polymorphism as a Putative Prognostic Factor for Metastasizing Breast Cancer Under Chemotherapy","authors":"Zhaleh Karimi Moghaddam, Bahareh Ekrami, Golnaz Asaadi Tehrani","doi":"10.30699/jambs.31.145.133","DOIUrl":"https://doi.org/10.30699/jambs.31.145.133","url":null,"abstract":"Association between Polymorphisms of X-ray Repair Cross Complementing 5 and 6 Promoter Genes and the Risk of Metastatic Breast Cancer","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134955750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Dietary Protein Intake with Body Composition and Physical Status in Patients with Knee Osteoarthritis","authors":"N. Dolatkhah, V. Toopchizadeh, Azizeh Farshbaf Khalili, Sanaz Emamizad, Y. Salekzamani, Negar Taleschian Tabrizi, Maryam Hashemian","doi":"10.30699/jambs.31.145.158","DOIUrl":"https://doi.org/10.30699/jambs.31.145.158","url":null,"abstract":"","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47589905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Portulaca oleracea Protects H9c2 Cardiomyocytes Against Doxorubicin-Induced Toxicity by Inhibition of Oxidative Stress and Apoptosis","authors":"A. Hosseini, M. Alavi, Soroush Mohammadi, Zahra Tayarani Najjaran, Arezoo Rajabian","doi":"10.30699/jambs.31.145.177","DOIUrl":"https://doi.org/10.30699/jambs.31.145.177","url":null,"abstract":"","PeriodicalId":36550,"journal":{"name":"Journal of Advances in Medical and Biomedical Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48300554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}