JAP Academy Journal最新文献

{"title":"Predictors and Outcomes of Intraoperative Blood Transfusion in Cirrhotic Veterans","authors":"Awni Shahait, Adam Pearl, K. Saleh","doi":"10.58877/japaj.v1i2.33","DOIUrl":"https://doi.org/10.58877/japaj.v1i2.33","url":null,"abstract":"Background: Cirrhotic patients are at increased risk of postoperative complications and mortality following any surgical procedure. One of the independent predators of adverse outcomes is intraoperative transfusion (IOT). In this study we examine the profile of cirrhotic patients requiring IOT to determine its predictors. \u0000Methods: The Veterans Affairs Surgical Quality Improvement Program (VASQIP) was utilized to identify all patients with cirrhosis and ascites who underwent any non-liver transplant procedures from 2008 to 2015. Univariate and multivariate regression were used to identify predictors of increased risk of IOT and associated outcomes. \u0000Results: A total of 1,957 cirrhotic patients were identified, of which only 358 (18.8%) required IOT ≥1 unit. IOT group were older, more frail, higher Model for End-stage Liver Disease (MELD) score, anemic (hematocrit <30%), hypoalbuminemic. This group also had more emergent procedures, higher rates of preoperative sepsis, longer operative time, longer postoperative length of stay, and higher morbidity and mortality rates. On multivariate logistic regression, pancreatic resections, open hernia repair, anemia, gastric resections, hypoalbuminemia, acute renal failure, emergency procedure, preoperative sepsis, and preoperative weight loss >10% were significant predictors of IOT. \u0000Conclusion: IOT in cirrhotic patients is associated with worse outcomes. Pancreatic procedures, open hernia repair, and gastric resection were associated with increased IOT. This aid in preoperative planning and blood products preparation. ","PeriodicalId":364383,"journal":{"name":"JAP Academy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131728183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Use of Belantamab Mafodotin in Relapsed/Refractory Multiple Myeloma: A Systematic Review","authors":"Abdelrahman Nanah, Samer Al Hadidi","doi":"10.58877/japaj.v1i2.56","DOIUrl":"https://doi.org/10.58877/japaj.v1i2.56","url":null,"abstract":"Belantamab mafodotin is an antibody drug conjugate directed against B-cell maturation antigen and was approved by the Food and Drug Administration under accelerated approval for use in the US in August 2020 for adult patients with relapsed or refractory multiple myeloma who have received at least 4 prior therapies, including an anti-CD38 monoclonal antibody, a proteasome inhibitor, and an immunomodulatory drug. In November 2022 belantamab mafodotin was withdrawn from the US market after failure of a required confirmatory trial. In our review, we provide a systematic review on the use of belantamab mafodotin efficacy and safety in a real-world setting.","PeriodicalId":364383,"journal":{"name":"JAP Academy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122440106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Passenger lymphocyte syndrome from Transfusion Medicine's standpoint: Short Communication","authors":"Mohammad Barouqa, H. Jum'ah, Yousef Janbek, M. Reyes Gil","doi":"10.58877/japaj.v1i2.66","DOIUrl":"https://doi.org/10.58877/japaj.v1i2.66","url":null,"abstract":"","PeriodicalId":364383,"journal":{"name":"JAP Academy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123817144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Hospitalization and Post-Hospitalization Outcomes among Family Medicine Hospitalists and Internal Medicine Hospitalists in a Tertiary Center: A Prospective Cohort Study","authors":"Moaath K. Mustafa Ali, S. Mustafa, M. Sabha, M. Banifadel, K. Aburayyan, M. Awad, M. Ghanim, A. Ramahi, Z. Nesheiwat","doi":"10.58877/japaj.v1i1.11","DOIUrl":"https://doi.org/10.58877/japaj.v1i1.11","url":null,"abstract":"Background: There is a lack of studies comparing hospitalization and post-hospitalization outcomes between internal medicine (IM) hospitalists and family medicine (FM) hospitalists.  \u0000Objective: To compare the length of stay (LOS), hospital cost, and 30-day all-cause readmission rate among patients treated by IM hospitalists and FM hospitalists.   \u0000Design and Setting: Prospective cohort study in a referral center. Propensity score matching was used to balance baseline characteristics between comparative arms. \u0000Participants: 747 patients 18 years and older who were admitted to hospitalist services. \u0000Intervention: Treatment by IM hospitalists and FM hospitalists. \u0000Main Measures:  LOS, hospital cost, and 30-day all-cause readmission. Treatment arms were compared by two methods. We compared patients who were seen by FM exclusively with those treated exclusively by IM services. Covariate adjusted differences in outcomes were estimated by multivariable regression. For a secondary set of analyses, exposure to FM and IM was converted to a continuous independent variable. \u0000Key Results: Forty, 333, and 374 patients were seen by FM, IM, and a combination of both services, respectively. Using average treatment on the treated as the estimand, FM care provided a shorter weight-adjusted LOS by 0.5 days (CI: -0.92- -0.04, P =0.026) compared to IM, but no difference in hospital cost (-126, CI: -906-653, P=.74).  There was no difference in adjusted hazard for 30-day readmission between FM and IM (HR: 2, CI: 0.67-6.2, P =0.062). Propensity weight-adjusted multiple regression models of the complete cohort (n=747) did not show any difference in any outcomes with increased exposure to FM care.  \u0000Conclusions: Understanding variation in practices and outcomes between different hospitalist models opens opportunities to improve care and decrease the length of stay.","PeriodicalId":364383,"journal":{"name":"JAP Academy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130814335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Plasma Cell Leukemia","authors":"Samer Al Hadidi","doi":"10.58877/japaj.v1i1.21","DOIUrl":"https://doi.org/10.58877/japaj.v1i1.21","url":null,"abstract":"","PeriodicalId":364383,"journal":{"name":"JAP Academy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129329514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge of medical students in Jordan regarding monkeypox outbreak","authors":"Mohammad Al Mse`adeen, Sadeen Zein Eddin, Saja Zuaiter, Hanaa K. Mousa, Eman M. Abd el-Sattar, Mohammad Daradkeh, M. Al-Jafari, Namareq Al Mse’adeen, Mohammad Abu-Jeyyab","doi":"10.58877/japaj.v1i1.10","DOIUrl":"https://doi.org/10.58877/japaj.v1i1.10","url":null,"abstract":"Abstract \u0000Introduction \u0000Human Monkeypox (HMP) is an infectious disease attributed to the orthopoxvirus. HMP was firstly documented in humans in 1970 in the Congo. Since May 2022, multiple cases of HMP were identified in several non-endemic countries including some Middle Eastern countries. \u0000 Objective \u0000 This study aims to assess the knowledge about HMP among medical students in Jordan. \u0000Methodology \u0000 A cross-sectional study was conducted using online based questionnaire. A sample of 565 medical students completed the questionnaire during May 2022. The questionnaire collected data regarding source of knowledge, causative organism, natural host, mode of transmission, incubation period, signs and symptoms, duration diagnosis prevention, treatment and complications of the disease. \u0000Results \u0000Males constituted (39.6 %) of the total sample. Significantly higher rate of knowledge was detected among males (35.7%) vs. females χ2 =10.0, P = 0.002, fifth (60.9%) and sixth (43.8%), vs. first, second and third academic years, χ2 = 83, P<0.001. Correct knowledge about signs and symptoms showed the highest rate (43.0%), followed by an Incubation period, duration and prevention of disease, (33.3%, 32.6% & 31.0%, respectively). On the other hand lowest knowledge exhibited regarding; natural host (5.0%), mode of transmission, (9.2%), psychosocial impact, (9.2%), vulnerable age group (14.2%), and complications (14.2%). Majority of students (82.3%) claimed that their knowledge was earned from social media followed by TV (16.3 %,), and the    university (8,5%).TV had the highest rate (47.8%) with adequate knowledge, χ2 =20.6, p <0.001            interestingly, 71,7% of the respondents had inadequate knowledge about the outbreak and 70,7% of them, the social media was their source of knowledge. \u0000  \u0000Conclusion \u0000Gender and higher academic year are significantly associated with adequate knowledge. Social media is significantly associated with inadequate knowledge among students. \u0000  \u0000Key words: Knowledge, Monkeypox, Social Media, Infectious Disease","PeriodicalId":364383,"journal":{"name":"JAP Academy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127306144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The smallest metastatic solitary vaginal nodule from a primary recto-sigmoid tumor – Case Report","authors":"M. K. Abou Chaar, Lara Rabah, Omar Tassabehji, A. Gharaibeh, Omar Jaber, F. Alawneh","doi":"10.58877/japaj.v1i1.16","DOIUrl":"https://doi.org/10.58877/japaj.v1i1.16","url":null,"abstract":"","PeriodicalId":364383,"journal":{"name":"JAP Academy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126283630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastro-esophageal reflux disease (GERD) among medical students during COVID-19 pandemic","authors":"Mohammad Zaidan, Suzan Al-Hawash, N. Abu Farsakh, Khalid Khairallah","doi":"10.58877/japaj.v1i1.6","DOIUrl":"https://doi.org/10.58877/japaj.v1i1.6","url":null,"abstract":"Abstract: \u0000Importance: Gastroesophageal reflux disease (GERD) is a common digestive disorder in which acid-containing contents in your stomach persistently leak back up into the esophagus, especially in stressful lifestyle such as medical students. \u0000Objective: The aim of this study is to estimate the prevalence of GERD in Medical students in Jordan, assess factors which affect the occurrence of GERD in the study population, access the stressors of medical students during the pandemic, assess, if any, effect is present related to COVID-19 pandemic, and to look for possible preventive measures for GERD. \u0000Design: cross-sectional study including a questionnaire of 6 questions of the duration of seven days prepared on google forms and electronically. Data was collected in the period between 31st January 2021 and 18th April 2021. \u0000Setting: Medical Faculties and hospitals in Jordan. \u0000Participants: population-based sample; medical students studying in Jordan. \u0000Main outcomes and Measures: Medical students' lifestyles are stressful, and a lot of risk factors attributed to GERD are common among medical students. COVID-19 infection is known to cause GI symptoms and as an infection, it could be a stressor especially during the pandemic. Statistical methods included descriptive analysis, Cramer's V statistics, and the Chi-square test as measures of effect sizes. Our findings were not significant enough to confirm that COVID-19 infection causes GERD. However, alternation in GERD symptoms was found to be significant. \u0000Results: Out of 1009 subjects, 43.4% were males, and 56.6% were females. The most common symptoms were heartburn and regurgitations and were found in 421 (41.7%) and 325 (32.2%) students, respectively. 199 (19.7%) of students were affected by COVID-19 but it was not statistically significant (P >0.05). However, alteration in the feeling of GERD symptoms in those who were infected with COVID-19 was found to be statistically significant (P < 0.05). \u0000Conclusion and relevance: Our findings suggest that the most frequent symptoms of GERD reported by medical students are heartburn and regurgitation. In addition to that, the students who were infected with COVID-19 were in the high-risk group. Therefore, more efforts and studies are needed to look for the pathophysiology of COVID-19 infection's effect on the GERD symptoms. \u0000  \u0000Keywords: \u0000 GERD, Regurgitation, COVID-19, Pandemic.","PeriodicalId":364383,"journal":{"name":"JAP Academy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127692996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Informatics (A Jordanian physician’s perspective)","authors":"EzzAddin Al Wahsh","doi":"10.58877/japaj.v1i1.27","DOIUrl":"https://doi.org/10.58877/japaj.v1i1.27","url":null,"abstract":"","PeriodicalId":364383,"journal":{"name":"JAP Academy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115048581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pompe disease, a rare condition in two patients, case reports","authors":"O. Yousef, M. Al-Jafari, Mohammad Jaber, Mutayam Abu-Qudairi, Raja Al-Zreqat, Mohammad Abu-Jeyyab","doi":"10.58877/japaj.v1i1.23","DOIUrl":"https://doi.org/10.58877/japaj.v1i1.23","url":null,"abstract":"Pompe disease, or type II glycogen storage disease, is a lysosomal storage disorder in which a deficiency in alpha-glucosidase results in the accumulation of glycogen, which eventually causes weakness to progressively increase and heart enlargement. \u0000 Infantile-onset and late-onset forms of Pompe illness are distinguished. The heart is the organ most impacted by glycogen buildup in infantile-onset Pompe illness. A late-onset form, however, frequently presents as a weakening of the skeletal muscles that worsens over time. \u0000The key factor used to make the diagnosis of Pompe illness is enzymology, which shows a lack of lysosomal acid alpha-glucosidase (GAA) activity, although molecular genetic testing for GAA mutations can also be used to confirm the diagnosis. \u0000Recombinant human a glucosidase alfa and a large multidisciplinary team are required for the treatment of patients with Pompe disease (rhGAA, MyozymeR). \u0000Two cases of Pompe disease are presented in this case-report. A 13-year-old female patient who is still alive and receiving enzyme replacement therapy, and a 5-month-old newborn who died from cardiomyopathy.","PeriodicalId":364383,"journal":{"name":"JAP Academy Journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129022598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}