中华消化外科杂志Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-9752.2020.01.003
Jia Fan
{"title":"Research advances in molecular classification for precision diagnosis and treatment of hepatocellular carcinoma","authors":"Jia Fan","doi":"10.3760/CMA.J.ISSN.1673-9752.2020.01.003","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-9752.2020.01.003","url":null,"abstract":"Hepatocellular carcinoma (HCC), a highly prevalent malignancy and one of the leading cause of cancer death in China, remains a major public health problem in the next decades. Owing to the tremendous achievements in early diagnosis, precision liver surgery, molecular targeted therapy and immunotherapy, we have witnessed significant improvements in the long-time survival of HCC patients, if properly treated. However, HCC is a highly heterogeneous disease. Even for patients within the same clinical stage, their clinical outcome and treatment efficacy vary significantly. Great efforts to improve the molecular classification of HCC patients are needed to foster precision medicine, paving the way for novel therapeutic strategies. Advances in multi-omics, single-cell analysis, molecular imaging and artificial intelligence will lead to better understanding of the molecular classification and refine precision treatment in HCC, ultimately excluding this neoplasm from the risk list of our Healthy China. \u0000 \u0000 \u0000Key words: \u0000Hepatic neoplasms; Molecular classification; Diagnosis; Treatment","PeriodicalId":36400,"journal":{"name":"中华消化外科杂志","volume":"19 1","pages":"28-31"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42035859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中华消化外科杂志Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-9752.2020.01.009
H. Yao
{"title":"How to promote the standardization of colorectal cancer surgical practice based upon the data analysis of Chinese Colorectal Cancer Surgery Database","authors":"H. Yao","doi":"10.3760/CMA.J.ISSN.1673-9752.2020.01.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-9752.2020.01.009","url":null,"abstract":"China has the largest group of patients with colorectal cancer in the world, however, there are few international guidelines for the diagnosis and treatment of colorectal cancer from China, or research of high-level evidence in China. In recent years, colorectal surgery has developed rapidly in China, and great progress has been made both in clinical practice and in clinical research. But there are still many imbalances and under-regulations. In 2018, Chinese Society of Colorectal Surgery led the establishment of Chinese Colorectal Cancer Surgery Database (CCCD). The retrospective and prospective data collection coming from CCCD showed that the standardization of colorectal cancer surgery and data management needed to be improved, and the awareness of clinical research needed to be further improved. Therefore, how to carry out good clinical research and obtain high-level evidence based upon CCCD will be the great challenge for colorectal surgery in China. \u0000 \u0000 \u0000Key words: \u0000Colorectal neoplasms; Standardization; Registry database; Data collection; Clinical research","PeriodicalId":36400,"journal":{"name":"中华消化外科杂志","volume":"19 1","pages":"55-58"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44015673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中华消化外科杂志Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-9752.2020.01.010
Zhanlong Shen, Y. Ye, M. Yin, Z. Gao, Jian Cao, Long Zhao
{"title":"Application value of multidisciplinary team model in normatively carrying out transanal total mesorectal excision","authors":"Zhanlong Shen, Y. Ye, M. Yin, Z. Gao, Jian Cao, Long Zhao","doi":"10.3760/CMA.J.ISSN.1673-9752.2020.01.010","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-9752.2020.01.010","url":null,"abstract":"With certain advantages of superior surgical fields and better chances for anus reservation, transanal total mesorectal excision (TaTME) is a novel surgical approach for low rectal cancer. Guidelines recommend multidisciplinary team (MDT) work as a clinical routine for standardized treatment of rectal cancer. Indication of TaTME depends on multidisciplinary discussion including preoperative staging, prediction of recurrence risks. Standardized preoperative evaluation by MDT and decisions after MDT discussion are the guarantee for the stan-dardized implementation and reasonable promotion of TaTME. Meanwhile, as a procedure for improving local efficacy of rectal cancer, TaTME could save a part of patients with low rectal cancer the trouble of neoadjuvant chemoradiotherapy based on accurate staging by radiologists. That might upgrade status of colorectal surgeons in the MDT and contribute to optimize both curative effects and health economics. \u0000 \u0000 \u0000Key words: \u0000Rectal neoplasms; Transanal total mesorectal excision; Multidisciplinary team; Surgery; Standardization; Diagnosis; Treatment; Model","PeriodicalId":36400,"journal":{"name":"中华消化外科杂志","volume":"19 1","pages":"59-62"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70016912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中华消化外科杂志Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-9752.2020.01.007
Lei Zhang
{"title":"Enlightenment and reflection of laparoscopic radical cholecystectomy","authors":"Lei Zhang","doi":"10.3760/CMA.J.ISSN.1673-9752.2020.01.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-9752.2020.01.007","url":null,"abstract":"Gallbladder cancer is a biliary malignant disease with difficulty in early diagnosis, high malignancy and poor prognosis. Radical resection is the most effective approach to improve the prognosis of patients. With the update of minimally invasive devices and the accumulation of surgeon experience, laparoscopic surgery has achieved satisfactory results in the treatment of malignant tumors of the digestive tract, but there is still controversy in its application in gallbladder cancer treatment, mainly due to lack of reliable evidence for improved survival outcomes. The current studies indicated that laparoscopic surgery could benefit some patients with early gallbladder cancer in perioperative period and survival. For advanced gallbladder cancer, although there is still no consensus on the resection extent, laparoscopic staging can prevent patients from unnecessary expanded resection. The minimally invasive process of radical cholecystectomy needs to be promoted through a high-quality diagnosis and treatment process. Only in this way can there be practical clinical evidence to guide the best clinical practice. \u0000 \u0000 \u0000Key words: \u0000Bile duct neoplasms; Treatment; Ra-dical cholecystectomy; Laparoscopy","PeriodicalId":36400,"journal":{"name":"中华消化外科杂志","volume":"19 1","pages":"46-49"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49613662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
中华消化外科杂志Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1673-9752.2020.01.008
Chang-ming Huang
{"title":"Enlightenment and reflection of splenic hilar lymph node dissection for advanced proximal gastric cancer","authors":"Chang-ming Huang","doi":"10.3760/CMA.J.ISSN.1673-9752.2020.01.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1673-9752.2020.01.008","url":null,"abstract":"Splenic hilar lymph node (LN) is the difficulty and focus of perigastric LN dissection during radical gastrectomy for advanced proximal gastric cancer (APGC). Although the new edition of Japanese Gastric Cancer Treatment Guidelines excluded the splenic hilar LN from the D2 lymphadenectomy in patients with APGC, there are still few high-level evidences. Meanwhile, the guideline recommends that splenectomy is still necessary for patients with APGC involving the greater curvature. With the support of increasing evidences, the spleen-preserving splenic hilar LN dissection has been recognized by more and more scholars. Additionally, the technique of laparoscopy provides a new method for splenic hilar LN dissection. Our center proposed a new technique named Huang′s three-step maneuver for laparoscopic spleen-preserving splenic hilar lymphadenectomy, which not only reduces the difficulty of operation, but also makes the technique easier to popularize and with a significance of minimally invasive effect. During the clinical practice, the dissection of LNs behind the splenic portal vessels is also one of the controversies. Therefore, the difficult technique of splenic hilar LN dissection not only requires us to make a technical exploration, but also requires us to explore precise indications, in order to avoid unnecessary operation in patients who do not require dissection of the No.10 LNs and to avoid missing the opportunity for radical surgery in high-risk patients because of the difficult techniques. \u0000 \u0000 \u0000Key words: \u0000Gastric neoplasms; Surgical procedure, operative; Splenic hilar lymph node; Lymphadenectomy; Laparoscopy","PeriodicalId":36400,"journal":{"name":"中华消化外科杂志","volume":"19 1","pages":"50-54"},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47403875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}