Thursday 06 October 2022 from 17:30 to 19:00最新文献

S12.3 Type I interferons induce TIE2-mediated endothelial cell dysfunction in systemic lupus erythematosus I型干扰素诱导系统性红斑狼疮中tie2介导的内皮细胞功能障碍

Thursday 06 October 2022 from 17:30 to 19:00 Pub Date : 2022-09-27 DOI: 10.1136/lupus-2022-elm2022.27

C. Rafael Vidal, S. Martinez Ramos, B. Malvar Fernández, C. Mouriño Rodríguez, I. Altabás González, JM Pego Reigosa, S. García Pérez

引用次数: 0

S04.2 Medication adherence in patients with systemic lupus erythematosus: results from a Swedish survey 系统性红斑狼疮患者的药物依从性:来自瑞典的一项调查结果

Thursday 06 October 2022 from 17:30 to 19:00 Pub Date : 2022-09-27 DOI: 10.1136/lupus-2022-elm2022.10

S. Emamikia, A. Gomez Gonzalez, T. Ådahl, G. von Perner, Y. Enman, K. Chatzidionysiou, E. Arkema, I. Parodis

引用次数: 0

S12.1 Il-16 – a urinary biomarker for proliferative lupus nephritis S12.1 Il-16 -增殖性狼疮性肾炎的尿液生物标志物

Thursday 06 October 2022 from 17:30 to 19:00 Pub Date : 2022-09-27 DOI: 10.1136/lupus-2022-elm2022.25

A. Häyry, F. Faustini, A. Zickert, A. Larsson, B. Sundelin, E. Svenungsson, V. Oke, I. Gunnarsson

引用次数: 0

S12.2 Type I interferons and their autoantibodies in the context of systemic lupus erythematosus S12.2 I型干扰素及其自身抗体在系统性红斑狼疮中的作用

Thursday 06 October 2022 from 17:30 to 19:00 Pub Date : 2022-09-27 DOI: 10.1136/lupus-2022-elm2022.26

L. Haljasmägi, H. Bradford, M. Menon, P. Peterson, M. Vanker, C. Wincup, V. Bondet, D. Duffy, D. Isenberg, K. Kisand, C. Mauri

{"title":"S12.2 Type I interferons and their autoantibodies in the context of systemic lupus erythematosus","authors":"L. Haljasmägi, H. Bradford, M. Menon, P. Peterson, M. Vanker, C. Wincup, V. Bondet, D. Duffy, D. Isenberg, K. Kisand, C. Mauri","doi":"10.1136/lupus-2022-elm2022.26","DOIUrl":"https://doi.org/10.1136/lupus-2022-elm2022.26","url":null,"abstract":"PurposeType I IFNs and their autoantibodies are implicated in the pathogenesis of Systemic lupus erythematosus (SLE), but their incidence and importance is still unclear. Neutralizing autoantibodies against IFNα have been previously reported in patients with autoimmune polyendocrinopathy syndrome type I (APS-1), rheumatoid arthritis, thymoma and more recently life-threatening COVID-19 patients. We hypothesized that autoantibodies towards type I IFNs, that develop in some patients with SLE, are neutralizing and may interfere with the course of the disease.MethodsLuciferase immunoprecipitation (LIPS) analysis was used to screen 474 SLE patient and 312 control serum samples for the presence of IFNα binding autoantibodies and determine their subclasses. Type I IFN neutralizing capacity was tested using a reporter cell line. Circulating levels of IFNα were measured with Single Molecule Array (Simoa).Results14% of SLE patients were positive for anti-IFNα and 13% were positive for anti-IFNω. The autoantibodies against IFNα were predominantly of IgG1 subclass and neutralized IFNα bioactivity in approximately one half of the positive cases. Once developed, anti-IFNα autoantibodies were present throughout the disease course. IFNα2 and -α8 were targeted first in two informative follow-up cases. The reactivity broadened to other IFNα subtypes and IFNω within several months. Serum levels of IFNα correlated negatively with anti-IFNα neutralizing titers. Patients with high levels of autoantibodies against IFNα had significantly lower levels of circulating IFNα compared to anti-IFNα negative patients. Interestingly, patients with high IFNα neutralizing capacity displayed significantly lower disease activity than patients without these autoantibodies.ConclusionsBased on our results we suggest that autoantibodies that are able to neutralize the circulating levels of all IFNα subtypes may have a beneficial effect to SLE disease course.","PeriodicalId":363462,"journal":{"name":"Thursday 06 October 2022 from 17:30 to 19:00","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127889620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0