WikiJournal of Medicine最新文献_第2页

Incidental Finding of Complete Bilateral Persistent Sciatic Arteries 偶然发现完整的双侧坐骨动脉

WikiJournal of Medicine Pub Date : 2021-01-01 DOI: 10.15347/wjm/2021.002

S. M. Ramos, Reinhardt G. Dreyer, Thandi E. Buthelezi

引用次数: 0

Working with Bipolar Disorder During the COVID-19 Pandemic: Both Crisis and Opportunity 在COVID-19大流行期间与双相情感障碍合作:危机与机遇

WikiJournal of Medicine Pub Date : 2020-04-20 DOI: 10.31234/osf.io/wg4bj

E. Youngstrom, S. Hinshaw, A. Stefana, Jun Chen, K. Michael, A. V. Van Meter, Victoria Maxwell, E. Michalak, Emma G Choplin, Logan T. Smith, C. Vincent, A. Loeb, E. Vieta

引用次数: 10

Emotional and Psychological Impact of Interpreting for Clients with Traumatic Histories on interpreters: a review of qualitative articles 有创伤史的客户对口译员的情绪和心理影响:一篇定性文章的回顾

WikiJournal of Medicine Pub Date : 2020-01-01 DOI: 10.15347/wjm/2020.003

Aasia Rajpoot, S. Rehman, P. Ali

引用次数: 1

Epidemiology of the Hepatitis D virus 丁型肝炎病毒的流行病学

WikiJournal of Medicine Pub Date : 2020-01-01 DOI: 10.15347/wjm/2020.001

M. Rizzetto

引用次数: 1

Mealtime difficulty in older people with dementia 老年痴呆症患者的进餐困难

WikiJournal of Medicine Pub Date : 2019-11-08 DOI: 10.15347/wjm/2019.006

S. Rehman, Gloria Likupe, R. Watson

引用次数: 2

Dioxins and dioxin-like compounds: toxicity in humans and animals, sources, and behaviour in the environment 二恶英和类二恶英化合物:对人类和动物的毒性、来源和在环境中的行为

WikiJournal of Medicine Pub Date : 2019-01-01 DOI: 10.15347/wjm/2019.008

J. Tuomisto

{"title":"Dioxins and dioxin-like compounds: toxicity in humans and animals, sources, and behaviour in the environment","authors":"J. Tuomisto","doi":"10.15347/wjm/2019.008","DOIUrl":"https://doi.org/10.15347/wjm/2019.008","url":null,"abstract":"Dioxins and dioxin-like compounds comprise a group of chemicals including polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF), as well as certain dioxin-like polychlorinated biphenyls (dlPCB), and potentially others. They act via a common mechanism, stimulation of aryl hydrocarbon receptor (AH receptor, AHR), a vital transcription factor in cells. There are very high differences in potency among these compounds, i.e. in the ability to stimulate the receptor. This leads to ten thousand-fold or higher differences in doses causing similar toxic effects. Most of these compounds are eliminated very slowly in the environment, animals, or humans, which makes them persistent. They are much more soluble in fat than in water, and therefore they tend to accumulate in lipid or fatty tissues, and concentrate along the food web (bioaccumulation and biomagnification). PCDD/PCDFs are formed mostly as side products in burning processes, but PCBs were oils manufactured for many purposes. Because of toxicity and persistence, dioxin-like compounds have been regulated strictly since 1980s, and their levels in the environment and animals have decreased by an order of magnitude or more. Therefore the effects on wildlife have clearly decreased, and even populations at the top of the food web such as fish-eating birds or seals have recovered after serious effects on their reproductive capacity and developmental effects in their young especially in 1970s and 1980s. This does not exclude the possibility of some remaining effects. In humans the intake is mostly from food of animal sources, but because our diet is much more diverse than that of such hallmark animals as white-tailed eagles or seals, the concentrations never increased to similar levels. However, during 1970s and 1980s effects were probably also seen in humans, including developmental effects in teeth, sexual organs, and the development of immune systems. Both scientists and administrative bodies debate at the moment about the importance of remaining risks. This is very important, because the AH receptors seem to be physiologically important regulators of growth and development of organs, immunological development, food intake and hunger, and in addition regulate enzymes protecting us from many chemicals. Thus a certain level of activation is needed, although inappropriate stimulation of the receptor is harmful. This dualism emphasizes the importance of benefit versus risk analysis. As a whole, regulating the emissions to the environment is still highly important, but one should be very cautious in limiting consumption of important and otherwise healthy food items and e.g. breast feeding. Distinct toxic effects of high doses of dioxins in humans have been clearly demonstrated by frank poisonings and the highest occupational exposures. Hallmark effects have been skin lesions called chloracne, various developmental effects of children, and a slightly increased risk of total cancer ra","PeriodicalId":36272,"journal":{"name":"WikiJournal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86895348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Western African Ebola virus epidemic 西非埃博拉病毒流行

WikiJournal of Medicine Pub Date : 2019-01-01 DOI: 10.15347/wjm/2019.001

O. Anis

{"title":"Western African Ebola virus epidemic","authors":"O. Anis","doi":"10.15347/wjm/2019.001","DOIUrl":"https://doi.org/10.15347/wjm/2019.001","url":null,"abstract":"The Western African Ebola virus epidemic (2013–2016) was the most widespread outbreak of Ebola virus disease (EVD) in history—causing major loss of life and socioeconomic disruption in the region, mainly in the countries of Guinea, Liberia, and Sierra Leone. The first cases were recorded in Guinea in December 2013; later, the disease spread to neighboring Liberia and Sierra Leone,[1] with minor outbreaks occurring elsewhere. It caused significant mortality, with the case fatality rate reported which was initially considerable,[1][2][3][note 1] while the rate among hospitalized patients was 57–59%,[4] the final numbers 28,616 people, including 11,310 deaths, for a case-fatality rate of 40%.[5]* Small outbreaks occurred in Nigeria and Mali,[6][7]* and isolated cases were recorded in Senegal,[8] the United Kingdom and Italy.[3][9] In addition, imported cases led to secondary infection of medical workers in the United States and Spain but did not spread further.[10]*[11] The number of cases peaked in October 2014 and then began to decline gradually, following the commitment of substantial international resources. As of 8 May 2016, the World Health Organization (WHO) and respective governments reported a total of 28,616 suspected cases and 11,310 deaths[12] (39.5%), though the WHO believes that this substantially understates the magnitude of the outbreak.[13][14]* On 8 August 2014, a Public Health Emergency of International Concern was declared[15] and on 29 March 2016, the WHO terminated the Public Health Emergency of International Concern status of the outbreak.[16][17][18] Subsequent flare-ups occurred; the last was declared over on 9 June 2016, 42 days after the last case tested negative on 28 April 2016 in Monrovia.[19] The outbreak left about 17,000 survivors of the disease, many of whom report post-recovery symptoms termed post-Ebola syndrome, often severe enough to require medical care for months or even years. An additional cause for concern is the apparent ability of the virus to \"hide\" in a recovered survivor's body for an extended period of time and then become active months or years later, either in the same individual or in a sexual partner.[20]* In December 2016, the WHO announced that a two-year trial of the rVSV-ZEBOV vaccine appeared to offer protection from the variant of EBOV responsible for the Western Africa outbreak. The vaccine has not yet been given regulatory approval, but it is considered to be effective and is the only prophylactic which offers protection hence 300,000 doses have been stockpiled.[21][22]* Note: Due to the nature of the subject, many citations are drawn from contemporary media reports as sources and have been marked with an *.","PeriodicalId":36272,"journal":{"name":"WikiJournal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89737363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

An overview of Lassa fever 拉沙热概述

WikiJournal of Medicine Pub Date : 2019-01-01 DOI: 10.15347/WJM/2019.002.2

Abdulmutalab Musa

{"title":"An overview of Lassa fever","authors":"Abdulmutalab Musa","doi":"10.15347/WJM/2019.002.2","DOIUrl":"https://doi.org/10.15347/WJM/2019.002.2","url":null,"abstract":"Lassa fever is a viral hemorrhagic fever caused by Lassa virus (Lassa mammarenavirus), a negative-sense singlestranded RNA virus of the Arenaviridae family.[1][2] In most cases Lassa virus infection is asymptomatic (presenting no symptom).[1] When symptomatic it is characterized by mild acute febrile disease to a chronic fatal disease with severe toxaemia, capillary leak, hemorrhagic situations, shock and multiple organ failure.[3] Early diagnosis of Lassa fever is very important because of the transmissibility of infection, the need for potent isolation of infected persons and for containing potentially infectious specimens during laboratory testing.[4][5] Lassa fever was first elucidated in the 1950s, but the virus was not recognized until 1969 when it infected two missionary nurses in Lassa Village, Borno State, Northeastern Nigeria.[1] Natal multimammate rat or common African rat of Mastomys genus are the reservoir of Lassa virus.[1] When the rodents become infected with Lassa virus, they infect humans through their urine and faeces, but remain unharmed.[6] Because of its similarities with other febrile diseases such as malaria, typhoid, Ebola hemorrhagic fever, early detection is difficult. Thus when persons have persistent fever not responding to normal conventional therapies, they should be screened for other possible causes (especially in endemic regions). When the presence of Lassa fever is established in a community, immediate isolation of infected individuals, screening, standard infection prevention and control practices and meticulous contact tracing can halt outbreaks.[1] Treatment involves supportive measures and early use of the antiviral drug ribavirin. Note: This article has been updated since its initial publication on 15 Jun 2019 (summary of changes). The previous version is archived at this link as a record.","PeriodicalId":36272,"journal":{"name":"WikiJournal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83353648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Orientia tsutsugamushi, the agent of scrub typhus 恙虫病东方体，恙虫病的病原

WikiJournal of Medicine Pub Date : 2019-01-01 DOI: 10.15347/wjm/2019.004

K. Lalchhandama

{"title":"Orientia tsutsugamushi, the agent of scrub typhus","authors":"K. Lalchhandama","doi":"10.15347/wjm/2019.004","DOIUrl":"https://doi.org/10.15347/wjm/2019.004","url":null,"abstract":"Orientia tsutsugamushi is a mite-borne bacterium belonging to the family Rickettsiaceae and is responsible for the disease scrub typhus in humans. It is an obligate intracellular parasite of trombiculid mites, in which natural transmission is maintained from the female to its eggs (transovarial transmission) and from the eggs to adults (transstadial transmission). With a genome of only 2.0–2.7 Mb, it has the most repeated DNA sequences among bacteria. It is transmitted by mite larvae (chiggers) from rodents, the natural hosts of mites, to humans through accidental bites. Naosuke Hayashi first described it in 1920, giving it the name Theileria tsutsugamushi, but it was renamed to Orientia tsutsugamushi in 1995, owing to its unique properties. Unlike other Gram-negative bacteria, its cell wall lacks lipophosphoglycan and peptidoglycan. It instead has a unique 56-kDa type-specific antigen (TSA56), which gives rise to many strains (sub-types) of the bacterium such as Karp, Gilliam, Kato, Shimokoshi, Kuroki, and Kawasaki. It is most closely related to Candidatus Orientia chuto, a species described in 2010. Primarily indicated by undifferentiated febrile illnesses, the infection can be complicated and often fatal. Diagnosis is difficult and requires laborious detection methods such as the Weil–Felix test, rapid immunochromatographic test, immunofluorescence assays, ELISA, or PCR. Eschar, if present on the skin, is a good diagnostic indicator. One million infections are estimated to occur annually in the endemic region called the Tsutsugamushi Triangle, which covers the Russian Far East in the north, Japan in the east, northern Australia in the south, and Afghanistan in the west. However, infections have also spread to Africa, Europe and South America. Antibiotics such as azithromycin and doxycycline are the main prescription drugs. There is no vaccine for the infection.","PeriodicalId":36272,"journal":{"name":"WikiJournal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82485234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Readability of English Wikipedia's health information over time 英文维基百科健康信息随时间变化的可读性

WikiJournal of Medicine Pub Date : 2019-01-01 DOI: 10.15347/wjm/2019.007

Aleksandar Brezar, James M Heilman

{"title":"Readability of English Wikipedia's health information over time","authors":"Aleksandar Brezar, James M Heilman","doi":"10.15347/wjm/2019.007","DOIUrl":"https://doi.org/10.15347/wjm/2019.007","url":null,"abstract":"Objective: To assess and compare the readability of the twenty-five most accessed English medical articles on Wikipedia 0, 1, 5 and 10 years ago. Design: The twenty-five most accessed Wikipedia articles on diseases in August 2018 were identified for this study. The content of the lead paragraphs was formatted to remove any hyperlinks, decimals, colons, semicolons and periods used in abbreviations. An online tool was then used to assign a score to the readability of each text sample using the following formulae: Gunning FOG (Frequency of Gobbledygook) index, Flesch-Kincaid Grade Level (F-K), Simple Measure of Gobbledygook (SMOG) and Flesch Reading Ease (FRE). A single reading grade (RG) was calculated for each passage by averaging scores from the FOG, SMOG and F-K tests to facilitate interpretation. These steps were repeated for the lead paragraph of the same medical articles as visible 1, 5 and 10 years ago on Wikipedia. Main Outcome Measures: Readability grade (RG) and reading ease (FRE score) Results: The average (mean) RG of the twenty-five most accessed Wikipedia articles on diseases in 2018 was 12.73 (95% CI = 12.07-13.38), and the average FRE score was 39.91 (95% CI = 36.09-43.74), a score considered “difficult”. The number of articles that were easier to read (lower RG and higher FRE) in 2018 was significantly higher when compared to 2013 and 2008 (p<0.0001), but not significantly different when compared to 2017. When paired by titles and compared over time, a statistically significant difference in readability (RG and FRE) was seen in 2018 when compared to earlier years: 2017 (Friedman Chi-squared=13.70, p=0.0002), 2013 (Friedman Chisquared=46.08, p<0.0001) and 2008 (Friedman Chi-squared=33.03, p=0.0001). None of the pages were written at the 7th or 8th grade level as recommended by the U.S. National Institutes of Health (NIH). Conclusions: The average readability of English Wikipedia’s medical pages has improved in 2018 when compared to previous years. Most of the health information, however, remains written at a level above the reading ability of average adults.","PeriodicalId":36272,"journal":{"name":"WikiJournal of Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86891900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6