Horm. metabol. Res.最新文献

RIN m5F (Rat Insulinoma) Cells Possess Receptors for Atrial Natriuretic Peptide (ANP) and a Functioning cGMP System RIN m5F(大鼠胰岛素瘤)细胞具有心房钠肽(ANP)受体和功能良好的cGMP系统

Horm. metabol. Res. Pub Date : 1988-12-01 DOI: 10.1055/s-2007-1010944

E. Verspohl, M. Kühn, H. Ammon

{"title":"RIN m5F (Rat Insulinoma) Cells Possess Receptors for Atrial Natriuretic Peptide (ANP) and a Functioning cGMP System","authors":"E. Verspohl, M. Kühn, H. Ammon","doi":"10.1055/s-2007-1010944","DOIUrl":"https://doi.org/10.1055/s-2007-1010944","url":null,"abstract":"Atrial natriuretic peptide (ANP) has been shown to be present in rat plasma as fragment (ANP-(99-126)) containing 28 amino acids {Schwartz, Getter, Manning, Siegel, Fok, Smith and Needleman 1985). ANP exerts a wide spectrum of cardiovascular, renal and endocrine actions (reviewed by Weidman, Gnadinger, Ziswiler, Shaw, Bachmann, Rascher, Uehlinger, Hosier and Reubi 1986): ANP increases circulating insulin levels by 50% while plasma glucose levels remain unaffected (Weidmann et al. 1986; Weidmann, Hellmiller, Uehlinger, Lang, Gnddiger, Hasler, Shaw and Bachmann 1986a). After binding to specific receptors in various cells ANP activates a particulate guanylate cyclase which extremely elevates cGMP levels (Winquist, Faison, Waldman, Schwarz, Murad and Rapoport 1984; Gerzer, Tremblay, Pang, Vinay, DeLean and Hamet 1985). It can be speculated whether the aforementioned elevation of plasma insulin levels is a direct or indirect effect of ANP. Insulin-secreting cell lines from the rat are a convenient model for studies of hormone release mechanisms (Wollheim and Pozzan 1984). It was the aim of the present study (first) to prove an ANP-sensitive cGMP system in RIN m5F cells and (second) to investigate a possible direct effect of ANP via ANP receptors on insulin release.","PeriodicalId":361893,"journal":{"name":"Horm. metabol. Res.","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1988-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133893193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Professor Albert E. Renold Albert E. Renold教授

Horm. metabol. Res. Pub Date : 1988-11-01 DOI: 10.1055/S-2007-1010931

E. Pfeiffer, G. Reaven

引用次数: 0

Introductory Remarks of the Editor-in-Chief 总编辑导言

Horm. metabol. Res. Pub Date : 1988-07-01 DOI: 10.1055/S-2007-1010847

E. Pfeiffer

{"title":"Introductory Remarks of the Editor-in-Chief","authors":"E. Pfeiffer","doi":"10.1055/S-2007-1010847","DOIUrl":"https://doi.org/10.1055/S-2007-1010847","url":null,"abstract":"A multitude of reasons exist to study phylogeny. Man is part of the biological entity of all life on earth. Besides, hemoglobins insulin structures of different vertebrates contribute substantially to the clarification of evolutionary steps on a molecular basis. The animal kingdom is divided into two major groups. Most of the invertebrates (worms, arthropodes and molluscs) belong to the protostomia, while deuterostomia contain ectinoderms, prochordates and all the vertebrates. It is a fascinating revelation to find homologies on a molecular basis between the two groups. As early as 1966 my own group was able to demonstrate insulin-like activity in Helix pomatia, in the footpad and in the hepatopancreas. One of the most successful laboratories, headed by Sture Falkmer, published the insulin structure of the hag fish, later on the decisive question was, whether or not unicellular organism produce insulin too. Over the past ten years several groups working in the field of Comparative Endocrinology claimed that classical peptide hormones, especially of the insulin family, must have been present in earlier, presumably less complicated forms. Peptide hormone-producing cells have a common origin in the neural ectoderm. However, in this area several principal difficulties arise:","PeriodicalId":361893,"journal":{"name":"Horm. metabol. Res.","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1988-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127914748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutant Insulin Syndromes 突变型胰岛素综合征

Horm. metabol. Res. Pub Date : 1988-03-01 DOI: 10.1055/s-2007-1010792

A. Vinik, G. Bell

引用次数: 0

Influence of the Thymus Extract on the Immunological Function of Animals with Experimental Diabetes 胸腺提取物对实验性糖尿病动物免疫功能的影响

Horm. metabol. Res. Pub Date : 1987-01-01 DOI: 10.1055/s-2007-1011723

M. Hadzija, M. Slijepčević, V. Šverko, M. Poljak‐Blaži

{"title":"Influence of the Thymus Extract on the Immunological Function of Animals with Experimental Diabetes","authors":"M. Hadzija, M. Slijepčević, V. Šverko, M. Poljak‐Blaži","doi":"10.1055/s-2007-1011723","DOIUrl":"https://doi.org/10.1055/s-2007-1011723","url":null,"abstract":"After immunization with SRBC, the number of plaque-forming cells (PFC) in the spleen of alloxan-diabetic mice, in nondiabetic TIR mice and in alloxan-diabetic TIR mice was significantly decreased as compared with control non-diabetic donors. The ability of lymphocytes from alloxan-diabetic mice to adoptively restore the suppressed immune response of TIR mice, was reduced in comparison with the effect of lymphocytes from normal, nondiabetic donors. Local GVH reaction in nondiabetic rat recipients provoked by lymphocytes from control healthy mice was 5.6 +/- 0.7 mm. Significantly lower rate of local GVH reaction after injection of lymphocytes from diabetic donors was found in diabetic as in nondiabetic recipients as well. Treatment of alloxan-diabetic mice with thymus extract or with insulin, partly restored depressed function of the humoral and cellular system. Treatment of diabetic mice with both thymus extract and insulin, was even more effective in restoring of their immune reactivity. Diabetic condition strongly influenced the function of the immune system. This could be attributed to depletion of T-lymphocytes, changed relations between the lymphocyte subpopulations in diabetic donors, and disturbance of lymphocyte metabolism.","PeriodicalId":361893,"journal":{"name":"Horm. metabol. Res.","volume":"122 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1987-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116842836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Trifluoperazine Inhibits Thyrotropin-Releasing Hormone-Stimulated TSH Secretion 三氟拉嗪抑制促甲状腺激素释放激素刺激的促甲状腺激素分泌

Horm. metabol. Res. Pub Date : 1986-09-01 DOI: 10.1055/s-2007-1012389

I. Z̆ofková, J. Bednar

{"title":"Trifluoperazine Inhibits Thyrotropin-Releasing Hormone-Stimulated TSH Secretion","authors":"I. Z̆ofková, J. Bednar","doi":"10.1055/s-2007-1012389","DOIUrl":"https://doi.org/10.1055/s-2007-1012389","url":null,"abstract":"In previous work changes of the thyrotropic secretion after administration of some substances affecting the calcium content in the cytosol were demonstrated. The object of the present investigation was to assess the hormonal response to the administration of trifluoperazine, a psychopharmaceutical preparation, the main mechanism of its action being the inactivation of the cytosol receptor for the calcium signal - calmodulin. The poor utilization of intracellular calcium of the secretory cell is then the factor which inhibits secretion proper. The thyrotropic secretory reserve (delta TSH) was assessed in the same subjects before and after trifluoperazine administration by the TRH test as the difference of values at rest and TRH-stimulated TSH levels during the 20th, 30th, 40th and 60th minute following intravenous administration of 200 micrograms TRH. It was revealed that this calmodulin antagonist administered for one week in amounts of 6-12 mg per day by mouth significantly inhibits the secretory response of TSH to TRH in healthy subjects during the 20th and 40th min. (P less than 0.05). The reproducibility of the TRH test repeated in a group of subjects not treated with trifluoperazine, however, under equal conditions and after the same time intervals as in the experiment with trifluoperazine was very satisfactory and thus physiological inhibition caused by repeated TRH administration could be ruled out. The inhibition of the secretory TSH response to TRH can be therefore considered the consequence of the direct effect of trifluoperazine on the thyrotropic secretory mechanism. Trifluoperazine significantly reduced serum calcium levels and raised phosphate levels, while it did not affect the blood levels of magnesium.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":361893,"journal":{"name":"Horm. metabol. Res.","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1986-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127206401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Behavior of Hepatic Phosphorylase b Kinase, Phosphorylase a and b after Administration of Glucagon to Patients with Glycogen Storage Disease Type VIa 胰高血糖素治疗VIa型糖原储存病后肝脏磷酸化酶b激酶、磷酸化酶a和b的变化

Horm. metabol. Res. Pub Date : 1986-08-01 DOI: 10.1055/s-2007-1012370

D. Pieniążek, E. Pronicka, J. Pawłowska

引用次数: 1

Prolactin Response to Morphine and Stress in Brattleboro Hetero- and Homozygous Rats Brattleboro杂合子和纯合子大鼠对吗啡和应激的催乳素反应

Horm. metabol. Res. Pub Date : 1985-07-01 DOI: 10.1055/s-2007-1013552

J. Jur̀čovičová, M. Vigaš

引用次数: 1

The Depot-Form of Glucocorticoid Decreases Cortisol but not ACTH and Beta-Endorphin Levels in Human Plasma 储存形式的糖皮质激素降低皮质醇，但不能降低人血浆中ACTH和-内啡肽水平

Horm. metabol. Res. Pub Date : 1983-02-01 DOI: 10.1055/S-2007-1018642

A. Łypka, J. Łazowski, A. Szczudlik, Z. Wasek

{"title":"The Depot-Form of Glucocorticoid Decreases Cortisol but not ACTH and Beta-Endorphin Levels in Human Plasma","authors":"A. Łypka, J. Łazowski, A. Szczudlik, Z. Wasek","doi":"10.1055/S-2007-1018642","DOIUrl":"https://doi.org/10.1055/S-2007-1018642","url":null,"abstract":"Although the inhibitory effect of exogenous glucocorticoids on the hypothalamus-pituitary-adrenal axis has been long known, the site and mechanism of this effect has not been definitely established. There are many evidences from in vivo and in vitro animal studies indicating that synthetic corticosteroids, such as dexamethasone, suppress ACTH synthesis or release from the pituitary gland. The studies on this topic in human subjects are still scant (Fang, Tricon, Robertson and Meltzer 1981 ; Fehm, Voigt, Kummer, Lang and Pfeiffer 1979). Our study was undertaken to determine the influence of the depot-form of glucocorticoid administered intramuscularly in a common ly used dose on plasma Cortisol, ACTH and beta-endorphin (B-EP) levels. We examined 12 asthmatic patients of both sexes without any hormonal and metabolic disorders. 60 mg of acetonide triamcinolone (Kenalog 40®, E.R. Squibb & S.) was injected i.m. The blood samples were collected immediately before and on the 3-rd, 7-th, 14-th, 21-st and 35-th day after Kenalog injection, always between 8.00 and 10.00 a.m. All the investigated substances were determined radioimmunologically using commercial kits (Cortisol and ACTH - Amersham, B-EP - New England Nuclear). Our findings (see Fig. 1) suggest that one dose of the depot-form of triamcinolone has not effect on ACTH plasma level and are different from the results described by Clement-Jones, Lowry, Ress and Besser (1980) who have observed a decrease of plasma ACTH after 2 mg dexamethasone given to 7 normal subjects at","PeriodicalId":361893,"journal":{"name":"Horm. metabol. Res.","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1983-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127278719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Effect of Streptozotocin Diabetes on the Pituitary-Testicular Axis in the Rat 链脲佐菌素糖尿病对大鼠垂体-睾丸轴的影响

Horm. metabol. Res. Pub Date : 1982-12-01 DOI: 10.1055/s-2007-1019121

J. Díaz, A. Benitez, C. Galaz

引用次数: 0