American Research Journal of Pharmacy最新文献

Assessment of Components, Antibacterial and Antioxidant Effects of Vernonia Amygdalina Del. 苦扁桃的成分、抗菌及抗氧化作用评价。

American Research Journal of Pharmacy Pub Date : 1900-01-01 DOI: 10.21694/2380-5706.21001

S. Duong-Quy, Trinh Tang-Le-Quynh, Linh Nguyen-Thi-Nhat, Linh Nguyen-Thi-Thuy, -. HaNgo-Duy, Tuy, Tram Tang-Thi-Thao, T. Nguyen-Van, Chi Nguyen-Thi-Lan, Nguyet Do-Thi, Ha Le-Thi-Ngoc, Huong Cao-Thi-Thu, Dinh Tran-Thanh, Hung Tran-Quoc

{"title":"Assessment of Components, Antibacterial and Antioxidant Effects of Vernonia Amygdalina Del.","authors":"S. Duong-Quy, Trinh Tang-Le-Quynh, Linh Nguyen-Thi-Nhat, Linh Nguyen-Thi-Thuy, -. HaNgo-Duy, Tuy, Tram Tang-Thi-Thao, T. Nguyen-Van, Chi Nguyen-Thi-Lan, Nguyet Do-Thi, Ha Le-Thi-Ngoc, Huong Cao-Thi-Thu, Dinh Tran-Thanh, Hung Tran-Quoc","doi":"10.21694/2380-5706.21001","DOIUrl":"https://doi.org/10.21694/2380-5706.21001","url":null,"abstract":"Vernonia amygdalina Del. Asteraceae family, is used traditionally to treat inflammation, pain, fever and cancer. This study aimed to determine the bioactive composition of leaf extracts of Vernonia amygdalina Del. for evaluating the antibacterial and anti-oxidant effects of these extracts. Analysis of the active ingredients in the aqueous extracts of Vernonia amygdalina leaves showed the presence of pharmaceutical substances such as: tannins, flavonoids, saponins, alkaloid, phenol, phytalate and oxalate. The results of determining the antibacterial activity of fresh and dried leaf extracts with concentrations of 100%, 50%, 25%, 12,5%, and 7,5% showed that Staphylococcus aureus and Escherichia coli are very sensitive to these extracts, especially the aqueous extracts. The antioxidant activity of Vernonia amygdalina leaf and stem extracts at different concentrations was determined by the DPPH and β-carotene-linoleic acid method compared with BHA, BHT, and quercetin. A positive correlation of radical scavenging activity (p value < 0.05) was observed in all the extracts from Vernonia amygdalina by their electron transfer or hydrogen donating ability.","PeriodicalId":360753,"journal":{"name":"American Research Journal of Pharmacy","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131848215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Case Report of Peripheral Cyanosis Associated with a Rare Adverse Reaction of Vaxzevria - AstraZeneca COVID-19 Vaccine Vaxzevria - AstraZeneca COVID-19疫苗罕见不良反应伴外周发绀1例报告

American Research Journal of Pharmacy Pub Date : 1900-01-01 DOI: 10.21694/2380-5706.21003

引用次数: 1

Evaluation of Phytochemical Constituents and Sedative Activity of Passiflora Edulis Sims Extracts 西番莲提取物的化学成分及镇静作用研究

American Research Journal of Pharmacy Pub Date : 1900-01-01 DOI: 10.21694/2380-5706.21002

H. T. Quoc, Trinh Tang-Le-Quynh, Nguyet Do-Thi, Chi Nguyen-Thi-Lan, T. Nguyen-Van, Hà, Le-Thi-Ngoc, Tram Tang-Thi-Thao, Anh Nguyen-Tuan, Ha Ngo-Duy-Tuy, S. Duong-Quy

{"title":"Evaluation of Phytochemical Constituents and Sedative Activity of Passiflora Edulis Sims Extracts","authors":"H. T. Quoc, Trinh Tang-Le-Quynh, Nguyet Do-Thi, Chi Nguyen-Thi-Lan, T. Nguyen-Van, Hà, Le-Thi-Ngoc, Tram Tang-Thi-Thao, Anh Nguyen-Tuan, Ha Ngo-Duy-Tuy, S. Duong-Quy","doi":"10.21694/2380-5706.21002","DOIUrl":"https://doi.org/10.21694/2380-5706.21002","url":null,"abstract":"Passiflora edulis Sims, Passifloraceae is widely grown in Lam Dong, Vietnam for its fruit as a beverage. This study is an attempt to explore the phytochemical constituents using the chemical reagents and evaluate the sedative, anti anxiety activity of ethanol and water extract of leaves and rhizomes using the elevated plus-maze model and dark light box test in mice. The phytochemical screening results showed the presence of alkaloids, tannins, phenolic compounds, flavonoids in leaves and rhizomes of Passiflora edulis, and the leaf have more alkaloids and flavonoids than the rhizomes. Moreover, treatment with the leaf extract significantly (p<0.001) demonstrated sedative, anti-anxiety activity as compared to vehicle control, in which the activity of ethanol extracts was significantly (p<0.001) better than water extracts. In addition, at dosage of 300mg/kg the leaf ethanol extracts showed significantly (p<0.001) lower than diazepam 2mg/kg. These finding are an important factor in evaluating the pharmacological effects and orienting the process of preparing sedative tea products using Passiflora edulis leaf grown in Lam Dong, Vietnam in the future. KeywORDs: anti-anxiety, phytochemical, elevated plus-maze, dark light box, sedative Passiflora edulis Sims","PeriodicalId":360753,"journal":{"name":"American Research Journal of Pharmacy","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128449844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns of Self Medication Among Educated and Uneducated Population in a University Setting in Lahore, Pakistan: A Cross Sectional Survey 巴基斯坦拉合尔一所大学中受教育和未受教育人群的自我用药模式:一项横断面调查

American Research Journal of Pharmacy Pub Date : 1900-01-01 DOI: 10.21694/2380-5706.19001

Sehrish Khalid, Ishrat Younus, Saima Hussain, Faiza Naveed, Javaid Iqbal

{"title":"Patterns of Self Medication Among Educated and Uneducated Population in a University Setting in Lahore, Pakistan: A Cross Sectional Survey","authors":"Sehrish Khalid, Ishrat Younus, Saima Hussain, Faiza Naveed, Javaid Iqbal","doi":"10.21694/2380-5706.19001","DOIUrl":"https://doi.org/10.21694/2380-5706.19001","url":null,"abstract":"Background and Objective: Self-medication is gaining attention and is becoming a public health concern. Malpractice of self-medication is associated with risks such as misdiagnosis, overdose, prolonged duration, drug interactions and poly-pharmacy; which causes increased burden on the individual and is problematic in the elderly. This study evaluated the prevalence and patterns of self-medication among Educated and Uneducated population in a university setting in Pakistan. Methods: A descriptive crosssectional study was conducted in 100 individuals (educated: 50 and uneducated: 50). A questionnaire was filled consisting questions related to symptoms that necessitate self-medication, motive for self-medication and the sources of information about medication. Results: There was no significant difference in prevalence of self-medication in educated (68%) and uneducated samples (60%). Headache (32%), fever (30%), cough (16%) and gastric problems (8%) were the common symptoms for which self-medication were sought. However, Self-mediation for headache (36% vs 28%) and fever (32% vs 28%) was significantly higher in uneducated vs educated sample. The main reasons to selfmedicate among educated population vs uneducated included conditions not serious (48% vs 32%); lack of time (48% vs. 20%), whereas, 44% uneducated reported to save money as compared to 4% educated sample. The common source for self-medication in both the samples were past experience (56%) and advice from others (24%), however, advertisement as a source of self-medication prevailed in uneducated sample (20%) as compared to educated sample (8%). Conclusion: Self-medication is prevalent in educated and uneducated population. The drug authorities must regulate policies to provide safe and cost effective products, in particular to safe antibiotic usage and prevent adverse effects of drugs. Standards should be applied to the provision of information and advertisement to ensure responsible self-medication.","PeriodicalId":360753,"journal":{"name":"American Research Journal of Pharmacy","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125318910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0