C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS最新文献

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Role of LIM Kinase 1 in Driving Epithelial Plasticity in COPD LIM激酶1在COPD中驱动上皮可塑性中的作用
C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6142
C. Swaby, K. Wilmsen, A. Wally, A. Lagowala, C. Cortez, A. Niederkofler, B. Ghosh, V. Sidhaye
{"title":"Role of LIM Kinase 1 in Driving Epithelial Plasticity in COPD","authors":"C. Swaby, K. Wilmsen, A. Wally, A. Lagowala, C. Cortez, A. Niederkofler, B. Ghosh, V. Sidhaye","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6142","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6142","url":null,"abstract":"","PeriodicalId":358595,"journal":{"name":"C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS","volume":"141 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116377810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Baff-MYC Axis in the Vascular Niche Drives B Cell Recruitment and Proliferation in Severe Emphysema 血管壁龛中的Baff-MYC轴驱动严重肺气肿中的B细胞募集和增殖
C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6149
N. McKenna, S. Ochsner, J. Rojas-Quintero, R. San José Estépar, I. Rosas, F. Kheradmand, F. Polverino
{"title":"A Baff-MYC Axis in the Vascular Niche Drives B Cell Recruitment and Proliferation in Severe Emphysema","authors":"N. McKenna, S. Ochsner, J. Rojas-Quintero, R. San José Estépar, I. Rosas, F. Kheradmand, F. Polverino","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6149","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6149","url":null,"abstract":"","PeriodicalId":358595,"journal":{"name":"C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS","volume":"51 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130331702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crosstalk Between Memory B Cells and Fibroblasts Contributes to COPD Pathogenesis 记忆B细胞和成纤维细胞之间的串扰有助于COPD的发病
C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6151
K. Bracke, M. Jacobs, J. Anckaert, A. Faiz, F. Van Gaever, S. Verschraegen, B. Salhi, T. Schynkel, K. Venken, D. Elewaut, P. Hansbro, G. Brusselle, P. Mestdagh, Leen Seys
{"title":"Crosstalk Between Memory B Cells and Fibroblasts Contributes to COPD Pathogenesis","authors":"K. Bracke, M. Jacobs, J. Anckaert, A. Faiz, F. Van Gaever, S. Verschraegen, B. Salhi, T. Schynkel, K. Venken, D. Elewaut, P. Hansbro, G. Brusselle, P. Mestdagh, Leen Seys","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6151","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6151","url":null,"abstract":"","PeriodicalId":358595,"journal":{"name":"C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116238340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of HuR Depletion in the Airway Epithelium in COPD 慢性阻塞性肺病患者气道上皮HuR耗竭的影响
C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6155
A. Dabo, O. Evgrafov, T. Feng, M. Salathé, N. Baumlin, P. Geraghty, R. Foronjy
{"title":"The Effect of HuR Depletion in the Airway Epithelium in COPD","authors":"A. Dabo, O. Evgrafov, T. Feng, M. Salathé, N. Baumlin, P. Geraghty, R. Foronjy","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6155","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6155","url":null,"abstract":"","PeriodicalId":358595,"journal":{"name":"C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114793098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exhausted CD8+ T Cells Interacting With Myeloid and Non-immune Cells in the COPD Pathogenesis: Single-cell Analysis of Human Lung Tissue 衰竭CD8+ T细胞与髓系和非免疫细胞在COPD发病机制中的相互作用:人肺组织的单细胞分析
C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6152
S. Shin, K.-T. Kim, J. Kim, K. Han, D. Park, E. Choi, S.W. Lee, H.Y. Park
{"title":"Exhausted CD8+ T Cells Interacting With Myeloid and Non-immune Cells in the COPD Pathogenesis: Single-cell Analysis of Human Lung Tissue","authors":"S. Shin, K.-T. Kim, J. Kim, K. Han, D. Park, E. Choi, S.W. Lee, H.Y. Park","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6152","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6152","url":null,"abstract":"","PeriodicalId":358595,"journal":{"name":"C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117033116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accumulation of PiZ Alpha-1 Antitrypsin Induces Pulmonary Toxicity PiZ α -1抗胰蛋白酶积累诱导肺毒性
C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6147
X. Ma, M. Goldklang, A. Gerber, K. Stearns, J. D'Armiento
{"title":"Accumulation of PiZ Alpha-1 Antitrypsin Induces Pulmonary Toxicity","authors":"X. Ma, M. Goldklang, A. Gerber, K. Stearns, J. D'Armiento","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6147","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6147","url":null,"abstract":"","PeriodicalId":358595,"journal":{"name":"C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132930955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophage Inflammatory and Metabolic Function Is Reduced With Loss of Adenine Nucleotide Translocase 1 (ANT1) in COPD 慢性阻塞性肺病患者腺嘌呤核苷酸转位酶1 (ANT1)缺失导致巨噬细胞炎症和代谢功能降低
C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6156
J. Sui, J. Shi, S. Shiva, C. Kliment
{"title":"Macrophage Inflammatory and Metabolic Function Is Reduced With Loss of Adenine Nucleotide Translocase 1 (ANT1) in COPD","authors":"J. Sui, J. Shi, S. Shiva, C. Kliment","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6156","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6156","url":null,"abstract":"","PeriodicalId":358595,"journal":{"name":"C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS","volume":"123 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121343336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pulmonary Epithelial Gain-of-Function Toxicity in Alpha-1 Antitrypsin Deficiency α -1抗胰蛋白酶缺乏症的肺上皮功能获得毒性
C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6144
K. Abo, C. Merritt, M. Basil, S. Lin, E. Cantu, M. Morley, P. Bawa, E. Morrisey, A.A. Wilson
{"title":"Pulmonary Epithelial Gain-of-Function Toxicity in Alpha-1 Antitrypsin Deficiency","authors":"K. Abo, C. Merritt, M. Basil, S. Lin, E. Cantu, M. Morley, P. Bawa, E. Morrisey, A.A. Wilson","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6144","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6144","url":null,"abstract":"","PeriodicalId":358595,"journal":{"name":"C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125415113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical Activation of Protein Phosphatase 2A Slows Progression of Alpha-1 Antitrypsin Deficiency Associated Loss of Lung Function 蛋白磷酸酶2A的化学激活减缓α -1抗胰蛋白酶缺乏相关肺功能丧失的进展
C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6141
H. Ahmed, M. Pillai, M. Ohlmeyer, L. Costanzo, B. Jundi, C. Mueller, P. Geraghty
{"title":"Chemical Activation of Protein Phosphatase 2A Slows Progression of Alpha-1 Antitrypsin Deficiency Associated Loss of Lung Function","authors":"H. Ahmed, M. Pillai, M. Ohlmeyer, L. Costanzo, B. Jundi, C. Mueller, P. Geraghty","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6141","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6141","url":null,"abstract":"Introduction/rationale to the study: We previously reported that the activity of protein phosphatase 2A (PP2A), a serine threonine phosphatase, is reduced in cells from alpha‐1 antitrypsin (AAT) deficient patients. Our group recently demonstrated that chemical activation of PP2A reduces loss of lung function in smoke‐exposed mice. Here we hypothesis that treatment with a PP2A activator would reduce loss of lung function decline in aged AAT deficient mice. Methods used: Male and female age‐matched Serpina1a‐e knockout mice daily received 5 mg/kg of an improved small molecule activator of PP2A, ATUX‐792, by oral administration for 4 months. Forced oscillation and expiratory measurements were recorded in each animal using the Scireq Flexivent System. Airspace enlargements were quantified by mean linear intercept measurements. The PP2A activator utilized here, ATUX‐792, is a tricyclic‐sulfonamide compound with improved metabolic stability and oral bioavailability compared to the prototype PP2A activator used in our previous study. Results of the study: Long‐term ATUX‐792 administration resulted in no notable toxicity in mice, with external appearance, behavior, and body weight similar to vehicle groups. As expected, aged AAT deficient animals receiving a placebo had changes in pressure volume loops, airway inflammation, lung compliance, inspiratory capacity and FEV0.05/FVC compared to wild type age matched controls. Importantly, treatment with ATUX‐792 reduced progression of these disease parameters in AAT deficient mice. ATUX‐792 treated animals had enhanced PP2A activity within their lungs and reduced phosphorylation of MAP kinases. Conclusions of the study: Our study indicates that the decrease in PP2A activity that occurs in AAT deficiency could be restored by PP2A","PeriodicalId":358595,"journal":{"name":"C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131471644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apoptosis Inhibitor of Macrophage (AIM)/CD5l Is Involved in the Pathogenesis of Emphysema 巨噬细胞凋亡抑制剂(AIM)/CD5l参与肺气肿的发病机制
C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS Pub Date : 2023-05-01 DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6153
M. Takimoto-Sato, Masatoshi Suzuki, H. Kimura, G. Haiyan, M. Matsumoto, S. Konno
{"title":"Apoptosis Inhibitor of Macrophage (AIM)/CD5l Is Involved in the Pathogenesis of Emphysema","authors":"M. Takimoto-Sato, Masatoshi Suzuki, H. Kimura, G. Haiyan, M. Matsumoto, S. Konno","doi":"10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6153","DOIUrl":"https://doi.org/10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a6153","url":null,"abstract":"","PeriodicalId":358595,"journal":{"name":"C108. IMMUNITY AND INFLAMMATION IN COPD: NOVEL FINDINGS","volume":"130 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114546166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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