Acta medica (Hradec Kralove)最新文献_第6页

Ovotesticular Disorder of Sexual Development and Non-Palpable Testis. 性发育的卵睾丸障碍和不可触及的睾丸。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.7

Radek Štichhauer, Antonín Šafus, David Neumann, Ivo Novák, Vladana Skutilová, Jan Laco

{"title":"Ovotesticular Disorder of Sexual Development and Non-Palpable Testis.","authors":"Radek Štichhauer, Antonín Šafus, David Neumann, Ivo Novák, Vladana Skutilová, Jan Laco","doi":"10.14712/18059694.2021.7","DOIUrl":"https://doi.org/10.14712/18059694.2021.7","url":null,"abstract":"Disorders of sexual development (DSD) refers to a group of diseases that links the mismatch between an individual's genetic and gonadal development and its phenotype. Ovotesticular DSD (true hermaphroditism) is one such disease, in which both male and female gonads are present. A 15-year-old boy with a history of surgery for non-palpable testis was examined due to bilateral gynecomastia and known gonosomal mosaic of Klinefelter syndrome. The external genital was matured as male and, in the left half of the scrotum, there was a testicle of normal size. Despite uncertain resistance on the right side, however, the right testis was not palpable. Revision of the right groin revealed a surprising finding in the form of an ovary with a dilated fallopian tube, both of which were completely removed. Surgical revision of the left testis with biopsy was performed. The surgery was completed with a bilateral mastectomy. The postoperative course was uncomplicated, and the boy is content and fully integrated into his peer group. True hermaphroditism is a rare type of DSD. In the case described, DSD was not exhibited until puberty, after an examination for gynecomastia. The case also confirms the necessity of clarification and long-term follow-up of patients with unclear findings during surgery for non-palpable testis. Diagnostic laparoscopy is clearly indicated in these situations.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38881041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Association of Tortuous Common Carotid Artery with Abnormal Distribution of the Ansa Cervicalis: A Case Report. 颈总动脉弯曲与颈袢异常分布的关系:1例报告。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.22

George Paraskevas, Konstantinos Koutsouflianiotis, Chrysanthos Chrysanthou, Kalliopi Iliou, Nikolaos Syrmos, Marios Salmas

{"title":"Association of Tortuous Common Carotid Artery with Abnormal Distribution of the Ansa Cervicalis: A Case Report.","authors":"George Paraskevas, Konstantinos Koutsouflianiotis, Chrysanthos Chrysanthou, Kalliopi Iliou, Nikolaos Syrmos, Marios Salmas","doi":"10.14712/18059694.2021.22","DOIUrl":"https://doi.org/10.14712/18059694.2021.22","url":null,"abstract":"In the current study, we display a rare association of an aberrant innervation of the sternocleidomastoid muscle by the ansa cervicalis (AC) with a tortuous common carotid artery (TCCA). In specific, in a male cadaver we observed on the right side of the cervical region, a nerval branch of remarkable size originating from the most distal part of the AC's superior root and after piercing the superior belly of the omohyoid muscle innervated the distal portion of the sternocleidomastoid muscle. Furthermore, we noticed a tortuous course of the initial part of the right common carotid artery. We discuss the surgical significance of the awareness of AC's variations during neurotisation of the recurrent laryngeal nerve in cases of its damage, as well as the importance of aberrant innervation of the sternocleidomastoid muscle by AC for the preservation of muscle's functionality after accessory nerve's damage. Furthermore, we highlight the fact, that the knowledge of the relatively uncommon variant, such as TCCA is crucial for the physician in order to proceed more effectively in differential diagnosis of a palpable mass of the anterior cervical region or deal with symptoms such as dyspnea, dysphagia or symptoms of cerebrovascular insufficiency.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39261817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Failure of Warfarin Anticoagulation Therapy after Administration of Oral Terbinafine. 口服特比萘芬后华法林抗凝治疗失败。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.23

Ivana Štětkářová, Jitka Čupáková

{"title":"Failure of Warfarin Anticoagulation Therapy after Administration of Oral Terbinafine.","authors":"Ivana Štětkářová, Jitka Čupáková","doi":"10.14712/18059694.2021.23","DOIUrl":"https://doi.org/10.14712/18059694.2021.23","url":null,"abstract":"Warfarin is widely used anticoagulant drug for a variety of diseases (thromboembolic disease, atrial fibrillation, etc.). It has three most important parallel metabolic pathways, CYP1A2, CYP3A4 and CYP2C9. Terbinafine is a potent CYP2D6 inhibitor. A possible drug interaction could lead to an increased pharmacological effect of the above drugs. Enzyme induction with CYP3A4, CYP2C9, CYP1A2 inducers may have occurred. Case report: We present a case report of an 88-year-old male patient who has been successfully anticoagulated with warfarin due to atrial fibrillation. He was orally administered terbinafine to treat onychomycosis. Two weeks after initiation of this drug the patient experienced dizziness and feelings of instability, for which he was admitted to the neurology department. A low-efficient INR level was found at the baseline, presumably due to warfarin interaction with terbinafine. The induction of liver enzymes lasts 10-14 days, which matches the introduction of the antifungal agent. Conclusion: Combined therapy with warfarin and oral terbinafine is actually rarely prescribed but, if used, their interaction can have serious consequences in many clinical situations for which anticoagulation therapy with warfarin is indicated.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39261818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Exogenous Intake of Fluorides in Caries Prevention: Benefits and Risks. 外源性摄入氟化物预防龋齿:益处和风险。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.13

Romana Koberová Ivančaková, Vladimíra Radochová, Flóra Kovácsová, Vlasta Merglová

{"title":"Exogenous Intake of Fluorides in Caries Prevention: Benefits and Risks.","authors":"Romana Koberová Ivančaková, Vladimíra Radochová, Flóra Kovácsová, Vlasta Merglová","doi":"10.14712/18059694.2021.13","DOIUrl":"https://doi.org/10.14712/18059694.2021.13","url":null,"abstract":"Caries incidence and prevalence have decreased significantly over the last few decades due to widespread use of fluoride. However, an increase in the prevalence of dental fluorosis has been reported in both fluoridated and non-fluoridated communities. Care must be taken to ensure that a balance between the optimal fluoride preventive effect at the individual and community level and minimal risk of dental fluorosis is maintained. This review describes the main sources of fluoride intake that have been identified: fluoridated drinking water, dietary fluoride supplement, and topical forms comprising toothpastes, rinses, gels and varnishes. The cited data were taken from meta-analytic studies and reports from Cochrane database systematic reviews up to December 2019. Efficiency, but safety, of topically applied fluorides in individual home care is dependent on the degree of compliance of individuals/parents and on the level of competence of providers of preventive counselling. The broad spectrum of these resources allows individualization of fluoride prevention based on risk analysis of caries attack and taking into consideration other preventive measures.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39261880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Effect of Lactobacillus casei on Experimental Porcine Inflammatory Bowel Disease Induced by Dextran Sodium Sulphate. 干酪乳杆菌对右旋糖酐硫酸钠诱导的实验性猪炎性肠病的影响。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.15

Jan Bureš, Darina Kohoutová, Jaroslav Květina, Věra Radochová, Michal Pavlík, Aleš Tichý, Stanislav Rejchrt, Marcela Kopáčová, Tomáš Douda, David Vysloužil, Jaroslav Pejchal

{"title":"The Effect of Lactobacillus casei on Experimental Porcine Inflammatory Bowel Disease Induced by Dextran Sodium Sulphate.","authors":"Jan Bureš, Darina Kohoutová, Jaroslav Květina, Věra Radochová, Michal Pavlík, Aleš Tichý, Stanislav Rejchrt, Marcela Kopáčová, Tomáš Douda, David Vysloužil, Jaroslav Pejchal","doi":"10.14712/18059694.2021.15","DOIUrl":"https://doi.org/10.14712/18059694.2021.15","url":null,"abstract":"Background: Gastrointestinal injury caused by dextran sodium sulphate (DSS) is a reliable porcine experimental model of inflammatory bowel disease (IBD). The purpose of this study was to evaluate the effect of probiotic Lactobacillus casei DN 114001 (LC) on DSS-induced experimental IBD.Results: Eighteen female pigs (Sus scrofa f. domestica, weight 33-36 kg, age 4-5 months) were divided into 3 groups (6 animals per group): controls with no treatment, DSS, and DSS + LC. LC was administered to overnight fasting animals in a dietary bolus in the morning on days 1-7 (4.5 × 1010 live bacteria/day). DSS was applied simultaneously on days 3-7 (0.25 g/kg/day). On day 8, the pigs were sacrificed. Histopathological score and length of crypts/glands (stomach, jejunum, ileum, transverse colon), length and width of villi (jejunum, ileum), and mitotic and apoptotic indices (jejunum, ileum, transverse colon) were assessed. DSS increased the length of glands in the stomach, length of crypts and villi in the jejunum and ileum, and the histopathological score of gastrointestinal damage, length of crypts and mitotic activity in the transverse colon. Other changes did not achieve any statistical significance. Administration of LC reduced the length of villi in the jejunum and ileum to control levels and decreased the length of crypts in the jejunum.Conclusions: Treatment with a probiotic strain of LC significantly accelerated regeneration of the small intestine in a DSS-induced experimental porcine model of IBD.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39261882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Laparoscopic Right Hemicolectomy for Appendiceal Mucocele. 腹腔镜右半结肠切除术治疗阑尾黏液囊肿。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.28

Eva Kudelová, Martin Grajciar, Marek Smolar, Michal Kalman, Ludovit Laca

引用次数: 0

Chondroblastoma of the Temporal Bone: A Case Report and Literature Review. 颞骨成软骨细胞瘤1例报告及文献复习。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.29

Katarína Obtulovičová, Marián Sičák, Adrian Kališ, Tomáš Buday

{"title":"Chondroblastoma of the Temporal Bone: A Case Report and Literature Review.","authors":"Katarína Obtulovičová, Marián Sičák, Adrian Kališ, Tomáš Buday","doi":"10.14712/18059694.2021.29","DOIUrl":"https://doi.org/10.14712/18059694.2021.29","url":null,"abstract":"Introduction: Temporal bone chondroblastoma is a rare, locally aggressive tumour originating from immature cartilage, which recurs to a high degree. Treatment is surgical. Radiotherapy is reserved for recurrence. We describe a case of a 15-year-old-boy choosing a conservative surgical approach with reconstruction of the posterior canal wall. This study aims to report a rare pediatric case.Methods: A literature review was performed to better understand temporal bone chondroblastomas, to describe their histopathological and radiological characteristics and to establish the optimal surgical and non-surgical treatments. The research of previous published data was done using PubMed with keywords mentioned below.Results: Authors present a case of a 15-year-old boy with hearing impairment and facial nerve palsy. Conservative surgery with reconstruction of the tympanic membrane and posterior wall of the external auditory canal, restoring the hearing has been performed. We did not administer any adjuvant therapies. No sign of recurrence was observed 1 year after primary surgery. Facial nerve function is normal, and hearing is satisfactory.Conclusion: Chondroblastomas account for less than 1% of primary bone tumours. Temporal bone chondroblastoma is rare, locally aggressive, with a high prevalence of recurrence. This study describes specific histopathological and radiological findings, the chosen surgical approach and follow-up to improve the management and the prognosis of patients affected with this particular clinical entity.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39892207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Reference Values for Cardiopulmonary Exercise Testing in Young Male Slovak Athletes. 斯洛伐克年轻男性运动员心肺运动测试的参考值。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.20

Filip Olekšák, Pavol Dvoran, Ľubica Jakušová, Peter Ďurdík, Matúš Igaz, Peter Bánovčin

引用次数: 1

Rare Complication of Necrotizing Pancreatitis: Extension of Retroperitoneal Abscess into Femoral Region. 坏死性胰腺炎的罕见并发症:腹膜后脓肿延伸至股区。

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.8

Maja Karin, Ante Bogut, Ivan Romic, Hrvoje Silovski, Josip Figl, Danijel Pravdic, Mile Volaric, Emil Babic, Branko Bakula, Renata Romic

引用次数: 0

Gene Expression of Antioxidant Enzymes in the Resected Intestine in Crohn's Disease. 克罗恩病切除肠中抗氧化酶的基因表达

Acta medica (Hradec Kralove) Pub Date : 2021-01-01 DOI: 10.14712/18059694.2021.26

Otakar Sotona, Eva Peterová, Július Örhalmi, Tomáš Dušek, Alena Mrkvicová, Veronika Knoblochová, Petr Lochman, Ondřej Malý, Jiří Páral, Jan Bureš

{"title":"Gene Expression of Antioxidant Enzymes in the Resected Intestine in Crohn's Disease.","authors":"Otakar Sotona, Eva Peterová, Július Örhalmi, Tomáš Dušek, Alena Mrkvicová, Veronika Knoblochová, Petr Lochman, Ondřej Malý, Jiří Páral, Jan Bureš","doi":"10.14712/18059694.2021.26","DOIUrl":"https://doi.org/10.14712/18059694.2021.26","url":null,"abstract":"Introduction: The inflammatory process in Crohn's disease (CD) is closely associated with the formation of reactive oxygen species. Antioxidant enzymes can play an important role in the outcome of CD and may influence postoperative recurrence in these patients. The aim of our study was to evaluate gene expression of intracellular antioxidant enzymes in surgically resected intestinal specimens of patients with CD, both in macroscopically normal and in inflamed tissue.Methods: A total of 28 patients referred for elective bowel resection were enrolled in the study. Full-thickness small intestinal specimens were investigated. Gene expression of antioxidant enzymes - superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GSR) - was evaluated both in macroscopically normal and inflamed samples.Results: There were significantly lower levels of SOD1 mRNA (p = 0.007) and GSR mRNA (p = 0.027) in inflamed tissue compared to macroscopically normal areas. No significant differences were found between affected and non-affected intestinal segments in mRNA for SOD2, SOD3 and GPX.Conclusions: Our pilot data clearly showed that the gene expression of major antioxidant enzymes is not a uniform mechanism in the pathogenesis of Crohn's disease. Topically decreased gene expression of SOD1 and GSR might facilitate the segmental tissue injury caused by reactive oxygen species.","PeriodicalId":35758,"journal":{"name":"Acta medica (Hradec Kralove)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39892204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0