Acta Gastroenterologica Latinoamericana最新文献

{"title":"[Exocrine Pancreatic Insufficiency in Hepatic Cirrhosis: a Cross-Sectional Study].","authors":"Víctor Henríquez Auba, Carmen Hurtado, Carla Mancilla Asencio, Pauline Herman, Alexandra Neman, Zoltán Berger","doi":"10.52787/agl.v56i1.579","DOIUrl":"10.52787/agl.v56i1.579","url":null,"abstract":"<p><strong>Introduction: </strong>. Malnutrition and sarcopenia increase morbidity and mortality in patients with liver cirrhosis. Exocrine pancreatic insufficiency may further worsen nutritional deficits.</p><p><strong>Aim: </strong>. To evaluate exocrine pancreatic function using fecal elastase in patients with liver cirrhosis due to alcohol and other causes.</p><p><strong>Materials and methods: </strong>. Cross-sectional descriptive study including patients with cirrhosis who underwent fecal elastase testing at the Hospital Clínico Universidad de Chile between February 2016 and July 2023. Demographic, clinical, nutritional, and survival variables were evaluated.</p><p><strong>Results: </strong>. Eighty-five patients were included, with a median age of 60 years. The most frequent etiologies were alcohol consumption in 40 patients (47%) and metabolic dysfunction-associated steatotic liver disease in 21 (25%). Of the 85 patients, 88% had fecal elastase > 200 µg/g, 5% had values between 100 - 199 µg/g, and 7% had values < 100 µg/g. Fecal elastase levels were significantly lower in patients with alcohol-related cirrhosis compared with those with other etiologies (p = 0.003). Among patients with alcohol-related cirrhosis, 20% had fecal elastase < 200 µg/g (15% < 100 µg/g). Patients consuming > 20 g/day of alcohol had significantly lower fecal elastase levels (p = 0.013) than those with lower consumption.</p><p><strong>Conclusion: </strong>. In patients with alcohol-related cirrhosis, we found a 20% prevalence of reduced fecal elastase. Alcohol consumption > 20 g/day was associated with lower fecal elastase levels. Considering that malnutrition and sarcopenia influence prognosis and that exocrine pancreatic insufficiency may be clinically silent, measurement of fecal elastase could be justified in patients with alcohol-related cirrhosis, particularly when nutritional deficits are present.</p>","PeriodicalId":35700,"journal":{"name":"Acta Gastroenterologica Latinoamericana","volume":"56 1","pages":"94-101"},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Ileal Crohn's Disease as a Form of Presentation of Inflammatory Bowel Disease in Pediatrics].","authors":"Victoria Rodríguez, Martina Cereijo, Mariela Antoniska, Laura Busquet, Adriana Bottero, Mónica Contreras","doi":"10.52787/agl.v56i1.503","DOIUrl":"10.52787/agl.v56i1.503","url":null,"abstract":"<p><p>Pediatric Crohn's disease localized exclusively to the ileum is a rare condition in our setting. Due to its overlapping clinical presentation, a high index of suspicion is required, and differential diagnoses must be considered with respect to infectious, infiltrative, and other less frequent conditions. We present the case of an 11-year-old patient with a history of anemia, pain in the right iliac fossa, weight loss, and fever. Imaging studies revealed thickening of the terminal ileum and intestinal stenosis near the ileocecal valve, with prestenotic dilation. Video colonoscopy showed that the colonic mucosa was normal and revealed cicatricial stenosis of the ileocecal valve. The pathological anatomy was inconclusive, reporting moderate nonspecific colitis. Due to symptoms of subintestinal obstruction, a laparoscopic resection of the distal ileum, appendix, ileocecal valve, and cecum was performed, with creation of a double-barrel ostomy. Histology of the surgical specimen confirmed the diagnosis of Crohn's disease.</p>","PeriodicalId":35700,"journal":{"name":"Acta Gastroenterologica Latinoamericana","volume":"56 1","pages":"107-113"},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Endoscopic Ultrasound-Guided Biopsy as a Minimally Invasive Diagnostic Tool for Mesorectal Metastasis From Clear Cell Renal Carcinoma: A Case Report].","authors":"Nicole Marie Kahn, Mayra Florencia Defanti, Yanina Gabriela Carlino","doi":"10.52787/agl.v56i1.484","DOIUrl":"10.52787/agl.v56i1.484","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic ultrasound is a minimally invasive diagnostic technique that combines endoscopic and ultrasonographic imaging to evaluate gastrointestinal and adjacent tissue lesions. This report describes its use in the diagnosis of mesorectal metastases from renal clear cell carcinoma.</p><p><strong>Case presentation: </strong>. A 54-year-old woman with a history of renal clear cell carcinoma treated with right nephrectomy. Follow-up computed tomography revealed rectal wall thickening and mesorectal nodules. Endoscopic ultrasound identified a subepithelial rectal lesion and mesorectal nodules, and guided biopsy confirmed metastases from renal clear cell carcinoma (PAX8 and CD10-positive).</p><p><strong>Conclusion: </strong>. Endoscopic ultrasound is an effective method for diagnosing mesorectal metastases, and is particularly useful in rare renal clear cell carcinoma cases.</p>","PeriodicalId":35700,"journal":{"name":"Acta Gastroenterologica Latinoamericana","volume":"56 1","pages":"102-106"},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[[Frequency of Colorectal Polyps in Patiens Younger vs. Older Than Fifty Years: Analysis of 4718 Colonoscopies Through Data Mining]].","authors":"Medardo Fernández-Chávez, Juliana Paiz-Tierno, Adriana Vella-Milagro, Santiago Arcentales-Peralta, Leonardo Aveiga-Cedeño, María Carolina Conlon, Renata Alina Spiazzi, María Jimena Cerezo, Ana Omonte-Zambrana, María Claudia Milano, Fátima Fernández, Ricardo Gotti, Miguel Puga-Tejada","doi":"10.52787/agl.v56i1.581","DOIUrl":"10.52787/agl.v56i1.581","url":null,"abstract":"","PeriodicalId":35700,"journal":{"name":"Acta Gastroenterologica Latinoamericana","volume":"56 1","pages":"78-85"},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Infantile Hepatic Hemangioendothelio- ma with Elevated Alpha-fetoprotein: Case Report and Review].","authors":"María Laura Valberdi Lecce, María Cristina Arregui, Carmen Lucía Otegui Banno, Andrea Besga","doi":"10.52787/agl.v56i1.523","DOIUrl":"10.52787/agl.v56i1.523","url":null,"abstract":"<p><p>Infantile hemangioendothelioma is the most common benign mesenchymal tumor of the liver and usually occurs within the first six months of life. Although serum alpha-fetoprotein is a significant tumor marker in cases of hepatoblastoma, hepatocellular carcinoma and germ cell tumors, elevated levels are rarely observed in patients with infantile hepatic hemangioendothelioma. In such cases, given that the differential diagnoses have different prognoses, accessible diagnostic options should be sought in order to to guide clinical management. The exact cause of alpha-fetoprotein elevation in hemangioendothelioma has not yet been clarified, although some studies have shown that hepatocytes trapped near the tumor are responsible for the increased serum levels. In this paper, we describe a clinical case of solitary infantile hepatic hemangioendothelioma as a rare clinical presentation with elevation of this tumor marker.</p>","PeriodicalId":35700,"journal":{"name":"Acta Gastroenterologica Latinoamericana","volume":"56 1","pages":"114-118"},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis C Screening and Gender Disparities in Positivity Rates in Argentina: A Multicenter Study.","authors":"Manuel Barbero, Ignacio Roca, Lucía Navarro, Nicolás Domínguez, Omar Galdame, María Del Carmen Puente, Laura González, Lucía Guillén, María Virginia Gustincic, Fernando Cairo","doi":"10.52787/agl.v56i1.595","DOIUrl":"10.52787/agl.v56i1.595","url":null,"abstract":"<p><strong>Introduction: </strong>. Anti-HCV seropositivity is a public-health concern in Argentina, with potential disparities by gender. We estimated anti-HCV seropositivity in a multicenter public laboratory network, described gender-based differences, and examined the association with all-cause mortality.</p><p><strong>Methods: </strong>Retrospective observational study with centralized chemiluminescent immunoassay testing at Hospital El Cruce, using samples from 64 public centers from January 1, 2013 to December 31, 2023. The analyses were performed at the patient level (the first test per person) and the positivity rate was calculated for each testing site. Vital status information was obtained from hospital records and RENAPER (with a cut-off date of December 2024). Mortality by anti-HCV serostatus was assessed using logistic regression with a prespecified 2:1 matching on age, gender, and testing site.</p><p><strong>Results: </strong>Of the 74,503 adults tested, 1,101 (1.48%) were anti-HCV-positive. Of those tested, 83.0% were women (61,837/74,503) and 17.0% were men (12,666/74,503). Within gender seropositivity was 0.73% in women (451/61,837) and 5.05% in men (639/12,666). The per-test positivity rate was 0.5% in peripheral centers (451/90,194) and 5.1% in the hospital (922/18,082). Of the individuals who tested positive for anti-HCV, 25.0% (275/1,101) were deceased at the cut-off date. In a matched cohort of 2:1 by age, gender, and site, anti-HCV positivity was associated with a higher risk of death (adjusted OR 4.75; 95% CI 3.82 - 5.94; p < 0.001).</p><p><strong>Conclusions: </strong>Men were tested much less frequently than women (17.0% versus 83.0% of those tested), yet they were far more likely to test positive for anti-HCV (5.05% versus 0.73% within gender), accounting for the majority of positive results (58%). Therefore, screening policies should prioritize increasing testing among men, especially in high-yield hospital settings, and ensure rapid linkage to care. The association between anti-HCV seropositivity and higher mortality reinforces the urgency of these actions.</p>","PeriodicalId":35700,"journal":{"name":"Acta Gastroenterologica Latinoamericana","volume":"56 1","pages":"71-77"},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Advances in the Treatment of Refractory Pediatric Constipation].","authors":"Cecilia Zubiri, Anabella Zosi, Román Bigliardi","doi":"10.52787/agl.v56i1.576","DOIUrl":"10.52787/agl.v56i1.576","url":null,"abstract":"<p><p>Refractory functional constipation is a persistent challenge inpediatrics. Beyond polyethylene glycol and traditional laxatives, newpharmacological and non-pharmacological therapies are emerging. Amongthe innovative medications, prosecretory agents like linaclotide(already approved for children over 6 years old), lubiprostone andplecanatide, wich increase intestinal secretion, stand out. Other drugs,such as prucalopride (5HT-4 agonist) and pyridostigmine, aim to improvemotility. Rectal and interventional therapies include transanalirrigation, -which has shown good results-; antegrade enemas andbotulinum toxin A injections, which are useful for specificdysfunctions. Biofeedback remains an effective tool. Neuromodulation isemerging as a promising option. Implanted sacral nerve stimulation andnon-invasive techniques such as percutaneous/transcutaneous tibial nervestimulation and transcutaneous sacral neuromodulation demonstrateimprovements in symptoms and quality of life. There are therapies thathave been little explored but show promise for the future, such asvibrating capsules, magnetic neurostimulation, and mind-body approacheslike hypnosis. Specific pediatric research and an individualizedtreatment approach are crucial to optimize adherence and outcomes inthese complex patients.</p>","PeriodicalId":35700,"journal":{"name":"Acta Gastroenterologica Latinoamericana","volume":"56 1","pages":"41-56"},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[[Role of Artificial Intelligence in Clinical Research: MethodologicalApplications and Current Challenges]].","authors":"Santiago Decotto, Rodolfo Pizarro","doi":"10.52787/agl.v56i1.619","DOIUrl":"10.52787/agl.v56i1.619","url":null,"abstract":"","PeriodicalId":35700,"journal":{"name":"Acta Gastroenterologica Latinoamericana","volume":"56 1","pages":"7-11"},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[[Redefining the Initial Endoscopy Evaluation of Esophageal Symptoms: Toward a PrecisionBased Diagnostic Paradigm]].","authors":"Juan I Olmos, John E Pandolfino","doi":"10.52787/agl.v56i1.601","DOIUrl":"10.52787/agl.v56i1.601","url":null,"abstract":"","PeriodicalId":35700,"journal":{"name":"Acta Gastroenterologica Latinoamericana","volume":"56 1","pages":"17-28"},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Más allá de lo frecuente. Un desafío diagnóstico en dolor abdominal.","authors":"Tatiana Noemí Uehara, Juan Manuel de Arechavala, Fernanda Dorado, Verónica Eugenia Corvalán, Fernando Bocelo, Betiana Pucci","doi":"10.52787/agl.v56i1.551","DOIUrl":"10.52787/agl.v56i1.551","url":null,"abstract":"","PeriodicalId":35700,"journal":{"name":"Acta Gastroenterologica Latinoamericana","volume":"56 1","pages":"57-58"},"PeriodicalIF":0.0,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13450850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}