Annals of Cancer Research and Therapy最新文献

{"title":"A Brief Review On Cancer Research And Its Treatment Through Mathematical Modelling","authors":"K. Dehingia, H. K. Sarmah, M. B. Jeelani","doi":"10.4993/ACRT.29.34","DOIUrl":"https://doi.org/10.4993/ACRT.29.34","url":null,"abstract":"Mathematical models have been proposed in different aspects of disease dynamics over the last few decades. Mathematical modelling gives a better insight, which helps us to understand the biological process during disease period. In this review work, we have discussed some well-known research work on cancer dynamics performed by researcher for dif- ferent aspects through mathematical modelling. We have found few significant works, which have been discussed by us in a systematic manner. Treatment of cancer is also a wide research area for medical sciences and health care systems. For these aspects, few works are discussed here based on the different treatment regimens. We have found that combination of two or more therapies may perform well in cancer eradication processes than a monotherapy. and perspective. Agent based model; Compartmental model; Continuous-time model; Discrete-time model; model;","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46332274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adverse effects of prolonged postoperative hospital stay on long-term survival of pancreatic adenocarcinoma","authors":"S. Uemura, T. Sugiura, Y. Okamura, Takaaki Ito, Yusuke Yamamoto, R. Ashida, K. Hanazaki, K. Uesaka","doi":"10.4993/ACRT.29.11","DOIUrl":"https://doi.org/10.4993/ACRT.29.11","url":null,"abstract":"Objective: The relationship between the length of postoperative hospital stay, postoperative morbidity, and long-term sur- vival after pancreatectomy was investigated. Patients and methods: Data of 295 patients who underwent surgical resection for pancreatic adenocarcinoma between 2007 and 2014 were analyzed. Results: Pancreatoduodenectomy was performed in 228 patients, and portal vein resection was performed in 118 patients. Postoperative complications of any grade occurred in 165 patients, and median postoperative hospital stay was 20 days (7–189 days). No complications of any grade affected the postoperative survival. However, postoperative hospital stay was significantly correlated poor prognosis (median survival time: 14 months in patients with a hospital stay >6 weeks and 26 months in those with a hospital stay <6 weeks, p = 0.008). Multivariate analyses for the long-term prognosis identified 5 independent factors: lymph node metastases (odds ratio [OR]: 2.92, p < 0.001), absence of adjuvant chemotherapy (OR: 1.73, p = 0.002), elevated serum level of CA19-9 ≥300 U/ml (OR: 1.79, p < 0.001), age >70 (OR: 1.39, P = 0.038) and postopera- tive hospital stay ≥6 weeks (OR: 1.82, p = 0.005). The types of complication and severe complications with grade IIIb/IV of Clavien-Dindo classification were not found to be related to the survival. Conclusion: In the present study, Clavien-Dindo classification was not associated with long-term survival rates after pancreatectomy for pancreatic adenocarcinoma. The length of postoperative hospital stay is related to the long-term survival after pancreatectomy.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44994683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flavonoids kaempferol (KAE) and quercetine (QUE) inhibited proliferation of human leukemia THP-1 cells by up regulation of pro-apoptotic protein Bax and caspase 3/8 expression and down regulation of anti-apoptotic proteins Bcl-2, Bcl-xl and Mcl-1 expression","authors":"Hamid Reza Ghaderi Jafarbeigloo, Sedigheh Sheibani, Abbas Zakeri Bazmandeh","doi":"10.4993/ACRT.29.41","DOIUrl":"https://doi.org/10.4993/ACRT.29.41","url":null,"abstract":"Acute myeloid leukemia (AML) is a type of leukemia robustly affecting the normal proliferation and maturation proce- dure of human hematopoietic myeloid lineage. Nowadays, Flavonoids, well-known types of natural product, because of their acceptable efficacy and lower side effects have attracted increasing consideration in the context of AML therapy using natu- ral products and herbal medicine. Herein, we evaluated flavonoid kaempferol (KAE) and quercetin (QUE) on acute myeloid leukemia THP-1cells proliferation. To address the anti-leukemic potential of KAE and QUE in leukemia THP-1 cells, these cells were treated with KAE (40 µM), QUE (40 µM), and KAE plus QUE within 12, 24, 48, and 72 hours of exposure. Then, cell proliferation was evaluated using methylthiazolyldiphenyl-tetrazolium bromide (MTT) assay. Moreover, expression rates of the pro-apoptotic protein Bax and anti-apoptotic protein Bcl-2, Mcl-1, and Bcl-xL along with caspase 3 and caspase 8 were assessed by real-time PCR (RT-PCR) during 24 and 48 hours of exposure with KAE (40 µM), QUE (40 µM), and KAE plus QUE. After that, the candidate’s gene expression levels were compared with control THP-1 cells. Based on MTT assay results, KAE and QUE at 40 µM concentration reserved proliferation of THP-1 cells compared with control cells, while the anti-proliferative effects of the QUE had superiority over KAE in treated cells. Importantly, results evidenced the synergistic effects of the KAE plus QUE on THP-1 cell proliferation during all periods of the experiment. On the other, these compounds could improve Bax, caspase 3, and caspase 8 expressions, and conversely stimulated a significant and robust reduction in Bcl-2, Mcl-1, and Bcl-xl expression at mRNA levels in the treated cell compared with control cells. In sum, we suggested that the use of the KAE plus QUE could more evidently abrogate proliferation and viability of human leukemia THP-1 cells targeting survival involved genes expression, delivering the proof of the concept that combines the application of KAE and QUE is a rational strategy to treat AML.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46057235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutrients Consumed by the Inflammatory Bowel Disease Jordanian Patients","authors":"Y. Rayyan, Tamara R Qalqili, A. Abu-Sneineh, R. Tayyem","doi":"10.4993/ACRT.29.22","DOIUrl":"https://doi.org/10.4993/ACRT.29.22","url":null,"abstract":"Background: Inflammatory bowel disease (IBD) is a chronic inflammation of the intestine that affects adults more than children, and can be associated with serious long-term complications like colon cancer. Nutrition has an important role in the management of patients with IBD which can ameliorate macro and micro-nutrient deficiencies in these individuals, and may reverse the physiopathological consequences of such deficiencies, and exert an anti-inflammatory therapeutic benefit. Therefore, this study aimed to compare the differences between macro and micro-nutrients intake among IBD cases and IBD-free controls in a selected sample of Jordanian adults. Methods: A case control study was conducted between November 2018 and December 2019. Three hundred thirty-five Jordanian adults aged between 18-68 years were recruited: 185 were recently diagnosed with IBD (100 (n = UC) and 85 (n = CD)) and 150 IBD-free controls. Nutrients intake and dietary data were collected from all participants using validated food frequency questionnaire. Results: The IBD group showed significantly (p < 0.05) higher intake of energy from fat, saturated fat, amount of total pro- tein, carbohydrates, sugars, fiber, MUFA, trans-fat and cholesterol compared to the control group. Besides, the IBD group showed significant (p < 0.05) higher intakes of vitamins A, D, E, B12, C and folate, beta-carotene, retinol, calcium, potas- sium, iron, Omega-3 and Omega-6 when compared to the control group. However, the control group had a higher intakes of vitamin K and caffeine when compared to the IBD group (p < 0.05). Conclusions: Nutrients consumption in IBD patients often changes because of the impaired digestive tract function which may negatively impact the intake and status of macro- and micronutrients. Patients with IBD had a higher intake of some macro and micro-nutrients when compared to the control group, while the control group had higher intake of vitamin K and caffeine when compared to the IBD.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46980303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome for esophageal cancer following thoraco-laparoscopic esophagectomy: A single institution experience","authors":"H. H. Thien, T. N. Trung, P. T. Vỹ, P. Thanh, N. T. Xuan, P. X. Dong, M. T. Hieu, V. Nhan, P. N. Hiệp","doi":"10.4993/ACRT.29.68","DOIUrl":"https://doi.org/10.4993/ACRT.29.68","url":null,"abstract":"Background: The feasibility and the safety of the thoraco-laparoscopic esophagectomy (TLE) was proved by several prominent academic institutions. This technique is technically challenging and requires advanced laparoscopic and thora-coscopic skills. With experience gained from open esophagectomy as well as laparoscopic surgery, thoraco-laparoscopic esophagectomy was introduced in our hospital in 2016. We report our experience in performing TLE. Materials and Methods: We conducted a prospective, nonrandomized, observational study in Hue central hospital, which is one of the biggest hospitals in Vietnam, from January 2016 to January 2021. This study included the esophageal cancers that were diagnosed by endoscopy and confirmed by pathology. Esophageal cancer with cT1b-3N0M0 using chest CT, ultrasound-endoscopy, abdominal CT was indicated for resection initially, while esophageal cancer with cT4N0M0 or T3N(+)M0 was indicated for resection after neoadjuvant therapy. The patients had the ASA I-III. All the data were analyzed statistically using SPSS software (SPSS, Inc, Chicago, IL). Results: We used the TLE technique to operate for 52 consecutive patients. All patients were in a semi-prone position. The male/female ratio was 47/5. The mean age was 57.3±6.3 years, and the mean BMI was 20.5±3.3 kg/m2. The preoperative location of the esophageal cancer was the upper one-third in two (3.8%), the middle one-third in 24 (46.1%), and the lower one-third in 26 (50.0%). The majority of our patients had cTNM stage II (30, 57.7%). Only seven patients (13.7%) had cTNM stage I, whereas 15 patients (31.4%) had cTNM stage III. Of the 45 patients (stage II and III) who needed the neoadjuvant therapy, 30 (57.7%) received short-courses, 15 (28.8%) received long-course of chemotherapy. For 24 patients (46.1%), the histopathology was squamous cell carcinoma. The remaining 28 patients (53.8%) had adenocarcinomas. The operative time was 311.2±45.9 minutes. We did not record either conversion or intraoperative events. The mortality and morbidity rates were 1.9% and 23%, respectively. The hospital stay was 15.6±7.2 days. The median follow-up time was 22±1.5 months, and the overall survival rate at one year was 84.7%. Conclusion: Thoraco-laparoscopic esophagectomy for esophageal cancer with the patient in a semi-prone position is safe and effective, including the lower morbidity rate and the shorter operative time while preserving the long-term outcomes. © 2021, PJD Publications Ltd. All rights reserved.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44217635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Epstein-Barr virus (EBV) incidence in umbilical cord blood (UCB) and assessment of virus DNA via Real-time PCR","authors":"Afsaneh Jahangiryan, M. Kheirandish, S. Samiee, Z. Sharifi, Mastaneh Alaei","doi":"10.4993/acrt.29.114","DOIUrl":"https://doi.org/10.4993/acrt.29.114","url":null,"abstract":"","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48169496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological features of colorectal cancers in Morocco based on the registry of the National Institute of Oncology in Rabat","authors":"Zineb Aoullay, M. Slaoui, R. Razine, B. Meddah, Y. Cherrah","doi":"10.4993/ACRT.29.73","DOIUrl":"https://doi.org/10.4993/ACRT.29.73","url":null,"abstract":"Background and objectives: Colorectal cancer (CRC) is rising steadily, particularly in developing nations. In Morocco, colorectal cancer is ranking third most incident. Via this study, we present the epidemiological profile, clinical features of colorectal cancers, and chemotherapy outcome in a Moroccan population. Materials and methods: This study is a retrospective investigation, run between January and December 2013 of 290 patients with colorectal cancer. A descriptive and analytical study was carried out via statistical analysis to correlate clini- copathological data with overall chemotherapy-related toxicity occurrence, by the Chi2 test. The non-parametric Mann-Whitney test was used for comparison between the occurrence of diarrhea and bilirubin levels. Results: Most of the cases were between 40–59 years, and 50.5% (n = 147) were men. KRAS (12, 13 codon) was mutant in 10 patients (3.4%). Chemotherapy was administered to 146 patients (50.4%), and 85.6% had suffered from at least one toxic event during CMT treatment. The mean total bilirubin and mean conjugated bilirubin were found to be significantly high in patients who do not de- velop diarrhea, compared to those with diarrheal toxicity with a p-value of 0.02 and 0.03 respectively. Conclusion: Our study reveals a significant percentage of toxicity occurrence among patients who underwent chemothera- py.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45775156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic Effects of Methanolic Extract of Ferula assa-foetida on SKOV-3 and MIA PaCa-2 Cells","authors":"E. Aali, Saeed Aamadi, A. Bajelan, Mehdi Ghaebi","doi":"10.4993/ACRT.29.110","DOIUrl":"https://doi.org/10.4993/ACRT.29.110","url":null,"abstract":"Introduction: Previous studies have demonstrated cytotoxic effects of Ferula assa-foetida. In the present study, the anti- proliferative effect of this plant on two species of cancer cells related to pancreatic cancer (MIA PaCa-2) and ovarian cancer (SKOV-3) was investigated. Materials and Methods: 100 grams of powdered herb dissolved in 500 milliliter of methanol was placed in Soxhlet extractor for 72 hours. After adding trypsin to the medium, cells were cultured in serum containing medium. A serial dilution of extract was created with 25, 50, 100, 200 and 400 microgram per milliliter concentrations. Plates were fed with 200 microliters of new mediums at the end of their growth and 50 microliters of MTT were added to all wells of 1 to 11 columns. After incubation, mediums and MTT were removed from the wells and remaining crystals were resolved by adding DMSO. After adding glycine buffer (25 μl per well), we immediately read the results at wavelength of 570 nanometer using an ELISA reader. Results: Concentrations of 25, 50, 100, 200 and 400 micrograms per milliliter of methanolic extract of Ferula asa-foetida had significant cytotoxic effect on SKOV-3 and MIA PaCa-2 cancer cells with a P-Value of <0.05. These changes were time-dependent. Discussion and Conclusion: Besides their several medical uses, medicinal herbs have recently turned out to have antineoplastic effects. One of these herbs is Ferula assa-foetida. In the present study, we evaluated the anti-proliferative effects of this plant on ovarian and pancreatic cancer cells.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46447891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Grain and Legume Intakes and Breast Cancer Risk among Women","authors":"S. Hammad, Reema Mahmoud, Lina Marie, Dana N Abdelrahim, R. Tayyem","doi":"10.4993/acrt.28.81","DOIUrl":"https://doi.org/10.4993/acrt.28.81","url":null,"abstract":"Background: Breast cancer (BrC) is the most commonly diagnosed cancer and a prominent cause of cancer deaths in women worldwide. The main objective of this study was to evaluate the association of grain and legume intakes and BrC risk among Jordanian women. Methods: A case-control design was used in this study. All BrC patients were taken from the main two hospitals in Jordan that offer cancer therapy. A total of 400 Jordanian women with 20–65 years of age were recruited in this case-control study. About 200 recently diagnosed BrC women were matched in age, income and marital status to 200 BrC-free women. Dietary data were gathered through in-person interview using a validated food frequency questionnaire between October 2016 and September 2017. Results: The weekly consumption of 1–6 servings of whole wheat bread showed >70% protected odds of having BrC, while the consumption of bulgur was significantly associated with great likelihood of having BrC (OR: 2.33, CI: 1.25–4.32). The consumption of 1–6 servings weekly of breakfast cereals had 72% lower risk of having BrC (p-trend: <0.001). The consumption of more than one serving per day of cooked white rice was detected to be associated with 7 folds higher chance of having BrC. The findings of this study also showed 90% protective odds of the consumption of 1–6 servings per week of cooked beans. Daily consumption of more than one serving of fried foods increased the risk of BrC; daily consumption of “Falafel” and fried potatoes had 256% and 515% higher risks of having BrC. Similar results were detected among overweight and obese participants. Conclusion: This study detected a few food items that may modify the risk of BrC. The findings highlighted the importance of quality of dietary choices and the significance of healthy foods in reducing disease risk.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45168077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of Pegfilgrastim over Filgrastim in the Treatment of Chemotherapy-induced Neutropenia","authors":"M. Mohseni, M. Arab-Zozani, A. Ahmadi, Babak Salimi, A. Sari","doi":"10.4993/acrt.28.71","DOIUrl":"https://doi.org/10.4993/acrt.28.71","url":null,"abstract":"Introduction: Neutropenia is a major common complication in patients who are treated with myelosuppressive chemo- therapy. Prophylaxis with granulocyte colony-stimulating factors (G-CSFs) has been used to reduce the incidence, duration, and severity of chemotherapy-induced neutropenia (CIN). Methods: This study aimed to examine the efficacy and safety of pegfilgrastim compared with filgrastim in treating che-motherapy-induced febrile neutropenia. PubMed/MEDLINE, Cochrane Library, Scopus, Embase, and Web of science were searched until December 2015. The search was updated in January 2018. Also, the reference lists of included studies were screened for additional citations. The quality of studies was evaluated using the Cochrane risk of bias tools and the random effect model was applied for analyzing the result. Results: Eleven studies with 1,578 participants (799 in pegfilgrastim arm and 779 in filgrastim arm) fulfilled the inclusion criteria. The incidence of grade 4 neutropenia and febrile neutropenia, the duration of grade 4 neutropenia, and recovery of the absolute neutrophil count were slightly reduced in the pegfilgrastim group, though this difference was not statistically significant. For bone pain, despite the observed superiority in the pegfilgrastim group, there was no significant difference between the two drugs. Conclusion: The results of our review suggest that there is no overall treatment benefit for a median 10–14 days of filgrastim compared to a single dose of pegfilgrastim in the incidence of grade 4 neutropenia, incidence of febrile neutropenia, duration of grade 4 neutropenia, and recovery of absolute neutrophil count and bone pain in the treatment of CIN.","PeriodicalId":35647,"journal":{"name":"Annals of Cancer Research and Therapy","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43748862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}