JHN Journal最新文献_第7页

A Methodology for Systematic Volumetric Analysis of Perioperative Cranial Imaging in Neurosurgical Patients 神经外科患者围手术期颅成像系统容积分析方法

JHN Journal Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.011.2.002

K. Atsina, R. Gorniak, A. Sharan, Chengyuan Wu

引用次数: 1

Emotional/Psychiatric Symptom Change and Amygdala Volume After Anterior Temporal Lobectomy 前颞叶切除术后情绪/精神症状改变和杏仁核体积

JHN Journal Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.010.1.003

Ba Daniel Moadel, G. Doucet, D. Pustina, R. Rider, Ba Nathan Taylor, P. Barnett, M. Sperling, A. Sharan, J. Tracy

引用次数: 0

A Case Report and Overview of Familial Cerebral Cavernous Malformation Pathogenesis in an Adult Patient 成人家族性脑海绵状血管瘤发病机制1例报告及综述

JHN Journal Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.013.2.003

B. Arul, O. Khanna, M. Gooch

引用次数: 0

A Metastatic Middle Cerebral Artery Aneurysm Caused by an Intraluminal Bronchogenic Tumor Embolus 由腔内支气管源性肿瘤栓子引起的转移性大脑中动脉动脉瘤

JHN Journal Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.004.3.006

C. Randazzo, A. Sharan

{"title":"A Metastatic Middle Cerebral Artery Aneurysm Caused by an Intraluminal Bronchogenic Tumor Embolus","authors":"C. Randazzo, A. Sharan","doi":"10.29046/JHNJ.004.3.006","DOIUrl":"https://doi.org/10.29046/JHNJ.004.3.006","url":null,"abstract":"Objective and Importance: To describe the clinical presentation and neuropathological findings of metastatic cerebral aneurysms of bronchogenic origin. Metastatic bronchogenic cerebral aneurysms are exceptionally rare and have only been reported in association with high grade hemorrhage. Clinical Presentation: One patient presenting with a history of headache, speech difficulty, left-sided “numbness”, left seventh nerve palsy and left hemiparesis was found to have intraparenchymal and subarachnoid hemorrhage with an aneurysm of the right distal Sylvian middle cerebral artery. Intervention: Pterional craniotomy with excision of mycotic segment. Surgical specimen sent to pathology for routine histology and immunohistochemistry. Conclusion: Patients with metastatic cerebral aneuryms of bronchogenic origin usually present with subarachnoid hemorrhage, contrary to prior observations that “hemorrhage from neoplasia-induced aneurysms is paradoxically rare.” A tumor embolus should be considered in the differential diagnosis of a mycotic aneurysm. Cerebral aneurysms have been reported as a complication of primary extracranial neoplasms. The preponderance of such cases has been associated with cardiac myxomas and choriocarcinomas. Olmsted and McGee5 report approximately a 45% systemic embolization rate, half of which may be cerebral, in patients with left atrial myxoma. Weir et al.7 described mycotic aneurysms from choriocarcinoma as specifically being distal, lobulated, and fusiform. Pullar et al.6 reported a series of eight cases of metastatic cerebral aneurysms secondary to choriocarcinoma. There have only been four reported cases of metastatic cerebral aneurysm of bronchogenic origin1-4 The first case was described in 1982 by Ho2. Ho described a fatal intracerebral hemorrhage associated with an aneurysm in the medial aspect of the occipital lobe. Histologically, the lumen of the vessel contained collections of neoplastic cells that had invaded the vessel wall and destroyed the native cytoarchitecture. Kochi et al.3 described an intracerebral hematoma from rupture of a metastatic cerebral bronchogenic aneurysm in a cortical branch of the left posterior temporal artery. Murata et al.4 reported intracerebral hematoma from rupture of a metastatic cerebral bronchogenic aneurysm from a cortical branch of the posterior cerebral artery. Gliemroth et al.1 reported recurrent and fatal subarachnoid hemorrhage from rupture of a metastatic cerebral bronchogenic aneurysm of the anterior inferior cerebellar artery. This patient also developed a mycotic neoplastic aneurysm in the contralateral anterior inferior cerebellar artery. Previous reports* of metastatic cerebral aneurysms postulated a low rate of hemorrhage. The four cases reported to date of metastatic cerebral bronchogenic aneurysm and our case, representing the fifth, have all presented with high grade subarachnoid hemorrhage. Case Report A 43-year-old female with a history of hypertension, asthma, intraven","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127349578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Referral Patterns for Medically Refractory Epilepsy 医学上难治性癫痫的转诊模式

JHN Journal Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.005.1.001

Peter G. Campbell

引用次数: 0

Ventral Intramedullary Cervical Spinal Cord AVM 腹侧颈髓内脊髓AVM

JHN Journal Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.004.3.008

Sanjay Yadla, P. Jabbour, R. Rosenwasser

{"title":"Ventral Intramedullary Cervical Spinal Cord AVM","authors":"Sanjay Yadla, P. Jabbour, R. Rosenwasser","doi":"10.29046/JHNJ.004.3.008","DOIUrl":"https://doi.org/10.29046/JHNJ.004.3.008","url":null,"abstract":"Abstract Spinal Cord Arteriovenous Malformations (SCAVMs) are rare vascular lesions. AVMs of the cervical spinal cord are a small proportion of these. SCAVMs are generally classified into four categories based on location and structure. They may cause significant neurologic symptoms by direct mass effect or venous congestion. Surgery of these lesions may be associated with considerable morbidity and thus a multimodality approach using endovascular and radiosurgery techniques is required.Spinal Cord AVMs are rare lesions, only one-tenth as common as their cranial counterparts 1 . They may clinically present with progressive symptoms from direct mass effect or venous hypertension or acutely after hemorrhage. In 1992, Anson and Spetzler, published the most widely used classification of SCAVMs (Table 1) 2 .Type II or Glomus AVMs typically have multiple arterial feeders and drain into a venous plexus around the spinal cord. They can be particularly difficult to treat because they are intramedullary, within the spinal cord parenchyma. The mortality rate related to Type II AVMs has been reported as close to 18%. After initial hemorrhage, the rebleed rate is 10% within the first month and 40% within the first year","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121323679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Endovascular Neurosurgery: A History of Electricity, Balloons, Wires and Glue 血管内神经外科:电、气球、电线和胶水的历史

JHN Journal Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.004.4.004

Fernando Gonzalez, M. Maltenfort

引用次数: 2

Phase 1 Trial of Vaccination with Autologous Tumor Cells and Antisense Directed Against the Insulin Growth Factor Type 1 Receptor (IGF-1R AS ODN) in Patients with Recurrent Glioblastoma 自体肿瘤细胞和针对胰岛素生长因子1型受体(IGF-1R AS ODN)的反义靶向疫苗在复发性胶质母细胞瘤患者中的一期试验

JHN Journal Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.013.1.002

D. Andrews, K. Judy, L. Harshyne, D. Hooper

{"title":"Phase 1 Trial of Vaccination with Autologous Tumor Cells and Antisense Directed Against the Insulin Growth Factor Type 1 Receptor (IGF-1R AS ODN) in Patients with Recurrent Glioblastoma","authors":"D. Andrews, K. Judy, L. Harshyne, D. Hooper","doi":"10.29046/JHNJ.013.1.002","DOIUrl":"https://doi.org/10.29046/JHNJ.013.1.002","url":null,"abstract":"Background: Extending a previous Phase I study, we report the results of a second Phase I autologous tumor cell vaccination trial for patients with recurrent glioblastomas (IND 14379-101, NCT01550523). Methods: Following surgery, subjects were treated by 24 hour implantation in the rectus sheath of ten biodiffusion chambers containing irradiated autologous tumor cells and IGF-1R AS ODN with the objective of stimulating tumor immunity. Patients were monitored for safety, clinical and radiographic as well as immune responses. Results: There were no Grade 3 toxicities related to protocol treatment and overall median survival from initial diagnosis was 91.4 weeks. Two protocol survival cohorts with median survivals of 48.2 and 10 weeks were identified and predicted by our pre-treatment assessments of immune function, corroborated by post-vaccination pro-inflammatory cytokine profiles. Longer survival subjects had imaging findings including transient elevations in cerebral blood volume (rCBV) and sustained elevations of apparent diffusion coefficient (ADC) interpreted as transient hyperemia and cell loss. Conclusions: The vaccine paradigm was well-tolerated with a favorable median survival. Our data support this as a novel treatment paradigm that promotes anti-tumor immunity.","PeriodicalId":355574,"journal":{"name":"JHN Journal","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132915488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behind the Technology: CT Perfusion in the Setting of Acute Stroke Management 技术背后:CT灌注在急性脑卒中管理中的应用

JHN Journal Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.005.2.001

B. Zussman, A. Flanders, R. Rosenwasser, P. Jabbour

引用次数: 3

Stereotactic Radiosurgery for Management of Cavernous Malformations 立体定向放射外科治疗海绵状血管瘤

JHN Journal Pub Date : 1900-01-01 DOI: 10.29046/JHNJ.010.1.002

Ba Bs Brian Nasca, Matthew J. Viereck, N. Chalouhi, P. Jabbour, R. Rosenwasser, S. Tjoumakaris

引用次数: 0