发布求助
文献互助 智能选刊 最新文献

Heart and Metabolism最新文献

筛选
英文 中文
Gene therapy for cardiovascular manifestations of lysosomal storage diseases. 溶酶体贮积病心血管表现的基因治疗。
Heart and Metabolism Pub Date : 2008-01-01
Meg M Sleeper, Mark E Haskins, Katherine P Ponder
{"title":"Gene therapy for cardiovascular manifestations of lysosomal storage diseases.","authors":"Meg M Sleeper, Mark E Haskins, Katherine P Ponder","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cardiac disease causes morbidity in several lysosomal storage diseases, which are the result of deficient activity of lysosomal enzymes. Mucopolysaccharidosis (MPS) causes aortic and valvular disease, Pompe disease causes cardiac muscle weakness, and Fabry disease causes left ventricular hypertrophy. Enzyme replacement therapy involves intravenous injection of enzyme modified with mannose 6-phosphate, which can be taken up by cells, and is currently approved for some lysosomal storage diseases. Gene therapy can result in secretion of mannose 6-phosphate-modified enzyme into blood, from where it can; similarly, be taken up by cells. Gene therapy has been effective in animal models of lysosomal storage disease, and holds great promise.</p>","PeriodicalId":35477,"journal":{"name":"Heart and Metabolism","volume":"41 ","pages":"21-24"},"PeriodicalIF":0.0,"publicationDate":"2008-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronary computed tomographic angiography: current and future uses. 冠状动脉计算机断层血管造影：当前和未来的应用。
Heart and Metabolism Pub Date : 2007-01-01
Birgit Kantor, Ronald S Kuzo, Thomas C Gerber
{"title":"Coronary computed tomographic angiography: current and future uses.","authors":"Birgit Kantor, Ronald S Kuzo, Thomas C Gerber","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Coronary computed tomographic angiography (CCTA) is a direct but minimally invasive method of visualizing coronary arteries. Acceptable indications for this technique include the assessment of suspected or known coronary artery anomalies, the evaluation of chest pain syndromes in patients with non diagnostic stress tests or who are unable to exercise, and exclusion of an ischemic etiology in patients with unexplained left ventricular dysfunction. Assessment of coronary stents with a diameter of <3.0 mm and imaging of asymptomatic patients with a goal of establishing prognosis are currently not accepted indications for CCTA.</p>","PeriodicalId":35477,"journal":{"name":"Heart and Metabolism","volume":"34 ","pages":"5-9"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792929/pdf/nihms-130604.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28596177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信