力学学报最新文献

{"title":"[Study of urinary markers of different podocytopathies by proteomic analysis].","authors":"A A Vinogradov, N V Chebotareva, A E Bugrova, A G Brzhozovskiy, T N Krasnova, K Z Nasibullina, A S Kononikhin, S V Moiseev","doi":"10.26442/00403660.2023.06.202266","DOIUrl":"10.26442/00403660.2023.06.202266","url":null,"abstract":"<p><strong>Background: </strong>Focal segmental glomerulosclerosis (FSGS) is a primary podocytopathy characterized by primary podocyte detection and high proteinuria. The search for biomarkers and factors associated with the progression of this disease is an important task nowdays.</p><p><strong>Aim: </strong>To assess the proteomic profile of urine in patients with FSGS and to isolate urinary biomarkers of podocytopathies.</p><p><strong>Materials and methods: </strong>The study included 41 patients diagnosed with chronic glomerulonephritis, 27 men and 14 women. According to the morphological study, 28 patients were diagnosed with FSGS, 9 with steroid-sensitive nephrotic syndrome and 14 with steroid-resistant nephrotic syndrome. The comparison group included 13 patients with membranous nephropathy. The study of the urinary proteome was carried out by targeted liquid chromatography-mass spectrometry using multiple reaction monitoring with synthetic stable isotope labelled peptide standards.</p><p><strong>Results: </strong>The main differences in the protein profile of urine were found in the subgroups of steroid-sensitive (SS) and steroid-resistant (SR) FSGS. In the FSGS SR group, at the onset of the disease, there was a high concentration of proteins reflecting damage to the glomerular filter (apo-lipoprotein A-IV, orosomucoid, cadherin, hemopexin, vitronectin), as well as proteins associated with tubulo-interstitial inflammation and accumulation of extracellular matrix (retinol- and vitamin D-binding proteins, kininogen-1, lumican and neurophilin-2). Compared with the membranous nephropathy group, FSGS patients had significantly higher urinary concentrations of carnosinase, orosomucoid, cadherin-13, tenascin X, osteopontin, and zinc-alpha-2-glycoprotein.</p><p><strong>Conclusion: </strong>Thus, in patients with SR FSGS, the proteomic profile of urine includes more proteins at elevated concentrations, which reflects severe damage to various parts of the nephron compared with patients with SS FSGS and membranous nephropathy.</p>","PeriodicalId":35433,"journal":{"name":"力学学报","volume":"35 1","pages":"457-461"},"PeriodicalIF":0.3,"publicationDate":"2023-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80185304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"骨齿对龟甲骨质层中骨缝结构强度和韧性的影响","authors":"Peiran Li, Zheyuan Yu, Zhilong Peng, Bo Zhang, Yin Yao, Shaohua Chen","doi":"10.1007/s10409-023-23097-x","DOIUrl":"https://doi.org/10.1007/s10409-023-23097-x","url":null,"abstract":"","PeriodicalId":35433,"journal":{"name":"Lixue Xuebao/Chinese Journal of Theoretical and Applied Mechanics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52097446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"未冻结和冻结粗砂的本构模型研究","authors":"D. Chang, Jiankun Liu, Anhua Xu","doi":"10.1007/s10409-023-23108-x","DOIUrl":"https://doi.org/10.1007/s10409-023-23108-x","url":null,"abstract":"","PeriodicalId":35433,"journal":{"name":"Lixue Xuebao/Chinese Journal of Theoretical and Applied Mechanics","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52097472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"考虑动态失速和Gurney襟翼的风力机翼型气动建模","authors":"Junwei Yang, Huai Yang, Xiangjun Wang","doi":"10.1007/s10409-023-23056-x","DOIUrl":"https://doi.org/10.1007/s10409-023-23056-x","url":null,"abstract":"","PeriodicalId":35433,"journal":{"name":"Lixue Xuebao/Chinese Journal of Theoretical and Applied Mechanics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52097414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"菱形压力传感器的大变形力学性能及电容性能理论模型与 实验验证","authors":"Weipeng Song, Tianyuan Wang, Li-Hua Shao","doi":"10.1007/s10409-023-22497-x","DOIUrl":"https://doi.org/10.1007/s10409-023-22497-x","url":null,"abstract":"","PeriodicalId":35433,"journal":{"name":"Lixue Xuebao/Chinese Journal of Theoretical and Applied Mechanics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52097103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"变翼展的仿生扑翼尾迹特征","authors":"Xin-lai He, Yi Liu, Yixin Chen, Shizhao Wang","doi":"10.1007/s10409-023-23061-x","DOIUrl":"https://doi.org/10.1007/s10409-023-23061-x","url":null,"abstract":"","PeriodicalId":35433,"journal":{"name":"Lixue Xuebao/Chinese Journal of Theoretical and Applied Mechanics","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52097430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"维诺梯度随机晶格结构多尺度设计及实验验证","authors":"Lianxiong Chen, Yu Pan, X. Chu, Hui Liu, Xinzhong Wang","doi":"10.1007/s10409-023-22445-x","DOIUrl":"https://doi.org/10.1007/s10409-023-22445-x","url":null,"abstract":"","PeriodicalId":35433,"journal":{"name":"Lixue Xuebao/Chinese Journal of Theoretical and Applied Mechanics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52097044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"滑动反射对称声子晶体界面: 主题变化","authors":"Vincent Laude, Julio Andrés Iglesias Martínez, Nicolas Laforge, Muamer Kadic, Emil Prodan","doi":"10.1007/s10409-023-23016-x","DOIUrl":"https://doi.org/10.1007/s10409-023-23016-x","url":null,"abstract":"","PeriodicalId":35433,"journal":{"name":"Lixue Xuebao/Chinese Journal of Theoretical and Applied Mechanics","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52097136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"紧耦合旋涡环缝式雾化器的初级液体雾化机理研究","authors":"M. Zhang, Zhao Zhang, Qiusheng Liu","doi":"10.1007/s10409-023-22476-x","DOIUrl":"https://doi.org/10.1007/s10409-023-22476-x","url":null,"abstract":"","PeriodicalId":35433,"journal":{"name":"Lixue Xuebao/Chinese Journal of Theoretical and Applied Mechanics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52097080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"曲线网格下带有自由流和涡流保存特性的低耗散数值方案","authors":"Jingqi Li, Cheng Liu, Ruoqing Gao, Changhong Hu","doi":"10.1007/s10409-022-22422-x","DOIUrl":"https://doi.org/10.1007/s10409-022-22422-x","url":null,"abstract":"","PeriodicalId":35433,"journal":{"name":"Lixue Xuebao/Chinese Journal of Theoretical and Applied Mechanics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52097016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}