Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry最新文献

{"title":"Investigation of Chemical Constituents of <i>Chamaenerion latifolium</i> L.","authors":"Zhanar Iskakova,&nbsp;Akmaral Kozhantayeva,&nbsp;Gaukhar Tazhkenova,&nbsp;Togzhan Mashan,&nbsp;Kuldi Tosmaganbetova,&nbsp;Yerbolat Tashenov","doi":"10.2174/1871523022666221125111235","DOIUrl":"https://doi.org/10.2174/1871523022666221125111235","url":null,"abstract":"<p><strong>Background: </strong>Chamaenerion latifolium is a perennial herbaceous plant of the Onagraceae family. The purpose of this study was to evaluate and compare the volatile chemical components of the aerial parts of Chamaenerion latifolium growing in the Republic of Kazakhstan.</p><p><strong>Methods: </strong>The leaves and stems of Chamaenerion latifolium were extracted with hexane and analysed by gas chromatography-mass spectrometry (GC-MS).</p><p><strong>Results: </strong>The regularisation of peak areas method was used to calculate the concentrations of the sixty-five identified compounds.</p><p><strong>Conclusion: </strong>Among them, the major components are alkanes (leaves 31.339%, stems 48.158%), esters (leaves 10.216%, stems 12.196%), alcohols (leaves 5.483% and stems 5.14%), aldehydes (leaves 3.155%, stems 1.592%), triterpenoids (leaves 2.247% stems 3.785%).</p>","PeriodicalId":35423,"journal":{"name":"Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10854539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacrimal Gland Histopathology and Secretory Function in Sjögren's Syndrome Mice Model Treated with <i>Moringa oleifera</i> Lam. Leaf Extract.","authors":"Agus Joko Susanto,&nbsp;Bambang Purwanto,&nbsp;Ambar Mudigdo,&nbsp;Brian Wasita","doi":"10.2174/1871523022666221026145110","DOIUrl":"https://doi.org/10.2174/1871523022666221026145110","url":null,"abstract":"<p><strong>Background: </strong>The pathogenesis of Sjögren's syndrome involves the activation of NF- κB, producing proinflammatory cytokines such as tumor necrosis factor-α, interleukin (IL)-1α, IL- 1β, IL-6, IL-17, and interferon-γ. Through oxidative stress, they will cause necrosis and apoptosis of lacrimal gland cells, resulting in impaired secretory function or reduced tear production. Moringa oleifera leaf extract is known to have strong anti-inflammatory and antioxidant activities.</p><p><strong>Objective: </strong>To determine the effect of Moringa oleifera leaf extract on lacrimal gland histopathology and secretory function in Sjögren's syndrome mice model.</p><p><strong>Methods: </strong>The experimental study had a post-test only control group design with 32 eight-week-old male mice of the BALB/c strain divided into four groups, negative control (C-), which was not induced by SS, positive control (C+), treatment 1 (T1), and treatment 2 (T2) induced by Sjögren's syndrome by immunizing with the 60-kD Ro antigen (SSA) as much as 100 μg. After 42 days, the T1 group was given dexamethasone 1.23 mg/kg BW/day orally for 14 days, whereas T2 was given dexamethasone 1.23 mg/kg BW/day and Moringa oleifera leaf ethanol extract 200 mg/kg BW/day orally for 14 days. At the end of the study, lacrimal gland histopathology and secretory function (tear production) were examined. Statistical analysis using F ANOVA/Kruskal-Wallis was followed by partial difference test with the Least Significant Difference post hoc test/Mann-Whitney. Significant if p < 0.05.</p><p><strong>Results: </strong>The comparison of lacrimal gland histopathology in T1 (p = 0.044) and T2 groups (p = 0.020) obtained significant results (p < 0.05) when compared to C+. However, the comparison of tear production in T1 (p = 0.127) and T2 groups (p = 0.206) was not significant (p > 0.05) when compared to the C+ group.</p><p><strong>Conclusion: </strong>The administration of Moringa oleifera leaf extract 200 mg/kg BW for 14 days could significantly improve lacrimal gland histopathology but was not effective in increasing tear production in Sjögren's syndrome mice model.</p>","PeriodicalId":35423,"journal":{"name":"Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/94/AIAAMC-21-166.PMC10226169.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9546391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory Activity: <i>In silico</i> and <i>In vivo</i> of Sapogenins Present in <i>Agave brittoniana</i> subsp. <i>brachypus</i> (Trel.).","authors":"Dayana Resino-Ruiz,&nbsp;Yisel Gonzalez-Madariaga,&nbsp;Leisy Nieto,&nbsp;Yilka Mena Linares,&nbsp;Jose Orestes Guerra León,&nbsp;Arlena Vázquez Martín,&nbsp;Arianna Valido Díaz,&nbsp;Francisco Torrens,&nbsp;Juan A Castillo-Garit","doi":"10.2174/1871523022666230419103027","DOIUrl":"10.2174/1871523022666230419103027","url":null,"abstract":"<p><strong>Background: </strong>Agave brittoniana subsp. brachypus is an endemic plant of Cuba, which contains different steroidal sapogenins with anti-inflammatory effects. This work aims to develop computational models which allow the identification of new chemical compounds with potential anti-inflammatory activity.</p><p><strong>Methods: </strong>The in vivo anti-inflammatory activity was evaluated in two rat models: carrageenaninduced paw edema and cotton pellet-induced granuloma. In each study, we used 30 Sprague Dawley male rats divided into five groups containing six animals. The products isolated and administrated were fraction rich in yuccagenin and sapogenins crude.</p><p><strong>Results: </strong>The obtained model, based on a classification tree, showed an accuracy value of 86.97% for the training set. Seven compounds (saponins and sapogenins) were identified as potential antiinflammatory agents in the virtual screening. According to in vivo studies, the yuccagenin-rich fraction was the greater inhibitor of the evaluated product from Agave.</p><p><strong>Conclusion: </strong>The evaluated metabolites of the Agave brittoniana subsp. Brachypus showed an interesting anti-inflammatory effect.</p>","PeriodicalId":35423,"journal":{"name":"Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10497729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibition of Interleukin-6 Dependent Metalloproteinases-9/2 Expression in Cancer Cells by Diet Polyphenols.","authors":"Rosaria Arcone,&nbsp;Rosarita Nasso,&nbsp;Valentina Pagliara,&nbsp;Antonio D'Errico,&nbsp;Maria Letizia Motti,&nbsp;Stefania D'Angelo,&nbsp;Gabriele Carbonara,&nbsp;Mariorosario Masullo","doi":"10.2174/1871523022666230718113806","DOIUrl":"https://doi.org/10.2174/1871523022666230718113806","url":null,"abstract":"<p><p>Among inflammatory cytokines, Interleukin-6 (IL-6) is one of the major activators of acute phase response and is also involved in immune response and cancer progression. IL-6 is involved in the up-regulation of enzymes and growth factors acting on the extracellular matrix (ECM) remodelling components in physio-pathological processes. IL-6 enhances the expression of metalloproteases (MMP-)2/9, enzymes that play a key role in ECM degradation and therefore contribute to the process of tumor metastasis. To counteract and/or prevent cancer diseases, many efforts have been devoted to the identification of factors able to inhibit the IL-6-dependent MMP-9/2 expression. Recently, diet polyphenols have been identified as molecules manifesting anti-inflammatory and anti-cancer properties beyond their well-known capacity to promote health on the basis of their antioxidant effects. This review summarizes the recent advances in this field, focusing on the protective effects exerted by diet polyphenols on the proliferation and invasiveness of tumor cells, with specific emphasis on the ability of these molecules to inhibit the IL-6-dependent upregulation of MMP-2/9.</p>","PeriodicalId":35423,"journal":{"name":"Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10116194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Anti-Inflammatory and Anti-Allergy Agents: Herbs and Botanical Ingredients.","authors":"R. Saini, Neena K. Dhiman","doi":"10.2174/1871523021666220411111743","DOIUrl":"https://doi.org/10.2174/1871523021666220411111743","url":null,"abstract":"Allergies have known to be an abnormally vigorous immune response in which the immune system fights off an allergen or antigen initiating mast cells to release histamine into the blood. Substances which prevent mast cells from releasing histamine are considered as antiallergic agents. The drugs utilized for the treatment of allergy are mast cell stabilizers, steroids, anti-histamine, leukotriene receptor antagonists, and decongestants. Anti-histamine drugs have side effects such as drowsiness, confusion, constipation, difficulty urinating, blurred vision, etc. The use of medicinal plants for effective and safe management of diseases has recently received much attention. Various herbs are utilized for their antiallergic and anti-histaminic properties. Some of the herbs useful in the management of allergic diseases of the respiratory tract like Piper longum, Ocimum tenuiflorum, Solanum xanthocarpum have been discussed. Ample scientific evidence is available for the anti-histaminic and antiallergic activity of Azadirachta indica, Aloe vera, Tinospora cordifolia, and a number of other such herbs which are safer to use as antiallergic agents have been reported. The review summarizes a wide variety of herbs and botanical ingredients with their common scientific names and distribution for their easy identification and usage as safe antiallergic agents, also discussing their molecular mechanisms involved in combating allergic reactions.","PeriodicalId":35423,"journal":{"name":"Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45105593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation Of Anti-Inflammatory Mediated Anti-Hemorrhoidal Activity of Lawsonia Inermis On Croton Oil Induced Hemorrhoidal Rats.","authors":"Sai Krishna Nallajerla, S. Ganta","doi":"10.2174/1871523021666220330143845","DOIUrl":"https://doi.org/10.2174/1871523021666220330143845","url":null,"abstract":"BACKGROUND\u0000Hemorrhoids are a common recto-anal disorder commonly known as piles or tissue clumps in the rectum. In normal individuals, they were known as anal cushions. In the anus, they are composed of rectal blood vessels, muscles, and elastic fibres when bulged,it can cause bleeding, constipation, itching, severe pain, and bleeding in the anus. Inflammation of the anal cushion remains major pathogenesis for the development of hemorrhoids. Inflammatory mediators like neutrophils, TNF-α, and IL-6 seem to play a major role in the development of disease.\u0000\u0000\u0000OBJECTIVE\u0000This study aims to carry out the ethanolic leaf extract of Lawsonia inermis (L. inermis) and evaluate its anti-hemorrhoidal activity both invitro and in vivo. Furthermore, Molecular Docking was performed on the crystal structure of COX-2 with the selective compound 23d-(R) (PDB ID: 3NTG) protein.\u0000\u0000\u0000METHODS\u0000The current study is to estimate an anti-inflammatory mediated anti-hemorrhoidal activity of ethanolic leaf extract of L. inermis at different doses of 200 mg/kg/ir and 400 mg/kg/ir in croton oil-induced hemorrhoidal rats. Pilex ointment is taken as a reference standard in the present study. Evan's blue extravasation technique were applied in the study to quantify the proinflammatory protein.\u0000\u0000\u0000RESULTS\u0000From the study results, a dose-dependent effect was found for ethanolic leaf extract of Lawsonia inermis at 200 mg/kg and 400 mg/kg causing a significant reduction of serum Pro-inflammatory mediators TNF-α, IL-6, and plasma neutrophils in croton oil-induced hemorrhoidal rats.\u0000\u0000\u0000CONCLUSION\u0000Studies represented that the plant extract can significantly inhibit protein denaturation of egg albumin in invitro and has a beneficial role in anti-hemorrhoidal agent.","PeriodicalId":35423,"journal":{"name":"Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43239394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post COVID-19 Syndrome Clinical Manifestations: A Systematic Review.","authors":"M. Abdel-Gawad, M. Zaghloul, S. Abd-Elsalam, M. Hashem, S. A. Lashen, A. Mahros, A. Mohammed, Amro M. Hassan, Ahmed Bekhit, W. Mohammed, M. Alboraie","doi":"10.2174/1871523021666220328115818","DOIUrl":"https://doi.org/10.2174/1871523021666220328115818","url":null,"abstract":"BACKGROUND\u0000Coronavirus disease-2019 (COVID-19) is a global pandemic health problem which causes a wide spectrum of clinical manifestations and considerable mortality rates. Unfortunately, recovered patients who survive COVID-19 may continue to report wide varieties of clinical manifestations of multisystem affection such as fatigue, dyspnea, myalgia, anxiety, depression, acute myocardial infarction, peripheral and pulmonary embolisms.\u0000\u0000\u0000OBJECTIVE\u0000We aimed to assess the prevalence of post-COVID-19 manifestations.\u0000\u0000\u0000METHODS\u0000We conducted a systematic review on post COVID-19 manifestations by searching Pubmed, Scopus, Web of Science (WOS), EBSCO, Wily, and World health organization (WHO) databases. Screening, selection, data extraction, data synthesis and quality assessment were done by two independent reviewers.\u0000\u0000\u0000RESULTS\u0000Of 1,371 references, 817 references remained after duplicates, reviews; case reports, commentaries, and any article containing non-original information were removed. According to eligibility criteria for this systematic review, 12 studies were included for qualitative synthesis. The overall prevalence of post-COVID-19 manifestations ranged from 35% to 90.5%. Fatigue, dyspnea, neuropsychological disorders, and pain were the most frequent post COVID-19 symptoms.\u0000\u0000\u0000CONCLUSIONS\u0000This systematic review showed that 35% to 90.5% of recovered patients who survive COVID-19 continue to have wide varieties of clinical manifestations and fatigue, dyspnea, neuropsychological disorders, and pain were the most frequent post COVID-19 symptoms.","PeriodicalId":35423,"journal":{"name":"Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47849119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diosgenin: mechanistic insights on its anti-inflammatory effects.","authors":"S. Karami-Mohajeri, R. Mohammadinejad, M. Ashrafizadeh, N. Mohamadi, M. Mohajeri, F. Sharififar","doi":"10.2174/1871523021666220328121721","DOIUrl":"https://doi.org/10.2174/1871523021666220328121721","url":null,"abstract":"Diosgenin (DG), a well-known steroid saponin, has shown anti-inflammatory effects. This review was aimed to discuss all published literature concerning the anti-inflammatory effects of diosgenin. Based on the modulatory impact of DG on the NF-κB pathway, its supplementation is associated with downregulation of NF-κB pathway and TGF-β, resulting in inhibition of inflammation. It appears that upstream modulators of NF-κB signaling pathway such as Tlrs and downstream mediators include iNOS and COX-2, leading to the inhibition of the inflammatory response and development of pathological conditions. Due to the low toxicity of the herbal compounds, the risk of the side effects of DG use for the management of inflammatory disorders such as asthma, rheumatism, rhinitis, and arthritis are lower than that of synthetic glucocorticoids. It has been shown that regulation of NF-κB and oxidative stress signaling pathways by DG is beneficial against cardiotoxicity induced by chemotherapeutic agents such as doxorubicin.","PeriodicalId":35423,"journal":{"name":"Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41806594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Xylopic acid Suppresses Adjuvant-induced Arthritis in Sprague Dawley rats via Reduction in Serum Levels of IL-6 And TNF-alpha.","authors":"Newman Osafo, A. Antwi, Sarah Otu-Boakye","doi":"10.2174/1871523021666220310094218","DOIUrl":"https://doi.org/10.2174/1871523021666220310094218","url":null,"abstract":"BACKGROUND\u0000Xylopic acid (XA) is the principal constituent obtained from the biofractionation of the dried fruits of Xylopia aethiopica. Our initial reports have established the acute anti-inflammatory activity of this kaurene diterpene.\u0000\u0000\u0000OBJECTIVE\u0000Currently, we investigate the chronic anti-inflammatory activity of xylopic acid.\u0000\u0000\u0000METHOD\u0000The adjuvant-induced arthritis model in rats was employed in carrying out the study.\u0000\u0000\u0000RESULTS\u0000It was observed from the study that XA significantly (P < 0.05) suppressed the oedema associated with adjuvant arthritis while preventing associated joint deformation as identified from the radiographs. Histopathological analysis of joints of treated animals revealed signs of bone reformation and re-calcification following XA administration. From the haematological analysis, xylopic acid significantly decreased eosinophil sedimentation rate (ESR) while also decreasing white blood cells (WBC) which was increased after arthritis induction. Serum analysis showed the inhibitory effect of XA on serum expression of IL-6 and TNF-alpha in arthritic rats.\u0000\u0000\u0000CONCLUSION\u0000Our study demonstrates the anti-arthritic activity of orally administered XA while pointing to a possible mechanism of its anti-inflammatory action.","PeriodicalId":35423,"journal":{"name":"Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43625969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Acylhydrazone Derivatives on Experimental Pulmonary Inflammation by Chemical Sensitization.","authors":"Katharina Rodrigues de Lima Porto Ramos,&nbsp;Sandra Cabral da Silva,&nbsp;Pascal Marchand,&nbsp;Fernanda Virgínia Barreto Mota,&nbsp;Julyanne Cunha de Assis Correia,&nbsp;Jéssica de Andrade Gomes Silva,&nbsp;George Torres de Lima,&nbsp;Marllon Alex Santana,&nbsp;Willian Charles da Silva Moura,&nbsp;Vanda Lúcia Dos Santos,&nbsp;Ricardo Olímpio Moura,&nbsp;Teresinha Gonçalves da Silva","doi":"10.2174/1871523021666220729141608","DOIUrl":"https://doi.org/10.2174/1871523021666220729141608","url":null,"abstract":"<p><strong>Background: </strong>Chronic lung diseases are characterized by airway inflammation and remodelling of the lung parenchyma that triggers considerable impairment of respiratory function.</p><p><strong>Objective: </strong>In this study, two compounds belonging to the N-acylhydrazone class were evaluated, aiming to identify new therapeutic agents for pulmonary inflammatory diseases.</p><p><strong>Materials and methods: </strong>The acute toxicity of 2-cyano-N'-(3-ethoxy-4-hydroxybenzylidene)- acetohydrazide (JR-12) and N'-benzylidene-2-cyano-3-phenylacrylohydrazide (JR09-Bz) was evaluated. Afterwards, they were tested in models of ovalbumin (OVA)-induced allergic asthma and pleurisy, bleomycin-induced pulmonary fibrosis, in addition to mucolytic activity.</p><p><strong>Results and discussion: </strong>The compounds did not show toxicity at the dose of 2,000 mg/kg, and no animal died. On OVA-induced pleurisy, animals treated with JR-12 or JR09-Bz at a dose of 10 mg/kg (orally) showed significant inhibition of the leukocyte infiltrate in the bronchoalveolar lavage by 62.5% and 61.5%, respectively, compared to the control group. The compounds JR-12 and JR09-Bz were also active in blocking the allergic asthmatic response triggered by OVA, reducing the leukocyte infiltrate by 73.1% and 69.8%, respectively. Histopathological changes and mast cell migration in treated animals with JR-12 or JR09-Bz were similar to treatment with the reference drugs dexamethasone and montelukast. JR-12 and JR09-Bz also reversed airway remodeling in animals on the bleomycin-induced fibrosis model compared to the control group. Furthermore, it was observed that N-arylhydrazone derivatives showed expectorant and mucolytic activities, increasing mucus secretion by 45.6% and 63.8% for JR-12 and JR09-Bz, respectively.</p><p><strong>Conclusion: </strong>Together, the results show that JR-12 and JR09-Bz showed promising activity against airway inflammation, as well as low toxicity.</p>","PeriodicalId":35423,"journal":{"name":"Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40588120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}