武汉大学学报(医学版)最新文献

{"title":"Summary of perioperative analgesia and sedation management of 19 lung transplant recipients","authors":"R. Zhu, S. Yu, W. Gao, L. Zhan","doi":"10.14188/j.1671-8852.2021.6013","DOIUrl":"https://doi.org/10.14188/j.1671-8852.2021.6013","url":null,"abstract":"Objective: To summarize and explore the management experience of postoperative analgesia and sedation in lung transplant recipients. Methods: A total of 19 cases of lung transplantation were performed in Renmin Hospital of Wuhan University from December 2016 to December 2020, and all of them were transferred back to intensive care unit after surgery, the clinical data were retrospectively analyzed. Results: Among the 19 patients, the main diagnoses were chronic obstructive pulmonary disease in 5 cases, idiopathic pulmonary fibrosis in 6 cases, bronchiectasis in 2 cases, pneumoconiosis in 4 cases, Kartagener syndrome in 1 case and COVID-19 pneumonia with advanced pulmonary fibrosis in 1 case. There were 12 cases of double lung transplantation, and 7 cases of unilateral lung transplantation in (4 cases of left single lung transplantation and 3 cases of right single lung transplantation). Nine patients used ECMO to complete the operation, and 5 cases took ECMO back to the intensive care unit. All patients were treated with opioid analgesia, mainly sufentanil at a dose of 0.2-0.3 μg/(kg•h), midazolam and propofol are mainly used as sedatives at doses of 0.02-0.1 mg/(kg•h) and 0.3-0.4 mg/(kg•h), respectively, and the Richmond agitation sedation scale was -3.01±1.32 within 24 hours after operation. The main postoperative adverse events were delirium (1 case) and respiratory depression (1 case). There were 6 deaths during the perioperative period. One case died of multi-drug resistant bacteria infection, 1 case died of circulatory failure caused by active thoracic hemorrhage post-operation, the third case died of intraoperative cardiac arrest, and the other 3 cases were given up because of multiple organs failure. Conclusion: Analgesia and sedation is an important treatment for patients after lung transplantation. Choosing the depth of sedation according to the functional state of organs of lung transplant recipients and implementing the sedation strategy aiming at organ function protection is helpful to maintain the stability of cardiopulmonary function after lung transplantation. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66656950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influencing factors of occupational stress of front⁃line medical workers under the epidemic of COVID‑19","authors":"H. Lin, H. Ai, X. Guo, X. Wu, B. Chen","doi":"10.14188/j.1671-8852.2020.0288","DOIUrl":"https://doi.org/10.14188/j.1671-8852.2020.0288","url":null,"abstract":"Objective: To understand the influencing factors of occupational stress of front‑line medical workers and provide scientific decision‑making basis for health management departments, and to avoid post‑epidemic stress disorders of medical workers. Methods: Using the method of random sampling, the electronic questionnaire was sent in the forms of Wechat link and picture QR code. Results: Frequent night shift, frequent headache and tiredness, fear of COVID‑19, anxiety and tension caused by overwork, job burnout and self‑remorse due to the death of patients were the influencing factors of self‑stress perception of front‑line medical workers. Conclusion: The occupational pressure of anti‑epidemic front‑line medical workers is great, and measures such as psychological counseling and reasonable shift arrangement should be taken. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":"42 1","pages":"729-732"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66657064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of extracorporeal membrane oxygenation in the perioperative period of lung transplantation","authors":"C. Ma, J. Bai, M. Wu, X. Du","doi":"10.14188/j.1671-8852.2021.6011","DOIUrl":"https://doi.org/10.14188/j.1671-8852.2021.6011","url":null,"abstract":"Objective: To investigate the application of extracorporeal membrane oxygenation (ECMO) in the perioperative period of lung transplantation, and summarize the experience. Methods: The clinical data of 19 patients receiving lung transplantation operation in Renmin Hospital of Wuhan University from December 2016 to December 2020 were retrospectively analyzed. Patients were divided into groups according to whether ECMO support was used, and their clinical data were compared. Results: Among the 19 patients, there were 5 cases of chronic obstructive pulmonary disease, 3 cases of bronchiectasis, 4 cases of pneumoconiosis, 4 cases of idiopathic pulmonary fibrosis, 1 case of connective tissue disease interstitial pulmonary fibrosis, 1 case of Kartagener syndrome, and 1 case of COVID-19 with advanced pulmonary fibrosis. Among the 10 patients in the non-ECMO group, 1 died during the operation, 1 died after abandoning treatment, and 1 was discharged after abandoning treatment. There were 9 patients in the ECMO group, 2 patients received ECMO bridged treatment before surgery, and the remaining 7 patients received ECMO adjuvant treatment after anesthesia. In the ECMO group, 1 patient died, 1 patient was discharged after abandoning treatment, and the rest patients were all improved and discharged after successful weaning of ECMO. The two groups only differed in the way of preoperative respiratory support (P=0.033). There were no significant differences in gender, age, preoperative assessment, surgical process, length of hospital stay, ICU stay, postoperative multi-drug resistant organism infection, and outcome. Conclusion: ECMO is an important auxiliary tool during the perioperative period of lung transplantation. The use of ECMO did not increase the risk of postoperative infection with multidrug-resistant bacteria, nor did it lead to an increase in mortality. In the other hand, the choice of preoperative respiratory support method has reference for perioperative patients whether to use ECMO. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":"42 1","pages":"558-563"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66656916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors related to viral clearance time in patients with critical COVID‑19","authors":"L. Li, B. He, S. Zhang, S. Wang, M. Zhang, Q. Zhao","doi":"10.14188/j.1671-8852.2020.0499","DOIUrl":"https://doi.org/10.14188/j.1671-8852.2020.0499","url":null,"abstract":"Objective: To evaluate the related factors to virus clearance time in patients with critical COVID‑19. Methods: A total of 63 patients with critical COVID‑19 who had viral clearance were enrolled from Feb 1 to Mar 20, 2020, in Renmin Hospital of Wuhan University. Univariate analyses were used to compare the related factors between groups with different viral clearance time (≤30 days viral clearance group versus >30 days viral clearance group). COX regression analysis was also used to evaluate the factors related to virus clearance time. Results: A total of 63 critical patients with COVID‑19 who had viral clearance were collected, including 35 male and 28 female. The mean age was (63.65±14.06) years, range from 29 to 89 years. The median viral clearance time was 27 days ( IQR, 21~36 days). In univariate analysis, the following factors had significant differences between ≤30 days viral clearance group and >30 days viral clearance group (all P 70 years old, COPD, WBC>9.5×109/L, LYM 50 mg/L, D‑dimer>5 mg/L, CK>200 U/L, LDH>300 U/L, CD4+ T‑cell 70 years old ( HR : 0.207, 95% CI : 0.090‑0.479), LYM 5 mg/L ( HR : 0.243, 95% CI : 0.105‑0.563), and ALT>50 U/L ( HR : 0.483, 95% CI : 0.239‑0.973) were inconducive to the elimination of the virus. Conclusion: Critical COVID‑19 patients have longer hospital stays and significantly different virus clearance time. There are many factors that affect viral clearance time. As adverse factors, age>70 years old, LYM 5 mg/L and ALT>50 U/L may prolong the viral clearance time. Early detection of related factors and timely treatment are beneficial to shorten the time of viral clearance and improve the prognosis of the disease. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":"42 1","pages":"689-693"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66656929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of COVID‑19 complicated with pleural and pericardial effusion in 10 patients","authors":"Y. Guo, L. Zhang, R. Li, S. Tian, W. Dong","doi":"10.14188/j.1671-8852.2020.0559","DOIUrl":"https://doi.org/10.14188/j.1671-8852.2020.0559","url":null,"abstract":"Objective: To retrospectively analyze the clinical characteristics of corona virus disease 2019 (COVID‑19) patients with pleural and pericardial effusion. Methods: We retrospectively reviewed and compared data of 60 COVID‑19 inpatients including 10 patients with pleural effusion (PLE) and pericardial effusion (PCE) and 50 cases without PLE/PCE, from January 20, 2020 to March 23, 2020 in Renmin Hospital of Wuhan University. The patients' medical history, clinical features, physical findings, laboratory test results, and chest tomographic imaging were recorded and analyzed. Statistical significance was determined using the chi‑square test, Fisher's exact test, and the Mann‑Whitney U‑test. Results: COVID‑19 patients with PLE and PCE had a higher temperature (P<0.001), a higher incidence of breath shortness (P=0.024) and faster respiratory frequency (P=0.004) than those without PLE and PCE. Laboratory findings showed that patients with PLE and PCE had higher levels of C‑reactive protein (CRP,P=0.039) and D‑dimer (P=0.038), and lower levels of lymphocytes (P=0.024), hemoglobin (P=0.003), CD4+T cell counts (P=0.016), and oxygen saturation (P=0.037). Meanwhile, patients with PLE and PCE had higher incidence of severe or critical illness and mortality rates as compared with those without PLE and PCE (all P<0.05). Conclusion: PLE and PCE were indicators for severe inflammation and poor clinical outcomes, and might be independent risk factors for critical type in COVID‑19 patients. It suggests that the treatment for the COVID‑19 patients with PLE and PCE should be more active and timely. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":"42 1","pages":"878-883"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66657087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of remote fetal heart rate monitoring during the pandemic of COVID‑19","authors":"Y. Xu, F. Huang","doi":"10.14188/j.1671-8852.2021.0006","DOIUrl":"https://doi.org/10.14188/j.1671-8852.2021.0006","url":null,"abstract":"Objective: To explore the application of remote fetal heart rate monitoring during the pandemic of COVID‑19. Methods: The rate of cesarean section, the incidence of neonatal asphyxia, the times of self‑care, the false positive rate, and the degree of anxiety were compared between the remote fetal heart rate monitoring group and control group. Results: There was no significant difference in cesarean section rate and neonatal asphyxia rate between the two groups( P >0.05). The frequency of self‑care and the incidence of false positive in the remote fetal heart monitoring group were better than in control group( P <0.01). Compared with the remote fetal heart rate monitoring group, the control group were more likely to be anxious( P <0.01). Conclusion: Remote fetal heart rate monitoring is suitable as an effective supplement for hospital prenatal examination during the epidemic period, and it has good application prospects. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":"48 1","pages":"733-736"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66656751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors analysisi for COVID‑19 in the elderly","authors":"Z. Wang, H. Wang, Q. Yin, J. Peng, Y. Wang, H. Ye","doi":"10.14188/j.1671-8852.2021.0064","DOIUrl":"https://doi.org/10.14188/j.1671-8852.2021.0064","url":null,"abstract":"Objective: To analyze the clinical characteristics and prognosis of the coronavirus disease 2019 (COVID‑19) in the elderly(aged 60 or above), and to explore the high risk factors of severe disease progression for early identification and prevention. Methods: Novel coronavirus pneumonia patients aged 60 or above diagnosed in Hubei Veterans Hospital from January 20 to February 29 in year 2020 were collected. According to the degrees of disease, the patients were divided into mild and severe groups, and their clinical features, laboratory examination, chest CT features, treatment, and outcome were compared. Results: A total of 108 patients were included, including 69 in mild group and 39 in severe group. The average age of the severe group was higher than that of the mild group ( P <0.001). The clinical symptoms of fever, expectoration, dyspnea, fatigue and diarrhea in the severe group were severer and more common than those in the mild group (all P <0.001). The proportion of hypertension ( P <0.05), respiratory system diseases (such as chronic bronchitis and COPD) ( P <0.05), and hypoproteinemia ( P <0.001) combined with COVID⁃19 were higher in severe groupthe severe group. Leukocyte count (WBC), neutrophil count (NEUT), CRP and SAA in the severe group were significantly higher ( P <0.05), while lymphocyte count (LY) and eosinophil count (EOS) were lower than those in the mild group ( P <0.05). Lung CT images showed that patients in the severe group had more bilateral lung involvements and pleural effusion than those in the mild group ( P <0.05). Among the 108 cases, 96 (88.9%) were cured and improved, 12 (11.1%) died. Conclusion: Age, basic comorbidities, decreasing in lymphocytes and acidophilic granulocytes, and multiple bacterial infections are risk factors for severe COVID‑19. Hypoalbuminemia may be a potential and independent adverse prognostic indicator for the elderly COVID‑19. Symptoms of dyspnea and diarrhea, bilateral lung involvements, the pleural effusion are high risk signs for the elderly COVID‑19 patients progressing to severe. These findings are valuable for the early recognition, early diagnosis and treatment for COVID⁃19. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":"42 1","pages":"714-717"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66656769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes of antibodies in COVID‑19 patients: A 10‑month prospective study","authors":"M. Jia, L. Liu, X. Cai, X. Wu","doi":"10.14188/j.1671-8852.2021.0357","DOIUrl":"https://doi.org/10.14188/j.1671-8852.2021.0357","url":null,"abstract":"Objective: To explore the law of antibody changes in patients diagnosed with COVID‑19 after the onset of the disease. Methods: A total of 215 patients who were diagnosed with COVID‑19 by RT‑PCR in Wuchang District, Wuhan City, Hubei Province were recruited as the research subjects. The rapid colloidal gold immunochromatography assay was performed on every newly diagnosed patient at the time points of (10±3) d, (100±3) d, (190±3) d, and (280±3) d after the onset of the disease. Results: In terms of antibody types, among the 215 patients,the positive rate of IgM antibodies was 36.7% at (10±3) d. The antibody levels were 22.5%, 5.0%, and 4.7% at (100±3) d, (190±3) d, and (280±3) d respectively. In general, the levels of IgG antibody were high. The positive rate of antibody within (10±3) days was 87.0%, and the rate decreased to 80.8% at (100±3) d, 49.7% and 46.5% at (190±3) d and (280±3) d, respectively. The number of IgM and IgG antibodies homo‑positive samples gradually decreased over time. At the meantime, the proportion of IgM+IgG antibodies both negative samples gradually increases. According to the clinical classification, in the early stage of the disease, the positive rate of IgM antibody was different in patients with different severity of clinical symptoms. The more severe the clinical symptoms, the higher the positive rate of IgM antibodies. Around 190 days after the onset of symptoms, the positive rate of IgG antibodies decreased more slowly in mild and common patients. At the 280‑day during follow‑up, IgM antibodies showed a higher positive rate in severe and critical patients. From the trend of antibody changes in the same patient within 10 months, among the 70 patients, only 55 cases (32.4%) showed continuous positive in IgG antibody, with 77 cases (45.3%) in the IgG antibody positive‑to‑negative group,and 21 cases (12.4%) in the IgG antibody positive‑to‑negative‑to‑positive group. Three cases (1.8%) showed IgG antibody negative converting to positive. However, there were 14 cases (8.2%) remaining with negative IgG antibody. For IgM antibodies, 97 cases (57.1%) were persistently negative, wth 5 cases (2.9%) in the negative‑to‑positive group, and 65 cases (38.2%) in the positive‑to‑negative group. IgM antibody continued to be positive within 10 months has not been observed yet, and there were 3 cases (1.8%) in the IgM antibody positive‑to‑negative‑to‑positive group. Conclusion: After the new coronavirus infection, the serological response is unstable. In the early stage of the disease, antibody detection has important auxiliary value for the diagnosis of the disease;but in the late stage, the diagnostic value is not great. The antibody response may be positively correlated with the severity of the disease. Nearly 50% of patients can remain positive for IgG antibodies within 10 months, which indicates that nearly half of patients recovering from COVID‑19 can obtain longer‑lasting immunity. However, IgG antibodies in some patients contin","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":"42 1","pages":"861-866"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66656805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of Lopinavir-Ritonavir combined with interferon alpha in COVID-19","authors":"Y. Wang, T. Suo, H. Fan, K. Zhao, J. Zou, D. Wu, G. Tang, G. Chen","doi":"10.14188/j.1671-8852.2020.0400","DOIUrl":"https://doi.org/10.14188/j.1671-8852.2020.0400","url":null,"abstract":"Objective: To evaluate the clinical efficacy of Lopinavir-Ritonavir combined with interferon alpha on coronavirus disease 2019 (COVID-19). Methods: A prospective and real-world observational clinical research was conducted on COVID-19 cases who were admitted to the Renmin Hospital of Wuhan University from January 25, 2020 to February 12, 2020. Of the 109 cases involved, 58 cases were treated with interferon alpha (group A), while 58 cases were treated with Lopinavir-Ritonavir combined with interferon alpha (group B). The recent outcomes were compared between the two groups by Kruskal Wallis test or Chi square test. Results: The baseline data of the two groups were basically the same. On the 7th day after treatment, the lung inflammation in group B was higher than in group A, and the leukocyte count and neutrophil count in the normal range increased as compared with the baseline value in group B. On the 14th day after treatment, the leukocyte count, lymphocyte count, CD4/CD8 cell count increased as compared with the baseline value, while CRP decreased from baseline in the B group, with statistically significant differnce. Conclusion: Lopinavir-Ritonavir combined with interferon alpha can accelerate the improvement of pulmonary inflammation, and increase the levels of immune cells in COVID-19 patients. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":"42 1","pages":"594-598"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66656792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of twenty children with COVID⁃19","authors":"Y. Xu, X. Song, A. Zhang, W. Lu, Q. Yuan, X. Peng, B. Yao","doi":"10.14188/j.1671-8852.2020.0502","DOIUrl":"https://doi.org/10.14188/j.1671-8852.2020.0502","url":null,"abstract":"Objective: To investigate the characteristics of disease transmission, diagnosis, and treatment of COVID‑19 in children. Methods: We retrospectively studied 20 children with COVID‑19 from 4 medical centers in Hubei, China. Results: Among the 20 children, 18 (90.0%) were contaminated by close contact and characterized by family clustering. Seven cases (35.0%) had all family members infected, and 11 cases (55.0%) were confirmed by either of the parents infected. Twelve cases (60.0%) had fever, which was the primary symptom in 10 cases (50.0%). Only one child was in severe degree and combined with severe underlying disease (congenital heart disease). Seven cases (35.0%) presented typical ground‑glass opacity in CT. All patients were confirmed to be infected with SARS‑CoV‑2. Eleven cases (55.0%) had normal white blood cell counts, and one case (5.0%) with severe COVID‑19 showed a continuous decline in T cells subsets. Conclusion: COVID‑19 in children is transmitted by close contact and characterized by family clustering. Fever is the most common symptom or initial symptom. However, the sustained low levels of T cells and underlying diseases are risk factors for severe COVID‑19 children. © 2021, Editorial Board of Medical Journal of Wuhan University. All right reserved.","PeriodicalId":35402,"journal":{"name":"Medical Journal of Wuhan University","volume":"42 1","pages":"718-723"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"66656994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}