{"title":"Assessment of Acute Oral Toxicity Study of Trasina®, an Ayurvedic Herbal Formulation on Experimental Models","authors":"S. Darbar, S. Chattopadhyay","doi":"10.30799/JPMR.036.19040102","DOIUrl":"https://doi.org/10.30799/JPMR.036.19040102","url":null,"abstract":"Article history: Received 18 January 2019 Accepted 15 February 2019 Available online 01 April 2019 In the safety evaluation of a test substance, determination of acute oral toxicity is generally the initial step and provides information on health hazards that may arise from an acute exposure by the oral route. It may also provide early information on the mode of toxic action of a substance. The study was aimed to assess the possible toxic effects and to identify the preliminary safety profile of Trasina®, a polyherbal capsule (M/S Dey's Medical Stores Manufacturing Limited, Kolkata, West Bengal, India) after single oral administration in mice according to the OECD guidelines. In the present study, a single administration of the poly herbal extract at a dose of 2000 mg/kg, respectively, was given to the swiss albino mice. During the study period the mice were observed for general appearance, behavior, body weight, adverse effects, mortality and necropsy up to 14 days post-treatment. No toxicological changes or mortalities related to the test substance were also observed after the administration in experimental animals. No changes in general appearance and mortality was observed. Trasina was found to be safe at dose of 2000 mg/kg. In the conclusion these results demonstrate that the extract may not have any single dose toxicity.","PeriodicalId":352927,"journal":{"name":"Volume 4,Issue 1, 2019","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129551525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Indigenous Knowledge on Cattle Health Care Practices in Selected Villages of Madurai District in Tamil Nadu, India","authors":". S.SargunaSundaram, K. Suresh","doi":"10.30799/jpmr.037.19040101","DOIUrl":"https://doi.org/10.30799/jpmr.037.19040101","url":null,"abstract":"The present study was aimed to investigate the Indigenous knowledge on cattle health care practices in selected villages located in foot bases of Azhagar hills in Madurai district, Tamil Nadu. The informations related to ethnoveterinary practices were collected through questionnaire as well as personal interviews during field trips made from August, 2014 to June, 2018. It has been shown that 41 medicinal plants of 24 families used by traditional healers to cure cattle diseases were documented from study sites. The ancestral traditional knowledge of people who have been using the native plants for the preparation of drugs and methods of their administration were recorded. From this present investigation, the practical knowledge of people in herbal medicines reveals that they are capable of treating various diseases.","PeriodicalId":352927,"journal":{"name":"Volume 4,Issue 1, 2019","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124510496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}