{"title":"阿育吠陀草药制剂Trasina®急性口服毒性的实验模型研究","authors":"S. Darbar, S. Chattopadhyay","doi":"10.30799/JPMR.036.19040102","DOIUrl":null,"url":null,"abstract":"Article history: Received 18 January 2019 Accepted 15 February 2019 Available online 01 April 2019 In the safety evaluation of a test substance, determination of acute oral toxicity is generally the initial step and provides information on health hazards that may arise from an acute exposure by the oral route. It may also provide early information on the mode of toxic action of a substance. The study was aimed to assess the possible toxic effects and to identify the preliminary safety profile of Trasina®, a polyherbal capsule (M/S Dey's Medical Stores Manufacturing Limited, Kolkata, West Bengal, India) after single oral administration in mice according to the OECD guidelines. In the present study, a single administration of the poly herbal extract at a dose of 2000 mg/kg, respectively, was given to the swiss albino mice. During the study period the mice were observed for general appearance, behavior, body weight, adverse effects, mortality and necropsy up to 14 days post-treatment. No toxicological changes or mortalities related to the test substance were also observed after the administration in experimental animals. No changes in general appearance and mortality was observed. Trasina was found to be safe at dose of 2000 mg/kg. In the conclusion these results demonstrate that the extract may not have any single dose toxicity.","PeriodicalId":352927,"journal":{"name":"Volume 4,Issue 1, 2019","volume":"99 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Assessment of Acute Oral Toxicity Study of Trasina®, an Ayurvedic Herbal Formulation on Experimental Models\",\"authors\":\"S. Darbar, S. Chattopadhyay\",\"doi\":\"10.30799/JPMR.036.19040102\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Article history: Received 18 January 2019 Accepted 15 February 2019 Available online 01 April 2019 In the safety evaluation of a test substance, determination of acute oral toxicity is generally the initial step and provides information on health hazards that may arise from an acute exposure by the oral route. It may also provide early information on the mode of toxic action of a substance. The study was aimed to assess the possible toxic effects and to identify the preliminary safety profile of Trasina®, a polyherbal capsule (M/S Dey's Medical Stores Manufacturing Limited, Kolkata, West Bengal, India) after single oral administration in mice according to the OECD guidelines. In the present study, a single administration of the poly herbal extract at a dose of 2000 mg/kg, respectively, was given to the swiss albino mice. During the study period the mice were observed for general appearance, behavior, body weight, adverse effects, mortality and necropsy up to 14 days post-treatment. No toxicological changes or mortalities related to the test substance were also observed after the administration in experimental animals. No changes in general appearance and mortality was observed. Trasina was found to be safe at dose of 2000 mg/kg. In the conclusion these results demonstrate that the extract may not have any single dose toxicity.\",\"PeriodicalId\":352927,\"journal\":{\"name\":\"Volume 4,Issue 1, 2019\",\"volume\":\"99 1\",\"pages\":\"0\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Volume 4,Issue 1, 2019\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.30799/JPMR.036.19040102\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Volume 4,Issue 1, 2019","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.30799/JPMR.036.19040102","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
文章历史:2019年1月18日收到2019年2月15日接受2019年4月1日在线提供2019年4月1日在测试物质的安全性评估中,急性口服毒性的测定通常是第一步,并提供有关口服途径急性暴露可能引起的健康危害的信息。它还可以提供关于物质毒性作用方式的早期信息。该研究的目的是评估可能的毒性作用,并确定Trasina®的初步安全性,Trasina®是一种多草药胶囊(M/S Dey's Medical Stores Manufacturing Limited, Kolkata, West Bengal, India)在小鼠单次口服后的安全性。在本研究中,分别以2000 mg/kg的剂量给瑞士白化病小鼠单次给药。在研究期间,观察小鼠的一般外观、行为、体重、不良反应、死亡率和尸检,直至治疗后14天。实验动物给药后未见与试验物质有关的毒理学变化或死亡。总体外观和死亡率未见变化。Trasina在2000mg /kg的剂量下是安全的。综上所述,这些结果表明,提取物可能没有任何单剂量毒性。
Assessment of Acute Oral Toxicity Study of Trasina®, an Ayurvedic Herbal Formulation on Experimental Models
Article history: Received 18 January 2019 Accepted 15 February 2019 Available online 01 April 2019 In the safety evaluation of a test substance, determination of acute oral toxicity is generally the initial step and provides information on health hazards that may arise from an acute exposure by the oral route. It may also provide early information on the mode of toxic action of a substance. The study was aimed to assess the possible toxic effects and to identify the preliminary safety profile of Trasina®, a polyherbal capsule (M/S Dey's Medical Stores Manufacturing Limited, Kolkata, West Bengal, India) after single oral administration in mice according to the OECD guidelines. In the present study, a single administration of the poly herbal extract at a dose of 2000 mg/kg, respectively, was given to the swiss albino mice. During the study period the mice were observed for general appearance, behavior, body weight, adverse effects, mortality and necropsy up to 14 days post-treatment. No toxicological changes or mortalities related to the test substance were also observed after the administration in experimental animals. No changes in general appearance and mortality was observed. Trasina was found to be safe at dose of 2000 mg/kg. In the conclusion these results demonstrate that the extract may not have any single dose toxicity.