The Journal of rheumatology. Supplement最新文献_第9页

Frequency of Symptomatic Adverse Events in Rheumatoid Arthritis: An Exploratory Online Survey 类风湿关节炎症状性不良事件的频率:一项探索性在线调查

The Journal of rheumatology. Supplement Pub Date : 2022-03-01 DOI: 10.3899/jrheum.210688

G. Hazlewood, O. Schieir, V. Bykerk, Kamso Mujaab, P. Tugwell, G. Wells, D. Richards, L. Proulx, Pauline M Hull, S. Bartlett

{"title":"Frequency of Symptomatic Adverse Events in Rheumatoid Arthritis: An Exploratory Online Survey","authors":"G. Hazlewood, O. Schieir, V. Bykerk, Kamso Mujaab, P. Tugwell, G. Wells, D. Richards, L. Proulx, Pauline M Hull, S. Bartlett","doi":"10.3899/jrheum.210688","DOIUrl":"https://doi.org/10.3899/jrheum.210688","url":null,"abstract":"Objective To generate initial data on the frequency and effect of symptomatic adverse events (AEs) associated with rheumatoid arthritis (RA) drug therapy from the patient perspective. Methods We conducted an exploratory online survey asking patients with RA to indicate whether they currently or had ever experienced the 80 different symptomatic AEs included in the Patient-Reported Outcomes of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). Results were summarized to report their frequency, and regression models were used to estimate their associations with RA medication use and overall bother. Results The 560 patients who completed the survey and reported taking ≥ 1 RA medication (disease-modifying antirheumatic drugs [DMARDs], steroids, nonsteroidal antiinflammatory drugs [NSAIDs]), had a mean disease duration of 8 years, and were on a wide range of DMARDs. The number of symptomatic AEs experienced in the past 7 days was none (6%), 1–10 (28%), 11–20 (28%), and > 20 (38%). Overall, most participants reported that side effects bothered them somewhat (28%), quite a bit (24%), or very much (15%). In multivariable regression analyses, current prednisone and NSAID use were associated with the greatest number of current side effects (26 and 22, respectively). Many of the strongest associations between current symptomatic AEs and medication use aligned with known side effect profiles. Conclusion In this exploratory online survey, patients with RA reported frequent symptomatic AEs with their medications that are bothersome. Further work is needed to develop and validate a measure for use in patients with rheumatic disease.","PeriodicalId":35278,"journal":{"name":"The Journal of rheumatology. Supplement","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88509870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Central Obesity in Axial Spondyloarthritis: The Missing Link to Understanding Worse Outcomes in Women? 中枢性肥胖与中枢性脊柱性关节炎:了解女性不良预后的缺失环节?

The Journal of rheumatology. Supplement Pub Date : 2022-03-01 DOI: 10.3899/jrheum.211062

S. Maguire, F. Wilson, P. Gallagher, F. O’Shea

{"title":"Central Obesity in Axial Spondyloarthritis: The Missing Link to Understanding Worse Outcomes in Women?","authors":"S. Maguire, F. Wilson, P. Gallagher, F. O’Shea","doi":"10.3899/jrheum.211062","DOIUrl":"https://doi.org/10.3899/jrheum.211062","url":null,"abstract":"Objective. To determine (1) the prevalence of central obesity in axial spondyloarthritis (axSpA) and its effect on disease-related outcomes and (2) how this differs between sexes. Methods. Data were extracted from the Ankylosing Spondylitis Registry of Ireland. Patients with physical measurements for the calculation of anthropometric measures were included. BMI and waist-to-hip ratio (WHR) were used to compare classifications of obesity. Comparison analyses based on sex and central obesity were carried out. Multivariate analysis examined the effects of these factors on the following patient-reported outcomes: the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the Bath Ankylosing Spondylitis Functional Index (BASFI), the Ankylosing Spondylitis Quality of Life (ASQoL) questionnaire, and the Health Assessment Questionnaire (HAQ). Results. In total, 753 patients were included in the analysis. Of these patients, 29.6% (n = 223) were classified as obese based on their BMI, and 41.3% (n = 311) were classified as centrally obese according to the WHR. The prevalence of central obesity was significantly higher among women with axSpA compared to men (71.6% vs 29.9%, P < 0.01). Central obesity had a clear effect on patient outcomes, regardless of sex. Presence of central obesity was associated with significantly worse BASFI scores (P < 0.01), HAQ scores (P < 0.01), and ASQoL questionnaire scores (P = 0.01), with a nonsignificant trend toward worse BASDAI scores (P = 0.07). Conclusion. There was a high prevalence of central obesity as assessed by the WHR in axSpA, most notably among women with axSpA. This modifiable comorbidity was significantly associated with worse quality of life, greater impairment of functional ability, and a trend toward worse disease activity. Regular use of the WHR to screen for central obesity as part of an axSpA assessment would provide an opportunity for prompt identification and intervention for at-risk patients.","PeriodicalId":35278,"journal":{"name":"The Journal of rheumatology. Supplement","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79094610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Association of Health Literacy and Numeracy With Lupus Knowledge and the Creation of the Lupus Knowledge Assessment Test 健康素养、算术与狼疮知识的关系及狼疮知识评估测验的创设

The Journal of rheumatology. Supplement Pub Date : 2022-03-01 DOI: 10.3899/jrheum.210708

Mithu Maheswaranathan, A. Eudy, A. C. Barr, C. Howe, J. Doss, R. Sadun, Lisa G. Criscione-Schreiber, K. Sun, Eliana M. Perrin, S. Bailey, S. Hastings, M. Clowse, Jennifer L Rogers

{"title":"Association of Health Literacy and Numeracy With Lupus Knowledge and the Creation of the Lupus Knowledge Assessment Test","authors":"Mithu Maheswaranathan, A. Eudy, A. C. Barr, C. Howe, J. Doss, R. Sadun, Lisa G. Criscione-Schreiber, K. Sun, Eliana M. Perrin, S. Bailey, S. Hastings, M. Clowse, Jennifer L Rogers","doi":"10.3899/jrheum.210708","DOIUrl":"https://doi.org/10.3899/jrheum.210708","url":null,"abstract":"Objective. Limited health literacy and numeracy are associated with worse patient-reported outcomes and higher disease activity in systemic lupus erythematosus (SLE), but which factors may mediate this association is unknown. We sought to determine the association of health literacy and numeracy with SLE knowledge. Methods. Patients with SLE were recruited from an academic center clinic. Participants completed validated assessments of health literacy (Newest Vital Sign [NVS]; n = 96) and numeracy (Numeracy Understanding in Medicine Instrument, Short Version [S-NUMI]; n = 85). They also completed the Lupus Knowledge Assessment Test (LKAT), which consists of 4 questions assessing SLE knowledge that were determined through consensus expert opinion for their wide applicability and importance related to self-management of the disease. Descriptive statistics and multivariable logistic regression modeling were used to analyze the results. Results. In our SLE cohort (n = 125), 33% (32/96) had limited health literacy and 76% (65/85) had limited numeracy. The majority correctly identified that hydroxychloroquine prevented SLE flares (91%); however, only 23% of participants correctly answered a numeracy question assessing which urine protein to creatinine (UPC) ratio was > 1000 mg/g. The mean LKAT score was 2.7 out of 4.0. Limited health literacy, but not numeracy, was associated with lower knowledge about SLE as measured by the LKAT, even after adjusting for education. Conclusion. Patients with SLE with limited health literacy had lower knowledge about SLE. The LKAT could be further refined and/or used as a screening tool to identify patients with knowledge gaps. Further work is needed to improve patients’ understanding of proteinuria and investigate whether literacy-sensitive education can improve care.","PeriodicalId":35278,"journal":{"name":"The Journal of rheumatology. Supplement","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86514572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Immunogenicity of COVID-19 Vaccination in Patients With Axial Spondyloarthritis: A Monocentric Prospective Belgian Cohort Study COVID-19疫苗接种对轴型脊柱炎患者的免疫原性:一项单中心前瞻性比利时队列研究

The Journal of rheumatology. Supplement Pub Date : 2022-03-01 DOI: 10.3899/jrheum.211313

T. Vandergraesen, L. Mekkaoui, H. Dahma, M. Soyfoo, L. Tant

引用次数: 1

COVID-19 Update for the GRAPPA 2021 Annual Meeting: Focus on COVID-19 Vaccination. GRAPPA 2021年年会的COVID-19更新:重点关注COVID-19疫苗接种。

The Journal of rheumatology. Supplement Pub Date : 2022-03-01 DOI: 10.3899/jrheum.211319

P. Mease, K. Winthrop, W. Olsder, J. Curtis

{"title":"COVID-19 Update for the GRAPPA 2021 Annual Meeting: Focus on COVID-19 Vaccination.","authors":"P. Mease, K. Winthrop, W. Olsder, J. Curtis","doi":"10.3899/jrheum.211319","DOIUrl":"https://doi.org/10.3899/jrheum.211319","url":null,"abstract":"The efficacy and safety of coronavirus disease 2019 (COVID-19) vaccination in patients with autoimmune inflammatory diseases (AIRDs) who are treated with immunomodulatory therapies was the focus of a symposium at the 2021 virtual annual meeting of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA). The keynote address was delivered by Dr. Jeffrey Curtis, chair of the American College of Rheumatology COVID-19 Vaccine Clinical Guidance task force, detailing what we do and do not know about vaccine efficacy and safety in patients with AIRDs and providing guidance about the need for modification of dosing in some immunomodulatory medications for optimal vaccine response. A consensus of the task force was that all patients with AIRDs should be vaccinated as soon as it is allowed in their respective locations, since the benefits of increased protection against COVID-19 infection outweigh the potential for vaccination reactions, including flares of underlying disease, or for reduced efficacy of vaccination because of disease state or medications. Key issues among patient research partners with psoriatic disease expressed in the premeeting survey and panel discussion/question-and-answer period included: vaccine efficacy and safety, the need to continue safe social habits and masking, how to assess efficacy of vaccination, how to deal with vaccine hesitancy among social contacts, medication management relative to vaccination, and concerns about the adequacy of ongoing telehealth visits vs the convenience of that technology.","PeriodicalId":35278,"journal":{"name":"The Journal of rheumatology. Supplement","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83525561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Looking Back and Marching Forward: New Features in 2022 回顾与前进:2022年的新特点

The Journal of rheumatology. Supplement Pub Date : 2022-03-01 DOI: 10.3899/jrheum.211412

Non Picart Riola, Lindsay E. Madden, E. Silverman

引用次数: 0

Correlation of Fibromyalgia Survey Questionnaire and Quantitative Sensory Testing Among Patients With Active Rheumatoid Arthritis 活动期类风湿关节炎患者纤维肌痛调查问卷与定量感觉测试的相关性

The Journal of rheumatology. Supplement Pub Date : 2021-07-20 DOI: 10.21203/RS.3.RS-715260/V1

M. N. Moore, Beth I Wallace, Jing Song, L. Muhammad, Andrew C. Heisler, D. Clauw, M. Bolster, W. Marder, T. Neogi, Alyssa Wohlfahrt, D. Dunlop, Yvonne C. Lee

{"title":"Correlation of Fibromyalgia Survey Questionnaire and Quantitative Sensory Testing Among Patients With Active Rheumatoid Arthritis","authors":"M. N. Moore, Beth I Wallace, Jing Song, L. Muhammad, Andrew C. Heisler, D. Clauw, M. Bolster, W. Marder, T. Neogi, Alyssa Wohlfahrt, D. Dunlop, Yvonne C. Lee","doi":"10.21203/RS.3.RS-715260/V1","DOIUrl":"https://doi.org/10.21203/RS.3.RS-715260/V1","url":null,"abstract":"Objective Patients with rheumatoid arthritis (RA) commonly demonstrate disordered pain processing associated with high pain sensitization. Pain sensitization is often assessed using quantitative sensory testing (QST), which is burdensome to patients. The self-administered Fibromyalgia Survey Questionnaire (FSQ) has been proposed as a low-burden, surrogate measure of central pain sensitization. We examined the correlation between FSQ and QST in patients with active RA. Methods Participants in the Central Pain in Rheumatoid Arthritis (CPIRA) cohort underwent FSQ and QST evaluation at enrollment. QST measures included pressure pain threshold (PPT) at the thumb, trapezius, wrist, and knee; temporal summation (TS) at the wrist and arm; and conditioned pain modulation (CPM). Partial Spearman correlation between FSQ and each QST measure was assessed, adjusted for demographic factors, study site, disease characteristics, and pain catastrophizing. Sensitivity analyses included (1) stratified analysis by sex and (2) evaluation of how each component of FSQ associates with the QST measures. Results Among 285 participants with active RA, FSQ was weakly but statistically significantly correlated with PPT (r range = –0.31 to –0.21), and TS (r range = 0.13-0.15) at all sites in unadjusted analyses. After adjustment, statistically significant correlations persisted for TS at the wrist and PPT at all sites (except the thumb). Sensitivity analyses did not identify differences in association based on sex or with individual FSQ components. Conclusion FSQ and QST were correlated among participants with active RA, but the strength of association was weak. QST and FSQ are not interchangeable measures of pain sensitization.","PeriodicalId":35278,"journal":{"name":"The Journal of rheumatology. Supplement","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74258398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Report of the Skin Research Working Groups From the GRAPPA 2020 Annual Meeting. GRAPPA 2020年年会皮肤研究工作组报告

The Journal of rheumatology. Supplement Pub Date : 2021-06-01 DOI: 10.3899/jrheum.201668

Lourdes M Perez-Chada, Alison Kohn, Alice B Gottlieb, April W Armstrong, Lihi Eder, Philip J Mease, Alexis Ogdie, Vibeke Strand, Joseph F Merola

引用次数: 3

GRAPPA Trainee Symposium 2020: A Summary of Oral and Poster Presentations. 2020年GRAPPA培训生研讨会:口头和海报报告总结。

The Journal of rheumatology. Supplement Pub Date : 2021-06-01 DOI: 10.3899/jrheum.201670

Christopher T Ritchlin, April Armstrong, Hanna Johnsson, Michelle L M Mulder

引用次数: 0

Magnetic Resonance Imaging of Axial and Peripheral Disease in Psoriatic Arthritis: A Report From the 2020 GRAPPA Annual Meeting. 银屑病关节炎中轴和外周疾病的磁共振成像:来自2020年GRAPPA年会上的报告

The Journal of rheumatology. Supplement Pub Date : 2021-06-01 DOI: 10.3899/jrheum.201676

Walter P Maksymowych, Mikkel Østergaard

引用次数: 0